NO309705B1 - Anvendelse av insulin-liknende vekstfaktor for fremstilling av et medikament for redusering av perifer neuropati - Google Patents

Anvendelse av insulin-liknende vekstfaktor for fremstilling av et medikament for redusering av perifer neuropati Download PDF

Info

Publication number: NO309705B1
Authority: NO; Norway
Prior art keywords: igf; insulin; neuropathy; vincristine; iii
Prior art date: 1992-06-12

Application number

NO944780A

Other languages

English (en)

Norwegian (no)

Other versions

NO944780L (no

NO944780D0 (no

Inventor

Michael E Lewis

Stuart C Apfel

John A Kessler

Original Assignee

Cephalon Inc

Einstein Coll Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-12

Filing date

1994-12-09

Publication date

2001-03-19

1993-04-16 Priority claimed from US08/051,191 external-priority patent/US5420112A/en

1994-12-09 Application filed by Cephalon Inc, Einstein Coll Med filed Critical Cephalon Inc

1994-12-09 Publication of NO944780L publication Critical patent/NO944780L/no

1994-12-09 Publication of NO944780D0 publication Critical patent/NO944780D0/no

2001-03-19 Publication of NO309705B1 publication Critical patent/NO309705B1/no

Links

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238000012353 t test Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000008542 thermal sensitivity Effects 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
201000011296 tyrosinemia Diseases 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical compound OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 description 1
229960002110 vincristine sulfate Drugs 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019158 vitamin B6 Nutrition 0.000 description 1
239000011726 vitamin B6 Substances 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
208000030401 vitamin deficiency disease Diseases 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Surgical Instruments (AREA)
External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Apparatus For Radiation Diagnosis (AREA)

NO944780A 1992-06-12 1994-12-09 Anvendelse av insulin-liknende vekstfaktor for fremstilling av et medikament for redusering av perifer neuropati NO309705B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US89907092A	1992-06-12	1992-06-12
US08/051,191 US5420112A (en)	1992-06-12	1993-04-16	Prevention and treatment of peripheral neuropathy
PCT/US1993/005203 WO1993025219A1 (en)	1992-06-12	1993-06-01	Prevention and treatment of peripheral neuropathy

Publications (3)

Publication Number	Publication Date
NO944780L NO944780L (no)	1994-12-09
NO944780D0 NO944780D0 (no)	1994-12-09
NO309705B1 true NO309705B1 (no)	2001-03-19

Family

ID=26729153

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO944780A NO309705B1 (no)	1992-06-12	1994-12-09	Anvendelse av insulin-liknende vekstfaktor for fremstilling av et medikament for redusering av perifer neuropati

Country Status (16)

Country	Link
US (3)	US5569648A (de)
EP (1)	EP0659083B1 (de)
JP (1)	JP3623502B2 (de)
AT (1)	ATE187889T1 (de)
AU (1)	AU683215B2 (de)
CA (1)	CA2136969C (de)
DE (1)	DE69327402T2 (de)
DK (1)	DK0659083T3 (de)
ES (1)	ES2140463T3 (de)
FI (1)	FI945840A0 (de)
GR (1)	GR3032844T3 (de)
HU (1)	HU217543B (de)
NO (1)	NO309705B1 (de)
NZ (2)	NZ280523A (de)
PT (1)	PT659083E (de)
WO (1)	WO1993025219A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU693489B2 (en) *	1993-11-15	1998-07-02	Celtrix Pharmaceuticals, Inc.	Method of treating neurological disorders
US5728676A (en) *	1994-09-08	1998-03-17	Ciba-Geigy Corporation	Use of insulin-like growth factors I and II for inhibition of inflammatory response
US5741776A (en) *	1995-05-22	1998-04-21	Genentech, Inc.	Method of administration of IGF-I
US6420518B1 (en)	1997-04-04	2002-07-16	Genetech, Inc.	Insulin-like growth factor agonist molecules
US6121416A (en)	1997-04-04	2000-09-19	Genentech, Inc.	Insulin-like growth factor agonist molecules
US6916790B2 (en)	1997-05-05	2005-07-12	Mayo Foundation For Medical Education And Research	Treatment of osteoporosis
US6548482B1 (en)	1997-05-05	2003-04-15	Mayo Foundation For Medical Education And Research	Treatment of osteoporosis
WO1998050428A1 (en) *	1997-05-05	1998-11-12	Mayo Foundation For Medical Education And Research	Treatment of osteoporosis
AU1080899A (en)	1997-10-14	1999-05-03	Nadine A. Tatton	Methods for increasing schwann cell survival
EP1047449B1 (de) *	1997-10-28	2003-09-10	The University Of British Columbia	Immunologische zusammensetzungen und verfahren zur transienten änderung des zentralnervensystem-myelins der saügetiere und förderung der nerven-regenerierung
ES2146530B1 (es) *	1997-12-26	2001-04-16	Consejo Superior Investigacion	Utilizacion del factor de crecimiento igf-i en la fabricacion de composiciones utiles en el tratamiento de la ataxia cerebelar.
US6043259A (en) *	1998-07-09	2000-03-28	Medicure Inc.	Treatment of cardiovascular and related pathologies
AU762351B2 (en)	1999-01-06	2003-06-26	Genentech Inc.	Insulin-like growth factor (IGF) I mutant variants
CA2366602A1 (en)	1999-03-08	2000-09-14	Medicure Inc.	Pyridoxal analogues for vitamin b-6 disorders
US20050008641A1 (en) *	1999-04-28	2005-01-13	University Of British Columbia	Composition for neuronal regeneration comprising myelin-specific antibodies and complement proteins
CA2376029A1 (en)	1999-07-13	2001-01-18	Medicure Inc.	Use of pyridoxin derivatives for the treatment of diabetes and related complications
US6677356B1 (en) *	1999-08-24	2004-01-13	Medicure International Inc.	Treatment of cardiovascular and related pathologies
US6534300B1 (en)	1999-09-14	2003-03-18	Genzyme Glycobiology Research Institute, Inc.	Methods for producing highly phosphorylated lysosomal hydrolases
US6770468B1 (en)	1999-09-14	2004-08-03	Genzyme Glycobiology Research Institute, Inc.	Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway
US6632429B1 (en)	1999-12-17	2003-10-14	Joan M. Fallon	Methods for treating pervasive development disorders
WO2001064692A1 (en)	2000-02-29	2001-09-07	Medicure International Inc.	Cardioprotective phosphonates and malonates
US7442689B2 (en) *	2000-02-29	2008-10-28	Medicure International Inc.	Cardioprotective phosphonates and malonates
CA2404329A1 (en)	2000-03-28	2001-10-04	Medicure International Inc.	Treatment of cerebrovascular disease
ATE389416T1 (de)	2000-05-16	2008-04-15	Genentech Inc	Behandlung von knorpelerkrankungen
US6897228B2 (en) *	2000-07-07	2005-05-24	Medicure International Inc.	Pyridoxine and pyridoxal analogues: new uses
NZ523815A (en)	2000-07-07	2004-07-30	Medicure Int Inc	Pyridoxine and pyridoxal analogues: cardiovascular therapeutics
US6548519B1 (en)	2001-07-06	2003-04-15	Medicure International Inc.	Pyridoxine and pyridoxal analogues: novel uses
AU2001284865A1 (en) *	2000-08-14	2002-02-25	Joan M. Fallon	Methods for diagnosing and treating dysautonomia and other dysautonomic conditions
US20070053895A1 (en)	2000-08-14	2007-03-08	Fallon Joan M	Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US8030002B2 (en)	2000-11-16	2011-10-04	Curemark Llc	Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US7273698B2 (en)	2000-12-13	2007-09-25	Baylor College Of Medicine	Defects in periaxin associated with myelinopathies
CN100439397C (zh)	2001-02-09	2008-12-03	基因技术股份有限公司	Igf-1的结晶
US20040121988A1 (en) *	2001-03-28	2004-06-24	Medicure International Inc.	Treatment of cerebrovascular disease
US7714020B2 (en) *	2001-05-24	2010-05-11	Neuren Pharmaceuticals Limited	Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate
EP1401808B1 (de)	2001-05-24	2009-07-08	Neuren Pharmaceuticals Limited	Gpe-analoga und peptidomimetika
US7605177B2 (en) *	2001-05-24	2009-10-20	Neuren Pharmaceuticals Limited	Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration
US20070004641A1 (en) *	2001-05-24	2007-01-04	Neuren Pharmaceuticals Limited	Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate
US6905856B2 (en) *	2001-12-21	2005-06-14	Genzyme Glycobiology Research Institute, Inc.	Soluble GlcNAc phosphotransferase
US20030124652A1 (en) *	2001-12-21	2003-07-03	Novazyme Pharmaceuticals, Inc.	Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells
US6800472B2 (en) *	2001-12-21	2004-10-05	Genzyme Glycobiology Research Institute, Inc.	Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase
ES2207387B1 (es) *	2002-02-28	2005-07-16	Consejo Sup. Investig. Cientificas	Composicion quimica de igf-i para el tratamiento y prevencion de enfermedades neurodegenerativas.
US20040186077A1 (en) *	2003-03-17	2004-09-23	Medicure International Inc.	Novel heteroaryl phosphonates as cardioprotective agents
JP2008505126A (ja) *	2004-07-07	2008-02-21	メディキュアインターナショナルインコーポレイテッド	血小板凝集薬を用いる併用療法
US20070060549A1 (en) *	2004-08-10	2007-03-15	Friesen Albert D	Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
JP2008511838A (ja) *	2004-08-30	2008-04-17	テルシカ・インク	インシュリン様成長因子欠乏疾患の診断及び治療のための方法及び装置
US20060198838A1 (en) *	2004-09-28	2006-09-07	Fallon Joan M	Combination enzyme for cystic fibrosis
US20060094749A1 (en) *	2004-10-28	2006-05-04	Medicure International Inc.	Substituted pyridoxines as anti-platelet agents
US7459468B2 (en) *	2004-10-28	2008-12-02	Medicure International, Inc.	Aryl sulfonic pyridoxines as antiplatelet agents
EP1817288A4 (de) *	2004-10-28	2009-08-26	Medicure Int Inc	Duale antiplättchen-/antikoagulans-pyridoxinanaloge
US20080058282A1 (en)	2005-08-30	2008-03-06	Fallon Joan M	Use of lactulose in the treatment of autism
US20070116695A1 (en) *	2005-09-21	2007-05-24	Fallon Joan M	Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
JP2009517411A (ja) *	2005-11-28	2009-04-30	メディキュアインターナショナルインコーポレーテッド	心血管及び関連病状の処置のための調剤
US8658163B2 (en)	2008-03-13	2014-02-25	Curemark Llc	Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) *	2008-04-18	2011-12-27	Curemark Llc	Method for the treatment of the symptoms of drug and alcohol addiction
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EP2318035B1 (de) *	2008-07-01	2019-06-12	Curemark, Llc	Verfahren und zusammensetzungen zur behandlung von symptomen von neurologischen und geistesstörungen
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US20100092447A1 (en)	2008-10-03	2010-04-15	Fallon Joan M	Methods and compositions for the treatment of symptoms of prion diseases
CA2747611C (en)	2009-01-06	2019-09-17	Curemark Llc	Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces
WO2010080835A1 (en)	2009-01-06	2010-07-15	Curemark Llc	Compositions and methods for the treatment or the prevention oral infections by e. coli
US9056050B2 (en)	2009-04-13	2015-06-16	Curemark Llc	Enzyme delivery systems and methods of preparation and use
US9511125B2 (en)	2009-10-21	2016-12-06	Curemark Llc	Methods and compositions for the treatment of influenza
WO2011109448A1 (en) *	2010-03-05	2011-09-09	Baylor Research Institute	Involvement of androgen/androgen receptor pathway in fabry disease
WO2012102100A1 (ja)	2011-01-26	2012-08-02	雪印メグミルク株式会社	感覚改善剤
JP5976100B2 (ja)	2011-04-21	2016-08-23	キュアマークリミテッドライアビリティカンパニー	神経精神障害の処置のための化合物
EP2771367B1 (de)	2011-10-25	2017-12-06	Indiana University Research and Technology Corporation	Gigaxoninfusionsprotein und verfahren zur behandlung von axonaler neuropathie
US10350278B2 (en)	2012-05-30	2019-07-16	Curemark, Llc	Methods of treating Celiac disease
US12226464B2 (en)	2017-04-10	2025-02-18	Curemark, Llc	Compositions for treating addiction
US11541009B2 (en)	2020-09-10	2023-01-03	Curemark, Llc	Methods of prophylaxis of coronavirus infection and treatment of coronaviruses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1275922C (en) *	1985-11-28	1990-11-06	Harunobu Amagase	Treatment of cancer
SE8703625D0 (sv) *	1987-09-18	1987-09-18	Kabivitrum Ab	New medical use
ATE116335T1 (de) *	1987-12-24	1995-01-15	Gropep Pty Ltd	Peptid-analoge vom insulinähnlichen wachstums- faktor 1 (igf-1) oder faktor 2 (igf-2).
US5093317A (en) *	1989-06-05	1992-03-03	Cephalon, Inc.	Treating disorders by application of insulin-like growth factor
EP0597033B1 (de) *	1991-08-01	1997-04-09	Genentech, Inc.	IGF-I zur Verbesserung der neuronale Lage
US5420112A (en) *	1992-06-12	1995-05-30	Lewis; Michael E.	Prevention and treatment of peripheral neuropathy

1993
- 1993-06-01 HU HU9403544A patent/HU217543B/hu unknown
- 1993-06-01 WO PCT/US1993/005203 patent/WO1993025219A1/en not_active Ceased
- 1993-06-01 ES ES93915178T patent/ES2140463T3/es not_active Expired - Lifetime
- 1993-06-01 JP JP50154894A patent/JP3623502B2/ja not_active Expired - Lifetime
- 1993-06-01 DE DE69327402T patent/DE69327402T2/de not_active Expired - Lifetime
- 1993-06-01 DK DK93915178T patent/DK0659083T3/da active
- 1993-06-01 PT PT93915178T patent/PT659083E/pt unknown
- 1993-06-01 EP EP93915178A patent/EP0659083B1/de not_active Expired - Lifetime
- 1993-06-01 NZ NZ280523A patent/NZ280523A/en not_active IP Right Cessation
- 1993-06-01 NZ NZ253867A patent/NZ253867A/en not_active IP Right Cessation
- 1993-06-01 CA CA002136969A patent/CA2136969C/en not_active Expired - Lifetime
- 1993-06-01 AT AT93915178T patent/ATE187889T1/de active
- 1993-06-01 AU AU45262/93A patent/AU683215B2/en not_active Expired
1994
- 1994-12-09 NO NO944780A patent/NO309705B1/no not_active IP Right Cessation
- 1994-12-12 FI FI945840A patent/FI945840A0/fi not_active Application Discontinuation
- 1994-12-29 US US08/365,796 patent/US5569648A/en not_active Expired - Lifetime
- 1994-12-29 US US08/366,049 patent/US5633228A/en not_active Expired - Lifetime
1996
- 1996-06-04 US US08/658,198 patent/US5648335A/en not_active Expired - Lifetime
2000
- 2000-03-03 GR GR20000400536T patent/GR3032844T3/el unknown

Also Published As

Publication number	Publication date
US5633228A (en)	1997-05-27
ATE187889T1 (de)	2000-01-15
NZ253867A (en)	1996-08-27
US5648335A (en)	1997-07-15
JP3623502B2 (ja)	2005-02-23
DE69327402D1 (de)	2000-01-27
NO944780L (no)	1994-12-09
FI945840A0 (fi)	1994-12-12
NZ280523A (en)	1997-07-27
CA2136969C (en)	2009-03-24
WO1993025219A1 (en)	1993-12-23
AU4526293A (en)	1994-01-04
DE69327402T2 (de)	2000-05-04
PT659083E (pt)	2000-05-31
JPH07507799A (ja)	1995-08-31
AU683215B2 (en)	1997-11-06
GR3032844T3 (en)	2000-07-31
HU9403544D0 (en)	1995-02-28
EP0659083A1 (de)	1995-06-28
CA2136969A1 (en)	1993-12-23
DK0659083T3 (da)	2000-06-13
EP0659083A4 (de)	1996-03-20
HU217543B (hu)	2000-02-28
ES2140463T3 (es)	2000-03-01
US5569648A (en)	1996-10-29
EP0659083B1 (de)	1999-12-22
NO944780D0 (no)	1994-12-09
HUT70450A (en)	1995-10-30

Legal Events

Date	Code	Title	Description
2013-06-10	MK1K	Patent expired

Publication	Publication Date	Title
NO309705B1 (no)	2001-03-19	Anvendelse av insulin-liknende vekstfaktor for fremstilling av et medikament for redusering av perifer neuropati
US5420112A (en)	1995-05-30	Prevention and treatment of peripheral neuropathy
Lewis et al.	1993	Insulin-like growth factor-I: potential for treatment of motor neuronal disorders
Apfel	2002	Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold?
Luttinger et al.	1982	The effect of neurotensin on food consumption in the rat
US7994127B2 (en)	2011-08-09	Treatment of rett syndrome
US6680295B1 (en)	2004-01-20	Method and pharmaceutical composition for prevention and treatment of brain damage
WO1996009318A1 (en)	1996-03-28	Method and pharmaceutical composition for prevention and treatment of brain damage
EP0388226B1 (de)	1995-08-09	Mittel zur Behandlung von seniler Demenz, Gedächtnisstörungen und ähnlichen Zuständen
WO2003049761A1 (en)	2003-06-19	Use of insuline-like growth factor-i for promoting remyelination of axons
Conte et al.	2003	Neurotrophic factors: Pathophysiology and therapeutic applications in traumatic brain injury
US6143714A (en)	2000-11-07	Methods of using hepatocyte growth factor to promote survival, growth and differentiation of motor neurons
Vaught et al.	2007	Potential utility of rhIGF‐1 in neuromuscular and/or degenerative disease
AU754982B2 (en)	2002-11-28	Compositions for promoting nerve regeneration
US20220111012A1 (en)	2022-04-14	Methods of promoting remyelination
JP2007534746A (ja)	2007-11-29	化学療法誘発性ニューロパシーの治療または予防のためのｉｌ−６
Hernandez et al.	1985	Pupillary effects of neurotensin: structure-activity relationships
Rask et al.	1999	Neurotrophin treatment of peripheral sensory neuropathies
Vaught et al.	2008	Potential utility of rhlGF-1 in neuromuscular and/or degenerative
KR20180027924A (ko)	2018-03-15	글루카곤 유사 펩타이드-1(glp-1), glp-1 유래 펩타이드, 또는 glp-1 분해 억제제를 포함하는 근감소증 또는 근위축증 치료용 약학 조성물
WO2004091651A1 (de)	2004-10-28	Prongf als pharmazeutisch wirksames mittel zur behandlung demyelinisierender erkrankungen