NO20091334L - Fremgangsmate for syntese av klopidogrel og nye former for farmasoytisk akseptable salter derav - Google Patents

Fremgangsmate for syntese av klopidogrel og nye former for farmasoytisk akseptable salter derav

Info

Publication number
NO20091334L
NO20091334L NO20091334A NO20091334A NO20091334L NO 20091334 L NO20091334 L NO 20091334L NO 20091334 A NO20091334 A NO 20091334A NO 20091334 A NO20091334 A NO 20091334A NO 20091334 L NO20091334 L NO 20091334L
Authority
NO
Norway
Prior art keywords
clopidogrel
synthesis
pharmaceutically acceptable
acceptable salts
novel forms
Prior art date
Application number
NO20091334A
Other languages
English (en)
Norwegian (no)
Inventor
Rok Zupet
Igor Simonic
Primoz Benkic
Matej Smrkolj
Mitja Stukelj
Original Assignee
Krka Tovarna Zdravil Dd Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil Dd Novo Mesto filed Critical Krka Tovarna Zdravil Dd Novo Mesto
Publication of NO20091334L publication Critical patent/NO20091334L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
NO20091334A 2006-09-22 2009-03-31 Fremgangsmate for syntese av klopidogrel og nye former for farmasoytisk akseptable salter derav NO20091334L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200600220A SI22383A (sl) 2006-09-22 2006-09-22 Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
PCT/EP2007/060127 WO2008034912A2 (en) 2006-09-22 2007-09-24 Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof

Publications (1)

Publication Number Publication Date
NO20091334L true NO20091334L (no) 2009-04-22

Family

ID=39092310

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091334A NO20091334L (no) 2006-09-22 2009-03-31 Fremgangsmate for syntese av klopidogrel og nye former for farmasoytisk akseptable salter derav

Country Status (9)

Country Link
EP (1) EP2078025B1 (pl)
ES (1) ES2577294T3 (pl)
HR (1) HRP20160809T1 (pl)
HU (1) HUE029319T2 (pl)
NO (1) NO20091334L (pl)
PL (1) PL2078025T3 (pl)
SI (2) SI22383A (pl)
WO (1) WO2008034912A2 (pl)
ZA (1) ZA200902575B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
WO2011051976A2 (en) * 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
WO2012007019A1 (en) * 2010-07-13 2012-01-19 Pharmathen S.A. Process for the preparation of clopidogrel and salts thereof
CN102120745B (zh) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
US9815848B2 (en) * 2014-12-31 2017-11-14 Tianjin University Method for preparing spherical Clopidogrel Hydrogen Sulfate polymorph I
CN111606923B (zh) * 2020-06-24 2021-08-24 武汉理工大学 一种外消旋氯吡格雷的合成方法
CN118791459A (zh) * 2024-06-17 2024-10-18 山东信立泰药业有限公司 苯磺酸-2-噻吩乙酯的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
KR20060040758A (ko) * 2001-01-24 2006-05-10 카딜라 헬스케어 리미티드 티에노[3,2-ｃ]피리딘 유도체의 제조방법
CA2470479A1 (en) * 2001-12-18 2003-06-26 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
GB2393181A (en) * 2002-09-19 2004-03-24 Cipla Ltd Amorphous clopidogrel
WO2004108665A2 (en) * 2003-04-24 2004-12-16 Sun Pharmaceutical Industries Limited A process for preparation of clopidogrel
US20050059696A1 (en) * 2003-05-08 2005-03-17 Dr. Reddy's Laboratories Limited Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers
BR0318449A (pt) * 2003-08-04 2006-08-01 Wockhardt Ltd processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
HRP20160757T1 (hr) * 2004-04-19 2016-08-12 Krka, Tovarna Zdravil, D.D., Novo Mesto Postupak za proizvodnju polimorfnog oblika i od klopidogrel-vodik-sulfata
CZ20041048A3 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu
US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
KR20070094230A (ko) * 2006-03-17 2007-09-20 한미약품 주식회사 클로피도그렐 캄파술폰산염 또는 이의 결정다형을 함유하는약학 조성물

Also Published As

Publication number Publication date
SI22383A (sl) 2008-04-30
ZA200902575B (en) 2010-03-31
HUE029319T2 (en) 2017-02-28
WO2008034912A3 (en) 2008-08-07
EP2078025B1 (en) 2016-04-13
EP2078025A2 (en) 2009-07-15
HRP20160809T1 (hr) 2016-09-23
PL2078025T3 (pl) 2016-09-30
SI2078025T1 (sl) 2016-08-31
ES2577294T3 (es) 2016-07-14
WO2008034912A2 (en) 2008-03-27

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application