NO20092103L - Tetrahydrocyklopenta[B]indolforbindelser som androgenreseptormodulatorer - Google Patents

Tetrahydrocyklopenta[B]indolforbindelser som androgenreseptormodulatorer

Info

Publication number
NO20092103L
NO20092103L NO20092103A NO20092103A NO20092103L NO 20092103 L NO20092103 L NO 20092103L NO 20092103 A NO20092103 A NO 20092103A NO 20092103 A NO20092103 A NO 20092103A NO 20092103 L NO20092103 L NO 20092103L
Authority
NO
Norway
Prior art keywords
formula
tetrahydrocyclopenta
androgen receptor
receptor modulators
compound
Prior art date
Application number
NO20092103A
Other languages
English (en)
Other versions
NO342531B1 (no
Inventor
Donald Paul Matthews
Jonathan Edward Green
Prabhakar Kondaji Jadhav
Konstantinos Gavardinas
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20092103L publication Critical patent/NO20092103L/no
Publication of NO342531B1 publication Critical patent/NO342531B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer en forbindelse med formelen: Formel (I) eller et farmasøytisk akseptabelt salt derav; farmasøytiske sammensetninger som innbefatter en forbindelse med formel (I) i kombinasjon med en passende bærer, fortynningsmiddel eller eksipient; og fremgangsmåter for behandling av fysiologiske forstyrrelser, særlig redusert benmasse, osteoporose, osteopeni eller redusert muskelmasse eller styrke, som innbefatter administrering av en forbindelse med formel (I), eller et farmasøytisk akseptabelt salt derav.
NO20092103A 2006-11-20 2009-05-28 Tetrahydrocyklopenta[b]indolforbindelser som androgenreseptormodulatorer NO342531B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86648406P 2006-11-20 2006-11-20
PCT/US2007/083745 WO2008063867A2 (en) 2006-11-20 2007-11-06 Tetrahydrocyclopenta[b] indole compounds as androgen receptor modulators

Publications (2)

Publication Number Publication Date
NO20092103L true NO20092103L (no) 2009-05-28
NO342531B1 NO342531B1 (no) 2018-06-11

Family

ID=39415431

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092103A NO342531B1 (no) 2006-11-20 2009-05-28 Tetrahydrocyklopenta[b]indolforbindelser som androgenreseptormodulatorer

Country Status (36)

Country Link
US (1) US7968587B2 (no)
EP (1) EP2094658B1 (no)
JP (1) JP5399259B2 (no)
KR (1) KR101121471B1 (no)
CN (1) CN101541749B (no)
AR (1) AR063559A1 (no)
AT (1) ATE538091T1 (no)
AU (1) AU2007324046B2 (no)
BR (1) BRPI0719092B8 (no)
CA (1) CA2670340C (no)
CL (1) CL2007003182A1 (no)
CO (1) CO6190513A2 (no)
CR (1) CR10802A (no)
CY (1) CY1112284T1 (no)
DK (1) DK2094658T3 (no)
EA (1) EA015627B1 (no)
EC (1) ECSP099350A (no)
ES (1) ES2376048T3 (no)
HR (1) HRP20120032T1 (no)
IL (1) IL198410A (no)
JO (1) JO2800B1 (no)
MA (1) MA31072B1 (no)
MX (1) MX2009005251A (no)
MY (1) MY154547A (no)
NO (1) NO342531B1 (no)
NZ (1) NZ576296A (no)
PE (1) PE20081161A1 (no)
PL (1) PL2094658T3 (no)
PT (1) PT2094658E (no)
RS (1) RS52191B (no)
SI (1) SI2094658T1 (no)
TN (1) TN2009000189A1 (no)
TW (1) TWI398438B (no)
UA (1) UA98777C2 (no)
WO (1) WO2008063867A2 (no)
ZA (1) ZA200903096B (no)

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Also Published As

Publication number Publication date
HRP20120032T1 (hr) 2012-02-29
JO2800B1 (en) 2014-03-15
BRPI0719092A2 (pt) 2013-12-03
US7968587B2 (en) 2011-06-28
MY154547A (en) 2015-06-30
PL2094658T3 (pl) 2012-05-31
US20100069404A1 (en) 2010-03-18
WO2008063867A2 (en) 2008-05-29
CL2007003182A1 (es) 2008-06-27
ZA200903096B (en) 2010-07-28
CN101541749B (zh) 2013-03-27
DK2094658T3 (da) 2012-02-13
EA015627B1 (ru) 2011-10-31
CY1112284T1 (el) 2015-12-09
UA98777C2 (en) 2012-06-25
ES2376048T3 (es) 2012-03-08
WO2008063867A3 (en) 2008-07-31
CA2670340C (en) 2014-05-20
PE20081161A1 (es) 2008-08-15
ECSP099350A (es) 2009-06-30
KR20090082229A (ko) 2009-07-29
TW200827347A (en) 2008-07-01
BRPI0719092B8 (pt) 2021-05-25
EA200970500A1 (ru) 2009-10-30
NO342531B1 (no) 2018-06-11
JP5399259B2 (ja) 2014-01-29
JP2010510231A (ja) 2010-04-02
IL198410A0 (en) 2010-02-17
KR101121471B1 (ko) 2012-02-28
TN2009000189A1 (en) 2010-10-18
AU2007324046A1 (en) 2008-05-29
AR063559A1 (es) 2009-02-04
BRPI0719092B1 (pt) 2020-08-18
ATE538091T1 (de) 2012-01-15
TWI398438B (zh) 2013-06-11
CN101541749A (zh) 2009-09-23
HK1134089A1 (en) 2010-04-16
CA2670340A1 (en) 2008-05-29
MA31072B1 (fr) 2010-01-04
RS52191B (sr) 2012-10-31
CR10802A (es) 2009-07-13
SI2094658T1 (sl) 2012-04-30
EP2094658B1 (en) 2011-12-21
IL198410A (en) 2013-09-30
NZ576296A (en) 2011-11-25
CO6190513A2 (es) 2010-08-19
EP2094658A2 (en) 2009-09-02
AU2007324046B2 (en) 2012-04-05
PT2094658E (pt) 2012-02-22
MX2009005251A (es) 2009-08-19

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