NO307445B1 - Farmasøytiske preparater inneholdende nanokapsler og fremgangsmõte for fremstilling derav - Google Patents
Farmasøytiske preparater inneholdende nanokapsler og fremgangsmõte for fremstilling deravInfo
- Publication number
- NO307445B1 NO307445B1 NO940111A NO940111A NO307445B1 NO 307445 B1 NO307445 B1 NO 307445B1 NO 940111 A NO940111 A NO 940111A NO 940111 A NO940111 A NO 940111A NO 307445 B1 NO307445 B1 NO 307445B1
- Authority
- NO
- Norway
- Prior art keywords
- nanocapsules
- preparation
- suspension
- processes
- pharmaceutical preparations
- Prior art date
Links
- 239000002088 nanocapsule Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000000725 suspension Substances 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- -1 poly(alkyl 2-cyanoacrylate Chemical compound 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
- B01J13/18—In situ polymerisation with all reactants being present in the same phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939300875A GB9300875D0 (en) | 1993-01-18 | 1993-01-18 | Nanocapsule containing pharmaceutical compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO940111D0 NO940111D0 (no) | 1994-01-12 |
| NO940111L NO940111L (no) | 1994-07-19 |
| NO307445B1 true NO307445B1 (no) | 2000-04-10 |
Family
ID=10728864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO940111A NO307445B1 (no) | 1993-01-18 | 1994-01-12 | Farmasøytiske preparater inneholdende nanokapsler og fremgangsmõte for fremstilling derav |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5500224A (de) |
| EP (1) | EP0608207B1 (de) |
| JP (1) | JP3688731B2 (de) |
| KR (1) | KR100311056B1 (de) |
| AT (1) | ATE172111T1 (de) |
| AU (1) | AU670840B2 (de) |
| CA (1) | CA2113243C (de) |
| CY (1) | CY2132B1 (de) |
| DE (1) | DE69413857T2 (de) |
| DK (1) | DK0608207T3 (de) |
| ES (1) | ES2122217T3 (de) |
| FI (1) | FI111441B (de) |
| GB (1) | GB9300875D0 (de) |
| HU (1) | HUT67213A (de) |
| NO (1) | NO307445B1 (de) |
| NZ (1) | NZ250673A (de) |
| PL (1) | PL173254B1 (de) |
| RU (1) | RU2145498C1 (de) |
| SG (1) | SG43682A1 (de) |
| TW (1) | TW336174B (de) |
| ZA (1) | ZA94205B (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2721510B1 (fr) * | 1994-06-22 | 1996-07-26 | Rhone Poulenc Rorer Sa | Nanoparticules filtrables dans des conditions stériles. |
| PT808154E (pt) * | 1995-02-06 | 2001-06-29 | Elan Pharma Int Ltd | Formulacoes de compostos sob a forma de dispersoes em nanoparticulas em oleos ou acidos gordos digestiveis |
| JP3759986B2 (ja) * | 1995-12-07 | 2006-03-29 | フロイント産業株式会社 | シームレスカプセルおよびその製造方法 |
| FR2766368B1 (fr) * | 1997-07-24 | 2000-03-31 | Univ Claude Bernard Lyon | Procede de preparation de nanocapsules de type vesiculaire, utilisables notamment comme vecteurs colloidaux de principes actifs pharmaceutiques ou autres |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
| US6458383B2 (en) | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
| US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| EP1267946A4 (de) * | 2000-02-28 | 2008-07-02 | Genesegues Inc | Nanokapsel-einkapselungs-system und verfahren |
| FR2806005B1 (fr) * | 2000-03-10 | 2002-06-14 | Univ Claude Bernard Lyon | Procede de preparation de particules colloidales sous forme de nanocapsules |
| US7153525B1 (en) | 2000-03-22 | 2006-12-26 | The University Of Kentucky Research Foundation | Microemulsions as precursors to solid nanoparticles |
| WO2002089820A1 (en) * | 2001-05-09 | 2002-11-14 | Mediplex Corporation | Formulation of amphiphilic heparin derivatives for enhancing mucosal absorption |
| DK1429731T3 (da) * | 2001-09-19 | 2007-05-14 | Elan Pharma Int Ltd | Nanopartikelformuleringer indeholdende insulin |
| DE60231549D1 (de) * | 2001-12-03 | 2009-04-23 | Dor Biopharma Inc | Stabilisierte umkehr-mizellen-zusammensetzungen und ihre verwendung |
| US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| MXPA05000778A (es) | 2002-07-18 | 2005-08-29 | Helix Biopharma Corp | Uso de ureasa para inhibir el crecimiento de celulas cancerosas. |
| WO2004053056A2 (en) * | 2002-09-24 | 2004-06-24 | University Of Kentucky Research Foundation | Nanoparticle-based vaccine delivery system containing adjuvant |
| JP2006521366A (ja) * | 2003-03-28 | 2006-09-21 | シグモイド・バイオテクノロジーズ・リミテッド | シームレスマイクロカプセルを含む固形経口剤形 |
| US20060003002A1 (en) * | 2003-11-03 | 2006-01-05 | Lipocine, Inc. | Pharmaceutical compositions with synchronized solubilizer release |
| CA2581816A1 (en) * | 2004-09-27 | 2006-04-06 | Sigmoid Biotechnologies Limited | Microcapsules comprising a methylxanthine and a corticosteroid |
| FR2899800B1 (fr) * | 2006-04-13 | 2008-10-10 | Oreal | Emulsion eau dans l'huile pour le traitement des fibres keratiniques comprenant un monomere cyanoacrylate |
| FR2899797A1 (fr) * | 2006-04-13 | 2007-10-19 | Oreal | Emulsion eau dans l'huile pour le traitement des fibres keratiniques comprenant un monomere cyanoacrylate et de l'ammoniaque |
| EP2061440A2 (de) | 2007-04-04 | 2009-05-27 | Sigmoid Pharma Limited | Pharmazeutische tacrolimus-zusammensetzung |
| ES2963291T3 (es) | 2007-04-26 | 2024-03-26 | Sublimity Therapeutics Ltd | Fabricación de múltiples minicápsulas |
| CA2685591A1 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
| EP2257220B1 (de) * | 2008-03-13 | 2017-06-14 | Liebel-Flarsheim Company LLC | Fussbetätigte multifunktionssteuerung für bildgebungssystem |
| MX2010012136A (es) * | 2008-05-06 | 2010-12-17 | Glaxo Group Ltd | Encapsulacion de agentes biologicamente activos. |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| ES2530049T3 (es) | 2009-05-18 | 2015-02-26 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| BR112012002963A2 (pt) | 2009-08-12 | 2017-10-24 | Sigmoid Pharma Ltd | composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| RU2566069C2 (ru) * | 2013-05-31 | 2015-10-20 | Общество с ограниченной ответственностью "Изварино Фарма" | Система доставки вещества белковой природы в виде наночастиц и способ ее получения |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| US20170189344A1 (en) * | 2014-05-30 | 2017-07-06 | AbbVie Deutschland GmbH & Co. KG | Highly drug-loaded poly(alkyl 2-cyanoacrylate) nanocapsules |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| EP3188716B1 (de) | 2014-09-03 | 2022-10-26 | GeneSegues, Inc. | Therapeutische nanopartikel und zugehörige zusammensetzungen, verfahren und systeme |
| EA036036B1 (ru) | 2014-11-07 | 2020-09-16 | Сигмойд Фарма Лимитед | Композиции, содержащие циклоспорин |
| AU2016210551B2 (en) | 2015-01-23 | 2019-03-07 | Helix Biopharma Corp. | Antibody-urease conjugates for therapeutic purposes |
| RU2590651C1 (ru) * | 2015-03-30 | 2016-07-10 | Александр Александрович Кролевец | Способ получения нанокапсул рибофлавина в геллановой камеди |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| US20180147215A1 (en) | 2016-11-28 | 2018-05-31 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| US12150945B2 (en) | 2018-07-20 | 2024-11-26 | Lipocine Inc. | Liver disease |
| EP4433028A1 (de) * | 2021-11-19 | 2024-09-25 | Nanoform Finland Oyj | Zusammensetzung mit einem pharmazeutischen wirkstoff in nanogrösse |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2515960A1 (fr) * | 1981-11-06 | 1983-05-13 | Alkhouri Fallouh Nazir | Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application |
| JPS6061521A (ja) * | 1983-09-16 | 1985-04-09 | Kyowa Hakko Kogyo Co Ltd | マイクロカプセル化製剤 |
| DE3341001A1 (de) * | 1983-11-12 | 1985-05-23 | Krause, Hans Jürgen | Nanopartikel aus bioabbaubarem, synthetischem material, verfahren zu deren herstellung und ihre anwendung |
| FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
| FR2659554B1 (fr) * | 1990-03-16 | 1994-09-30 | Oreal | Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant. |
-
1993
- 1993-01-18 GB GB939300875A patent/GB9300875D0/en active Pending
-
1994
- 1994-01-05 DE DE69413857T patent/DE69413857T2/de not_active Expired - Fee Related
- 1994-01-05 DK DK94870001T patent/DK0608207T3/da active
- 1994-01-05 SG SG1995001958A patent/SG43682A1/en unknown
- 1994-01-05 ES ES94870001T patent/ES2122217T3/es not_active Expired - Lifetime
- 1994-01-05 EP EP94870001A patent/EP0608207B1/de not_active Expired - Lifetime
- 1994-01-05 AT AT94870001T patent/ATE172111T1/de not_active IP Right Cessation
- 1994-01-10 PL PL94301841A patent/PL173254B1/pl not_active IP Right Cessation
- 1994-01-10 US US08/179,205 patent/US5500224A/en not_active Expired - Lifetime
- 1994-01-11 FI FI940115A patent/FI111441B/fi active
- 1994-01-11 AU AU53097/94A patent/AU670840B2/en not_active Ceased
- 1994-01-11 CA CA002113243A patent/CA2113243C/en not_active Expired - Fee Related
- 1994-01-12 NO NO940111A patent/NO307445B1/no unknown
- 1994-01-12 TW TW083100197A patent/TW336174B/zh active
- 1994-01-12 ZA ZA94205A patent/ZA94205B/xx unknown
- 1994-01-13 RU RU94002474A patent/RU2145498C1/ru active
- 1994-01-13 JP JP00183094A patent/JP3688731B2/ja not_active Expired - Fee Related
- 1994-01-13 NZ NZ250673A patent/NZ250673A/en not_active IP Right Cessation
- 1994-01-14 KR KR1019940000574A patent/KR100311056B1/ko not_active Expired - Fee Related
- 1994-01-14 HU HU9400107A patent/HUT67213A/hu unknown
-
1999
- 1999-07-19 CY CY9900018A patent/CY2132B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI940115A0 (fi) | 1994-01-11 |
| AU5309794A (en) | 1994-07-21 |
| FI940115L (fi) | 1994-07-19 |
| EP0608207B1 (de) | 1998-10-14 |
| JP3688731B2 (ja) | 2005-08-31 |
| RU94002474A (ru) | 1996-11-10 |
| SG43682A1 (en) | 1997-11-14 |
| KR940018086A (ko) | 1994-08-16 |
| HUT67213A (en) | 1995-03-28 |
| FI111441B (fi) | 2003-07-31 |
| US5500224A (en) | 1996-03-19 |
| DE69413857D1 (de) | 1998-11-19 |
| HU9400107D0 (en) | 1994-05-30 |
| DE69413857T2 (de) | 1999-04-15 |
| PL173254B1 (pl) | 1998-02-27 |
| CA2113243C (en) | 2008-08-05 |
| PL301841A1 (en) | 1994-07-25 |
| ZA94205B (en) | 1994-08-22 |
| CY2132B1 (en) | 2002-06-21 |
| ATE172111T1 (de) | 1998-10-15 |
| NO940111D0 (no) | 1994-01-12 |
| AU670840B2 (en) | 1996-08-01 |
| NO940111L (no) | 1994-07-19 |
| JPH06256172A (ja) | 1994-09-13 |
| RU2145498C1 (ru) | 2000-02-20 |
| ES2122217T3 (es) | 1998-12-16 |
| TW336174B (en) | 1998-07-11 |
| DK0608207T3 (da) | 1999-06-23 |
| EP0608207A1 (de) | 1994-07-27 |
| CA2113243A1 (en) | 1994-07-19 |
| NZ250673A (en) | 1994-11-25 |
| GB9300875D0 (en) | 1993-03-10 |
| KR100311056B1 (ko) | 2002-03-21 |
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