PT98831A - Processo para a preparacao de pro-medicamentos de derivados de fenilalanina e fenetilamina n-substituidos com cicloalquilo e policicloalquilo beta-substituidos com triptofano e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de pro-medicamentos de derivados de fenilalanina e fenetilamina n-substituidos com cicloalquilo e policicloalquilo beta-substituidos com triptofano e de composicoes farmaceuticas que os contem

Info

Publication number: PT98831A
Authority: PT; Portugal
Prior art keywords: substituted; drugs; pro; agents; useful
Prior art date: 1990-08-31

Application number

PT98831A

Other languages

English (en)

Other versions

PT98831B (pt

Inventor

David Christopher Horwell

Reginald Stewart Richardson

Martyn Clive Pritchard

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-31

Filing date

1991-08-30

Publication date

1992-08-31

1991-07-12 Priority claimed from US07/726,653 external-priority patent/US5340825A/en

1991-08-30 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1992-08-31 Publication of PT98831A publication Critical patent/PT98831A/pt

1999-02-26 Publication of PT98831B publication Critical patent/PT98831B/pt

Links

229940002612 prodrug Drugs 0.000 title abstract 5
239000000651 prodrug Substances 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 title 1
150000001448 anilines Chemical class 0.000 title 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 title 1
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
102100021022 Gastrin Human genes 0.000 abstract 1
108010052343 Gastrins Proteins 0.000 abstract 1
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
206010033664 Panic attack Diseases 0.000 abstract 1
IMMPMHKLUUZKAZ-WMZOPIPTSA-N Trp-Phe Chemical class C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)N)C(O)=O)C1=CC=CC=C1 IMMPMHKLUUZKAZ-WMZOPIPTSA-N 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
229940005529 antipsychotics Drugs 0.000 abstract 1
239000003699 antiulcer agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
229960001948 caffeine Drugs 0.000 abstract 1
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
229960003920 cocaine Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 1
229960003529 diazepam Drugs 0.000 abstract 1
210000004211 gastric acid Anatomy 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229960002715 nicotine Drugs 0.000 abstract 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
229940005483 opioid analgesics Drugs 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT98831A 1990-08-31 1991-08-30 Processo para a preparacao de pro-medicamentos de derivados de fenilalanina e fenetilamina n-substituidos com cicloalquilo e policicloalquilo beta-substituidos com triptofano e de composicoes farmaceuticas que os contem PT98831B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57631590A	1990-08-31	1990-08-31
US07/726,653 US5340825A (en)	1990-08-31	1991-07-12	Pro drugs for CCK antagonists

Publications (2)

Publication Number	Publication Date
PT98831A true PT98831A (pt)	1992-08-31
PT98831B PT98831B (pt)	1999-02-26

Family

ID=27076930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98831A PT98831B (pt)	1990-08-31	1991-08-30	Processo para a preparacao de pro-medicamentos de derivados de fenilalanina e fenetilamina n-substituidos com cicloalquilo e policicloalquilo beta-substituidos com triptofano e de composicoes farmaceuticas que os contem

Country Status (14)

Country	Link
US (2)	US5554643A (pt)
EP (1)	EP0546108B1 (pt)
JP (1)	JP3356431B2 (pt)
AT (1)	ATE208400T1 (pt)
AU (1)	AU649077B2 (pt)
CA (1)	CA2088980C (pt)
DE (1)	DE69132805T2 (pt)
DK (1)	DK0546108T3 (pt)
ES (1)	ES2167312T3 (pt)
IE (1)	IE913079A1 (pt)
NO (1)	NO300324B1 (pt)
NZ (1)	NZ239591A (pt)
PT (1)	PT98831B (pt)
WO (1)	WO1992004038A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2088980C (en) *	1990-08-31	2002-04-16	David C. Horwell	Pro-drugs for cck antagonists
CA2110986A1 (en) *	1991-07-12	1993-01-21	Geoffrey Neil Woodruff	Cholecystokinin antagonists useful in the treatment of panic attacks
US5217957A (en) *	1991-08-20	1993-06-08	Warner-Lambert Company	Cholecystokinin antagonists useful for treating depression
US5380872A (en) *	1992-07-14	1995-01-10	Glaxo Inc.	Modulators of cholecystokinin
CA2140640A1 (en) *	1992-08-13	1994-03-03	David C. Horwell	Tachykinin antagonists
JP3419539B2 (ja)	1993-02-17	2003-06-23	中外製薬株式会社	インドリン−２−オン誘導体
US6869957B1 (en)	1993-11-17	2005-03-22	Eli Lilly And Company	Non-peptide tachykinin receptor antagonists
US6403577B1 (en)	1993-11-17	2002-06-11	Eli Lilly And Company	Hexamethyleneiminyl tachykinin receptor antagonists
US6129685A (en) *	1994-02-09	2000-10-10	The University Of Iowa Research Foundation	Stereotactic hypothalamic obesity probe
US7077822B1 (en)	1994-02-09	2006-07-18	The University Of Iowa Research Foundation	Stereotactic hypothalamic obesity probe
CA2152765A1 (en)	1994-06-30	1995-12-31	Jeroen Elisabeth-Joseph Knops	Methods for treating a physiological disorder associated with beta amyloid peptide
US7109326B2 (en) *	1997-04-15	2006-09-19	Genentech, Inc.	Halo-alkoxycarbonyl prodrugs
WO2008031221A1 (en)	2006-09-12	2008-03-20	Cephalin Pharmaceuticals Inc.	Isovaline for treatment of pain
US10752589B2 (en)	2016-03-14	2020-08-25	Sphaera Pharma Pvt. Ltd.	Trigonelline based compounds
US20200109117A1 (en) *	2018-10-02	2020-04-09	ACCESS Association	Modified Therapeutic Agent Analogs of Mefenamic Acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2364659A1 (fr) *	1976-09-21	1978-04-14	Commissariat Energie Atomique	Medicament antagoniste de l'action de la gastrine et des polypeptides apparentes
US4757151A (en) *	1985-11-14	1988-07-12	Warner-Lambert Company	2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
JPH03503650A (ja) *	1988-04-05	1991-08-15	アボツト・ラボラトリーズ	Ｃｃｋアンタゴニストとしてのトリプトファン誘導体
US4997950A (en) *	1989-04-20	1991-03-05	Richard Finbar Murphy	Novel C-terminal gastrin antagonists
NZ234264A (en) *	1989-06-29	1993-05-26	Warner Lambert Co	N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
US5278316A (en) *	1989-06-29	1994-01-11	Warner-Lambert Company	N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
CA2088980C (en) *	1990-08-31	2002-04-16	David C. Horwell	Pro-drugs for cck antagonists

1991
- 1991-08-29 CA CA002088980A patent/CA2088980C/en not_active Expired - Fee Related
- 1991-08-29 JP JP51666591A patent/JP3356431B2/ja not_active Expired - Fee Related
- 1991-08-29 AT AT91918120T patent/ATE208400T1/de not_active IP Right Cessation
- 1991-08-29 EP EP91918120A patent/EP0546108B1/en not_active Expired - Lifetime
- 1991-08-29 AU AU87250/91A patent/AU649077B2/en not_active Ceased
- 1991-08-29 ES ES91918120T patent/ES2167312T3/es not_active Expired - Lifetime
- 1991-08-29 WO PCT/US1991/006178 patent/WO1992004038A1/en not_active Ceased
- 1991-08-29 DE DE69132805T patent/DE69132805T2/de not_active Expired - Fee Related
- 1991-08-29 DK DK91918120T patent/DK0546108T3/da active
- 1991-08-29 NZ NZ23959191A patent/NZ239591A/en unknown
- 1991-08-30 PT PT98831A patent/PT98831B/pt not_active IP Right Cessation
- 1991-08-30 IE IE307991A patent/IE913079A1/en not_active Application Discontinuation
1993
- 1993-02-26 NO NO930710A patent/NO300324B1/no not_active IP Right Cessation
1994
- 1994-04-13 US US08/227,211 patent/US5554643A/en not_active Expired - Fee Related
1996
- 1996-06-10 US US08/661,254 patent/US5726200A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0546108A1 (en)	1993-06-16
US5554643A (en)	1996-09-10
NO930710D0 (no)	1993-02-26
EP0546108B1 (en)	2001-11-07
NZ239591A (en)	1994-07-26
AU649077B2 (en)	1994-05-12
ES2167312T3 (es)	2002-05-16
EP0546108A4 (en)	1993-09-22
NO300324B1 (no)	1997-05-12
NO930710L (no)	1993-04-21
ATE208400T1 (de)	2001-11-15
JP3356431B2 (ja)	2002-12-16
US5726200A (en)	1998-03-10
DE69132805T2 (de)	2002-10-24
JPH06501007A (ja)	1994-01-27
IE913079A1 (en)	1992-03-11
AU8725091A (en)	1992-03-30
PT98831B (pt)	1999-02-26
CA2088980C (en)	2002-04-16
CA2088980A1 (en)	1992-03-01
DK0546108T3 (da)	2002-02-18
DE69132805D1 (de)	2001-12-13
WO1992004038A1 (en)	1992-03-19

Legal Events

Date

Code

Title

Description

1992-08-31

BB1A

Laying open of patent application

Effective date: 19920409

1999-02-26

FG3A

Patent granted, date of granting

Effective date: 19981102

2005-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20050502

Publication	Publication Date	Title
PT94543A (pt)	1991-03-20	Processo para a preparacao de trp-phe-e fenetilaminas alfa-substituidas por ciclo-alquilo e poli-ciclo-alquilo n-substituidos
DK0546108T3 (da)	2002-02-18	Pro-drugs for CCK-antagonister
ATE195740T1 (de)	2000-09-15	Glucosamin-disaccharide, verfahren zu deren herstellung, pharmazeutische präparate davon und ihre verwendung
PT91351A (pt)	1990-03-08	Processo para a preparacao de derivados de alcoxi-4-(1h)-piridona e de composicoes farmaceuticas que os contem
ATE25525T1 (de)	1987-03-15	N-glycosylierte carbonsaeureamid-derivate, verfahren zu ihrer herstellung sowie ihre verwendung zur beeinflussung der koerpereigenen abwehr.
UA26403A (uk)	1999-08-30	Похідhі n-заміщеhого 4-феhіл-4-піперидиhкарбоксаміду та їх фармацевтичhо прийhятhі солі, що проявляють аhестезувальhу та аhальгезувальhу дію, спосіб їх одержаhhя та фармацевтичhа композиція
RU95111308A (ru)	1996-12-27	Производные 2-амино-4-фенил-4-оксомасляной кислоты, способы получения, фармацевтическая композиция
Lewis et al.	1984	Mode of action of ciguatoxin from the Spanish Mackerel, Scomberomorus commersoni, on the guinea-pig ileum and vas deferens.
RU94039545A (ru)	1997-04-27	Новые производные аденозина, способы их получения, фармацевтические композиции на их основе, способы получения фармацевтических композиций и их применение
NO885386L (no)	1988-12-02	Bisfenylalkylpiperzin-derivater, en fremgangsmaate ved fremstilling og et farmasoeytisk preparat.
PT92952A (pt)	1990-07-31	Processo para a preparacao de acidos 3-fenil-5,6-di-hidrobenz { c }acridina-7- carboxilicos, de compostos relacionados e de composicoes farmaceuticas que os contem
HUT48119A (en)	1989-05-29	Process for producing pharmaceutical compositions against addiction to nicotine and comprising 2-pyrimidinyl-1-piperazine derivatives
KR860007286A (ko)	1986-10-10	Grf 유도체의 제조방법
BR9610175A (pt)	1998-08-11	Composto processo de preparação do composto composição farmacêutica e utilização do composto
DK369387A (da)	1988-01-16	Proteinsynteseinhibitor og fremgangsmaade til fremstilling deraf samt deres anvendelse
DE69619868D1 (de)	2002-04-18	Piperazinylalkylthiopyrimidin derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellung
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Gillan et al.	1976	Investigation of the effects of drugs on morphine-induced contractions of the isolated colon of the rat [proceedings]
KR920702676A (ko)	1992-10-06	신규 입체이성질체
EP0790250A3 (en)	1997-09-17	Inhibitors of biogenic amine transporters
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