NO20091830L - Spiro-piperidinderivater som VIa reseptorantagonister - Google Patents

Spiro-piperidinderivater som VIa reseptorantagonister

Info

Publication number: NO20091830L
Authority: NO; Norway
Prior art keywords: spiro; receptor antagonists; piperidine derivatives; via receptor; present
Prior art date: 2006-12-07

Application number

NO20091830A

Other languages

English (en)

Norwegian (no)

Inventor

Patrick Schnider

Hasane Ratni

Caterina Bissantz

Christophe Grundschober

Mark Rogers-Evans

Rafaello Masciadri

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-07

Filing date

2009-05-11

Publication date

2009-07-06

2009-05-11 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-07-06 Publication of NO20091830L publication Critical patent/NO20091830L/no

Links

239000002464 receptor antagonist Substances 0.000 title abstract 2
229940044551 receptor antagonist Drugs 0.000 title abstract 2
JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical class C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
-1 their preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Pregnancy & Childbirth (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

NO20091830A 2006-12-07 2009-05-11 Spiro-piperidinderivater som VIa reseptorantagonister NO20091830L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06125634		2006-12-07
PCT/EP2007/062985 WO2008068185A1 (en)	2006-12-07	2007-11-29	Spiro-piperidine derivatives as via receptor antagonists

Publications (1)

Publication Number	Publication Date
NO20091830L true NO20091830L (no)	2009-07-06

Family

ID=39295880

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20091830A NO20091830L (no)	2006-12-07	2009-05-11	Spiro-piperidinderivater som VIa reseptorantagonister

Country Status (21)

Country	Link
US (3)	US20080146568A1 (de)
EP (1)	EP2102207B1 (de)
JP (1)	JP2010511661A (de)
KR (1)	KR101050568B1 (de)
CN (1)	CN101547923A (de)
AR (1)	AR064135A1 (de)
AT (1)	ATE469900T1 (de)
AU (1)	AU2007328995B2 (de)
BR (1)	BRPI0720004A2 (de)
CA (1)	CA2670674A1 (de)
CL (1)	CL2007003482A1 (de)
DE (1)	DE602007006990D1 (de)
ES (1)	ES2344131T3 (de)
IL (1)	IL198544A (de)
MX (1)	MX2009005504A (de)
NO (1)	NO20091830L (de)
PE (1)	PE20081252A1 (de)
RU (1)	RU2009119394A (de)
TW (1)	TW200838518A (de)
WO (1)	WO2008068185A1 (de)
ZA (1)	ZA200903496B (de)

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CN101563324A (zh)	2006-12-22	2009-10-21	弗·哈夫曼-拉罗切有限公司	螺-哌啶衍生物
EP2285808B1 (de)	2008-04-29	2013-11-20	Novartis AG	Spiro-indolderivate zur behandlung parasitischer krankheiten
JP6629855B2 (ja)	2014-11-14	2020-01-15	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	スピロチアゾロン
CN108884096B (zh) *	2016-02-08	2022-03-22	豪夫迈·罗氏有限公司	作为ddr1抑制剂的螺二氢吲哚酮
SG11202001498QA (en)	2017-09-05	2020-03-30	Blackthorn Therapeutics Inc	Vasopressin receptor antagonists and products and methods related thereto

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US3370091A (en) *	1964-06-15	1968-02-20	Hoffmann La Roche	2 aminobenzhydrylhalides
US3531467A (en) *	1966-12-23	1970-09-29	Hoffmann La Roche	Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives
US4209625A (en) *	1977-04-21	1980-06-24	American Hoechst Corporation	Spiro[indoline-3,4'-piperidine]s
DE3818830A1 (de)	1988-06-03	1989-12-14	Boehringer Mannheim Gmbh	Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
CA2037287A1 (en)	1990-03-02	1991-09-03	Ben E. Evans	Spirocyclic oxytocin antagonists
DK78692D0 (da)	1992-06-12	1992-06-12	Lundbeck & Co As H	Dimere piperidin- og piperazinderivater
JPH08502474A (ja)	1992-10-07	1996-03-19	メルクエンドカンパニーインコーポレーテッド	トコリティックオキシトシンレセプターアンタゴニスト
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US7109229B2 (en)	2000-09-29	2006-09-19	Eli Lilly And Company	Methods and compounds for treating proliferative diseases
MXPA04004982A (es)	2001-11-27	2004-08-11	Hoffmann La Roche	Derivados de benzotiazol.
FR2833948B1 (fr)	2001-12-21	2004-02-06	Sod Conseils Rech Applic	Nouveaux derives de benzimidazole et leur utilisation en tant que medicament
US20040152741A1 (en)	2002-09-09	2004-08-05	Nps Allelix Corporation	Arylglycine derivatives and their use as glycine transport inhibitors
AU2003263155A1 (en)	2002-09-20	2004-04-08	H. Lundbeck A/S	Method for manufacture of dihydroisobenzofuran derivatives
JP2006505570A (ja)	2002-10-17	2006-02-16	アムジエン・インコーポレーテツド	ベンズイミダゾール誘導体およびそれのバニロイド受容体リガンドとしての使用
AU2003215549A1 (en)	2003-02-03	2004-08-30	Janssen Pharmaceutica N.V.	Mercaptoimidazoles as ccr2 receptor antagonists
US7244852B2 (en) *	2003-02-27	2007-07-17	Abbott Laboratories	Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
DE602004027171D1 (de) *	2003-04-11	2010-06-24	High Point Pharmaceuticals Llc	Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
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EP1885713A1 (de)	2005-05-18	2008-02-13	Pfizer Limited	1,2,4-triazolderivate als vasopressinantagonisten
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2007
- 2007-11-29 CN CNA2007800448317A patent/CN101547923A/zh active Pending
- 2007-11-29 AT AT07847502T patent/ATE469900T1/de active
- 2007-11-29 ES ES07847502T patent/ES2344131T3/es active Active
- 2007-11-29 AU AU2007328995A patent/AU2007328995B2/en not_active Expired - Fee Related
- 2007-11-29 RU RU2009119394/04A patent/RU2009119394A/ru not_active Application Discontinuation
- 2007-11-29 EP EP07847502A patent/EP2102207B1/de not_active Not-in-force
- 2007-11-29 MX MX2009005504A patent/MX2009005504A/es active IP Right Grant
- 2007-11-29 WO PCT/EP2007/062985 patent/WO2008068185A1/en not_active Ceased
- 2007-11-29 KR KR1020097011665A patent/KR101050568B1/ko not_active Expired - Fee Related
- 2007-11-29 DE DE602007006990T patent/DE602007006990D1/de active Active
- 2007-11-29 JP JP2009539707A patent/JP2010511661A/ja active Pending
- 2007-11-29 BR BRPI0720004-8A patent/BRPI0720004A2/pt not_active IP Right Cessation
- 2007-11-29 CA CA002670674A patent/CA2670674A1/en not_active Abandoned
- 2007-11-30 US US11/947,934 patent/US20080146568A1/en not_active Abandoned
- 2007-11-30 US US11/947,953 patent/US8202993B2/en not_active Expired - Fee Related
- 2007-11-30 US US11/947,967 patent/US20080139554A1/en not_active Abandoned
- 2007-12-04 CL CL200703482A patent/CL2007003482A1/es unknown
- 2007-12-04 TW TW096146114A patent/TW200838518A/zh unknown
- 2007-12-05 AR ARP070105426A patent/AR064135A1/es unknown
- 2007-12-06 PE PE2007001736A patent/PE20081252A1/es not_active Application Discontinuation
2009
- 2009-05-04 IL IL198544A patent/IL198544A/en not_active IP Right Cessation
- 2009-05-11 NO NO20091830A patent/NO20091830L/no not_active Application Discontinuation
- 2009-05-20 ZA ZA200903496A patent/ZA200903496B/xx unknown

Also Published As

Publication number	Publication date
US20080146568A1 (en)	2008-06-19
BRPI0720004A2 (pt)	2013-12-17
EP2102207B1 (de)	2010-06-02
IL198544A0 (en)	2010-02-17
AU2007328995B2 (en)	2012-04-26
RU2009119394A (ru)	2011-01-20
KR20090079255A (ko)	2009-07-21
CL2007003482A1 (es)	2008-07-04
US8202993B2 (en)	2012-06-19
CA2670674A1 (en)	2008-06-12
PE20081252A1 (es)	2008-09-04
ES2344131T3 (es)	2010-08-18
CN101547923A (zh)	2009-09-30
TW200838518A (en)	2008-10-01
AU2007328995A1 (en)	2008-06-12
KR101050568B1 (ko)	2011-07-19
EP2102207A1 (de)	2009-09-23
US20080139553A1 (en)	2008-06-12
AR064135A1 (es)	2009-03-18
DE602007006990D1 (de)	2010-07-15
JP2010511661A (ja)	2010-04-15
MX2009005504A (es)	2009-06-03
WO2008068185A1 (en)	2008-06-12
ZA200903496B (en)	2010-03-31
ATE469900T1 (de)	2010-06-15
IL198544A (en)	2012-06-28
US20080139554A1 (en)	2008-06-12

Legal Events

Date	Code	Title	Description
2011-06-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20092342L (no)	2009-07-02	Azaspiroderivativater
NO20091766L (no)	2009-07-06	Spiro-piperidinderivater
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NO20085100L (no)	2009-01-07	Nye forbindelser
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