PL2078025T3 - Sposób syntezy klopidogrelu oraz nowe formy jego farmaceutycznie dopuszczalnych soli - Google Patents

Sposób syntezy klopidogrelu oraz nowe formy jego farmaceutycznie dopuszczalnych soli

Info

Publication number
PL2078025T3
PL2078025T3 PL07820533.3T PL07820533T PL2078025T3 PL 2078025 T3 PL2078025 T3 PL 2078025T3 PL 07820533 T PL07820533 T PL 07820533T PL 2078025 T3 PL2078025 T3 PL 2078025T3
Authority
PL
Poland
Prior art keywords
clopidogrel
synthesis
pharmaceutically acceptable
acceptable salts
new forms
Prior art date
Application number
PL07820533.3T
Other languages
English (en)
Inventor
Igor Simonic
Primoz Benkic
Rok Zupet
Matej Smrkolj
Mitja Stukelj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2078025T3 publication Critical patent/PL2078025T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
PL07820533.3T 2006-09-22 2007-09-24 Sposób syntezy klopidogrelu oraz nowe formy jego farmaceutycznie dopuszczalnych soli PL2078025T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI200600220A SI22383A (sl) 2006-09-22 2006-09-22 Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli

Publications (1)

Publication Number Publication Date
PL2078025T3 true PL2078025T3 (pl) 2016-09-30

Family

ID=39092310

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07820533.3T PL2078025T3 (pl) 2006-09-22 2007-09-24 Sposób syntezy klopidogrelu oraz nowe formy jego farmaceutycznie dopuszczalnych soli

Country Status (9)

Country Link
EP (1) EP2078025B1 (pl)
ES (1) ES2577294T3 (pl)
HR (1) HRP20160809T1 (pl)
HU (1) HUE029319T2 (pl)
NO (1) NO20091334L (pl)
PL (1) PL2078025T3 (pl)
SI (2) SI22383A (pl)
WO (1) WO2008034912A2 (pl)
ZA (1) ZA200902575B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
WO2011051976A2 (en) * 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
WO2012007019A1 (en) * 2010-07-13 2012-01-19 Pharmathen S.A. Process for the preparation of clopidogrel and salts thereof
CN102120745B (zh) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
US9815848B2 (en) * 2014-12-31 2017-11-14 Tianjin University Method for preparing spherical Clopidogrel Hydrogen Sulfate polymorph I
CN111606923B (zh) * 2020-06-24 2021-08-24 武汉理工大学 一种外消旋氯吡格雷的合成方法
CN118791459A (zh) * 2024-06-17 2024-10-18 山东信立泰药业有限公司 苯磺酸-2-噻吩乙酯的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
KR20060040758A (ko) * 2001-01-24 2006-05-10 카딜라 헬스케어 리미티드 티에노[3,2-ｃ]피리딘 유도체의 제조방법
CA2470479A1 (en) * 2001-12-18 2003-06-26 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
GB2393181A (en) * 2002-09-19 2004-03-24 Cipla Ltd Amorphous clopidogrel
WO2004108665A2 (en) * 2003-04-24 2004-12-16 Sun Pharmaceutical Industries Limited A process for preparation of clopidogrel
US20050059696A1 (en) * 2003-05-08 2005-03-17 Dr. Reddy's Laboratories Limited Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers
BR0318449A (pt) * 2003-08-04 2006-08-01 Wockhardt Ltd processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
HRP20160757T1 (hr) * 2004-04-19 2016-08-12 Krka, Tovarna Zdravil, D.D., Novo Mesto Postupak za proizvodnju polimorfnog oblika i od klopidogrel-vodik-sulfata
CZ20041048A3 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu
US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
KR20070094230A (ko) * 2006-03-17 2007-09-20 한미약품 주식회사 클로피도그렐 캄파술폰산염 또는 이의 결정다형을 함유하는약학 조성물

Also Published As

Publication number Publication date
SI22383A (sl) 2008-04-30
ZA200902575B (en) 2010-03-31
HUE029319T2 (en) 2017-02-28
WO2008034912A3 (en) 2008-08-07
NO20091334L (no) 2009-04-22
EP2078025B1 (en) 2016-04-13
EP2078025A2 (en) 2009-07-15
HRP20160809T1 (hr) 2016-09-23
SI2078025T1 (sl) 2016-08-31
ES2577294T3 (es) 2016-07-14
WO2008034912A2 (en) 2008-03-27

Similar Documents

Publication Publication Date Title
IL206500A0 (en) Process for the preparation of sitagliptin and pharmaceutically acceptable salts thereof
SI2086945T1 (sl) Novi postopek za pripravo statinov in njihovih farmacevtsko sprejemljivih soli
IL194522A0 (en) Process for the preparation of prasugrel
ZA200906899B (en) Process for preparation of erlotinib and its pharmaceutically acceptable salts
SI2024341T1 (sl) Novi postopek za statine in njihove farmacevtsko sprejemljive soli
IL198847A0 (en) New process for the preparation of 2-imino-thiazolidin-4-one derivatives
ZA200903889B (en) Process for the synthesis of moxifloxacin hydrochloride
SI1589005T1 (sl) Postopek sinteze ivabradina in njegovih farmacevtsko sprejemljivih kislinskih adicijskih soli
IL220430A0 (en) Process for the production of benzopyran-2-ol derivatives
ZA200806799B (en) Novel pyrone-indole derivatives and process for their preparation
EP2035410A4 (en) PROCESS FOR PREPARING ESOMEPRAZOLE AND ITS SALTS
IL226403A0 (en) A process for the synthesis of mendipropamide and its history
EP2069329A4 (en) PROCESS FOR THE PREPARATION OF BENZIMIDAZOLE DERIVATIVES AND THEIR SALTS
ZA200902451B (en) Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments
ZA200902575B (en) Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
IL205082A0 (en) Process for the preparation of tetranorlabdane derivatives
GB0606234D0 (en) Pharmaceutically acceptable salts and polymorphic forms
EP2121729A4 (en) PHARMACEUTICAL, SUBSTANTIVE SALTS OF THYMODEPRESSINE AND METHOD FOR THE PRODUCTION THEREOF
ZA201000802B (en) Process for the preparation of alfuzosin hydrochloride
SI2125761T1 (sl) Nov postopek za sintezo pramipeksola in njegovih farmacevtsko sprejemljivih soli
GB0613928D0 (en) Pharmaceutically acceptable salt and polymorphic forms
ZA201000159B (en) Process for the production of substituted 5-quinolyl-oxazoles and pharmaceutically acceptable salts thereof
PL1928883T3 (pl) Sposób otrzymywania chlorowodorku irynotekanu
GB0605344D0 (en) Pharmaceutically acceptable salts and polymorphic forms
HK1143142A (en) Process for the production of substituted 5-quinolyl-oxazoles and pharmaceutically acceptable salts thereof