NO307496B1 - Anvendelse av en <delta>-opioid antagonist for fremstilling av et antitussivt middel - Google Patents

Anvendelse av en <delta>-opioid antagonist for fremstilling av et antitussivt middel

Info

Publication number: NO307496B1
Authority: NO; Norway
Prior art keywords: opioid antagonist; parta; preparation; antitussive agent; antitussive
Prior art date: 1992-12-22

Application number

NO943070A

Other languages

English (en)

Norwegian (no)

Other versions

NO943070D0 (no

NO943070L (no

Inventor

Hiroshi Nagase

Junzo Kamei

Koji Kawai

Takashi Endo

Original Assignee

Toray Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-22

Filing date

1994-08-19

Publication date

2000-04-17

1994-08-19 Application filed by Toray Industries filed Critical Toray Industries

1994-08-19 Publication of NO943070D0 publication Critical patent/NO943070D0/no

1994-10-21 Publication of NO943070L publication Critical patent/NO943070L/no

2000-04-17 Publication of NO307496B1 publication Critical patent/NO307496B1/no

Links

229940124584 antitussives Drugs 0.000 title abstract 2
239000003434 antitussive agent Substances 0.000 title 1
239000003401 opiate antagonist Substances 0.000 title 1
230000000694 effects Effects 0.000 abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
230000000954 anitussive effect Effects 0.000 abstract 1
239000000857 delta opiate receptor antagonist Substances 0.000 abstract 1
PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
230000001771 impaired effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fats And Perfumes (AREA)
Saccharide Compounds (AREA)
Linear Motors (AREA)

NO943070A 1992-12-22 1994-08-19 Anvendelse av en <delta>-opioid antagonist for fremstilling av et antitussivt middel NO307496B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP34194792		1992-12-22
PCT/JP1993/001855 WO1994014445A1 (fr)	1992-12-22	1993-12-22	Antitussif

Publications (3)

Publication Number	Publication Date
NO943070D0 NO943070D0 (no)	1994-08-19
NO943070L NO943070L (no)	1994-10-21
NO307496B1 true NO307496B1 (no)	2000-04-17

Family

ID=18349997

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO943070A NO307496B1 (no)	1992-12-22	1994-08-19	Anvendelse av en <delta>-opioid antagonist for fremstilling av et antitussivt middel

Country Status (11)

Country	Link
US (1)	US5714483A (de)
EP (1)	EP0636371B1 (de)
KR (1)	KR950700065A (de)
CN (1)	CN1071117C (de)
AT (1)	ATE166229T1 (de)
AU (1)	AU674379B2 (de)
CA (1)	CA2130457A1 (de)
DE (1)	DE69318710T2 (de)
NO (1)	NO307496B1 (de)
TW (1)	TW366284B (de)
WO (1)	WO1994014445A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5849731A (en) *	1995-09-26	1998-12-15	Toray Industries, Inc.	Indole derivatives and medical application thereof
ES2217533T3 (es) *	1997-01-16	2004-11-01	Toray Industries, Inc.	Derivados de indolomorfinano y medicamentos/preventivos para transtornos cerebrales.
US6337330B1 (en) *	1997-07-09	2002-01-08	Toray Industries, Inc.	Antitussives
CN1374963A (zh) *	1999-07-19	2002-10-16	东丽株式会社	尿频或尿失禁的治疗或预防剂
RU2004107501A (ru) *	2001-08-14	2005-02-20	Байотай Терапис Корпорейшн (Fi)	Способ лечения алкоголизма или злоупотребления алкоголем
US20060052409A1 (en) *	2002-07-11	2006-03-09	Koji Kawai	Therapeutic or preventive agent for nausea/vomiting
CA2594987A1 (en) *	2004-12-14	2006-06-22	Shionogi & Co., Ltd.	Therapeutic agent for constipation
CA2625495A1 (en) *	2005-10-11	2007-04-19	Toray Industries, Inc.	Therapeutic agent for nausea and/or vomiting
JPWO2008001859A1 (ja) *	2006-06-30	2009-11-26	学校法人北里研究所	オピオイドδ受容体アゴニスト

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4613668A (en) *	1983-12-22	1986-09-23	The United States Of America As Represented By The Department Of Health And Human Services	Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4816586A (en) *	1987-07-29	1989-03-28	Regents Of The University Of Minnesota	Delta opioid receptor antagonists
PT95069B (pt) *	1989-08-24	1997-10-31	Searle & Co	Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
JP2906654B2 (ja) *	1989-11-28	1999-06-21	東レ株式会社	免疫抑制剤及びその製造方法
AU654275B2 (en) *	1991-04-30	1994-11-03	Ur Labs, Inc.	Method for reducing emesis and nausea induced by the administration of an emesis-causing agent
JPH04342529A (ja) *	1991-05-21	1992-11-30	Toray Ind Inc	抗アレルギー剤

1993
- 1993-12-22 KR KR1019940702877A patent/KR950700065A/ko not_active Abandoned
- 1993-12-22 WO PCT/JP1993/001855 patent/WO1994014445A1/ja not_active Ceased
- 1993-12-22 AU AU57156/94A patent/AU674379B2/en not_active Ceased
- 1993-12-22 CN CN93119935A patent/CN1071117C/zh not_active Expired - Fee Related
- 1993-12-22 EP EP94903039A patent/EP0636371B1/de not_active Expired - Lifetime
- 1993-12-22 US US08/290,837 patent/US5714483A/en not_active Expired - Fee Related
- 1993-12-22 DE DE69318710T patent/DE69318710T2/de not_active Expired - Fee Related
- 1993-12-22 AT AT94903039T patent/ATE166229T1/de not_active IP Right Cessation
- 1993-12-22 CA CA002130457A patent/CA2130457A1/en not_active Abandoned
1994
- 1994-01-21 TW TW083100512A patent/TW366284B/zh active
- 1994-08-19 NO NO943070A patent/NO307496B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO943070D0 (no)	1994-08-19
US5714483A (en)	1998-02-03
EP0636371A4 (de)	1995-03-01
DE69318710D1 (en)	1998-06-25
CN1099617A (zh)	1995-03-08
AU5715694A (en)	1994-07-19
CN1071117C (zh)	2001-09-19
ATE166229T1 (de)	1998-06-15
WO1994014445A1 (fr)	1994-07-07
AU674379B2 (en)	1996-12-19
NO943070L (no)	1994-10-21
KR950700065A (ko)	1995-01-16
EP0636371A1 (de)	1995-02-01
TW366284B (en)	1999-08-11
EP0636371B1 (de)	1998-05-20
DE69318710T2 (de)	1998-09-10
CA2130457A1 (en)	1994-07-07

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Legal Events

Date	Code	Title	Description
2003-07-28	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN JUNE 2003