NO20092759L - 2-substituerte-6-heterosykliske pyrimidonderivater som tauproteinkinase-1-inhibitorer - Google Patents

2-substituerte-6-heterosykliske pyrimidonderivater som tauproteinkinase-1-inhibitorer

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Publication number
NO20092759L
NO20092759L NO20092759A NO20092759A NO20092759L NO 20092759 L NO20092759 L NO 20092759L NO 20092759 A NO20092759 A NO 20092759A NO 20092759 A NO20092759 A NO 20092759A NO 20092759 L NO20092759 L NO 20092759L
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Norway
Prior art keywords
substituted
protein kinase
tau protein
heterocyclic
inhibitors
Prior art date
Application number
NO20092759A
Other languages
English (en)
Inventor
Fumiaki Uehara
Kazutoshi Watanabe
Kenji Fukunaga
Toshiyuki Kohara
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of NO20092759L publication Critical patent/NO20092759L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
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  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

en optisk aktiv isomer derav eller et farmasøytisk akseptabelt salt derav, hvori hver R1 står for et hydrogenatom eller lignende; X står for et oksygenatom eller lignende; A står for en C3-C7 syklo- alkylgruppe, en C6-C10 arylgruppe eller en heterosyklisk gruppe; R6 står for et halogenatom eller lignende; s står for 0 eller et heltall fra 1 til 5; Q står for en pyridinring som kan være substituert eller en pyrimidinring; og R2 står for et hydrogenatom eller lignende, som anvendes for forebyggende og/eller terapeutisk behandling av en sykdom som skyldes unormal aktivitet av tau-protein-kinase 1, f.eks. en nevrodegenera-tiv sykdom (f.eks. Alzheimers sykdom) .
NO20092759A 2006-12-26 2009-07-24 2-substituerte-6-heterosykliske pyrimidonderivater som tauproteinkinase-1-inhibitorer NO20092759L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006357476 2006-12-26
PCT/JP2007/075380 WO2008078837A1 (en) 2006-12-26 2007-12-26 2-substituted-6-heterocyclic pyrimidone derivatives as tau protein kinase 1 inhbitors

Publications (1)

Publication Number Publication Date
NO20092759L true NO20092759L (no) 2009-08-25

Family

ID=39144331

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092759A NO20092759L (no) 2006-12-26 2009-07-24 2-substituerte-6-heterosykliske pyrimidonderivater som tauproteinkinase-1-inhibitorer

Country Status (16)

Country Link
US (1) US8592417B2 (no)
EP (1) EP2097409B1 (no)
JP (1) JP5250553B2 (no)
KR (1) KR20090092314A (no)
CN (1) CN101652361A (no)
AR (1) AR064660A1 (no)
AU (1) AU2007339164A1 (no)
CA (1) CA2674557A1 (no)
EA (1) EA200970637A1 (no)
IL (1) IL199378A0 (no)
MX (1) MX2009006947A (no)
NO (1) NO20092759L (no)
NZ (1) NZ577803A (no)
TW (1) TW200845997A (no)
WO (1) WO2008078837A1 (no)
ZA (1) ZA200904236B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200813015A (en) * 2006-03-15 2008-03-16 Mitsubishi Pharma Corp 2-(cyclic amino)-pyrimidone derivatives
EP2193129B1 (en) * 2007-09-14 2012-10-24 Mitsubishi Tanabe Pharma Corporation 6-pyrimidinyl-pyrimid-2-one derivative
TW201043618A (en) 2009-03-10 2010-12-16 Sanofi Aventis Intermediate compound for synthesizing pharmaceutical agent and production method thereof
EP2464632A1 (en) 2009-08-13 2012-06-20 Mitsubishi Tanabe Pharma Corporation Pyrimidone derivatives used as tau protein kinase 1 inhibitors
EP2464639A1 (en) 2009-08-13 2012-06-20 Mitsubishi Tanabe Pharma Corporation Pyrimidone derivatives used as tau protein kinase 1 inhibitors
KR101631003B1 (ko) * 2012-01-12 2016-06-15 에프. 호프만-라 로슈 아게 미량 아민 결합 수용체(taar)로서 헤테로환형 유도체
US10421756B2 (en) 2015-07-06 2019-09-24 Rodin Therapeutics, Inc. Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
LT3319959T (lt) 2015-07-06 2021-12-27 Alkermes, Inc. Histono deacetilazės hetero-halogeno inhibitoriai
ES2909086T3 (es) 2017-01-11 2022-05-05 Alkermes Inc Inhibidores bicíclicos de histona desacetilasa
SG11202000970WA (en) 2017-08-07 2020-02-27 Rodin Therapeutics Inc Bicyclic inhibitors of histone deacetylase
JP7382944B2 (ja) * 2018-02-06 2023-11-17 シャンハイ ファーマシューティカルズ ホールディング カンパニー，リミティド 神経変性疾患を予防・治療するための新規な化合物及びその応用
CN115322197B (zh) * 2022-06-27 2023-09-29 北京师范大学 与Tau蛋白具有亲和力的咪唑并萘啶类化合物及其制备方法与应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI241298B (en) 1998-09-25 2005-10-11 Mitsubishi Chem Corp Pyrimidone derivatives
AU2001262150A1 (en) 2000-03-23 2001-10-03 Mitsubishi Pharma Corporation 2-(nitrogen-heterocyclic)pyrimidone derivatives
MXPA04002661A (es) 2001-09-21 2004-11-22 Sanofi Aventis Derivados de pirimidona 4, 3-sustituida.
ES2323576T3 (es) 2001-09-21 2009-07-21 Mitsubishi Tanabe Pharma Corporation Derivados de 4-pirimidona 3-sustituida.
TWI357408B (en) * 2003-03-26 2012-02-01 Mitsubishi Tanabe Pharma Corp 3-substituted-4-pyrimidone derivatives
AR050865A1 (es) 2004-09-09 2006-11-29 Sanofi Aventis Derivados de 2- morfolino-4-pirimidona
JP5186213B2 (ja) * 2004-09-29 2013-04-17 田辺三菱製薬株式会社 タウプロテインキナーゼ１阻害剤としての６−ピリジニル−４−ピリミドン誘導体
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
TW200813015A (en) 2006-03-15 2008-03-16 Mitsubishi Pharma Corp 2-(cyclic amino)-pyrimidone derivatives
CA2698818A1 (en) 2007-09-14 2009-03-19 Sanofi-Aventis 3-methyl-2- ( (2s) -2- (4- (3-methyl-1, 2, 4-oxadiazol-5-yl) phenyl) morpholino) -6- (pyrimidin-4-yl) pyrimidin-4 (3h) -one as tau protein kinase inhibitor

Also Published As

Publication number Publication date
CN101652361A (zh) 2010-02-17
NZ577803A (en) 2011-11-25
WO2008078837A1 (en) 2008-07-03
CA2674557A1 (en) 2008-07-03
JP2010514670A (ja) 2010-05-06
US20100113775A1 (en) 2010-05-06
IL199378A0 (en) 2010-03-28
JP5250553B2 (ja) 2013-07-31
EA200970637A1 (ru) 2009-12-30
AR064660A1 (es) 2009-04-15
ZA200904236B (en) 2010-08-25
EP2097409A1 (en) 2009-09-09
MX2009006947A (es) 2009-07-10
TW200845997A (en) 2008-12-01
US8592417B2 (en) 2013-11-26
EP2097409B1 (en) 2012-09-12
AU2007339164A1 (en) 2008-07-03
KR20090092314A (ko) 2009-08-31

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