NO304647B1 - (S)-alfa-fenyl-2-pyridinetanamin (S)-malat, farmas÷ytisk preparat inneholde denne forbindelsen og dens anvendelse til fremstilling av legemiddel - Google Patents

(S)-alfa-fenyl-2-pyridinetanamin (S)-malat, farmas÷ytisk preparat inneholde denne forbindelsen og dens anvendelse til fremstilling av legemiddel

Info

Publication number: NO304647B1
Authority: NO; Norway
Prior art keywords: malate; alpha; phenyl; pyridinethanamine; drug
Prior art date: 1993-04-01

Application number

NO951546A

Other languages

English (en)

Norwegian (no)

Other versions

NO953846L (no

NO953846D0 (no

Inventor

Robert John Murray

Donald Mathisen

Michael Balestra

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-01

Filing date

1995-09-28

Publication date

1999-01-25

1993-04-01 Priority claimed from PCT/GB1993/000689 external-priority patent/WO1993020052A1/fr

1995-09-28 Application filed by Astra Ab filed Critical Astra Ab

1995-09-28 Publication of NO953846D0 publication Critical patent/NO953846D0/no

1995-11-21 Publication of NO953846L publication Critical patent/NO953846L/no

1999-01-25 Publication of NO304647B1 publication Critical patent/NO304647B1/no

Links

KRCGPQRORHRZRC-SXWHKFHYSA-N (2s)-2-hydroxybutanedioic acid;(1s)-1-phenyl-2-pyridin-2-ylethanamine Chemical compound OC(=O)[C@@H](O)CC(O)=O.C([C@H](N)C=1C=CC=CC=1)C1=CC=CC=N1 KRCGPQRORHRZRC-SXWHKFHYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
239000004090 neuroprotective agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO951546A 1993-04-01 1995-09-28 (S)-alfa-fenyl-2-pyridinetanamin (S)-malat, farmas÷ytisk preparat inneholde denne forbindelsen og dens anvendelse til fremstilling av legemiddel NO304647B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/GB1993/000689 WO1993020052A1 (fr)	1992-04-03	1993-04-01	1-phenyl-2-(2-pyridinyl)ethylamine enantiomere pour le traitement de maladies de degenerescence du systeme nerveux
GB939320273A GB9320273D0 (en)	1993-04-01	1993-10-01	Compound useful in therapy
PCT/GB1994/000651 WO1994022831A1 (fr)	1993-04-01	1994-03-29	(s)-alpha-phenyl-2-pyridineethanamine (s)-malate et son utilisation en tant que medicament

Publications (3)

Publication Number	Publication Date
NO953846D0 NO953846D0 (no)	1995-09-28
NO953846L NO953846L (no)	1995-11-21
NO304647B1 true NO304647B1 (no)	1999-01-25

Family

ID=26302299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO951546A NO304647B1 (no)	1993-04-01	1995-09-28	(S)-alfa-fenyl-2-pyridinetanamin (S)-malat, farmas÷ytisk preparat inneholde denne forbindelsen og dens anvendelse til fremstilling av legemiddel

Country Status (19)

Country	Link
EP (1)	EP0691957B1 (fr)
JP (1)	JP3023987B2 (fr)
CN (1)	CN1047168C (fr)
AT (1)	ATE156813T1 (fr)
AU (1)	AU682348B2 (fr)
CA (1)	CA2159478C (fr)
DE (1)	DE69404974T2 (fr)
DK (1)	DK0691957T3 (fr)
DZ (1)	DZ1765A1 (fr)
ES (1)	ES2105672T3 (fr)
FI (1)	FI109018B (fr)
GB (1)	GB9320273D0 (fr)
GR (1)	GR3025081T3 (fr)
IL (1)	IL109108A (fr)
MA (1)	MA23154A1 (fr)
NO (1)	NO304647B1 (fr)
PH (1)	PH30950A (fr)
SG (1)	SG48204A1 (fr)
WO (1)	WO1994022831A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE135206T1 (de) *	1988-08-12	1996-03-15	Astra Ab	Arylalkylamine und -amide mit krampflösender und nervenschützender wirkung
ZA942140B (en) *	1993-04-01	1994-10-03	Fisons Corp	Salt of (S)-alpha-phenyl-2-pyridineethanamine useful in therapy
SE9901340D0 (sv) *	1999-04-15	1999-04-15	Astra Pharma Prod	Novel process
SE9901338D0 (sv) *	1999-04-15	1999-04-15	Astra Pharma Prod	Novel process
DE10301650A1 (de) *	2003-01-17	2004-07-29	Johannes-Gutenberg-Universität Mainz	Medizinisch nützliche 1-Phenyl-2-aminomethylnaphthaline, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Verwendung
PE20120249A1 (es)	2008-12-24	2012-04-19	Astrazeneca Ab	Compuestos etanaminicos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3422191A (en) *	1965-01-21	1969-01-14	Synergistics Inc	Compositions and methods for tranquilization employing salts of n-morpholine ethanol
ATE135206T1 (de) *	1988-08-12	1996-03-15	Astra Ab	Arylalkylamine und -amide mit krampflösender und nervenschützender wirkung
JP2514855B2 (ja) *	1990-08-08	1996-07-10	キッセイ薬品工業株式会社	光学活性なアラニンアニリド誘導体の酸付加塩
DE69317411T2 (de) *	1992-04-03	1998-07-30	Ab Astra, Soedertaelje	Enantiomere 1-phenyl-2-(2-pyridinyl)ethylamin für die behandlung neurodegenerativer störungen

1993
- 1993-10-01 GB GB939320273A patent/GB9320273D0/en active Pending
1994
- 1994-03-24 IL IL10910894A patent/IL109108A/en not_active IP Right Cessation
- 1994-03-29 CA CA002159478A patent/CA2159478C/fr not_active Expired - Lifetime
- 1994-03-29 WO PCT/GB1994/000651 patent/WO1994022831A1/fr not_active Ceased
- 1994-03-29 AU AU63802/94A patent/AU682348B2/en not_active Expired
- 1994-03-29 PH PH48016A patent/PH30950A/en unknown
- 1994-03-29 JP JP6521814A patent/JP3023987B2/ja not_active Expired - Lifetime
- 1994-03-29 EP EP94911232A patent/EP0691957B1/fr not_active Expired - Lifetime
- 1994-03-29 AT AT94911232T patent/ATE156813T1/de active
- 1994-03-29 DK DK94911232.0T patent/DK0691957T3/da active
- 1994-03-29 SG SG1996007883A patent/SG48204A1/en unknown
- 1994-03-29 ES ES94911232T patent/ES2105672T3/es not_active Expired - Lifetime
- 1994-03-29 DE DE69404974T patent/DE69404974T2/de not_active Expired - Lifetime
- 1994-03-30 DZ DZ940029A patent/DZ1765A1/fr active
- 1994-04-01 MA MA23459A patent/MA23154A1/fr unknown
- 1994-04-01 CN CN94103739A patent/CN1047168C/zh not_active Expired - Lifetime
1995
- 1995-09-28 NO NO951546A patent/NO304647B1/no not_active IP Right Cessation
- 1995-09-29 FI FI954645A patent/FI109018B/fi not_active IP Right Cessation
1997
- 1997-10-17 GR GR970402722T patent/GR3025081T3/el unknown

Also Published As

Publication number	Publication date
GB9320273D0 (en)	1993-11-17
FI954645A0 (fi)	1995-09-29
SG48204A1 (en)	1998-04-17
CA2159478C (fr)	2005-01-25
FI954645L (fi)	1995-11-29
GR3025081T3 (en)	1998-01-30
CA2159478A1 (fr)	1994-10-13
AU6380294A (en)	1994-10-24
FI109018B (fi)	2002-05-15
PH30950A (en)	1997-12-23
EP0691957A1 (fr)	1996-01-17
NO953846L (no)	1995-11-21
AU682348B2 (en)	1997-10-02
IL109108A0 (en)	1994-06-24
JP3023987B2 (ja)	2000-03-21
ATE156813T1 (de)	1997-08-15
WO1994022831A1 (fr)	1994-10-13
DE69404974T2 (de)	1997-12-18
IL109108A (en)	1999-01-26
EP0691957B1 (fr)	1997-08-13
CN1047168C (zh)	1999-12-08
JPH08508292A (ja)	1996-09-03
DE69404974D1 (de)	1997-09-18
DK0691957T3 (da)	1997-10-27
DZ1765A1 (fr)	2002-02-17
NO953846D0 (no)	1995-09-28
MA23154A1 (fr)	1994-12-31
ES2105672T3 (es)	1997-10-16
CN1098095A (zh)	1995-02-01

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Legal Events

Date	Code	Title	Description
2014-04-07	MK1K	Patent expired