NO307755B1 - Forbindelser som inhiberer matriks-metallproteaser samt farmasøytiske preparater inneholdende slike - Google Patents

Forbindelser som inhiberer matriks-metallproteaser samt farmasøytiske preparater inneholdende slike

Info

Publication number: NO307755B1
Authority: NO; Norway
Prior art keywords: alkoxycarbonyl; carboxy; alkyl; compounds; hydrogen
Prior art date: 1993-08-05

Application number

NO960447A

Other languages

English (en)

Norwegian (no)

Other versions

NO960447L (no

NO960447D0 (no

Inventor

Arlindo L Castelhano

Teng J Liak

Stephen Horne

Zhengyo Yuan

Alexander Krantz

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-05

Filing date

1996-02-02

Publication date

2000-05-22

1996-02-02 Application filed by Syntex Inc filed Critical Syntex Inc

1996-02-02 Publication of NO960447D0 publication Critical patent/NO960447D0/no

1996-04-01 Publication of NO960447L publication Critical patent/NO960447L/no

2000-05-22 Publication of NO307755B1 publication Critical patent/NO307755B1/no

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000011159 matrix material Substances 0.000 title abstract 2
102000035195 Peptidases Human genes 0.000 title 1
108091005804 Peptidases Proteins 0.000 title 1
239000004365 Protease Substances 0.000 title 1
239000002184 metal Substances 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
-1 mercapto, acetylthio, carboxy, hydroxyaminocarbonyl Chemical group 0.000 abstract 6
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 5
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
102000005741 Metalloproteases Human genes 0.000 abstract 1
108010006035 Metalloproteases Proteins 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000005499 phosphonyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO960447A 1993-08-05 1996-02-02 Forbindelser som inhiberer matriks-metallproteaser samt farmasøytiske preparater inneholdende slike NO307755B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10265593A	1993-08-05	1993-08-05
PCT/US1994/008510 WO1995004735A1 (en)	1993-08-05	1994-07-27	Matrix metalloprotease inhibitors

Publications (3)

Publication Number	Publication Date
NO960447D0 NO960447D0 (no)	1996-02-02
NO960447L NO960447L (no)	1996-04-01
NO307755B1 true NO307755B1 (no)	2000-05-22

Family

ID=22290977

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO960447A NO307755B1 (no)	1993-08-05	1996-02-02	Forbindelser som inhiberer matriks-metallproteaser samt farmasøytiske preparater inneholdende slike

Country Status (22)

Country	Link
EP (1)	EP0712403B1 (de)
JP (1)	JPH09501430A (de)
KR (1)	KR100347646B1 (de)
CN (1)	CN1040211C (de)
AT (1)	ATE157979T1 (de)
AU (1)	AU679109B2 (de)
BR (1)	BR9407217A (de)
CA (1)	CA2168791A1 (de)
CZ (1)	CZ290030B6 (de)
DE (1)	DE69405572T2 (de)
DK (1)	DK0712403T3 (de)
ES (1)	ES2105744T3 (de)
FI (1)	FI112660B (de)
GR (1)	GR3024698T3 (de)
HU (1)	HU222818B1 (de)
NO (1)	NO307755B1 (de)
NZ (1)	NZ271765A (de)
PL (1)	PL177661B1 (de)
RU (1)	RU2132851C1 (de)
UA (1)	UA50707C2 (de)
WO (1)	WO1995004735A1 (de)
ZA (1)	ZA945847B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6013792A (en) *	1993-08-05	2000-01-11	Syntex (U.S.A.), Inc.	Matrix metalloprotease inhibitors
US5773428A (en) *	1993-08-05	1998-06-30	Syntex (U.S.A.) Inc.	Matrix metalloprotease inhibitors
NZ322553A (en)	1995-11-23	1998-12-23	British Biotech Pharm	Metalloproteinase inhibitors
US6500948B1 (en)	1995-12-08	2002-12-31	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
EA003294B1 (ru) *	1995-12-08	2003-04-24	Агурон Фармасьютикалс, Инк.	Ингибиторы металлопротеиназы, фармацевтические композиции, их содержащие, и их фармацевтические применения
US6462023B1 (en)	1996-09-10	2002-10-08	British Biotech Pharmaceuticals, Ltd.	Cytostatic agents
JP4238334B2 (ja)	1996-09-10	2009-03-18	ヴァーナリス（アールアンドディー）リミテッド	細胞増殖抑制性ヒドロキサム酸誘導体
US6174915B1 (en)	1997-03-25	2001-01-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) *	1996-10-24	1999-12-28	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US5952320A (en) *	1997-01-07	1999-09-14	Abbott Laboratories	Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985911A (en) *	1997-01-07	1999-11-16	Abbott Laboratories	C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
US5985900A (en) *	1997-04-01	1999-11-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6329400B1 (en)	1998-08-26	2001-12-11	Glaxo Wellcome Inc.	Formamide compounds as therapeutic agents
GB9818605D0 (en)	1998-08-26	1998-10-21	Glaxo Group Ltd	Formamide compounds as therepeutic agents
US6172064B1 (en)	1998-08-26	2001-01-09	Glaxo Wellcome Inc.	Formamides as therapeutic agents
US6288261B1 (en)	1998-12-18	2001-09-11	Abbott Laboratories	Inhibitors of matrix metalloproteinases
GB9907055D0 (en) *	1999-03-29	1999-05-19	British Biotech Pharm	Antibacterial agents
CZ20032814A3 (cs) *	2001-04-20	2004-08-18	Pfizeráproductsáinc	Způsob přípravy �Ź@@substituovaných indenů a aryl@kondezovaných azapolycyklických sloučenin
AU2004203983A1 (en) *	2003-01-15	2004-07-29	Pfizer Products Inc.	Process for the preparation of aryl fused polycyclic lactams
RU2378279C1 (ru) *	2008-05-28	2010-01-10	Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН)	CПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 1,2,3,6-ТЕТРАГИДРОПИРРОЛО[1,2-d][1,4]ДИАЗОЦИНОВ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9000846D0 (en) *	1990-01-15	1990-03-14	Beecham Group Plc	Novel compounds
GB9022117D0 (en) *	1990-10-11	1990-11-21	Beecham Group Plc	Novel compounds
WO1992021360A1 (en) *	1991-05-28	1992-12-10	Merck & Co., Inc.	Substituted n-carboxyalkylpeptidyl derivatives as antidegenerative active agents
GB9122859D0 (en) *	1991-10-28	1991-12-11	Smithkline Beecham Plc	Novel compounds

1994
- 1994-07-27 NZ NZ271765A patent/NZ271765A/en unknown
- 1994-07-27 CA CA002168791A patent/CA2168791A1/en not_active Abandoned
- 1994-07-27 KR KR1019960700539A patent/KR100347646B1/ko not_active Expired - Fee Related
- 1994-07-27 AU AU75519/94A patent/AU679109B2/en not_active Ceased
- 1994-07-27 PL PL94312797A patent/PL177661B1/pl not_active IP Right Cessation
- 1994-07-27 UA UA96010343A patent/UA50707C2/uk unknown
- 1994-07-27 EP EP94925699A patent/EP0712403B1/de not_active Expired - Lifetime
- 1994-07-27 BR BR9407217A patent/BR9407217A/pt not_active Application Discontinuation
- 1994-07-27 ES ES94925699T patent/ES2105744T3/es not_active Expired - Lifetime
- 1994-07-27 JP JP7506449A patent/JPH09501430A/ja not_active Ceased
- 1994-07-27 DE DE69405572T patent/DE69405572T2/de not_active Expired - Fee Related
- 1994-07-27 WO PCT/US1994/008510 patent/WO1995004735A1/en not_active Ceased
- 1994-07-27 AT AT94925699T patent/ATE157979T1/de not_active IP Right Cessation
- 1994-07-27 CN CN94193630A patent/CN1040211C/zh not_active Expired - Fee Related
- 1994-07-27 CZ CZ1996308A patent/CZ290030B6/cs not_active IP Right Cessation
- 1994-07-27 DK DK94925699.4T patent/DK0712403T3/da active
- 1994-07-27 HU HU9600249A patent/HU222818B1/hu not_active IP Right Cessation
- 1994-07-27 RU RU96104354/04A patent/RU2132851C1/ru not_active IP Right Cessation
- 1994-08-04 ZA ZA945847A patent/ZA945847B/xx unknown
1996
- 1996-02-02 NO NO960447A patent/NO307755B1/no not_active IP Right Cessation
- 1996-02-02 FI FI960482A patent/FI112660B/fi not_active IP Right Cessation
1997
- 1997-09-11 GR GR970401215T patent/GR3024698T3/el unknown

Also Published As

Publication number	Publication date
UA50707C2 (uk)	2002-11-15
BR9407217A (pt)	1996-09-17
CZ30896A3 (en)	1996-07-17
FI960482A0 (fi)	1996-02-02
FI112660B (fi)	2003-12-31
DE69405572T2 (de)	1998-02-12
FI960482A7 (fi)	1996-02-02
AU7551994A (en)	1995-02-28
CZ290030B6 (cs)	2002-05-15
KR100347646B1 (ko)	2002-12-05
NO960447L (no)	1996-04-01
DE69405572D1 (de)	1997-10-16
DK0712403T3 (da)	1998-01-26
HUT74586A (en)	1997-01-28
ATE157979T1 (de)	1997-09-15
NO960447D0 (no)	1996-02-02
WO1995004735A1 (en)	1995-02-16
NZ271765A (en)	1996-11-26
JPH09501430A (ja)	1997-02-10
PL312797A1 (en)	1996-05-13
CA2168791A1 (en)	1995-02-16
HU222818B1 (hu)	2003-11-28
ZA945847B (en)	1996-02-05
CN1132511A (zh)	1996-10-02
RU2132851C1 (ru)	1999-07-10
EP0712403A1 (de)	1996-05-22
EP0712403B1 (de)	1997-09-10
CN1040211C (zh)	1998-10-14
ES2105744T3 (es)	1997-10-16
AU679109B2 (en)	1997-06-19
GR3024698T3 (en)	1997-12-31
PL177661B1 (pl)	1999-12-31

Legal Events

Date	Code	Title	Description
2006-02-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO960447D0 (no)	1996-02-02	Inhibitorer for matriks-metallproteaser
DE69404324D1 (de)	1997-08-21	Matrix metallprotease inhibitoren
MY100100A (en)	1989-10-10	N-[(4,6-dimethoxypyrimidin-2-y1) aminocarbonyl]-3- trifluoromethylpyridine-2- sulfonamide or salts thereof, herbicidal composition containing the same, and process for the production of the compound
MY137301A (en)	2009-01-30	Peptide analogs as irreversible interleukin-1b protease inhibitors
GEP20001915B (en)	2000-01-05	(54) Compounds of Sulfonamide, Pharmaceutical Compositions Comprising Same, Methods for Inhibiting Aspartil Protease Activity and Inverse Binding, Method for Preventing and Treating HIV Infection in Mammals
AU7001596A (en)	1997-04-09	Compounds potentiating retinoid
TW328536B (en)	1998-03-21	3,4,5-substituted benzoylguanidines, process for their preparatiheir use as a medicament or diagnostic and medicament containing them
NO953844D0 (no)	1995-09-28	1-amidinofenyl-pyrrolidoner piperidinoner azetinoner som plateaggregeringshemmere
AU674839B2 (en)	1997-01-16	Pyridinecarboximidamide compound and use thereof
AR002958A1 (es)	1998-05-27	Derivados de acidos alcanoicos o fosfinicos que tienen un sustituyente triciclico, composiciones que los contienen y procedimiento para su preparacion
DK0553016T3 (da)	1997-12-01	Hidtil ukendte naphtalenamider og -sulfonamider, fremgangsmåder til deres fremstilling samt farmaceutiske midler indeholdende dem
DK0804223T3 (da)	2000-01-24	Farmaceutiske præparater indeholdende hGH
IE821434L (en)	1982-12-16	Arylsulphonamides.
DE3381850D1 (de)	1990-10-04	Pharmazeutische zusammensetzung.
AU7623796A (en)	1997-06-11	Azahexane derivatives as substrate isosters of retroviral asparate proteases
DK0632026T3 (da)	1998-07-27	Alfa-aminosyrederivater, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger, der indeholder dem
TW339335B (en)	1998-09-01	Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
CA2131186A1 (en)	1993-09-16	Isosteric Antiherpes Peptide Derivatives
EP0712838A4 (de)	1996-03-19	Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhölte collagenaseaktivität verursachte krankheiten
GB1509818A (en)	1978-05-04	Pharmaceutical composition for controlling liver diseases
AU8038794A (en)	1995-02-23	New eburnane analogues, a process for the preparation thereof and pharmaceutical compositions containing them
GB1518376A (en)	1978-07-19	Pharmaceutical composition for controlling liver damages
DK0574312T3 (da)	1995-04-10	Diacylglycerolnicotinater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
AU2490688A (en)	1989-05-11	Pharmaceutical product containing vincristine and peptide
DK0578535T3 (da)	1996-12-09	Hidtil ukendt peptid-derivater, der er aktive i celleadhæsionsprocesser, fremgangsmåde til deres fremstilling samt farmaceutiske sammensætninger indeholdende derivarerne