NO20092264L - Spiro-piperidinderivater - Google Patents

Spiro-piperidinderivater

Info

Publication number: NO20092264L
Authority: NO; Norway
Prior art keywords: present; spiro; piperidine; relates; compounds
Prior art date: 2006-12-22

Application number

NO20092264A

Other languages

English (en)

Norwegian (no)

Inventor

Patrick Schnider

Hasane Ratni

Christophe Grundschober

Mark Rogers-Evans

Rafaello Masciadri

Caterina Bissantz

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-22

Filing date

2009-06-12

Publication date

2009-06-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39301516&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20092264(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-06-12 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-06-24 Publication of NO20092264L publication Critical patent/NO20092264L/no

Links

JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical compound C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
-1 their preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Other In-Based Heterocyclic Compounds (AREA)

NO20092264A 2006-12-22 2009-06-12 Spiro-piperidinderivater NO20092264L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06127078		2006-12-22
PCT/EP2007/063882 WO2008077811A1 (en)	2006-12-22	2007-12-13	Spiro-piperidine derivatives

Publications (1)

Publication Number	Publication Date
NO20092264L true NO20092264L (no)	2009-06-24

Family

ID=39301516

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20092264A NO20092264L (no)	2006-12-22	2009-06-12	Spiro-piperidinderivater

Country Status (18)

Country	Link
US (3)	US7495008B2 (de)
EP (1)	EP2125726B1 (de)
JP (1)	JP2010513385A (de)
KR (1)	KR101122969B1 (de)
CN (1)	CN101563323B (de)
AR (1)	AR064480A1 (de)
AT (1)	ATE517866T1 (de)
AU (1)	AU2007338116B2 (de)
BR (1)	BRPI0720845A2 (de)
CA (1)	CA2674518A1 (de)
CL (1)	CL2007003719A1 (de)
ES (1)	ES2370047T3 (de)
MX (1)	MX2009006446A (de)
NO (1)	NO20092264L (de)
PE (1)	PE20081486A1 (de)
RU (1)	RU2009123134A (de)
TW (1)	TWI339663B (de)
WO (1)	WO2008077811A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101563323B (zh) *	2006-12-22	2012-07-04	弗·哈夫曼-拉罗切有限公司	螺-哌啶衍生物
TWI466885B (zh)	2009-07-31	2015-01-01	Japan Tobacco Inc	含氮螺環化合物及其醫藥用途
KR101923367B1 (ko) *	2011-02-02	2018-12-04	버텍스 파마슈티칼스 인코포레이티드	이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드
EA029167B1 (ru) *	2013-12-19	2018-02-28	Ф. Хоффманн-Ля Рош Аг	Спиро-оксазолоны
CN104557777B (zh) *	2015-01-09	2016-08-31	万华化学集团股份有限公司	一种n-甲基哌嗪的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0450761A1 (de) *	1990-03-02	1991-10-09	Merck & Co. Inc.	Spirocyclische Oxtocin-Antagonisten
WO1994007496A1 (en)	1992-10-07	1994-04-14	Merck & Co., Inc.	Tocolytic oxytocin receptor antagonists
US5576321A (en)	1995-01-17	1996-11-19	Eli Lilly And Company	Compounds having effects on serotonin-related systems
US6166209A (en)	1997-12-11	2000-12-26	Hoffmann-La Roche Inc.	Piperidine derivatives
TWI279402B (en) *	1999-08-20	2007-04-21	Banyu Pharma Co Ltd	Spiro compounds having NPY antagonistic activities and agents containing the same
EP1347982B1 (de)	2000-12-12	2005-11-16	Neurogen Corporation	Spiro[isobenzofuran-1,4'-piperidin]-3-one und 3h-spiroisobenzofuran-1,4'-piperidine
US6596718B1 (en)	2001-11-27	2003-07-22	Hoffmann-La Roche Inc.	7-Morpholin-4yl-benzothiazole amide derivatives
EA010132B1 (ru) *	2003-12-22	2008-06-30	Пфайзер Инк.	Производные триазола в качестве антагонистов вазопрессина
CN101563323B (zh) *	2006-12-22	2012-07-04	弗·哈夫曼-拉罗切有限公司	螺-哌啶衍生物

2007
- 2007-12-13 CN CN2007800467055A patent/CN101563323B/zh not_active Expired - Fee Related
- 2007-12-13 AT AT07857529T patent/ATE517866T1/de active
- 2007-12-13 AU AU2007338116A patent/AU2007338116B2/en not_active Expired - Fee Related
- 2007-12-13 ES ES07857529T patent/ES2370047T3/es active Active
- 2007-12-13 RU RU2009123134/04A patent/RU2009123134A/ru not_active Application Discontinuation
- 2007-12-13 US US11/955,425 patent/US7495008B2/en not_active Expired - Fee Related
- 2007-12-13 MX MX2009006446A patent/MX2009006446A/es active IP Right Grant
- 2007-12-13 EP EP07857529A patent/EP2125726B1/de not_active Not-in-force
- 2007-12-13 JP JP2009542007A patent/JP2010513385A/ja active Pending
- 2007-12-13 KR KR1020097012843A patent/KR101122969B1/ko not_active Expired - Fee Related
- 2007-12-13 US US11/955,434 patent/US7678806B2/en not_active Expired - Fee Related
- 2007-12-13 BR BRPI0720845-6A patent/BRPI0720845A2/pt not_active IP Right Cessation
- 2007-12-13 CA CA002674518A patent/CA2674518A1/en not_active Abandoned
- 2007-12-13 US US11/955,440 patent/US7501432B2/en not_active Expired - Fee Related
- 2007-12-13 WO PCT/EP2007/063882 patent/WO2008077811A1/en not_active Ceased
- 2007-12-14 PE PE2007001812A patent/PE20081486A1/es not_active Application Discontinuation
- 2007-12-19 TW TW096148784A patent/TWI339663B/zh not_active IP Right Cessation
- 2007-12-20 CL CL200703719A patent/CL2007003719A1/es unknown
- 2007-12-20 AR ARP070105763A patent/AR064480A1/es not_active Application Discontinuation
2009
- 2009-06-12 NO NO20092264A patent/NO20092264L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20080280898A1 (en)	2008-11-13
CA2674518A1 (en)	2008-07-03
RU2009123134A (ru)	2011-01-27
ATE517866T1 (de)	2011-08-15
US20080167333A1 (en)	2008-07-10
EP2125726B1 (de)	2011-07-27
EP2125726A1 (de)	2009-12-02
TWI339663B (en)	2011-04-01
WO2008077811A1 (en)	2008-07-03
AR064480A1 (es)	2009-04-01
US20080161304A1 (en)	2008-07-03
US7678806B2 (en)	2010-03-16
MX2009006446A (es)	2009-06-26
PE20081486A1 (es)	2008-10-18
CL2007003719A1 (es)	2008-07-11
US7501432B2 (en)	2009-03-10
US7495008B2 (en)	2009-02-24
ES2370047T3 (es)	2011-12-12
TW200833696A (en)	2008-08-16
KR20090082505A (ko)	2009-07-30
BRPI0720845A2 (pt)	2014-03-04
KR101122969B1 (ko)	2012-03-22
AU2007338116A1 (en)	2008-07-03
CN101563323A (zh)	2009-10-21
CN101563323B (zh)	2012-07-04
AU2007338116B2 (en)	2012-04-26
JP2010513385A (ja)	2010-04-30

Legal Events

Date	Code	Title	Description
2013-07-29	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
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NO20070199L (no)	2007-01-11	Substituerte kinazoloner som anti-kreftmidler
NO20074258L (no)	2007-11-27	Pyridin-2-karboksamidderivater som MGLUR5 antagonister
NO20073876L (no)	2007-09-10	Pyrazolopyrimidinderivater som mGluR2-antagonister
NO20063469L (no)	2006-11-15	Polyeheterosykliske forbindelser og deres anvendelse som metabotrofe glutamat reseptorantagonister
NO20090328L (no)	2009-01-26	Nye forbindelser 385
NO20082709L (no)	2008-08-13	Kjemiske forbindelser
NO20072784L (no)	2007-07-17	Pyridenkarboksamidderivater for anvendelse som anticancer midler
NO20076060L (no)	2007-12-28	Piperidin-4-yl-amidderivater og deres anvendelse som SST-reseptor subtype 5-antagonister
NO20085100L (no)	2009-01-07	Nye forbindelser
NO20076197L (no)	2008-02-29	Nye 2-azetidinonderivater anvendbare i behandling av hyperlipidemiske tilstander
NO20070489L (no)	2007-03-07	3-aminocyklopentankarboksamider som modulatorer av kjemokinreseptorer.
NO20092689L (no)	2009-09-14	Quinuclidinolderivater som muskarin reseptorantagonister
NO20090327L (no)	2009-02-09	Nye forbindelser 384
NO20076195L (no)	2008-02-27	Nye 2-azetidinonderivater for behandling av hyperlipidemiske sykdommer
NO20084363L (no)	2008-11-17	2-Substituerte 4-benzylftalazinonderivater som histamin H1- og H3-antagonister
NO20065456L (no)	2007-01-04	Substituerte morfolinforbindelser for behandling av sykdommer i sentralnervesystemet
NO20076638L (no)	2007-12-21	Nye 8-sulfonylamino-3-aminosubstituerte kroman- eller tetrahydronaftalenderivater som modulerer 5HT6-reseptoren
NO20055688L (no)	2006-01-09	Organiske forbindelser
MX2009007411A (es)	2009-07-17	Derivados de espiropiperidina-glicinamida.