NO300324B1 - Analogifremgangsmåte til fremstilling av terapeutisk aktive forbindelser - Google Patents

Analogifremgangsmåte til fremstilling av terapeutisk aktive forbindelser Download PDF

Info

Publication number: NO300324B1
Authority: NO; Norway
Prior art keywords: amino; methyl; dec; tricyclo; oxo
Prior art date: 1990-08-31

Application number

NO930710A

Other languages

English (en)

Norwegian (no)

Other versions

NO930710L (no

NO930710D0 (no

Inventor

David Christopher Horwell

Martyn Clive Pritchard

Reginald Stewart Richardson

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-31

Filing date

1993-02-26

Publication date

1997-05-12

1991-07-12 Priority claimed from US07/726,653 external-priority patent/US5340825A/en

1993-02-26 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1993-02-26 Publication of NO930710D0 publication Critical patent/NO930710D0/no

1993-04-21 Publication of NO930710L publication Critical patent/NO930710L/no

1997-05-12 Publication of NO300324B1 publication Critical patent/NO300324B1/no

Links

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125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 51
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 38
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
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MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
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JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
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229940095064 tartrate Drugs 0.000 description 1
229950002757 teoclate Drugs 0.000 description 1
PPTXNAVFXKULIJ-UHFFFAOYSA-N tert-butyl 3-[[2-[2-[[2-(2-adamantyloxycarbonylamino)-3-(1h-indol-3-yl)-2-methylpropanoyl]amino]ethyl]phenyl]methylamino]but-2-enoate Chemical compound CC(C)(C)OC(=O)C=C(C)NCC1=CC=CC=C1CCNC(=O)C(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)CC1=CNC2=CC=CC=C12 PPTXNAVFXKULIJ-UHFFFAOYSA-N 0.000 description 1
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WWNNZCOKKKDOPX-UHFFFAOYSA-N trigonelline Natural products C[N+]1=CC=CC(C([O-])=O)=C1 WWNNZCOKKKDOPX-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO930710A 1990-08-31 1993-02-26 Analogifremgangsmåte til fremstilling av terapeutisk aktive forbindelser NO300324B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US57631590A	1990-08-31	1990-08-31
US07/726,653 US5340825A (en)	1990-08-31	1991-07-12	Pro drugs for CCK antagonists
PCT/US1991/006178 WO1992004038A1 (fr)	1990-08-31	1991-08-29	Pro-medicaments pour antagonistes de cholecystokinine

Publications (3)

Publication Number	Publication Date
NO930710D0 NO930710D0 (no)	1993-02-26
NO930710L NO930710L (no)	1993-04-21
NO300324B1 true NO300324B1 (no)	1997-05-12

Family

ID=27076930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO930710A NO300324B1 (no)	1990-08-31	1993-02-26	Analogifremgangsmåte til fremstilling av terapeutisk aktive forbindelser

Country Status (14)

Country	Link
US (2)	US5554643A (fr)
EP (1)	EP0546108B1 (fr)
JP (1)	JP3356431B2 (fr)
AT (1)	ATE208400T1 (fr)
AU (1)	AU649077B2 (fr)
CA (1)	CA2088980C (fr)
DE (1)	DE69132805T2 (fr)
DK (1)	DK0546108T3 (fr)
ES (1)	ES2167312T3 (fr)
IE (1)	IE913079A1 (fr)
NO (1)	NO300324B1 (fr)
NZ (1)	NZ239591A (fr)
PT (1)	PT98831B (fr)
WO (1)	WO1992004038A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU687754B2 (en) *	1990-08-31	1998-03-05	Warner-Lambert Company	Tachykinin antagonists
DE69132805T2 (de) *	1990-08-31	2002-10-24	Warner-Lambert Co., Ann Arbor	Pro-medikamente für cck-antagonisten
WO1993000897A1 (fr) *	1991-07-12	1993-01-21	Warner-Lambert Company	Antagonistes de cholecystokinine utiles dans le traitement de crises de panique
US5217957A (en) *	1991-08-20	1993-06-08	Warner-Lambert Company	Cholecystokinin antagonists useful for treating depression
US5380872A (en) *	1992-07-14	1995-01-10	Glaxo Inc.	Modulators of cholecystokinin
TW281669B (fr) *	1993-02-17	1996-07-21	Chugai Pharmaceutical Co Ltd
US6403577B1 (en) *	1993-11-17	2002-06-11	Eli Lilly And Company	Hexamethyleneiminyl tachykinin receptor antagonists
US6869957B1 (en)	1993-11-17	2005-03-22	Eli Lilly And Company	Non-peptide tachykinin receptor antagonists
US7077822B1 (en)	1994-02-09	2006-07-18	The University Of Iowa Research Foundation	Stereotactic hypothalamic obesity probe
US6129685A (en) *	1994-02-09	2000-10-10	The University Of Iowa Research Foundation	Stereotactic hypothalamic obesity probe
CA2152765A1 (fr)	1994-06-30	1995-12-31	Jeroen Elisabeth-Joseph Knops	Methodes pour traiter un trouble physiologique associe a un peptide amyloide beta
US7109326B2 (en) *	1997-04-15	2006-09-19	Genentech, Inc.	Halo-alkoxycarbonyl prodrugs
CA2664251A1 (fr)	2006-09-12	2008-03-20	Cephalin Pharmaceuticals Inc.	Traitement de la douleur par l'isovaline
CN109153639B (zh) *	2016-03-14	2022-07-29	斯法尔制药私人有限公司	葫芦巴碱类化合物
US20200109117A1 (en) *	2018-10-02	2020-04-09	ACCESS Association	Modified Therapeutic Agent Analogs of Mefenamic Acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2364659A1 (fr) *	1976-09-21	1978-04-14	Commissariat Energie Atomique	Medicament antagoniste de l'action de la gastrine et des polypeptides apparentes
US4757151A (en) *	1985-11-14	1988-07-12	Warner-Lambert Company	2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
EP0442878A4 (en) *	1988-04-05	1991-10-23	Abbott Laboratories	Derivatives of tryptophan as cck antagonists
US4997950A (en) *	1989-04-20	1991-03-05	Richard Finbar Murphy	Novel C-terminal gastrin antagonists
NZ234264A (en) *	1989-06-29	1993-05-26	Warner Lambert Co	N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
US5278316A (en) *	1989-06-29	1994-01-11	Warner-Lambert Company	N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
DE69132805T2 (de) *	1990-08-31	2002-10-24	Warner-Lambert Co., Ann Arbor	Pro-medikamente für cck-antagonisten

1991
- 1991-08-29 DE DE69132805T patent/DE69132805T2/de not_active Expired - Fee Related
- 1991-08-29 NZ NZ23959191A patent/NZ239591A/en unknown
- 1991-08-29 AT AT91918120T patent/ATE208400T1/de not_active IP Right Cessation
- 1991-08-29 WO PCT/US1991/006178 patent/WO1992004038A1/fr not_active Ceased
- 1991-08-29 AU AU87250/91A patent/AU649077B2/en not_active Ceased
- 1991-08-29 EP EP91918120A patent/EP0546108B1/fr not_active Expired - Lifetime
- 1991-08-29 CA CA002088980A patent/CA2088980C/fr not_active Expired - Fee Related
- 1991-08-29 DK DK91918120T patent/DK0546108T3/da active
- 1991-08-29 ES ES91918120T patent/ES2167312T3/es not_active Expired - Lifetime
- 1991-08-29 JP JP51666591A patent/JP3356431B2/ja not_active Expired - Fee Related
- 1991-08-30 PT PT98831A patent/PT98831B/pt not_active IP Right Cessation
- 1991-08-30 IE IE307991A patent/IE913079A1/en not_active Application Discontinuation
1993
- 1993-02-26 NO NO930710A patent/NO300324B1/no not_active IP Right Cessation
1994
- 1994-04-13 US US08/227,211 patent/US5554643A/en not_active Expired - Fee Related
1996
- 1996-06-10 US US08/661,254 patent/US5726200A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT98831B (pt)	1999-02-26
US5554643A (en)	1996-09-10
JP3356431B2 (ja)	2002-12-16
IE913079A1 (en)	1992-03-11
PT98831A (pt)	1992-08-31
AU8725091A (en)	1992-03-30
ATE208400T1 (de)	2001-11-15
JPH06501007A (ja)	1994-01-27
EP0546108B1 (fr)	2001-11-07
CA2088980A1 (fr)	1992-03-01
DE69132805T2 (de)	2002-10-24
US5726200A (en)	1998-03-10
DE69132805D1 (de)	2001-12-13
WO1992004038A1 (fr)	1992-03-19
ES2167312T3 (es)	2002-05-16
NO930710L (no)	1993-04-21
NZ239591A (en)	1994-07-26
DK0546108T3 (da)	2002-02-18
EP0546108A4 (en)	1993-09-22
CA2088980C (fr)	2002-04-16
AU649077B2 (en)	1994-05-12
EP0546108A1 (fr)	1993-06-16
NO930710D0 (no)	1993-02-26

Legal Events

Date	Code	Title	Description
2005-05-02	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
JP2972331B2 (ja)	1999-11-08	Ｎ―置換シクロアルキルおよびポリシクロアルキルα―置換Ｔｒｐ―Ｐｈｅ―およびフェネチルアミン誘導体
US5523306A (en)	1996-06-04	Amino acid derivatives cyclized at the C-terminal
NO300324B1 (no)	1997-05-12	Analogifremgangsmåte til fremstilling av terapeutisk aktive forbindelser
KR100222634B1 (ko)	1999-10-01	콜레시스토키닌길항제,그의제조방법및치료학적용도
US5574013A (en)	1996-11-12	N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp derivatives
US5278316A (en)	1994-01-11	N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
US5340825A (en)	1994-08-23	Pro drugs for CCK antagonists
US5244905A (en)	1993-09-14	N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives
PT98830A (pt)	1992-07-31	Processo para a preparacao de derivados de triptofano (trp) alfa-substituidos n-substituidos com cicloalquilo e policicloalquilo e de composicoes farmaceuticas que os contem