NO301193B1 - Testmetode og reagenssett for denne - Google Patents

Testmetode og reagenssett for denne Download PDF

Info

Publication number: NO301193B1
Authority: NO; Norway
Prior art keywords: gold; analyte; reagent; porous material; nanometers
Prior art date: 1988-01-13

Application number

NO903124A

Other languages

English (en)

Norwegian (no)

Other versions

NO903124D0 (no

NO903124L (no

Inventor

Egil Olsen

Oerjan Olsvik

Original Assignee

Nycomed Pharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-13

Filing date

1990-07-13

Publication date

1997-09-22

1990-07-13 Application filed by Nycomed Pharma As filed Critical Nycomed Pharma As

1990-07-13 Publication of NO903124D0 publication Critical patent/NO903124D0/no

1990-07-13 Publication of NO903124L publication Critical patent/NO903124L/no

1997-09-22 Publication of NO301193B1 publication Critical patent/NO301193B1/no

Links

239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 48
238000010998 test method Methods 0.000 title 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 92
239000002245 particle Substances 0.000 claims abstract description 75
239000012491 analyte Substances 0.000 claims abstract description 71
229910052737 gold Inorganic materials 0.000 claims abstract description 61
239000010931 gold Substances 0.000 claims abstract description 61
238000000034 method Methods 0.000 claims abstract description 46
230000027455 binding Effects 0.000 claims abstract description 26
239000007790 solid phase Substances 0.000 claims abstract description 22
230000009870 specific binding Effects 0.000 claims abstract description 17
239000000126 substance Substances 0.000 claims abstract description 10
239000011148 porous material Substances 0.000 claims description 21
239000007787 solid Substances 0.000 claims description 18
238000006243 chemical reaction Methods 0.000 claims description 13
239000002250 absorbent Substances 0.000 claims description 10
230000002745 absorbent Effects 0.000 claims description 10
239000007788 liquid Substances 0.000 claims description 8
239000000123 paper Substances 0.000 claims description 6
239000004677 Nylon Substances 0.000 claims description 5
239000000463 material Substances 0.000 claims description 5
229920001778 nylon Polymers 0.000 claims description 5
239000000020 Nitrocellulose Substances 0.000 claims description 3
239000012736 aqueous medium Substances 0.000 claims description 3
229920002301 cellulose acetate Polymers 0.000 claims description 3
229920001220 nitrocellulos Polymers 0.000 claims description 3
238000010521 absorption reaction Methods 0.000 claims description 2
238000009792 diffusion process Methods 0.000 claims description 2
238000007689 inspection Methods 0.000 claims description 2
239000002861 polymer material Substances 0.000 claims 2
150000002343 gold Chemical class 0.000 claims 1
238000012360 testing method Methods 0.000 abstract description 12
239000012528 membrane Substances 0.000 description 42
239000008279 sol Substances 0.000 description 24
239000000084 colloidal system Substances 0.000 description 22
239000000523 sample Substances 0.000 description 13
239000000243 solution Substances 0.000 description 12
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
239000000427 antigen Substances 0.000 description 7
108091007433 antigens Proteins 0.000 description 7
102000036639 antigens Human genes 0.000 description 7
238000003018 immunoassay Methods 0.000 description 7
239000000203 mixture Substances 0.000 description 6
239000007864 aqueous solution Substances 0.000 description 5
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238000011161 development Methods 0.000 description 5
102000004169 proteins and genes Human genes 0.000 description 5
108090000623 proteins and genes Proteins 0.000 description 5
239000012085 test solution Substances 0.000 description 5
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
241000283690 Bos taurus Species 0.000 description 4
108010074051 C-Reactive Protein Proteins 0.000 description 4
102100032752 C-reactive protein Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
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239000000872 buffer Substances 0.000 description 4
239000004800 polyvinyl chloride Substances 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
108060003951 Immunoglobulin Proteins 0.000 description 3
229920001213 Polysorbate 20 Polymers 0.000 description 3
108010071390 Serum Albumin Proteins 0.000 description 3
102000007562 Serum Albumin Human genes 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
230000008878 coupling Effects 0.000 description 3
238000010168 coupling process Methods 0.000 description 3
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238000001514 detection method Methods 0.000 description 3
238000010790 dilution Methods 0.000 description 3
239000012895 dilution Substances 0.000 description 3
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
239000003814 drug Substances 0.000 description 3
238000001493 electron microscopy Methods 0.000 description 3
238000001914 filtration Methods 0.000 description 3
239000012634 fragment Substances 0.000 description 3
102000018358 immunoglobulin Human genes 0.000 description 3
238000011534 incubation Methods 0.000 description 3
239000002953 phosphate buffered saline Substances 0.000 description 3
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
229920000915 polyvinyl chloride Polymers 0.000 description 3
239000012064 sodium phosphate buffer Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 2
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
108090001008 Avidin Proteins 0.000 description 2
239000001263 FEMA 3042 Substances 0.000 description 2
102000009123 Fibrin Human genes 0.000 description 2
108010073385 Fibrin Proteins 0.000 description 2
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
101000942118 Homo sapiens C-reactive protein Proteins 0.000 description 2
108090001090 Lectins Proteins 0.000 description 2
102000004856 Lectins Human genes 0.000 description 2
LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 2
108010090804 Streptavidin Proteins 0.000 description 2
229960002685 biotin Drugs 0.000 description 2
235000020958 biotin Nutrition 0.000 description 2
239000011616 biotin Substances 0.000 description 2
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239000001913 cellulose Substances 0.000 description 2
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150000001875 compounds Chemical class 0.000 description 2
238000001962 electrophoresis Methods 0.000 description 2
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230000003100 immobilizing effect Effects 0.000 description 2
239000002523 lectin Substances 0.000 description 2
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
108020004707 nucleic acids Proteins 0.000 description 2
102000039446 nucleic acids Human genes 0.000 description 2
150000007523 nucleic acids Chemical class 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000000376 reactant Substances 0.000 description 2
239000013049 sediment Substances 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
238000010186 staining Methods 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
239000000725 suspension Substances 0.000 description 2
LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 2
229940033123 tannic acid Drugs 0.000 description 2
235000015523 tannic acid Nutrition 0.000 description 2
229920002258 tannic acid Polymers 0.000 description 2
238000004448 titration Methods 0.000 description 2
238000005406 washing Methods 0.000 description 2
108010088751 Albumins Proteins 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
108020004711 Nucleic Acid Probes Proteins 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000011324 bead Substances 0.000 description 1
230000008033 biological extinction Effects 0.000 description 1
229910021538 borax Inorganic materials 0.000 description 1
229940098773 bovine serum albumin Drugs 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
239000003086 colorant Substances 0.000 description 1
229910000960 colored gold Inorganic materials 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000001803 electron scattering Methods 0.000 description 1
239000002532 enzyme inhibitor Substances 0.000 description 1
229940125532 enzyme inhibitor Drugs 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
230000005294 ferromagnetic effect Effects 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
108091008039 hormone receptors Proteins 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
238000011835 investigation Methods 0.000 description 1
239000003446 ligand Substances 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
230000005389 magnetism Effects 0.000 description 1
239000003550 marker Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
239000002609 medium Substances 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000002853 nucleic acid probe Substances 0.000 description 1
239000002777 nucleoside Substances 0.000 description 1
-1 nucleoside triphosphate Chemical class 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
238000006894 reductive elimination reaction Methods 0.000 description 1
238000002310 reflectometry Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
239000012089 stop solution Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
125000001302 tertiary amino group Chemical group 0.000 description 1
238000011282 treatment Methods 0.000 description 1
239000001226 triphosphate Substances 0.000 description 1
235000011178 triphosphate Nutrition 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
230000000007 visual effect Effects 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Physics & Mathematics (AREA)
Nanotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Automatic Analysis And Handling Materials Therefor (AREA)
Ultra Sonic Daignosis Equipment (AREA)

NO903124A 1988-01-13 1990-07-13 Testmetode og reagenssett for denne NO301193B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB888800702A GB8800702D0 (en)	1988-01-13	1988-01-13	Test method & reagent kit therefor
PCT/EP1989/000050 WO1989006801A1 (en)	1988-01-13	1989-01-11	Test method and reagent kit therefor

Publications (3)

Publication Number	Publication Date
NO903124D0 NO903124D0 (no)	1990-07-13
NO903124L NO903124L (no)	1990-07-13
NO301193B1 true NO301193B1 (no)	1997-09-22

Family

ID=10629878

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903124A NO301193B1 (no)	1988-01-13	1990-07-13	Testmetode og reagenssett for denne

Country Status (12)

Country	Link
US (2)	US5556756A (da)
EP (1)	EP0398913B1 (da)
JP (1)	JP2701949B2 (da)
AT (1)	ATE99060T1 (da)
AU (1)	AU614109B2 (da)
CA (1)	CA1336393C (da)
DE (1)	DE68911674T2 (da)
DK (1)	DK172179B1 (da)
FI (1)	FI92883C (da)
GB (1)	GB8800702D0 (da)
NO (1)	NO301193B1 (da)
WO (1)	WO1989006801A1 (da)

Families Citing this family (67)

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US6200820B1 (en)	1992-12-22	2001-03-13	Sienna Biotech, Inc.	Light scatter-based immunoassay
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US5851777A (en) *	1996-02-05	1998-12-22	Dade Behring Inc.	Homogeneous sol-sol assay
US7098320B1 (en)	1996-07-29	2006-08-29	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en)	1996-07-29	2003-06-24	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses thereof
US7169556B2 (en)	1996-07-29	2007-01-30	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en)	1996-07-29	2004-06-15	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en)	1996-07-29	2002-03-26	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en)	1996-07-29	2006-01-10	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
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US6136610A (en)	1998-11-23	2000-10-24	Praxsys Biosystems, Inc.	Method and apparatus for performing a lateral flow assay
EP1135682B1 (en)	1998-11-30	2007-07-11	Nanosphere, Inc.	Nanoparticles with polymer shells
JP4402263B2 (ja) *	1999-06-21	2010-01-20	パナソニック株式会社	クロマトグラフィー定量測定装置
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CA2396113C (en)	2000-01-13	2009-04-07	Nanosphere, Inc.	Nanoparticles having oligonucleotides attached thereto and uses therefor
DE60119170T2 (de)	2000-07-11	2007-05-24	Northwestern University, Evanston	Nachweismethode mittels verstärkter silberfärbung
US7435384B2 (en) *	2001-01-08	2008-10-14	Leonard Fish	Diagnostic instrument with movable electrode mounting member and methods for detecting analytes
DE10109777A1 (de) *	2001-03-01	2002-09-19	Infineon Technologies Ag	Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren
EP1379693B1 (en) *	2001-03-28	2009-05-20	Nanosphere, Inc.	Bio-barcodes based on oligonucleotide-modified particles
DE10120349B4 (de) *	2001-04-21	2004-10-28	Michael Schwertner	Verfahren zur Erfassung molekularer Bindungsereignisse auf Affinitätssensoren
US7147687B2 (en)	2001-05-25	2006-12-12	Nanosphere, Inc.	Non-alloying core shell nanoparticles
WO2002096262A2 (en)	2001-05-25	2002-12-05	Northwestern University	Non-alloying core shell nanoparticles
WO2002100444A1 (en) *	2001-06-08	2002-12-19	Biosphere Medical Inc.	Colloidal metal labelled microparticles, their production and use
JP2003066047A (ja) *	2001-06-14	2003-03-05	Matsushita Electric Ind Co Ltd	免疫反応測定方法及びそれに用いる免疫反応測定用試薬
US7186814B2 (en)	2001-11-09	2007-03-06	Nanosphere, Inc.	Bioconjugate-nanoparticle probes
CN1617938A (zh)	2002-01-16	2005-05-18	戴诺生物技术有限公司	从单个样品中分离核酸和蛋白质的方法
US20030211488A1 (en)	2002-05-07	2003-11-13	Northwestern University	Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
EP1540006B1 (en)	2002-07-02	2009-01-07	Nanosphere, Inc.	Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
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US20060105388A1 (en) *	2002-12-23	2006-05-18	Febit Biothch Gmbh	Incorporation of hapten groups during the production of carriers for the determination of analytes
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1988
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1989
- 1989-01-11 EP EP89901546A patent/EP0398913B1/en not_active Expired - Lifetime
- 1989-01-11 WO PCT/EP1989/000050 patent/WO1989006801A1/en not_active Ceased
- 1989-01-11 AT AT89901546T patent/ATE99060T1/de not_active IP Right Cessation
- 1989-01-11 DE DE89901546T patent/DE68911674T2/de not_active Expired - Lifetime
- 1989-01-11 AU AU29359/89A patent/AU614109B2/en not_active Ceased
- 1989-01-11 JP JP1501456A patent/JP2701949B2/ja not_active Expired - Lifetime
- 1989-01-12 CA CA000588034A patent/CA1336393C/en not_active Expired - Fee Related
1990
- 1990-07-09 DK DK164690A patent/DK172179B1/da not_active IP Right Cessation
- 1990-07-11 FI FI903515A patent/FI92883C/fi not_active IP Right Cessation
- 1990-07-13 NO NO903124A patent/NO301193B1/no not_active IP Right Cessation
1992
- 1992-06-05 US US07/895,244 patent/US5556756A/en not_active Expired - Fee Related
1995
- 1995-06-02 US US08/458,115 patent/US5616467A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5556756A (en)	1996-09-17
GB8800702D0 (en)	1988-02-10
JPH03502244A (ja)	1991-05-23
NO903124D0 (no)	1990-07-13
CA1336393C (en)	1995-07-25
WO1989006801A1 (en)	1989-07-27
EP0398913A1 (en)	1990-11-28
DK164690D0 (da)	1990-07-09
EP0398913B1 (en)	1993-12-22
ATE99060T1 (de)	1994-01-15
DE68911674T2 (de)	1994-04-07
FI92883C (fi)	1995-01-10
US5616467A (en)	1997-04-01
DK172179B1 (da)	1997-12-15
FI903515A0 (fi)	1990-07-11
FI92883B (fi)	1994-09-30
DK164690A (da)	1990-07-09
AU2935989A (en)	1989-08-11
JP2701949B2 (ja)	1998-01-21
AU614109B2 (en)	1991-08-22
DE68911674D1 (de)	1994-02-03
NO903124L (no)	1990-07-13

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2009-03-16	MK1K	Patent expired

Publication	Publication Date	Title
NO301193B1 (no)	1997-09-22	Testmetode og reagenssett for denne
RU2025732C1 (ru)	1994-12-30	Способ иммуноанализа аналита в водном образце
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US4960692A (en)	1990-10-02	Assay employing binding pair members on particles and on a filter or membrane
EP0564494B1 (en)	1994-12-14	Test method and reagent kit therefor
JPH03502246A (ja)	1991-05-23	物質の分析のための凝集方法
JPH11337553A (ja)	1999-12-10	免疫化学的標識およびこれを含有する水性懸濁液、ならびに該免疫化学的標識の製造方法
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JPH09504094A (ja)	1997-04-22	磁性ラテックス粒子および非磁性粒子を用いて免疫物質をアッセイする方法
JP3833358B2 (ja)	2006-10-11	被検体の亜集団の測定のための均一検出方法
FR2890173A1 (fr)	2007-03-02	Dispositif de determination d'un analyte dans un echantillon liquide par un test sandwich et un test de competition
JP4771941B2 (ja)	2011-09-14	免疫学的定量法と試薬
JP2003262637A (ja)	2003-09-19	検査片及び検査方法
HK1001235B (en)	1998-06-05	Test method and reagent kit therefor
HK1001235A (en)	1998-06-05	Test method and reagent kit therefor
HK1001234B (en)	1998-06-05	Test method and reagent kit therefor
HK1001234A (en)	1998-06-05	Test method and reagent kit therefor
CA1336163C (en)	1995-07-04	Enzyme quantitation wicking assay
AU6782596A (en)	1997-03-27	Method and apparatus for quantitative and semi-quantitative determination of an analyte