NO308214B1 - Ístrogenagonister/antagonister samt farmasøytisk preparat - Google Patents

Ístrogenagonister/antagonister samt farmasøytisk preparat

Info

Publication number
NO308214B1
NO308214B1 NO971814A NO971814A NO308214B1 NO 308214 B1 NO308214 B1 NO 308214B1 NO 971814 A NO971814 A NO 971814A NO 971814 A NO971814 A NO 971814A NO 308214 B1 NO308214 B1 NO 308214B1
Authority
NO
Norway
Prior art keywords
antagonists
well
pharmaceutical preparations
estrogen agonists
estrogen
Prior art date
Application number
NO971814A
Other languages
English (en)
Norwegian (no)
Other versions
NO971814L (no
NO971814D0 (no
Inventor
Chris Paul Miller
Michael David Collini
Bach Dinh Tran
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO971814D0 publication Critical patent/NO971814D0/no
Publication of NO971814L publication Critical patent/NO971814L/no
Publication of NO308214B1 publication Critical patent/NO308214B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NO971814A 1996-04-19 1997-04-18 Ístrogenagonister/antagonister samt farmasøytisk preparat NO308214B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63397696A 1996-04-19 1996-04-19
US63397296A 1996-04-19 1996-04-19

Publications (3)

Publication Number Publication Date
NO971814D0 NO971814D0 (no) 1997-04-18
NO971814L NO971814L (no) 1997-10-20
NO308214B1 true NO308214B1 (no) 2000-08-14

Family

ID=27092024

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971814A NO308214B1 (no) 1996-04-19 1997-04-18 Ístrogenagonister/antagonister samt farmasøytisk preparat

Country Status (23)

Country Link
EP (1) EP0802184B1 (de)
JP (1) JPH1036347A (de)
KR (1) KR970069986A (de)
CN (1) CN1103756C (de)
AR (1) AR006705A1 (de)
AT (1) ATE219485T1 (de)
AU (1) AU718888B2 (de)
BR (1) BR9701879A (de)
CO (1) CO4950540A1 (de)
CZ (1) CZ293065B6 (de)
DE (1) DE69713441T2 (de)
DK (1) DK0802184T3 (de)
EA (1) EA000815B1 (de)
ES (1) ES2179273T3 (de)
HU (1) HUP9700779A1 (de)
ID (1) ID16618A (de)
IL (1) IL120699A0 (de)
NO (1) NO308214B1 (de)
NZ (1) NZ314595A (de)
PT (1) PT802184E (de)
SK (1) SK282765B6 (de)
TW (1) TW397821B (de)
UA (1) UA47413C2 (de)

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US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
HRP20000778B1 (en) * 1998-05-15 2004-10-31 Wyeth Corp 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
AU2004200099B2 (en) * 1998-06-11 2006-11-02 Endorecherche, Inc. Medical Uses of A Selective Estrogen Receptor Modulator in Combination with Sex Steroid Precursors
EP1212335B1 (de) * 1999-09-13 2006-01-18 Wyeth Glucopyranosid-konjugate von 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-olen
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
AR029538A1 (es) * 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
AR029539A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Combinaciones de estatinas y agentes estrogenicos
EP1656938A1 (de) 2000-07-06 2006-05-17 Wyeth Kombinationen aus SSRI und Oestrogenmitteln
CN1635885A (zh) * 2000-07-06 2005-07-06 惠氏公司 应用取代吲哚化合物增强一氧化氮合酶活性
AR030064A1 (es) * 2000-07-06 2003-08-13 Wyeth Corp Metodos para inhibir los efectos uterotroficos de los agentes estrogenicos
US6509332B2 (en) 2000-07-06 2003-01-21 Wyeth Methods of treating excessive intraocular pressure
US6369051B1 (en) 2000-07-06 2002-04-09 American Home Products Corporation Combinations of SSRI and estrogenic agents
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
US6358991B2 (en) 2000-07-06 2002-03-19 American Home Products Corporation Methods of treating neuropeptide Y-related conditions
MXPA03000170A (es) * 2000-07-06 2003-05-27 Wyeth Corp Combinaciones de un inhibidor de recaptacion de serotonina selectivo y agentes estrogenicos.
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
WO2002003986A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating breast disorders
CA2420279C (en) * 2000-08-24 2011-07-19 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof
WO2002094788A1 (en) 2001-05-22 2002-11-28 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
EP1401446B1 (de) 2001-05-22 2005-02-09 Eli Lilly And Company Tetrahydrochinolin-derivate zur behandlung von krankheiten ausgelöst durch zu hohem oder zu niedrigem oestrogenspiegel
TW200536845A (en) 2004-04-07 2005-11-16 Wyeth Corp Crystalline polymorph of bazedoxifene acetate
SG151331A1 (en) 2004-04-07 2009-04-30 Wyeth Corp Crystalline polymorph of a bazedoxifene acetate
BRPI0509385A (pt) 2004-04-08 2007-09-18 Wyeth Corp composto, composição, métodos de preparar o sal, ea dispensão sólida, de tratar um mamìfero tendo uma doença ou sìndrome associadas com a deficiência de estrogênio ou excesso de estrogênio, uma doença ou distúrbio associados com a proliferação ou desenvolvimento anormal dos tecidos endometriais, de tratar cáncer de mama em um mamìfero, e uma mulher pós-menopáusica quanto a um ou mais distúrbios vasomotores, de reduzir colesterol, e de inibir perda óssea em um mamìfero, dispersão sólida, e, uso de um composto
EP1771169A1 (de) 2004-07-14 2007-04-11 PTC Therapeutics, Inc. Verfahren zur behandlung von hepatitis c
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008507518A (ja) 2004-07-22 2008-03-13 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するためのチエノピリジン
CN102357248A (zh) 2004-10-20 2012-02-22 恩多研究公司 单独的性甾体前体或与选择性雌激素受体调节剂联合用于防治绝经后女性的阴道疾病和病症
CN101277949A (zh) 2005-04-22 2008-10-01 阿兰托斯制药控股公司 二肽基肽酶-ⅳ抑制剂
US8268806B2 (en) 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions
US20100317635A1 (en) 2009-06-16 2010-12-16 Endorecherche, Inc. Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators
KR20160088947A (ko) 2010-06-16 2016-07-26 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
US9744177B2 (en) 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM
EP3302471B1 (de) 2015-05-29 2021-08-25 Eisai R&D Management Co., Ltd. Tetrasubstituierte alkenverbindungen und deren verwendung
DK3355884T3 (da) 2015-10-01 2021-08-02 Olema Pharmaceuticals Inc Tetrahydro-1h-pyrido[3,4-b]indol-antiøstrogenlægemidler
ES2935125T3 (es) 2015-12-09 2023-03-01 Univ Illinois Reguladores a la baja selectivos de los receptores de estrógenos con base en benzotiofeno
AU2017239348B2 (en) * 2016-03-25 2020-03-12 Luoxin Healthcare Science and Technology Development (Beijing) Ltd. Substituted-indole compounds as estrogen receptor down-regulators
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP4483875A3 (de) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclische degronimere für zielproteinabbau
EP3455219A4 (de) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. Amingebundene c3-glutarimiddegronimere für zielproteinabbau
BR112018077136A2 (pt) 2016-07-01 2019-04-30 G1 Therapeutics, Inc. composto, e, métodos para tratar um distúrbio associado com proliferação celular anormal e para reduzir o efeito de quimioterapia em células saudáveis.
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
MX385930B (es) 2016-11-28 2025-03-18 Eisai R&D Man Co Ltd Sales de derivado de indazol y cristales de las mismas.
AR110728A1 (es) 2017-01-06 2019-04-24 G1 Therapeutics Inc Terapia combinada para el tratamiento del cáncer
TW201835064A (zh) 2017-02-10 2018-10-01 美商G1治療公司 苯并噻吩雌激素受體調節劑
EP3641762B1 (de) 2017-06-20 2026-02-18 C4 Therapeutics, Inc. N/o-gebundene degrone und degronimere zum proteinabbau
CA3067873A1 (en) 2017-06-29 2019-01-03 G1 Therapeutics, Inc. Morphic forms of g1t38 and methods of manufacture thereof
CN120698983A (zh) 2018-12-20 2025-09-26 C4医药公司 靶向蛋白降解
CA3144791A1 (en) 2019-07-07 2021-01-14 Olema Pharmaceuticals, Inc. Regimens of estrogen receptor antagonists
US12428424B2 (en) 2019-07-22 2025-09-30 Radius Pharmaceuticals, Inc. Estrogen receptor-modulating compounds
EP4681715A3 (de) 2019-12-20 2026-01-28 C4 Therapeutics, Inc. Isoindolinon- und indazolverbindungen zum abbau von egfr
IL295709A (en) 2020-03-05 2022-10-01 C4 Therapeutics Inc Compounds for targeted degradation of brd9
EP4192458A4 (de) 2020-08-05 2024-09-04 C4 Therapeutics, Inc. Verbindungen zum gezielten ret-abbau
JP2024523839A (ja) 2021-06-08 2024-07-02 シーフォー セラピューティクス， インコーポレイテッド 突然変異体ｂｒａｆを分解する療法薬
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DE3232968A1 (de) * 1981-09-10 1983-06-09 Degussa Ag, 6000 Frankfurt Neue 2-(hydroxy-phenyl)-indole und verfahren zu deren herstellung
DE3821148A1 (de) * 1988-06-23 1989-12-28 Erwin Von Dr Angerer Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
GB9108811D0 (en) * 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole
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FR2708605A1 (fr) * 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
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GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
EP0746544B1 (de) * 1994-02-22 1998-09-09 Merrell Pharmaceuticals Inc. Indolderivate zur behandlung von östrogenabhängigen neoplasmen und krankheiten
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln

Also Published As

Publication number Publication date
HUP9700779A1 (hu) 1999-09-28
DE69713441D1 (de) 2002-07-25
ID16618A (id) 1997-10-23
HU9700779D0 (en) 1997-06-30
EP0802184A1 (de) 1997-10-22
SK47197A3 (en) 1997-11-05
DK0802184T3 (da) 2002-09-16
UA47413C2 (uk) 2002-07-15
AU1892197A (en) 1997-10-23
ES2179273T3 (es) 2003-01-16
JPH1036347A (ja) 1998-02-10
EA199700043A1 (ru) 1997-12-30
IL120699A0 (en) 1997-08-14
NZ314595A (en) 2000-04-28
PT802184E (pt) 2002-09-30
HK1002862A1 (en) 1998-09-25
SK282765B6 (sk) 2002-12-03
BR9701879A (pt) 1998-09-29
NO971814L (no) 1997-10-20
CZ293065B6 (cs) 2004-02-18
AU718888B2 (en) 2000-04-20
EA000815B1 (ru) 2000-04-24
AR006705A1 (es) 1999-09-08
CN1103756C (zh) 2003-03-26
KR970069986A (ko) 1997-11-07
CO4950540A1 (es) 2000-09-01
ATE219485T1 (de) 2002-07-15
TW397821B (en) 2000-07-11
DE69713441T2 (de) 2002-11-07
EP0802184B1 (de) 2002-06-19
CZ117697A3 (en) 1997-12-17
CN1168373A (zh) 1997-12-24
NO971814D0 (no) 1997-04-18

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