ATE219485T1 - N-benzyl-2-phenylindole als östrogene mittel - Google Patents

N-benzyl-2-phenylindole als östrogene mittel

Info

Publication number
ATE219485T1
ATE219485T1 AT97302577T AT97302577T ATE219485T1 AT E219485 T1 ATE219485 T1 AT E219485T1 AT 97302577 T AT97302577 T AT 97302577T AT 97302577 T AT97302577 T AT 97302577T AT E219485 T1 ATE219485 T1 AT E219485T1
Authority
AT
Austria
Prior art keywords
phenylindoles
benzyl
estrogenic agents
estrogenic
agents
Prior art date
Application number
AT97302577T
Other languages
English (en)
Inventor
Chris P Miller
Bach D Tran
Michael D Collini
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE219485T1 publication Critical patent/ATE219485T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT97302577T 1996-04-19 1997-04-15 N-benzyl-2-phenylindole als östrogene mittel ATE219485T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63397696A 1996-04-19 1996-04-19
US63397296A 1996-04-19 1996-04-19

Publications (1)

Publication Number Publication Date
ATE219485T1 true ATE219485T1 (de) 2002-07-15

Family

ID=27092024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97302577T ATE219485T1 (de) 1996-04-19 1997-04-15 N-benzyl-2-phenylindole als östrogene mittel

Country Status (23)

Country Link
EP (1) EP0802184B1 (de)
JP (1) JPH1036347A (de)
KR (1) KR970069986A (de)
CN (1) CN1103756C (de)
AR (1) AR006705A1 (de)
AT (1) ATE219485T1 (de)
AU (1) AU718888B2 (de)
BR (1) BR9701879A (de)
CO (1) CO4950540A1 (de)
CZ (1) CZ293065B6 (de)
DE (1) DE69713441T2 (de)
DK (1) DK0802184T3 (de)
EA (1) EA000815B1 (de)
ES (1) ES2179273T3 (de)
HU (1) HUP9700779A1 (de)
ID (1) ID16618A (de)
IL (1) IL120699A0 (de)
NO (1) NO308214B1 (de)
NZ (1) NZ314595A (de)
PT (1) PT802184E (de)
SK (1) SK282765B6 (de)
TW (1) TW397821B (de)
UA (1) UA47413C2 (de)

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HRP20000778B1 (en) * 1998-05-15 2004-10-31 Wyeth Corp 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens
EP1080073A1 (de) * 1998-05-15 2001-03-07 American Home Products Corporation Zusammensetzungen aus 2-phenyl-indol verbindungen und östrogen formulierungen
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
AU2004200099B2 (en) * 1998-06-11 2006-11-02 Endorecherche, Inc. Medical Uses of A Selective Estrogen Receptor Modulator in Combination with Sex Steroid Precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
NZ517645A (en) * 1999-09-13 2003-09-26 Wyeth Corp Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1- [4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
AR030064A1 (es) * 2000-07-06 2003-08-13 Wyeth Corp Metodos para inhibir los efectos uterotroficos de los agentes estrogenicos
AR029539A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Combinaciones de estatinas y agentes estrogenicos
AU2001271706A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Use of substituted indole compounds for treating breast disorders
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
US6509332B2 (en) 2000-07-06 2003-01-21 Wyeth Methods of treating excessive intraocular pressure
JP2004502729A (ja) * 2000-07-06 2004-01-29 ワイス Ｓｓｒｉおよびエストロゲン剤の組み合わせ
US6369051B1 (en) 2000-07-06 2002-04-09 American Home Products Corporation Combinations of SSRI and estrogenic agents
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
EP1656938A1 (de) 2000-07-06 2006-05-17 Wyeth Kombinationen aus SSRI und Oestrogenmitteln
CA2414111A1 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for increasing nitric oxide synthase activity
US6358991B2 (en) 2000-07-06 2002-03-19 American Home Products Corporation Methods of treating neuropeptide Y-related conditions
AR029538A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
CA2420279C (en) * 2000-08-24 2011-07-19 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof
US7056931B2 (en) 2001-05-22 2006-06-06 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
JP2004531559A (ja) 2001-05-22 2004-10-14 イーライ・リリー・アンド・カンパニー エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体
JP2007532548A (ja) 2004-04-07 2007-11-15 ワイス バゼドキシフェンアセテートの結晶質多形体
AU2005233133A1 (en) 2004-04-07 2005-10-27 Wyeth Crystalline polymorph of a bazedoxifene acetate
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JP2008506702A (ja) 2004-07-14 2008-03-06 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するための方法
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NZ553329A (en) 2004-07-22 2010-09-30 Ptc Therapeutics Inc Thienopyridines for treating hepatitis C
CN106138065A (zh) 2004-10-20 2016-11-23 恩多研究公司 性甾体前体单独或与选择性雌激素受体调节剂联合用于预防和治疗绝经后女性的性功能障碍
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US8268806B2 (en) 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions
US20100317635A1 (en) 2009-06-16 2010-12-16 Endorecherche, Inc. Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators
KR101731008B1 (ko) 2010-06-16 2017-04-27 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
US9744177B2 (en) 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM
PL3302471T3 (pl) 2015-05-29 2022-02-07 Eisai R&D Management Co., Ltd. Tetrapodstawione związki alkenowe i ich zastosowanie
KR102710603B1 (ko) 2015-10-01 2024-09-27 올레마 파마슈티컬스 인코포레이티드 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물
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TWI823845B (zh) 2017-01-06 2023-12-01 美商G1治療公司 用於治療癌症的組合療法
WO2018148576A1 (en) 2017-02-10 2018-08-16 G1 Therapeutics, Inc. Benzothiophene estrogen receptor modulators
CN110769822A (zh) 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
EP4455146A3 (de) 2017-06-29 2025-01-01 G1 Therapeutics, Inc. Morphische formen von git38 und verfahren zur herstellung davon
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JP7616794B2 (ja) 2019-07-07 2025-01-17 オレマ ファーマシューティカルズ インク． エストロゲン受容体アンタゴニストのレジメン
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Also Published As

Publication number Publication date
NO308214B1 (no) 2000-08-14
EP0802184B1 (de) 2002-06-19
EP0802184A1 (de) 1997-10-22
SK47197A3 (en) 1997-11-05
JPH1036347A (ja) 1998-02-10
HU9700779D0 (en) 1997-06-30
NO971814L (no) 1997-10-20
UA47413C2 (uk) 2002-07-15
BR9701879A (pt) 1998-09-29
AU718888B2 (en) 2000-04-20
ES2179273T3 (es) 2003-01-16
CN1103756C (zh) 2003-03-26
IL120699A0 (en) 1997-08-14
PT802184E (pt) 2002-09-30
AR006705A1 (es) 1999-09-08
HK1002862A1 (en) 1998-09-25
KR970069986A (ko) 1997-11-07
DE69713441T2 (de) 2002-11-07
CZ117697A3 (en) 1997-12-17
CN1168373A (zh) 1997-12-24
DK0802184T3 (da) 2002-09-16
TW397821B (en) 2000-07-11
NZ314595A (en) 2000-04-28
AU1892197A (en) 1997-10-23
ID16618A (id) 1997-10-23
CZ293065B6 (cs) 2004-02-18
EA199700043A1 (ru) 1997-12-30
HUP9700779A1 (hu) 1999-09-28
DE69713441D1 (de) 2002-07-25
NO971814D0 (no) 1997-04-18
CO4950540A1 (es) 2000-09-01
EA000815B1 (ru) 2000-04-24
SK282765B6 (sk) 2002-12-03

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