NO2479174T3 - - Google Patents
Info
- Publication number
- NO2479174T3 NO2479174T3 NO10814867A NO10814867A NO2479174T3 NO 2479174 T3 NO2479174 T3 NO 2479174T3 NO 10814867 A NO10814867 A NO 10814867A NO 10814867 A NO10814867 A NO 10814867A NO 2479174 T3 NO2479174 T3 NO 2479174T3
- Authority
- NO
- Norway
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101958233A CN102020639A (zh) | 2009-09-14 | 2009-09-14 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
| PCT/CN2010/001293 WO2011029265A1 (zh) | 2009-09-14 | 2010-08-26 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2479174T3 true NO2479174T3 (de) | 2018-03-17 |
Family
ID=43731939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO10814867A NO2479174T3 (de) | 2009-09-14 | 2010-08-26 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8901140B2 (de) |
| EP (1) | EP2479174B1 (de) |
| JP (1) | JP5684811B2 (de) |
| KR (1) | KR101738191B1 (de) |
| CN (2) | CN102020639A (de) |
| AU (1) | AU2010292790B2 (de) |
| BR (1) | BR112012005760A2 (de) |
| CA (1) | CA2774099C (de) |
| DK (1) | DK2479174T3 (de) |
| ES (1) | ES2647829T3 (de) |
| HR (1) | HRP20171748T1 (de) |
| HU (1) | HUE035873T2 (de) |
| LT (1) | LT2479174T (de) |
| MX (1) | MX2012002875A (de) |
| NO (1) | NO2479174T3 (de) |
| PL (1) | PL2479174T3 (de) |
| PT (1) | PT2479174T (de) |
| RU (1) | RU2536102C2 (de) |
| SI (1) | SI2479174T1 (de) |
| WO (1) | WO2011029265A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020639A (zh) | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
| CN102675287A (zh) * | 2011-03-11 | 2012-09-19 | 江苏恒瑞医药股份有限公司 | (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用 |
| CN103717590B (zh) * | 2011-05-17 | 2016-05-11 | 江苏康缘药业股份有限公司 | 喹唑啉-7-醚化合物及使用方法 |
| JP6437820B2 (ja) * | 2011-07-27 | 2018-12-12 | シャンハイ ファーマシューティカルズ ホールディング カンパニー，リミティド | キナゾリン誘導体、その製造方法、中間体、組成物及びその適用 |
| WO2013131424A1 (zh) * | 2012-03-09 | 2013-09-12 | 上海恒瑞医药有限公司 | 4-喹唑啉胺类衍生物及其用途 |
| CN103539783A (zh) * | 2012-07-12 | 2014-01-29 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的二马来酸盐的i型结晶及制备方法 |
| CN103588755B (zh) * | 2012-08-17 | 2016-06-22 | 正大天晴药业集团股份有限公司 | Neratinib的制备方法 |
| CN103965120B (zh) * | 2013-01-25 | 2016-08-17 | 上海医药集团股份有限公司 | 喹啉及喹唑啉衍生物、制备方法、中间体、组合物及应用 |
| TWI609012B (zh) | 2013-04-28 | 2017-12-21 | 廣東東陽光藥業有限公司 | 氨基喹唑啉類衍生物及其鹽和使用方法 |
| WO2015085654A1 (zh) | 2013-12-12 | 2015-06-18 | 天津合美医药科技有限公司 | 喹唑啉衍生物 |
| CN106068262B (zh) * | 2014-04-11 | 2019-10-29 | 海思科医药集团股份有限公司 | 喹唑啉衍生物及其制备方法和在医药上的应用 |
| CN107405345A (zh) | 2016-01-27 | 2017-11-28 | 江苏恒瑞医药股份有限公司 | 一种含有喹啉衍生物或其盐的药物组合物的制备方法 |
| TWI726978B (zh) | 2016-01-27 | 2021-05-11 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種含有喹啉衍生物或其鹽的藥物組成物 |
| WO2017129094A1 (zh) * | 2016-01-28 | 2017-08-03 | 江苏恒瑞医药股份有限公司 | 一种egfr/her2受体酪氨酸激酶抑制剂在制备治疗her2突变癌症药物中的用途 |
| CN105777604A (zh) * | 2016-04-14 | 2016-07-20 | 上海凯宝药业股份有限公司 | 一种n-甲基-反式-4-羟基-l-脯氨酸晶体化合物及其制备方法 |
| ES2903416T3 (es) | 2016-04-28 | 2022-04-01 | Jiangsu Hengrui Medicine Co | Método de preparación de un inhibidor de tirosina quinasa y de un derivado del mismo |
| CN106008471B (zh) * | 2016-05-25 | 2019-09-03 | 江苏医诺万细胞诊疗有限公司 | 一种喹唑啉类化合物的合成方法 |
| EP3517529B1 (de) | 2016-09-23 | 2022-03-23 | Shanghai Pharmaceuticals Holding Co., Ltd. | Salz eines chinazolinderivats, herstellungsverfahren dafür und verwendung davon |
| CN108289885B (zh) * | 2016-09-23 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 酪氨酸激酶抑制剂在制备治疗癌症药物中的用途 |
| CN106565692A (zh) * | 2016-11-03 | 2017-04-19 | 常茂生物化学工程股份有限公司 | 一种阿法替尼合成工艺的改进方法 |
| US20190358212A1 (en) * | 2017-01-22 | 2019-11-28 | Jiangsu Hengrui Medicine Co., Ltd. | Uses of egfr/her2 inhibitor combined with pyrimidine-type anti-metabolic drug |
| CN109963846A (zh) * | 2017-08-07 | 2019-07-02 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的二马来酸盐的晶型及其制备方法 |
| JP7333313B2 (ja) * | 2017-09-01 | 2023-08-24 | シャンハイ ファーマシューティカルズ ホールディング カンパニー，リミティド | 窒素含有複素環化合物、製造方法、中間体、組成物および使用 |
| WO2019076316A1 (zh) * | 2017-10-18 | 2019-04-25 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂及其中间体的制备方法 |
| KR20200078561A (ko) * | 2017-10-24 | 2020-07-01 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 퀴놀린 유도체를 함유하는 약학 조성물 |
| WO2019080889A1 (zh) * | 2017-10-26 | 2019-05-02 | 江苏恒瑞医药股份有限公司 | 抗csf-1r抗体、其抗原结合片段及其医药用途 |
| CN108314639B (zh) * | 2018-05-09 | 2019-04-30 | 山东铂源药业有限公司 | 化合物（e）-3-（1-甲基吡咯烷-2-基）-丙烯酸盐酸盐及合成方法 |
| US10857146B2 (en) | 2018-08-21 | 2020-12-08 | Jiangsu Hengrui Medicine Co., Ltd. | Method for preventing or treating tumor diseases with a combination of tyrosine kinase inhibitor and CDK4/6 inhibitor |
| CN110960529A (zh) * | 2018-09-30 | 2020-04-07 | 江苏恒瑞医药股份有限公司 | 一种降低了毒性杂质含量的酪氨酸激酶抑制剂的原料药 |
| BR112021007477A2 (pt) | 2018-10-22 | 2021-07-27 | Jiangsu Hengrui Medicine Co., Ltd. | forma cristalina de maleato de inibidor de tirosina quinase e método de preparação da mesma |
| US20220040324A1 (en) | 2018-12-21 | 2022-02-10 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
| CN112279838B (zh) | 2020-10-29 | 2021-07-13 | 苏州富士莱医药股份有限公司 | 一种吡咯替尼的制备方法 |
| CN112625025B (zh) * | 2020-12-31 | 2022-03-29 | 河南省医药科学研究院 | 吡啶基取代的喹啉类衍生物及其制备方法和用途 |
| CN112694439B (zh) * | 2020-12-31 | 2022-08-30 | 河南省医药科学研究院 | 苯基丙烯酰胺基喹啉类衍生物及其制备方法和用途 |
| CN112759583B (zh) * | 2020-12-31 | 2022-10-11 | 河南省医药科学研究院 | 包含呋喃基的喹啉类衍生物及其制备方法和用途 |
| CN115109036B (zh) | 2021-03-19 | 2024-06-11 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、组合物及其应用 |
| TW202330040A (zh) * | 2021-10-14 | 2023-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ｈｅｒ２抗體藥物偶聯物和酪胺酸激酶抑制劑聯合在製備治療腫瘤的藥物中的用途 |
| EP4682143A1 (de) * | 2023-03-10 | 2026-01-21 | Convalife Pharmaceuticals Co., Ltd. | Pharmazeutische zusammensetzung mit egfr-hemmer sowie herstellungsverfahren dafür und verwendung davon |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| ATE255575T1 (de) | 1998-09-29 | 2003-12-15 | Wyeth Corp | Substituierte 3-cyanochinoline als protein tyrosine kinase inhibitoren |
| WO2001077104A1 (de) * | 2000-04-08 | 2001-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10217689A1 (de) * | 2002-04-19 | 2003-11-13 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| US20040044014A1 (en) * | 2002-04-19 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10307165A1 (de) * | 2003-02-20 | 2004-09-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| US7399865B2 (en) | 2003-09-15 | 2008-07-15 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
| KR100832594B1 (ko) | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | 다중저해제로서의 퀴나졸린 유도체 및 이의 제조방법 |
| CN101824029A (zh) * | 2009-03-05 | 2010-09-08 | 厦门艾德生物医药科技有限公司 | 酪氨酸激酶不可逆抑制剂、其药物组合物及其用途 |
| CN102020639A (zh) | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
-
2009
- 2009-09-14 CN CN2009101958233A patent/CN102020639A/zh active Pending
-
2010
- 2010-08-26 ES ES10814867.7T patent/ES2647829T3/es active Active
- 2010-08-26 KR KR1020127009554A patent/KR101738191B1/ko active Active
- 2010-08-26 NO NO10814867A patent/NO2479174T3/no unknown
- 2010-08-26 SI SI201031574T patent/SI2479174T1/sl unknown
- 2010-08-26 CN CN201080030048.7A patent/CN102471312B/zh active Active
- 2010-08-26 PT PT108148677T patent/PT2479174T/pt unknown
- 2010-08-26 WO PCT/CN2010/001293 patent/WO2011029265A1/zh not_active Ceased
- 2010-08-26 DK DK10814867.7T patent/DK2479174T3/da active
- 2010-08-26 US US13/395,892 patent/US8901140B2/en active Active
- 2010-08-26 PL PL10814867T patent/PL2479174T3/pl unknown
- 2010-08-26 CA CA2774099A patent/CA2774099C/en active Active
- 2010-08-26 BR BR112012005760A patent/BR112012005760A2/pt not_active Application Discontinuation
- 2010-08-26 JP JP2012528211A patent/JP5684811B2/ja active Active
- 2010-08-26 RU RU2012110882/04A patent/RU2536102C2/ru active
- 2010-08-26 LT LTEP10814867.7T patent/LT2479174T/lt unknown
- 2010-08-26 AU AU2010292790A patent/AU2010292790B2/en active Active
- 2010-08-26 HR HRP20171748TT patent/HRP20171748T1/hr unknown
- 2010-08-26 HU HUE10814867A patent/HUE035873T2/en unknown
- 2010-08-26 EP EP10814867.7A patent/EP2479174B1/de active Active
- 2010-08-26 MX MX2012002875A patent/MX2012002875A/es active IP Right Grant
-
2014
- 2014-12-01 US US14/556,792 patent/US9358227B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150126550A1 (en) | 2015-05-07 |
| HK1163081A1 (en) | 2012-09-07 |
| AU2010292790B2 (en) | 2015-03-26 |
| DK2479174T3 (da) | 2017-11-27 |
| MX2012002875A (es) | 2012-04-20 |
| AU2010292790A1 (en) | 2012-05-10 |
| WO2011029265A1 (zh) | 2011-03-17 |
| PT2479174T (pt) | 2017-11-20 |
| CA2774099A1 (en) | 2011-03-17 |
| JP5684811B2 (ja) | 2015-03-18 |
| CN102471312B (zh) | 2014-06-18 |
| SI2479174T1 (sl) | 2017-12-29 |
| LT2479174T (lt) | 2017-11-27 |
| CA2774099C (en) | 2017-07-04 |
| US9358227B2 (en) | 2016-06-07 |
| CN102020639A (zh) | 2011-04-20 |
| RU2012110882A (ru) | 2013-11-10 |
| EP2479174A4 (de) | 2013-04-17 |
| JP2013504521A (ja) | 2013-02-07 |
| ES2647829T3 (es) | 2017-12-26 |
| US8901140B2 (en) | 2014-12-02 |
| HRP20171748T1 (hr) | 2017-12-29 |
| PL2479174T3 (pl) | 2018-02-28 |
| BR112012005760A2 (pt) | 2016-02-16 |
| CN102471312A (zh) | 2012-05-23 |
| US20120165352A1 (en) | 2012-06-28 |
| HUE035873T2 (en) | 2018-05-28 |
| EP2479174A1 (de) | 2012-07-25 |
| EP2479174B1 (de) | 2017-10-18 |
| RU2536102C2 (ru) | 2014-12-20 |
| KR20120081142A (ko) | 2012-07-18 |
| KR101738191B1 (ko) | 2017-05-19 |