NO20091826L - Fremgangsmater for dosering av oralt aktive 1,2,4-oksadiazol for nonsense mutasjonsuppresjonsterapi - Google Patents

Fremgangsmater for dosering av oralt aktive 1,2,4-oksadiazol for nonsense mutasjonsuppresjonsterapi

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Publication number
NO20091826L
NO20091826L NO20091826A NO20091826A NO20091826L NO 20091826 L NO20091826 L NO 20091826L NO 20091826 A NO20091826 A NO 20091826A NO 20091826 A NO20091826 A NO 20091826A NO 20091826 L NO20091826 L NO 20091826L
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NO
Norway
Prior art keywords
oxadiazole
nonsense
mutational
repression
therapy
Prior art date
Application number
NO20091826A
Other languages
English (en)
Other versions
NO342061B1 (no
Inventor
Samit Hirawat
Langdon Miller
Original Assignee
Ptc Therapeutics Inc
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39102963&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20091826(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of NO20091826L publication Critical patent/NO20091826L/no
Publication of NO342061B1 publication Critical patent/NO342061B1/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/16—Otologicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

Den foreliggende oppfinnelsen er relatert til spesifikke doser av og doseringsregimer for å benytte en 1,2,4-oksadiazolbenzosyreforbindelse i behandling eller forebygging av sykdommer assosiert med nonsense-mutasjoner. Spesielt er oppfinnelsen relatert til spesifikke doser og doseringsregimer for anvendelsen av 3-[5-(2-fluorfenyl)-[1,2,4]oksadiazol-3-yl]-benzosyre i pattedyr som har sykdommer assosiert med nonsense-mutasjoner.
NO20091826A 2006-10-12 2009-05-08 Forbindelse for behandling, forebygging eller håndtering av Duchenne muskulær dystrofi NO342061B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85145006P 2006-10-12 2006-10-12
PCT/US2007/021921 WO2008045566A1 (en) 2006-10-12 2007-10-11 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

Publications (2)

Publication Number Publication Date
NO20091826L true NO20091826L (no) 2009-07-08
NO342061B1 NO342061B1 (no) 2018-03-19

Family

ID=39102963

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091826A NO342061B1 (no) 2006-10-12 2009-05-08 Forbindelse for behandling, forebygging eller håndtering av Duchenne muskulær dystrofi

Country Status (23)

Country Link
US (7) US9226919B2 (no)
EP (2) EP2073805B1 (no)
JP (4) JP2010506840A (no)
KR (4) KR20160128468A (no)
CN (2) CN103211766B (no)
AU (1) AU2007308067B2 (no)
BR (2) BR122019020961B8 (no)
CA (1) CA2675518C (no)
CL (1) CL2007002923A1 (no)
DK (1) DK2073805T3 (no)
ES (1) ES2538359T3 (no)
HR (1) HRP20150590T1 (no)
IL (2) IL198147A (no)
MX (1) MX2009003909A (no)
NO (1) NO342061B1 (no)
PE (4) PE20160947A1 (no)
PL (1) PL2073805T3 (no)
PT (1) PT2073805E (no)
RS (1) RS54025B1 (no)
RU (1) RU2462247C2 (no)
SI (1) SI2073805T1 (no)
TW (1) TWI405570B (no)
WO (1) WO2008045566A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE047569T2 (hu) 2003-04-11 2020-04-28 Ptc Therapeutics Inc 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
RU2462246C2 (ru) * 2006-03-30 2012-09-27 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней
RS54025B1 (sr) * 2006-10-12 2015-10-30 Ptc Therapeutics Inc. Postupci doziranja oralno aktivnog 1,2,4-oksadiazola za supresionu terapiju nonsens mutacije
MY162940A (en) 2009-08-19 2017-07-31 Eisai R&D Man Co Ltd Quinoline derivative-containing pharmaceutical composition
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
KR102497273B1 (ko) * 2014-03-06 2023-02-07 피티씨 테라퓨틱스, 인크. 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염
PT3524595T (pt) 2014-08-28 2022-09-19 Eisai R&D Man Co Ltd Derivado de quinolina altamente puro e método para produção do mesmo
LT3263106T (lt) * 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
MX373231B (es) 2015-06-16 2020-05-08 Eisai R&D Man Co Ltd Agente anticancerigeno.
US12220398B2 (en) 2015-08-20 2025-02-11 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
JP2018531975A (ja) 2015-10-30 2018-11-01 ピーティーシー セラピューティクス，インコーポレーテッド てんかんの治療方法
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
EA202090980A1 (ru) 2017-10-19 2020-10-07 СИПЛА ЮЭсЭй, ИНК Синтез антибактериальных аминогликозидных аналогов
EP3713934B1 (en) 2017-11-23 2022-04-13 Universita' degli Studi di Palermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
EP3952867A4 (en) * 2019-04-10 2023-01-11 PTC Therapeutics, Inc. METHODS OF TREATMENT OF NONSENSE MUTATION MEDIATED DUCHENNE MUSCULAR DYSTROPHY IN PEDIATRIC PATIENTS
KR102378381B1 (ko) * 2021-08-23 2022-03-24 라이보텍(주) 넌센스-매개 mRNA 분해를 억제하기 위한 화합물
US20240156805A1 (en) * 2021-02-16 2024-05-16 Ribotech Co., Ltd. Compound for inhibiting nonsense-mediated mrna decay
EP4337267A1 (en) * 2021-05-11 2024-03-20 RegenxBio Inc. Treatment of duchenne muscular dystrophy and combinations thereof
KR102665711B1 (ko) * 2021-12-21 2024-05-14 재단법인 아산사회복지재단 Ras 활성도를 이용한 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 Ras 활성 억제제를 포함하는 신경섬유종증 예방 또는 치료용 약학적 조성물
CN119638642A (zh) * 2023-12-12 2025-03-18 暨南大学 双环类化合物及其药物组合物和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
JP2005504014A (ja) 2001-06-08 2005-02-10 サイトビア インコーポレイテッド カスパーゼの活性化因子およびアポトーシスの誘導因子としての置換された３−アリール−５−アリール−［１，２，４］−オキサジアゾール類および類似体、並びにその使用法
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
TW200424183A (en) 2002-08-09 2004-11-16 Nps Pharma Inc New compounds
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
HUE047569T2 (hu) 2003-04-11 2020-04-28 Ptc Therapeutics Inc 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
WO2004110351A2 (en) 2003-05-14 2004-12-23 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis c virus
US20050169992A1 (en) * 2003-12-23 2005-08-04 Frank Jao Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
PT2402002T (pt) * 2005-04-08 2018-10-08 Ptc Therapeutics Inc Composições de 1,2,4-oxadiazole oralmente activo para terapia de supressão de mutações nonsense
US20070010553A1 (en) 2005-07-01 2007-01-11 Astrazeneca Ab New use
MX2009002439A (es) 2006-09-08 2009-03-27 Ptc Therapeutics Inc Procesos para la preparacion de acidos 1,2,4-oxadiazolbenzoicos.
PL2076501T3 (pl) 2006-09-25 2016-06-30 Ptc Therapeutics Inc Postacie krystaliczne kwasu 3-[5-(2-fluorofenylo)[1,2,4]oksadiazol-3-ilo]-benzoesowego
RS54025B1 (sr) 2006-10-12 2015-10-30 Ptc Therapeutics Inc. Postupci doziranja oralno aktivnog 1,2,4-oksadiazola za supresionu terapiju nonsens mutacije

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BR122019020961B1 (pt) 2021-03-09
PT2073805E (pt) 2015-07-13
US20180140583A1 (en) 2018-05-24
MX2009003909A (es) 2009-05-25
KR101758341B1 (ko) 2017-07-14
PL2073805T3 (pl) 2015-08-31
RU2462247C2 (ru) 2012-09-27
TWI405570B (zh) 2013-08-21
JP6333227B2 (ja) 2018-05-30
DK2073805T3 (da) 2015-06-15
US20080114039A1 (en) 2008-05-15
PE20160947A1 (es) 2016-09-26
JP6129713B2 (ja) 2017-05-17
CA2675518A1 (en) 2008-04-17
IL198147A0 (en) 2009-12-24
CA2675518C (en) 2017-11-14
KR20150064244A (ko) 2015-06-10
PE20212245A1 (es) 2021-11-24
JP2014058533A (ja) 2014-04-03
IL236519A (en) 2017-03-30
BR122019020961B8 (pt) 2021-07-27
US20170304275A1 (en) 2017-10-26
BRPI0719276A2 (pt) 2014-04-29
US9737513B2 (en) 2017-08-22
EP2073805A1 (en) 2009-07-01
KR20090074231A (ko) 2009-07-06
CN101553226A (zh) 2009-10-07
PE20080982A1 (es) 2008-07-19
KR20160128468A (ko) 2016-11-07
AU2007308067A1 (en) 2008-04-17
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US20170049752A1 (en) 2017-02-23
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US20210038572A1 (en) 2021-02-11
IL236519A0 (en) 2015-02-26
RU2009117590A (ru) 2010-11-20
SI2073805T1 (sl) 2015-10-30
CN103211766A (zh) 2013-07-24
US20160101087A1 (en) 2016-04-14
US9877952B2 (en) 2018-01-30
PE20120670A1 (es) 2012-06-01
AU2007308067B2 (en) 2013-05-30
CN101553226B (zh) 2015-05-13
US10172836B2 (en) 2019-01-08
IL198147A (en) 2016-02-29
CL2007002923A1 (es) 2008-06-06
WO2008045566A1 (en) 2008-04-17
EP2073805B1 (en) 2015-03-04
ES2538359T3 (es) 2015-06-19
US9226919B2 (en) 2016-01-05
WO2008045566B1 (en) 2008-06-19
TW200820968A (en) 2008-05-16
CN103211766B (zh) 2015-03-11
HK1170690A1 (en) 2013-03-08
EP2460520A1 (en) 2012-06-06
JP2010506840A (ja) 2010-03-04
US10849885B2 (en) 2020-12-01
RS54025B1 (sr) 2015-10-30
HK1136214A1 (en) 2010-06-25
KR20170100072A (ko) 2017-09-01
NO342061B1 (no) 2018-03-19
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