NO309525B1 - Optisk aktive tiazolidinonderivater og farmasöytisk preparat inneholdende disse - Google Patents

Optisk aktive tiazolidinonderivater og farmasöytisk preparat inneholdende disse Download PDF

Info

Publication number: NO309525B1
Authority: NO; Norway
Prior art keywords: group; compound; acid; optically active; derivative according
Prior art date: 1995-03-02

Application number

NO974004A

Other languages

English (en)

Norwegian (no)

Other versions

NO974004L (no

NO974004D0 (no

Inventor

Sadao Ishihara

Fujio Saito

Yasuo Ohhata

Shigeki Miyake

Ryosuke Yorikane

Norio Fukuda

Keiichi Tabata

Mitsuko Makino

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-02

Filing date

1997-09-01

Publication date

2001-02-12

1997-09-01 Application filed by Sankyo Co filed Critical Sankyo Co

1997-09-01 Publication of NO974004D0 publication Critical patent/NO974004D0/no

1997-11-03 Publication of NO974004L publication Critical patent/NO974004L/no

2001-02-12 Publication of NO309525B1 publication Critical patent/NO309525B1/no

Links

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208000025865 Ulcer Diseases 0.000 claims description 10
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
125000004432 carbon atom Chemical group C* 0.000 claims description 6
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ZUWPBNPRLUORNS-WDSKDSINSA-N [(2s)-2-[[(4r)-2-oxo-1,3-thiazolidine-4-carbonyl]amino]butyl] nitrate Chemical compound [O-][N+](=O)OC[C@H](CC)NC(=O)[C@@H]1CSC(=O)N1 ZUWPBNPRLUORNS-WDSKDSINSA-N 0.000 claims description 2
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IPDJFBQALSQBOT-YUMQZZPRSA-N [(2s)-2-[[(4r)-2-oxo-1,3-thiazolidine-4-carbonyl]amino]hexyl] nitrate Chemical compound CCCC[C@@H](CO[N+]([O-])=O)NC(=O)[C@@H]1CSC(=O)N1 IPDJFBQALSQBOT-YUMQZZPRSA-N 0.000 claims 1
GHEFLHZNONXBIZ-YUMQZZPRSA-N [(2s)-4-methyl-2-[[(4r)-2-oxo-1,3-thiazolidine-4-carbonyl]amino]pentyl] nitrate Chemical compound [O-][N+](=O)OC[C@H](CC(C)C)NC(=O)[C@@H]1CSC(=O)N1 GHEFLHZNONXBIZ-YUMQZZPRSA-N 0.000 claims 1
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239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
KIWBRXCOTCXSSZ-UHFFFAOYSA-N hexyl carbonochloridate Chemical compound CCCCCCOC(Cl)=O KIWBRXCOTCXSSZ-UHFFFAOYSA-N 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
238000010191 image analysis Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
210000001758 mesenteric vein Anatomy 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
IZDROVVXIHRYMH-UHFFFAOYSA-N methanesulfonic anhydride Chemical compound CS(=O)(=O)OS(C)(=O)=O IZDROVVXIHRYMH-UHFFFAOYSA-N 0.000 description 1
ITYJDNHFRZSTJY-UHFFFAOYSA-N methanesulfonyl bromide Chemical compound CS(Br)(=O)=O ITYJDNHFRZSTJY-UHFFFAOYSA-N 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
DASJFYAPNPUBGG-UHFFFAOYSA-N naphthalene-1-sulfonyl chloride Chemical compound C1=CC=C2C(S(=O)(=O)Cl)=CC=CC2=C1 DASJFYAPNPUBGG-UHFFFAOYSA-N 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
229960001412 pentobarbital Drugs 0.000 description 1
239000002304 perfume Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
ABUYPZMWYIVOKQ-UHFFFAOYSA-N phenyl carbonobromidate Chemical compound BrC(=O)OC1=CC=CC=C1 ABUYPZMWYIVOKQ-UHFFFAOYSA-N 0.000 description 1
229940067107 phenylethyl alcohol Drugs 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
CPGRMGOILBSUQC-UHFFFAOYSA-N phosphoryl azide Chemical compound [N-]=[N+]=NP(=O)(N=[N+]=[N-])N=[N+]=[N-] CPGRMGOILBSUQC-UHFFFAOYSA-N 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229960003975 potassium Drugs 0.000 description 1
229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
235000015497 potassium bicarbonate Nutrition 0.000 description 1
239000011736 potassium bicarbonate Substances 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
235000011181 potassium carbonates Nutrition 0.000 description 1
239000011698 potassium fluoride Substances 0.000 description 1
235000003270 potassium fluoride Nutrition 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
QQKDTTWZXHEGAQ-UHFFFAOYSA-N propyl carbonochloridate Chemical compound CCCOC(Cl)=O QQKDTTWZXHEGAQ-UHFFFAOYSA-N 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
229960000957 prothipendyl Drugs 0.000 description 1
235000019423 pullulan Nutrition 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
125000005624 silicic acid group Chemical class 0.000 description 1
NGHMEZWZOZEZOH-UHFFFAOYSA-N silicic acid;hydrate Chemical compound O.O[Si](O)(O)O NGHMEZWZOZEZOH-UHFFFAOYSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
238000009495 sugar coating Methods 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
125000004434 sulfur atom Chemical group 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
IKFVLRLCFMEBDI-WDEREUQCSA-N tert-butyl (3r)-4-[[(2s)-1-hydroxypropan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-sulfanylidenebutanoate Chemical compound OC[C@H](C)NC(=S)[C@@H](CC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C IKFVLRLCFMEBDI-WDEREUQCSA-N 0.000 description 1
PDAFIZPRSXHMCO-ZCFIWIBFSA-N tert-butyl n-[(2r)-1-hydroxypropan-2-yl]carbamate Chemical compound OC[C@@H](C)NC(=O)OC(C)(C)C PDAFIZPRSXHMCO-ZCFIWIBFSA-N 0.000 description 1
SVULZUWODJYCNR-ZCFIWIBFSA-N tert-butyl n-[(2r)-1-nitrooxypropan-2-yl]carbamate Chemical compound [O-][N+](=O)OC[C@@H](C)NC(=O)OC(C)(C)C SVULZUWODJYCNR-ZCFIWIBFSA-N 0.000 description 1
LQRGWGOFPUXNOV-ZETCQYMHSA-N tert-butyl n-[(2s)-1-hydroxybutan-2-yl]carbamate Chemical compound CC[C@@H](CO)NC(=O)OC(C)(C)C LQRGWGOFPUXNOV-ZETCQYMHSA-N 0.000 description 1
PDAFIZPRSXHMCO-LURJTMIESA-N tert-butyl n-[(2s)-1-hydroxypropan-2-yl]carbamate Chemical compound OC[C@H](C)NC(=O)OC(C)(C)C PDAFIZPRSXHMCO-LURJTMIESA-N 0.000 description 1
WJSQQDPUDMZYQM-VIFPVBQESA-N tert-butyl n-[(2s)-1-nitrooxyhexan-2-yl]carbamate Chemical compound CCCC[C@@H](CO[N+]([O-])=O)NC(=O)OC(C)(C)C WJSQQDPUDMZYQM-VIFPVBQESA-N 0.000 description 1
SVULZUWODJYCNR-LURJTMIESA-N tert-butyl n-[(2s)-1-nitrooxypropan-2-yl]carbamate Chemical compound [O-][N+](=O)OC[C@H](C)NC(=O)OC(C)(C)C SVULZUWODJYCNR-LURJTMIESA-N 0.000 description 1
WAOWQLJJQBDGQC-UHFFFAOYSA-N tetraazanium;tetrafluoride Chemical compound [NH4+].[NH4+].[NH4+].[NH4+].[F-].[F-].[F-].[F-] WAOWQLJJQBDGQC-UHFFFAOYSA-N 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
231100000889 vertigo Toxicity 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Soil Working Implements (AREA)
Supplying Of Containers To The Packaging Station (AREA)

NO974004A 1995-03-02 1997-09-01 Optisk aktive tiazolidinonderivater og farmasöytisk preparat inneholdende disse NO309525B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP4223795		1995-03-02
JP27995195		1995-10-27
PCT/JP1996/000487 WO1996026931A1 (en)	1995-03-02	1996-03-01	Optically active thiazolidinone derivatives

Publications (3)

Publication Number	Publication Date
NO974004D0 NO974004D0 (no)	1997-09-01
NO974004L NO974004L (no)	1997-11-03
NO309525B1 true NO309525B1 (no)	2001-02-12

Family

ID=26381885

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO974004A NO309525B1 (no)	1995-03-02	1997-09-01	Optisk aktive tiazolidinonderivater og farmasöytisk preparat inneholdende disse

Country Status (17)

Country	Link
EP (1)	EP0812835B1 (da)
KR (1)	KR100292737B1 (da)
CN (1)	CN1066725C (da)
AT (1)	ATE201402T1 (da)
AU (1)	AU701977B2 (da)
CA (1)	CA2214386C (da)
CZ (1)	CZ290989B6 (da)
DE (1)	DE69612967T2 (da)
DK (1)	DK0812835T3 (da)
ES (1)	ES2158290T3 (da)
GR (1)	GR3036029T3 (da)
HU (1)	HU223094B1 (da)
NO (1)	NO309525B1 (da)
NZ (1)	NZ302391A (da)
PT (1)	PT812835E (da)
RU (1)	RU2141956C1 (da)
WO (1)	WO1996026931A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0798298T3 (da) *	1994-12-15	2001-10-22	Sankyo Co	Thiazolidinon- eller oxazolidonderivater til behandling af angina pectoris eller sammensætninger indeholdende samme som aktiv bestanddel
WO2002069967A1 (en) *	2001-03-01	2002-09-12	Sankyo Company, Limited	Percutaneous absorption compositions
JP2007513090A (ja)	2003-11-18	2007-05-24	ユニバーシティオブテネシーリサーチファウンデーション	チアゾリジノンアミド、チアゾリジンカルボン酸アミド、その製造方法、およびその使用方法
TWI400220B (zh)	2004-09-13	2013-07-01	Takeda Pharmaceutical	光活性胺衍生物的製法
US9029408B2 (en)	2008-06-16	2015-05-12	Gtx, Inc.	Compounds for treatment of cancer
US8822513B2 (en)	2010-03-01	2014-09-02	Gtx, Inc.	Compounds for treatment of cancer
US9447049B2 (en)	2010-03-01	2016-09-20	University Of Tennessee Research Foundation	Compounds for treatment of cancer
MX2010014066A (es)	2008-06-16	2011-06-01	Univ Tennessee Res Foundation	Compuestos para el tratamiento del cancer.
JP5879273B2 (ja)	2010-03-01	2016-03-08	ジーティーエックス・インコーポレイテッド	癌を処置するための化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8717068D0 (en) *	1987-07-20	1987-08-26	Fujisawa Pharmaceutical Co	Nitric ester derivative
AU647599B2 (en) *	1991-03-27	1994-03-24	Sankyo Company Limited	New thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators

1996
- 1996-03-01 WO PCT/JP1996/000487 patent/WO1996026931A1/ja not_active Ceased
- 1996-03-01 ES ES96904292T patent/ES2158290T3/es not_active Expired - Lifetime
- 1996-03-01 DE DE69612967T patent/DE69612967T2/de not_active Expired - Fee Related
- 1996-03-01 HU HU9900320A patent/HU223094B1/hu not_active IP Right Cessation
- 1996-03-01 CN CN96193568A patent/CN1066725C/zh not_active Expired - Fee Related
- 1996-03-01 KR KR1019970706114A patent/KR100292737B1/ko not_active Expired - Fee Related
- 1996-03-01 RU RU97114846A patent/RU2141956C1/ru not_active IP Right Cessation
- 1996-03-01 NZ NZ302391A patent/NZ302391A/en unknown
- 1996-03-01 AT AT96904292T patent/ATE201402T1/de not_active IP Right Cessation
- 1996-03-01 AU AU48438/96A patent/AU701977B2/en not_active Ceased
- 1996-03-01 CA CA002214386A patent/CA2214386C/en not_active Expired - Fee Related
- 1996-03-01 PT PT96904292T patent/PT812835E/pt unknown
- 1996-03-01 EP EP96904292A patent/EP0812835B1/en not_active Expired - Lifetime
- 1996-03-01 DK DK96904292T patent/DK0812835T3/da active
- 1996-03-01 CZ CZ19972734A patent/CZ290989B6/cs not_active IP Right Cessation
1997
- 1997-09-01 NO NO974004A patent/NO309525B1/no not_active IP Right Cessation
2001
- 2001-06-13 GR GR20010400882T patent/GR3036029T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK1003890A1 (en)	1998-11-13
CA2214386A1 (en)	1996-09-06
CN1066725C (zh)	2001-06-06
CZ290989B6 (cs)	2002-11-13
RU2141956C1 (ru)	1999-11-27
NO974004L (no)	1997-11-03
PT812835E (pt)	2001-08-30
AU701977B2 (en)	1999-02-11
KR100292737B1 (ko)	2001-09-17
WO1996026931A1 (en)	1996-09-06
DE69612967D1 (en)	2001-06-28
MX9706627A (es)	1997-11-29
AU4843896A (en)	1996-09-18
NZ302391A (en)	1999-04-29
DE69612967T2 (de)	2002-04-04
CA2214386C (en)	2001-12-04
KR19980702707A (ko)	1998-08-05
HK1016579A1 (en)	1999-11-05
ES2158290T3 (es)	2001-09-01
HUP9900320A3 (en)	1999-11-29
EP0812835A1 (en)	1997-12-17
HU223094B1 (hu)	2004-03-29
EP0812835A4 (en)	1998-04-29
CZ273497A3 (cs)	1998-02-18
GR3036029T3 (en)	2001-09-28
ATE201402T1 (de)	2001-06-15
NO974004D0 (no)	1997-09-01
HUP9900320A2 (hu)	1999-05-28
CN1183096A (zh)	1998-05-27
EP0812835B1 (en)	2001-05-23
DK0812835T3 (da)	2001-07-09

Legal Events

Date	Code	Title	Description
2005-11-14	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US6737411B2 (en)	2004-05-18	Racemization and enantiomer separation of clopidogrel
BRPI0415288B1 (pt)	2019-05-14	COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO O ÁCIDO 1-{[(a- ISOBUTANOILOXIETOXI) CARBONIL] AMINOMETIL}- 1-CICLO- HEXANO ACÉTICO CRISTALINO
US4508727A (en)	1985-04-02	Antihypertensive 2-oxo-imidazolidine derivatives
NO309525B1 (no)	2001-02-12	Optisk aktive tiazolidinonderivater og farmasöytisk preparat inneholdende disse
AU2009201233A1 (en)	2009-04-23	Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
NL8204159A (nl)	1983-05-16	Nieuwe 3-aminopregn-5-eenderivaten en zouten daarvan, werkwijze voor het bereiden van een en ander alsmede deze derivaten of hun zouten bevattende farmaceutische preparaten.
NO304311B1 (no)	1998-11-30	Tiazolidinon- og oksazolidinonderivater og farmas°ytisk preparat
KR100886805B1 (ko)	2009-03-05	탁산 유도체 결정 및 그 제조방법
US11685720B2 (en)	2023-06-27	Salt forms of URAT-1 inhibitors
JP2999669B2 (ja)	2000-01-17	ベンゾ［ｂ］フランカルボキサミド誘導体、その製法及び用途
US20080051435A1 (en)	2008-02-28	Crystalline and amorphous forms of tiagabine
CN114401948A (zh)	2022-04-26	用于改善认知功能和对抗物质成瘾的噻唑和二苯基取代的亚砜
KR100483221B1 (ko)	2005-04-15	Ｎ-치환된 피롤리딘 유도체 및 이의 제조방법
WO2008021518A2 (en)	2008-02-21	Crystalline forms of tiagabine hydrochloride and processes for the preparation of amorphous tiagabine hydrochloride
WO2024056079A1 (zh)	2024-03-21	内匹司他酸加成盐的多晶型及其制备方法和用途
WO2025104244A1 (en)	2025-05-22	Methods of preparing urea derivatives
US20070066594A1 (en)	2007-03-22	Crystalline forms fenoldopam mesylate
JPH0820586A (ja)	1996-01-23	１−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
KR101691954B1 (ko)	2017-01-02	신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
CA2359031C (en)	2005-05-24	Thiazolidinone or oxazolidinone derivatives for treatment of ulcerative disease
ZA200609248B (en)	2008-05-28	Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutica composition containing same
KR20100125124A (ko)	2010-11-30	피타바스타틴 헤미칼슘염의 신규한 결정형 및 그의 제조방법
JPH0121815B2 (da)	1989-04-24
CZ2001798A3 (en)	2001-06-13	Use of thia- or oxazolidinone derivatives for preparing a medicament for therapy or prevention of ulcer diseases
MXPA97006627A (es)	1998-07-03	Derivado de tiazolidinona opticamente activo