NO300067B1 - Fremgangsmåte for å tilveiebringe renset, biologisk aktiv CSF-1 dimer - Google Patents

Fremgangsmåte for å tilveiebringe renset, biologisk aktiv CSF-1 dimer Download PDF

Info

Publication number: NO300067B1
Authority: NO; Norway
Prior art keywords: csf; protein; refolding; lcsf; dimer
Prior art date: 1987-04-16

Application number

NO885555A

Other languages

English (en)

Norwegian (no)

Other versions

NO885555L (no

NO885555D0 (no

Inventor

Robert F Halenbeck

Kirston E Koths

Cynthia Ann Cowgill

Walter Joseph Laird

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-16

Filing date

1988-12-14

Publication date

1997-04-01

1988-12-14 Application filed by Chiron Corp filed Critical Chiron Corp

1988-12-14 Publication of NO885555D0 publication Critical patent/NO885555D0/no

1989-01-11 Publication of NO885555L publication Critical patent/NO885555L/no

1997-04-01 Publication of NO300067B1 publication Critical patent/NO300067B1/no

Links

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239000000710 homodimer Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000012051 hydrophobic carrier Substances 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
238000005462 in vivo assay Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
238000011031 large-scale manufacturing process Methods 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
210000005265 lung cell Anatomy 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000003550 marker Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
210000000440 neutrophil Anatomy 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
238000010979 pH adjustment Methods 0.000 description 1
208000008443 pancreatic carcinoma Diseases 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
101150019841 penP gene Proteins 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
101150009573 phoA gene Proteins 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
230000008707 rearrangement Effects 0.000 description 1
230000003134 recirculating effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
150000003355 serines Chemical class 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000012289 standard assay Methods 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
229960003495 thiamine Drugs 0.000 description 1
108060008226 thioredoxin Proteins 0.000 description 1
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125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
229960005356 urokinase Drugs 0.000 description 1
239000013598 vector Substances 0.000 description 1
239000011534 wash buffer Substances 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1
239000011686 zinc sulphate Substances 0.000 description 1
235000009529 zinc sulphate Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO885555A 1987-04-16 1988-12-14 Fremgangsmåte for å tilveiebringe renset, biologisk aktiv CSF-1 dimer NO300067B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4017487A	1987-04-16	1987-04-16
US11400187A	1987-10-27	1987-10-27
PCT/US1988/001189 WO1988008003A1 (en)	1987-04-16	1988-04-18	Production of purified, biologically active, bacterially produced recombinant human csf-1

Publications (3)

Publication Number	Publication Date
NO885555D0 NO885555D0 (no)	1988-12-14
NO885555L NO885555L (no)	1989-01-11
NO300067B1 true NO300067B1 (no)	1997-04-01

Family

ID=26716797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO885555A NO300067B1 (no)	1987-04-16	1988-12-14	Fremgangsmåte for å tilveiebringe renset, biologisk aktiv CSF-1 dimer

Country Status (10)

Country	Link
EP (2)	EP0818466B1 (de)
JP (1)	JP2656964B2 (de)
AT (2)	ATE167192T1 (de)
AU (1)	AU610182B2 (de)
BG (1)	BG49827A3 (de)
DE (2)	DE3856203T2 (de)
FI (1)	FI96872C (de)
IL (1)	IL86090A (de)
NO (1)	NO300067B1 (de)
WO (1)	WO1988008003A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5650297A (en) *	1986-09-17	1997-07-22	Otsuka Pharmaceutical Co., Ltd.	DNA encoding human colony-stimulating factors
US4931543A (en) *	1987-05-11	1990-06-05	Cetus Corporation	Process for recovering microbially produced interleukin-2
WO1989010407A1 (en) *	1988-04-29	1989-11-02	Genetics Institute, Inc.	Homogeneous dimeric m-csf and storage stable formulations thereof
EP0410751B1 (de) *	1989-07-27	1996-04-10	Denki Kagaku Kogyo Kabushiki Kaisha	Für M-CSF kodierendes Gen und dazu gehörende rekombinante Systeme
GB8927546D0 (en) *	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
JPH06500084A (ja) *	1990-08-20	1994-01-06	ノボ　ノルディスク　アクティーゼルスカブ	生物学的に活性な化合物、その製造方法及びその利用
AU664021B2 (en) *	1990-09-05	1995-11-02	Natinco Nv	Solubilization of proteins in active forms
US5288931A (en) *	1991-12-06	1994-02-22	Genentech, Inc.	Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
EP0668914B1 (de)	1992-06-09	2000-08-16	Chiron Corporation	Kristallisierung von m-csf
AU661914B2 (en) *	1992-08-18	1995-08-10	Jean-Louis Odore	Support structure for a shelter cover
FI951541A0 (fi) *	1993-08-04	1995-03-31	Ciba Geigy Ag	Suurimolekyylipainoinen desulfatohirudiini
US5407810A (en) *	1993-08-20	1995-04-18	Genentech, Inc.	Aqueous multiple-phase isolation of polypeptide
US5663304A (en) *	1993-08-20	1997-09-02	Genentech, Inc.	Refolding of misfolded insulin-like growth factor-I
TW517059B (en)	1994-07-25	2003-01-11	Ciba Geigy Ag	New process for the production of biologically active protein
FR2796071B1 (fr) *	1999-07-08	2001-09-07	Hoechst Marion Roussel Inc	Procede de purification de facteur de stimulation de colonies de granulocytes
US6808902B1 (en) *	1999-11-12	2004-10-26	Amgen Inc.	Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
DE102004041639A1 (de) *	2004-08-27	2006-03-02	Bioceuticals Arzneimittel Ag	Verfahren zur Gewinnung von biologisch aktivem humanen G-CSF aus Inclusion Bodies
EP3366692A1 (de)	2009-06-22	2018-08-29	Amgen, Inc	Proteinneufaltung mit einem chemisch gesteuerten redoxzustand
AU2010266093B2 (en)	2009-06-25	2013-06-27	Amgen Inc.	Capture purification processes for proteins expressed in a non-mammalian system
DE202009019091U1 (de)	2009-12-21	2016-05-23	Agilent Technologies, Inc. - A Delaware Corporation -	Fittingelement mit frontseitiger Einlage

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR79124B (de) *	1982-12-22	1984-10-02	Genentech Inc
DE3689391T2 (de) *	1985-02-05	1994-06-30	Cetus Oncology Corp., Emeryville, Calif.	Rekombinanter koloniestimulierender faktor-1.
MX9203130A (es) *	1986-05-06	1992-07-01	Genetics Inst	Produccion de m-csf
DK54589A (da) *	1988-02-08	1989-08-09	Otsuka Pharma Co Ltd	Humane kolonistmulerende faktorer

1988
- 1988-04-15 IL IL86090A patent/IL86090A/xx not_active IP Right Cessation
- 1988-04-18 EP EP97202737A patent/EP0818466B1/de not_active Expired - Lifetime
- 1988-04-18 EP EP88904086A patent/EP0309569B1/de not_active Expired - Lifetime
- 1988-04-18 AT AT88904086T patent/ATE167192T1/de not_active IP Right Cessation
- 1988-04-18 WO PCT/US1988/001189 patent/WO1988008003A1/en not_active Ceased
- 1988-04-18 AU AU17124/88A patent/AU610182B2/en not_active Expired
- 1988-04-18 AT AT97202737T patent/ATE301133T1/de not_active IP Right Cessation
- 1988-04-18 JP JP63503965A patent/JP2656964B2/ja not_active Expired - Lifetime
- 1988-04-18 DE DE3856203T patent/DE3856203T2/de not_active Expired - Lifetime
- 1988-04-18 DE DE3856581T patent/DE3856581T2/de not_active Expired - Lifetime
- 1988-12-14 NO NO885555A patent/NO300067B1/no not_active IP Right Cessation
- 1988-12-15 FI FI885807A patent/FI96872C/fi not_active IP Right Cessation
- 1988-12-16 BG BG086469A patent/BG49827A3/xx unknown

Also Published As

Publication number	Publication date
FI96872C (fi)	1996-09-10
JPH01503440A (ja)	1989-11-22
BG49827A3 (bg)	1992-02-14
DE3856581T2 (de)	2006-05-24
FI885807A0 (fi)	1988-12-15
NO885555L (no)	1989-01-11
EP0309569A1 (de)	1989-04-05
JP2656964B2 (ja)	1997-09-24
WO1988008003A1 (en)	1988-10-20
AU610182B2 (en)	1991-05-16
NO885555D0 (no)	1988-12-14
IL86090A (en)	1993-03-15
FI885807L (fi)	1988-12-15
ATE167192T1 (de)	1998-06-15
DE3856203T2 (de)	1998-10-08
EP0818466B1 (de)	2005-08-03
DE3856581D1 (de)	2005-09-29
EP0818466A3 (de)	1998-03-25
EP0309569B1 (de)	1998-06-10
IL86090A0 (en)	1988-09-30
ATE301133T1 (de)	2005-08-15
DE3856203D1 (de)	1998-07-16
FI96872B (fi)	1996-05-31
AU1712488A (en)	1988-11-04
EP0818466A2 (de)	1998-01-14

Legal Events

Date	Code	Title	Description
2008-06-23	MK1K	Patent expired

Publication	Publication Date	Title
US4929700A (en)	1990-05-29	Production of purified, biologically active, bacterially produced recombinant human CSF-1
NO300067B1 (no)	1997-04-01	Fremgangsmåte for å tilveiebringe renset, biologisk aktiv CSF-1 dimer
Ejima et al.	1999	High yield refolding and purification process for recombinant human interleukin‐6 expressed in Escherichia coli
US6593107B1 (en)	2003-07-15	Methods of refolding proteins
US5136025A (en)	1992-08-04	Method to purify basic fibroblast growth factor
JPH0696600B2 (ja)	1994-11-30	蛋白質の酸化方法
JP2002332294A (ja)	2002-11-22	改良型の塩基性線維芽細胞増殖因子
US4765903A (en)	1988-08-23	Purification of monomeric interferon
CA1339757C (en)	1998-03-17	Production of purified biologically active, bacterially produced recombinant human csf-1
AU622860B2 (en)	1992-04-30	Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US20080171857A1 (en)	2008-07-17	Process for the Purification of Recombinant Granulocyte-Colony Stimulating Factor
CN1323167C (zh)	2007-06-27	1型胎盘生长因子的突变蛋白及其制备方法和应用
EP1449848A1 (de)	2004-08-25	Verfahren zur Herstellung von Proteinen aus der Cystine-Knoten-Familie
DK173693B1 (da)	2001-06-25	Fremstilling af renset, biologisk aktivt, bakterielt fremstillet human-rekombinant-CSF-1
IE84354B1 (en)	2006-09-20	Purified, biologically active, bacterially produced recombinant human CSF-1
Jin et al.	1994	Purification and renaturation of recombinant human lymphotoxin (tumour necrosis factor beta) expressed in Escherichia coli as inclusion bodies
CA1337671C (en)	1995-11-28	Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
JPH09262093A (ja)	1997-10-07	蛋白質の活性化方法