NO308948B1 - Tetraliner som bærer en fenylsubstituent pÕ den aromatiske ringen, farmasøytisk preparat inneholdende slike forbindelser, deres anvendelse for behandling av epilepsi, slag og hjerne- eller spinaltrauma, og fremgangsmÕte for deres fremstilling - Google Patents

Tetraliner som bærer en fenylsubstituent pÕ den aromatiske ringen, farmasøytisk preparat inneholdende slike forbindelser, deres anvendelse for behandling av epilepsi, slag og hjerne- eller spinaltrauma, og fremgangsmÕte for deres fremstilling Download PDF

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Publication number
NO308948B1
NO308948B1 NO975087A NO975087A NO308948B1 NO 308948 B1 NO308948 B1 NO 308948B1 NO 975087 A NO975087 A NO 975087A NO 975087 A NO975087 A NO 975087A NO 308948 B1 NO308948 B1 NO 308948B1
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NO
Norway
Prior art keywords
alkyl
compound
acid addition
free base
addition salt
Prior art date
Application number
NO975087A
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English (en)
Norwegian (no)
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NO975087L (no
NO975087D0 (no
Inventor
Robert Swoboda
Original Assignee
Novartis Ag
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10774032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO308948(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO975087L publication Critical patent/NO975087L/no
Publication of NO975087D0 publication Critical patent/NO975087D0/no
Publication of NO308948B1 publication Critical patent/NO308948B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
NO975087A 1995-05-05 1997-11-04 Tetraliner som bærer en fenylsubstituent pÕ den aromatiske ringen, farmasøytisk preparat inneholdende slike forbindelser, deres anvendelse for behandling av epilepsi, slag og hjerne- eller spinaltrauma, og fremgangsmÕte for deres fremstilling NO308948B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9509156.7A GB9509156D0 (en) 1995-05-05 1995-05-05 Organic compounds
PCT/EP1996/001841 WO1996034849A1 (en) 1995-05-05 1996-05-03 Tetralines bearing a phenyl substituant on the aromatic ring and their use in the treatment of epilepsy, stroke and brain or spinal trauma

Publications (3)

Publication Number Publication Date
NO975087L NO975087L (no) 1997-11-04
NO975087D0 NO975087D0 (no) 1997-11-04
NO308948B1 true NO308948B1 (no) 2000-11-20

Family

ID=10774032

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975087A NO308948B1 (no) 1995-05-05 1997-11-04 Tetraliner som bærer en fenylsubstituent pÕ den aromatiske ringen, farmasøytisk preparat inneholdende slike forbindelser, deres anvendelse for behandling av epilepsi, slag og hjerne- eller spinaltrauma, og fremgangsmÕte for deres fremstilling

Country Status (32)

Country Link
US (1) US6169116B1 (de)
EP (1) EP0823892B1 (de)
JP (1) JP3194965B2 (de)
KR (1) KR100435009B1 (de)
CN (1) CN1122019C (de)
AR (1) AR004484A1 (de)
AT (1) ATE193884T1 (de)
AU (1) AU706392B2 (de)
BR (1) BR9608169A (de)
CA (1) CA2217855C (de)
CO (1) CO4440486A1 (de)
CZ (1) CZ292022B6 (de)
DE (1) DE69608891T2 (de)
DK (1) DK0823892T3 (de)
ES (1) ES2148772T3 (de)
FI (1) FI973530A7 (de)
GB (1) GB9509156D0 (de)
GR (1) GR3033715T3 (de)
HU (1) HUP9801068A3 (de)
IL (1) IL118141A (de)
MX (1) MX9708510A (de)
NO (1) NO308948B1 (de)
NZ (1) NZ308471A (de)
PE (1) PE54797A1 (de)
PL (1) PL182857B1 (de)
PT (1) PT823892E (de)
RU (1) RU2169727C2 (de)
SK (1) SK282022B6 (de)
TR (1) TR199701298T1 (de)
TW (1) TW359667B (de)
WO (1) WO1996034849A1 (de)
ZA (1) ZA963540B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514412A (ja) 2001-12-27 2005-05-19 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 中枢神経系疾患を処置するために有用なアロイルピロールヘテロアリールおよびメタノール類
AU2003241453A1 (en) * 2002-05-17 2003-12-02 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid vr1 receptor
WO2005037286A1 (en) * 2003-03-25 2005-04-28 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia
EP1956006A1 (de) * 2007-02-06 2008-08-13 Laboratorios del Dr. Esteve S.A. Heterocyclisch substituierte Tetrahydronaphthalenderivate als 5-HT7 Rezeptorliganden
EP1975161A1 (de) 2007-03-28 2008-10-01 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituierte Tetrahydronaphthalenamin-Derivate, ihre Herstellung und Verwendung als Arzneimittel
WO2008154044A1 (en) * 2007-06-15 2008-12-18 University Of Florida Research Foundation Therapeutic compounds and methods of use
EP2011786A1 (de) 2007-07-05 2009-01-07 Laboratorios del Dr. Esteve S.A. Indanamin-Derivate, ihre Herstellung und Verwendung als Arzneimittel
US11021435B2 (en) 2014-05-19 2021-06-01 Northeastern University Serotonin receptor-targeting compounds and methods
WO2022040395A2 (en) * 2020-08-19 2022-02-24 Northeastern University Serotonin receptor modulators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045179B2 (ja) * 1977-06-08 1985-10-08 フナイ薬品工業株式会社 新規環状アミノアルコ−ル類およびその製造法
EP0257285A3 (de) 1986-07-28 1989-12-27 Whitby Research Incorporated Verfahren und Zusammensetzungen zur Herabsetzung des Intraokular-Drucks von Säugetieren
DE3718317A1 (de) 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
EP0381902A1 (de) 1989-01-09 1990-08-16 Merrell Dow Pharmaceuticals Inc. Tetralin-Derivate
JP2931986B2 (ja) 1989-02-17 1999-08-09 武田薬品工業株式会社 アラルキルアミン誘導体
SE8901889D0 (sv) * 1989-05-26 1989-05-26 Astra Ab Novel 8-substituted-2-aminotetralines
ES2138639T3 (es) * 1993-08-27 2000-01-16 Hoffmann La Roche Derivados peptidicos de tetrahidronaftaleno.
FR2711139B1 (fr) * 1993-10-15 1995-12-01 Adir Nouveaux dérivés de 1,2,3,4-tétrahydronaphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
SK148597A3 (en) 1998-10-07
BR9608169A (pt) 1999-02-09
HUP9801068A2 (hu) 1999-05-28
KR100435009B1 (ko) 2004-08-16
EP0823892B1 (de) 2000-06-14
IL118141A0 (en) 1996-09-12
ATE193884T1 (de) 2000-06-15
SK282022B6 (sk) 2001-10-08
CZ348697A3 (cs) 1998-02-18
NZ308471A (en) 1999-01-28
KR19990008301A (ko) 1999-01-25
CA2217855C (en) 2008-12-09
JP3194965B2 (ja) 2001-08-06
FI973530A0 (fi) 1997-08-27
TW359667B (en) 1999-06-01
WO1996034849A1 (en) 1996-11-07
MX9708510A (es) 1998-03-31
TR199701298T1 (xx) 1998-02-21
DE69608891T2 (de) 2000-11-16
ZA963540B (en) 1997-11-03
HUP9801068A3 (en) 2000-02-28
DE69608891D1 (de) 2000-07-20
AU706392B2 (en) 1999-06-17
DK0823892T3 (da) 2000-10-02
CO4440486A1 (es) 1997-05-07
AR004484A1 (es) 1998-12-16
RU2169727C2 (ru) 2001-06-27
US6169116B1 (en) 2001-01-02
IL118141A (en) 2002-11-10
GB9509156D0 (en) 1995-06-28
EP0823892A1 (de) 1998-02-18
FI973530L (fi) 1997-11-04
PL323037A1 (en) 1998-03-02
HK1014929A1 (en) 1999-10-08
NO975087L (no) 1997-11-04
CN1183763A (zh) 1998-06-03
PL182857B1 (pl) 2002-03-29
CN1122019C (zh) 2003-09-24
FI973530A7 (fi) 1997-11-04
JPH10513479A (ja) 1998-12-22
NO975087D0 (no) 1997-11-04
CA2217855A1 (en) 1996-11-07
AU5812996A (en) 1996-11-21
ES2148772T3 (es) 2000-10-16
PE54797A1 (es) 1998-01-21
CZ292022B6 (cs) 2003-07-16
GR3033715T3 (en) 2000-10-31
PT823892E (pt) 2000-11-30

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