NO310077B1 - Isoksazolidinderivater - Google Patents

Isoksazolidinderivater Download PDF

Info

Publication number: NO310077B1
Authority: NO; Norway
Prior art keywords: formula; compounds; addition salt; 6alkyl; acid
Prior art date: 1996-04-12

Application number

NO981077A

Other languages

English (en)

Norwegian (no)

Other versions

NO981077D0 (no

NO981077L (no

Inventor

Jose Ignacio Andres-Gil

Pedro Martinez-Jimenez

Francisco Javi Fernandez-Gadea

Victor Karel Sipido

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1998-03-11

Publication date

2001-05-14

1998-03-11 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1998-03-11 Publication of NO981077D0 publication Critical patent/NO981077D0/no

1998-10-12 Publication of NO981077L publication Critical patent/NO981077L/no

2001-05-14 Publication of NO310077B1 publication Critical patent/NO310077B1/no

Links

150000001875 compounds Chemical class 0.000 claims abstract description 83
239000000203 mixture Substances 0.000 claims abstract description 37
150000003839 salts Chemical class 0.000 claims abstract description 27
-1 cyano, hydroxy Chemical group 0.000 claims abstract description 25
239000003814 drug Substances 0.000 claims abstract description 15
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims abstract description 12
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract description 8
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims abstract description 8
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims abstract description 7
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 6
125000000815 N-oxide group Chemical group 0.000 claims abstract description 5
239000001257 hydrogen Substances 0.000 claims abstract description 5
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 5
125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 5
125000000623 heterocyclic group Chemical group 0.000 claims abstract description 4
125000002757 morpholinyl group Chemical group 0.000 claims abstract description 4
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims abstract description 4
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125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 5
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Classifications

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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Photoreceptors In Electrophotography (AREA)
Developing Agents For Electrophotography (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO981077A 1996-04-12 1998-03-11 Isoksazolidinderivater NO310077B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96200991		1996-04-12
PCT/EP1997/001830 WO1997039001A1 (en)	1996-04-12	1997-04-09	Isoxazolidine derivatives

Publications (3)

Publication Number	Publication Date
NO981077D0 NO981077D0 (no)	1998-03-11
NO981077L NO981077L (no)	1998-10-12
NO310077B1 true NO310077B1 (no)	2001-05-14

Family

ID=8223869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO981077A NO310077B1 (no)	1996-04-12	1998-03-11	Isoksazolidinderivater

Country Status (20)

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US (1)	US6156747A (de)
EP (1)	EP0892804B1 (de)
JP (1)	JP4299884B2 (de)
KR (1)	KR100598724B1 (de)
CN (1)	CN1082963C (de)
AT (1)	ATE222911T1 (de)
AU (1)	AU716470B2 (de)
DE (1)	DE69714980T2 (de)
DK (1)	DK0892804T3 (de)
ES (1)	ES2182064T3 (de)
HU (1)	HU221608B (de)
IL (1)	IL123656A (de)
MY (1)	MY117456A (de)
NO (1)	NO310077B1 (de)
NZ (1)	NZ329954A (de)
PL (1)	PL186541B1 (de)
PT (1)	PT892804E (de)
TW (1)	TW514637B (de)
WO (1)	WO1997039001A1 (de)
ZA (1)	ZA973122B (de)

Families Citing this family (5)

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Publication number	Priority date	Publication date	Assignee	Title
AUPO588297A0 (en) *	1997-03-26	1997-04-24	Luminis Pty Limited	Mediation in melatonin production
US20050148018A1 (en)	1999-10-07	2005-07-07	David Weiner	Methods of identifying inverse agonists of the serotonin 2A receptor
UA77650C2 (en)	1999-12-06	2007-01-15	Lundbeck & Co As H	Use of serotonin reuptake inhibitor in combination with deramcyclane
HUP0303270A3 (en) *	2001-02-21	2007-03-28	Janssen Pharmaceutica Nv	Isoxazoline derivatives as anti-depressants, process for their preparation and pharmaceutical compositions containing them
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1997
- 1997-04-09 NZ NZ329954A patent/NZ329954A/xx not_active IP Right Cessation
- 1997-04-09 WO PCT/EP1997/001830 patent/WO1997039001A1/en not_active Ceased
- 1997-04-09 US US09/155,839 patent/US6156747A/en not_active Expired - Lifetime
- 1997-04-09 AT AT97919344T patent/ATE222911T1/de active
- 1997-04-09 KR KR1019980703537A patent/KR100598724B1/ko not_active Expired - Lifetime
- 1997-04-09 PT PT97919344T patent/PT892804E/pt unknown
- 1997-04-09 JP JP53673497A patent/JP4299884B2/ja not_active Expired - Lifetime
- 1997-04-09 PL PL97326871A patent/PL186541B1/pl unknown
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- 1997-04-09 HU HU9901875A patent/HU221608B/hu unknown
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- 1997-04-09 DK DK97919344T patent/DK0892804T3/da active
- 1997-04-09 EP EP97919344A patent/EP0892804B1/de not_active Expired - Lifetime
- 1997-04-09 DE DE69714980T patent/DE69714980T2/de not_active Expired - Lifetime
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1998
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Also Published As

Publication number	Publication date
KR100598724B1 (ko)	2006-10-25
NO981077D0 (no)	1998-03-11
DE69714980D1 (de)	2002-10-02
AU716470B2 (en)	2000-02-24
AU2385297A (en)	1997-11-07
EP0892804B1 (de)	2002-08-28
US6156747A (en)	2000-12-05
NO981077L (no)	1998-10-12
HUP9901875A2 (hu)	1999-09-28
ES2182064T3 (es)	2003-03-01
WO1997039001A1 (en)	1997-10-23
EP0892804A1 (de)	1999-01-27
MY117456A (en)	2004-06-30
CN1082963C (zh)	2002-04-17
PL186541B1 (pl)	2004-01-30
HU221608B (hu)	2002-11-28
PL326871A1 (en)	1998-10-26
DK0892804T3 (da)	2002-12-02
KR19990067515A (ko)	1999-08-25
TW514637B (en)	2002-12-21
NZ329954A (en)	1999-07-29
HUP9901875A3 (en)	2000-06-28
CN1205010A (zh)	1999-01-13
ATE222911T1 (de)	2002-09-15
IL123656A0 (en)	1998-10-30
ZA973122B (en)	1998-10-12
PT892804E (pt)	2003-01-31
JP4299884B2 (ja)	2009-07-22
DE69714980T2 (de)	2003-04-10
IL123656A (en)	2001-09-13
JP2000508328A (ja)	2000-07-04

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2017-04-24	MK1K	Patent expired

Publication	Publication Date	Title
NO317156B1 (no)	2004-08-30	Substituerte tetracykliske tetrahydrofuranderivater
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JPH0412269B2 (de)	1992-03-04
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Woo	2005	Inverse electron demand Diels-Alder reactions of imidazoles with heterocyclic azadienes and applications in the syntheses of heterocyclic natural products and scaffolds in chemical library development
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Margetić	2014	Synthesis of Biologically Relevant Heterocycles