NO20092389L - Fremgangsmate for fremstilling av precursorforbindelse for radioaktivt halogenmerket organisk forbindelse - Google Patents

Fremgangsmate for fremstilling av precursorforbindelse for radioaktivt halogenmerket organisk forbindelse

Info

Publication number
NO20092389L
NO20092389L NO20092389A NO20092389A NO20092389L NO 20092389 L NO20092389 L NO 20092389L NO 20092389 A NO20092389 A NO 20092389A NO 20092389 A NO20092389 A NO 20092389A NO 20092389 L NO20092389 L NO 20092389L
Authority
NO
Norway
Prior art keywords
compound
preparation
base
carbon atoms
sight
Prior art date
Application number
NO20092389A
Other languages
English (en)
Other versions
NO343437B1 (no
Inventor
Masahito Toyama
Akio Hayashi
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of NO20092389L publication Critical patent/NO20092389L/no
Publication of NO343437B1 publication Critical patent/NO343437B1/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)

Abstract

En fremgangsmåte for fremstilling av en merket forløper som er anvendelig for fremstilling av en radioaktiv fluormerket aminosyreforbindelse er tilveiebrakt. I reaksjonstrinnet for å introdusere en utgående gruppe til en blanding av syn-form og anti-form av FACBC er en base til stede i reaksjonssystemet for å fremstille et synutgående gruppeaddukt som ikke er reaktivt med basen og er svært stabilt og et antiutgående gruppeaddukt som kan reagere med basen for å danne en vannløselig forbindelse. Ved å anvende en renset fremgangsmåte som utnytter en slik forskjell i løselighet kan syn-utgående gruppeadduktet separeres selektivt. Basen kan være et lineærkjedet eller forgrenet primært til tertiært alkylamin som har I til 10 karbonatomer, en nitrogeninneholdende heterosyklisk forbindelse med 2 til 20 karbonatomer og nitrogeninneholdende heteroaromatisk forbindelse med 2 til 20 karbonatomer.
NO20092389A 2006-12-27 2009-06-23 Fremgangsmåte for fremstilling av forløperforbindelse for radioaktiv fluormerket organisk forbindelse NO343437B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006351883 2006-12-27
PCT/JP2007/074220 WO2008078589A1 (ja) 2006-12-27 2007-12-17 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法

Publications (2)

Publication Number Publication Date
NO20092389L true NO20092389L (no) 2009-09-21
NO343437B1 NO343437B1 (no) 2019-03-11

Family

ID=39562382

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20181508A NO345488B1 (no) 2006-12-27 2007-12-17 Fremgangsmåte for fremstilling av forløperforbindelse for radioaktiv fluormerket organisk forbindelse
NO20092389A NO343437B1 (no) 2006-12-27 2009-06-23 Fremgangsmåte for fremstilling av forløperforbindelse for radioaktiv fluormerket organisk forbindelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20181508A NO345488B1 (no) 2006-12-27 2007-12-17 Fremgangsmåte for fremstilling av forløperforbindelse for radioaktiv fluormerket organisk forbindelse

Country Status (12)

Country Link
US (1) US8563771B2 (no)
EP (2) EP3530648B1 (no)
JP (1) JP5518337B2 (no)
KR (1) KR101408727B1 (no)
CN (1) CN101573330B (no)
AU (1) AU2007337481B2 (no)
BR (1) BRPI0720465B8 (no)
CA (1) CA2672914C (no)
NO (2) NO345488B1 (no)
RU (1) RU2466984C2 (no)
TW (1) TWI402079B (no)
WO (1) WO2008078589A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2428415C2 (ru) 2005-11-29 2011-09-10 Нихон Меди-Физикс Ко., Лтд. Соединение-предшественник органического соединения, меченного радиоактивным галогеном
US20110184159A1 (en) * 2008-07-07 2011-07-28 Bayer Schering Pharma Aktiengesellschaft Process for production of radiopharmaceuticals
ES2643500T3 (es) * 2010-11-29 2017-11-23 Blue Earth Diagnostics Limited Preparación de precursor de PET
GB201021523D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
MX2013007186A (es) * 2010-12-20 2013-07-12 Ge Healthcare Ltd Purificacion de compuesto precursor mediante cristalizacion.
GB201021530D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
KR101904565B1 (ko) * 2011-03-08 2018-10-04 지이 헬쓰케어 리미티드 1-아미노-3-히드록시-시클로부탄-1-카르복실산 유도체의 제조
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
CN110312704A (zh) * 2017-03-07 2019-10-08 日本医事物理股份有限公司 放射性氟标记前体化合物及使用其的放射性氟标记化合物的制造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808146A (en) 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
JP2004056725A (ja) * 2002-07-24 2004-02-19 Matsushita Electric Works Ltd 設備管理サーバ、設備監視制御システムおよび設備管理サーバ用プログラム
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
GB0422004D0 (en) 2004-10-05 2004-11-03 Amersham Plc Method of deprotection
AU2006250594B2 (en) * 2005-05-23 2011-06-16 Nihon Medi-Physics Co., Ltd. Novel organic compound and method for producing radioactive halogen-labeled organic compound using the same
CA2612187C (en) * 2005-06-23 2013-05-07 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
RU2428415C2 (ru) * 2005-11-29 2011-09-10 Нихон Меди-Физикс Ко., Лтд. Соединение-предшественник органического соединения, меченного радиоактивным галогеном
PT2017258E (pt) 2006-05-11 2012-04-12 Nihon Mediphysics Co Ltd Processo de produção de um composto orgânico marcado com flúor radioactivo

Also Published As

Publication number Publication date
CN101573330A (zh) 2009-11-04
EP2128130A1 (en) 2009-12-02
CA2672914A1 (en) 2008-07-03
TW200826965A (en) 2008-07-01
NO345488B1 (no) 2021-03-01
WO2008078589A1 (ja) 2008-07-03
BRPI0720465B1 (pt) 2018-11-27
BRPI0720465A2 (pt) 2014-01-14
BRPI0720465B8 (pt) 2021-07-27
HK1135372A1 (en) 2010-06-04
EP2128130B1 (en) 2018-10-10
NO343437B1 (no) 2019-03-11
CN101573330B (zh) 2015-04-08
AU2007337481A1 (en) 2008-07-03
AU2007337481B2 (en) 2012-02-09
TWI402079B (zh) 2013-07-21
KR101408727B1 (ko) 2014-06-17
US20100016626A1 (en) 2010-01-21
EP3530648B1 (en) 2023-11-08
EP3530648A1 (en) 2019-08-28
EP2128130A4 (en) 2012-01-04
RU2466984C2 (ru) 2012-11-20
US8563771B2 (en) 2013-10-22
RU2009128664A (ru) 2011-02-10
JP5518337B2 (ja) 2014-06-11
NO20181508A1 (no) 2009-09-21
JPWO2008078589A1 (ja) 2010-04-22
KR20090093969A (ko) 2009-09-02
CA2672914C (en) 2014-02-04

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