NO304431B1 - Krystallinsk karbapenemderivat og farmas°ytisk preparat omfattende dette - Google Patents

Krystallinsk karbapenemderivat og farmas°ytisk preparat omfattende dette

Info

Publication number
NO304431B1
NO304431B1 NO934140A NO934140A NO304431B1 NO 304431 B1 NO304431 B1 NO 304431B1 NO 934140 A NO934140 A NO 934140A NO 934140 A NO934140 A NO 934140A NO 304431 B1 NO304431 B1 NO 304431B1
Authority
NO
Norway
Prior art keywords
pharmaceutical composition
carbapenem derivative
crystalline carbapenem
crystalline
derivative
Prior art date
Application number
NO934140A
Other languages
English (en)
Norwegian (no)
Other versions
NO934140D0 (no
NO934140L (no
Inventor
Isao Kawamoto
Masao Miyauchi
Rokuro Endo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO934140D0 publication Critical patent/NO934140D0/no
Publication of NO934140L publication Critical patent/NO934140L/no
Publication of NO304431B1 publication Critical patent/NO304431B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
NO934140A 1992-11-17 1993-11-16 Krystallinsk karbapenemderivat og farmas°ytisk preparat omfattende dette NO304431B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30688492 1992-11-17
JP17026793 1993-07-09

Publications (3)

Publication Number Publication Date
NO934140D0 NO934140D0 (no) 1993-11-16
NO934140L NO934140L (no) 1994-05-18
NO304431B1 true NO304431B1 (no) 1998-12-14

Family

ID=26493307

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934140A NO304431B1 (no) 1992-11-17 1993-11-16 Krystallinsk karbapenemderivat og farmas°ytisk preparat omfattende dette

Country Status (20)

Country Link
US (1) US5424306A (cs)
EP (1) EP0599512B1 (cs)
JP (1) JP2848552B2 (cs)
KR (1) KR100236845B1 (cs)
CN (1) CN1036714C (cs)
AT (1) ATE178066T1 (cs)
AU (1) AU677235B2 (cs)
CA (1) CA2103223C (cs)
CZ (1) CZ280507B6 (cs)
DE (1) DE69324106T2 (cs)
DK (1) DK0599512T3 (cs)
ES (1) ES2131560T3 (cs)
FI (1) FI103576B (cs)
GR (1) GR3029975T3 (cs)
HU (1) HU219582B (cs)
IL (1) IL107596A (cs)
NO (1) NO304431B1 (cs)
NZ (1) NZ250201A (cs)
PH (1) PH30464A (cs)
TW (1) TW360657B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2173147C2 (ru) * 1996-05-09 2001-09-10 Санкио Компани Лимитед Применение производных 1-метилкарбопенема, антибактериальная в отношении helicobacter pylori композиция, содержащая в качестве активного ингредиента 1-метилкарбопенемовые производные и способ профилактики или лечения инфекционных заболеваний
US7041660B2 (en) * 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
TWI250160B (en) 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
AU2003301425A1 (en) * 2002-10-18 2004-05-04 Meiji Seika Kaisha, Ltd. Process for producing carbapenem derivative and intermediate for use in the production
WO2005118586A1 (en) * 2004-06-02 2005-12-15 Sandoz Ag Meropenem intermediate in crystalline form
JP2009143808A (ja) * 2006-03-28 2009-07-02 Kaneka Corp メロペネム中間体の単離方法
PH12012502091A1 (en) 2007-01-12 2019-06-14 Novartis Ag Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0597821A1 (en) * 1988-04-01 1994-05-18 Sankyo Company Limited 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
JPH0745499B2 (ja) * 1988-05-10 1995-05-17 三共株式会社 １―メチルカルバペネム誘導体
EP0462521A1 (en) * 1990-06-19 1991-12-27 Takeda Chemical Industries, Ltd. Crystalline penem, its production and use

Also Published As

Publication number Publication date
FI935063L (fi) 1994-05-18
EP0599512A1 (en) 1994-06-01
AU677235B2 (en) 1997-04-17
TW360657B (en) 1999-06-11
KR940011463A (ko) 1994-06-21
GR3029975T3 (en) 1999-07-30
PH30464A (en) 1997-05-28
DE69324106D1 (de) 1999-04-29
FI103576B1 (fi) 1999-07-30
CZ245493A3 (en) 1995-08-16
EP0599512B1 (en) 1999-03-24
NZ250201A (en) 1995-04-27
HU219582B (hu) 2001-05-28
CA2103223C (en) 2002-09-24
IL107596A (en) 1998-02-08
ATE178066T1 (de) 1999-04-15
JP2848552B2 (ja) 1999-01-20
FI935063A0 (fi) 1993-11-16
KR100236845B1 (ko) 2000-02-01
IL107596A0 (en) 1994-02-27
US5424306A (en) 1995-06-13
ES2131560T3 (es) 1999-08-01
HUT66001A (en) 1994-08-29
NO934140D0 (no) 1993-11-16
CN1093366A (zh) 1994-10-12
CA2103223A1 (en) 1994-05-18
JPH07165759A (ja) 1995-06-27
DE69324106T2 (de) 1999-12-09
HK1011977A1 (en) 1999-07-23
CZ280507B6 (cs) 1996-02-14
FI103576B (fi) 1999-07-30
NO934140L (no) 1994-05-18
DK0599512T3 (da) 1999-10-11
CN1036714C (zh) 1997-12-17
AU5063193A (en) 1994-06-02

Similar Documents

Publication Publication Date Title
NO991056L (no) Enantiomerrene basiske aryl-cykloalkyl-hydroksykarboksylsyreestere, fremgangsmÕte for deres fremstilling og deres anvendelse i legemidler
NO304431B1 (no) Krystallinsk karbapenemderivat og farmas°ytisk preparat omfattende dette
GB9406143D0 (en) Heterocyclic derivatives
HUT58100A (en) Process for producing carbapenem derivatives with antibiotic effect and pharmaceutical compositions with antibiotic effect comprisings such compounds
CA2404703A1 (en) Novel crystal form of pyrrolidylthiocarbapenem derivative
HUT64071A (en) Process for producing antimicrobial carbapenem derivatives and pharmaceutical compositions comprising such compounds
CA2427762A1 (en) Process for the preparation of crystalline n-formimidoyl thienamycin monohydrate (imipenem monohydrate)
RU93051177A (ru) Кристаллическое производное карбапенема, способ получения, фармацевтическая композиция и способ лечения и/или профилактики
NZ332453A (en) (1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-[(2S,4S)-2-[(3R)-3-methylaminomethylpyrrolidin-1-ylcarbonyl]pyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylic acid for the prevention or treatment of bacterial infections
FI906464A7 (fi) Menetelmä (1R,5S,6S)-2-((6,7-dihydro-5H-pyratsolo(1,2-a)(1,2,4)triatsolium-6-yl))tio-6-((R)-1-hydroksietyyli)-1-metyylikarbapeneemi-3-karboksylaatin valmistamiseksi ja menetelmässä käytetyt lähtöaineet
AU686104B2 (en) Substituted amidinonaphthyl ester derivatives
HU894594D0 (en) Crystalline (5r,6s)-2-(carbomyl-oxy-methyl)-6-[(1r)-hydroxi-ethyl]-2-penem-carboxylic acid and pharmaceutical preparatives containing this compounds
ATE88706T1 (de) In 2-stellung substituierte (1r,5s,6s)-2-thio-6((r)-1-hydroxyethyl>-1-methyl-carbapenem-carbonsaeure-derivate.
JPS5726658A (en) 4r -4- 3-substituted carboxy-3-diazo-2-oxopropyl -2- azetidinone derivative and its preparation
AU2002318778A1 (en) Novel Heterocyclic Derivatives as Intermediates for 2-thiosubstituted Carbapenems
HK1058197A (en) Process for the preparation of crystalline n-formimidoyl thienamycin monohydrate (imipenem monohydrate)
TH10195B (th) อนุพันธ์คาร์แบเพแนมซึ่งเป็นผลึก
ES8600767A1 (es) Un procedimiento para la preparacion de derivados de 7-oxo-1-azabiciclo (3.2.0) hepteno

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees