NO310820B1 - Pyridazino[4,5-B]kinolin-5-oksidderivater, deres fremstilling og deres anvendelse i glysinantagonister - Google Patents

Pyridazino[4,5-B]kinolin-5-oksidderivater, deres fremstilling og deres anvendelse i glysinantagonister Download PDF

Info

Publication number: NO310820B1
Authority: NO; Norway
Prior art keywords: quinoline; hydroxy; oxo; dihydropyridazino; salt
Prior art date: 1996-07-25

Application number

NO19990306A

Other languages

English (en)

Norwegian (no)

Other versions

NO990306D0 (no

NO990306L (no

Inventor

Wojciech Danysz

Markus Gold

Ivars Kalvinsh

Christopher Graham Rap Parsons

Irene Piskunova

Eugene Rozhkov

Original Assignee

Merz & Co Gmbh & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1999-01-22

Publication date

2001-09-03

1999-01-22 Application filed by Merz & Co Gmbh & Co filed Critical Merz & Co Gmbh & Co

1999-01-22 Publication of NO990306D0 publication Critical patent/NO990306D0/no

1999-03-15 Publication of NO990306L publication Critical patent/NO990306L/no

2001-09-03 Publication of NO310820B1 publication Critical patent/NO310820B1/no

Links

238000002360 preparation method Methods 0.000 title claims description 18
YSDYDUVFUKPZCE-UHFFFAOYSA-N 5-oxidopyridazino[4,5-b]quinolin-5-ium Chemical class N1=NC=C2[N+]([O-])=C(C=CC=C3)C3=CC2=C1 YSDYDUVFUKPZCE-UHFFFAOYSA-N 0.000 title 1
229940127337 Glycine Antagonists Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 65
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238000000034 method Methods 0.000 claims description 31
239000000825 pharmaceutical preparation Substances 0.000 claims description 19
-1 methylenedioxy Chemical group 0.000 claims description 11
239000004480 active ingredient Substances 0.000 claims description 10
150000003248 quinolines Chemical class 0.000 claims description 10
239000004381 Choline salt Substances 0.000 claims description 9
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CZIVVSZSZNUYHA-UHFFFAOYSA-N C1=CC=C2[N+]([O-])=C3C(O)=NNC(=O)C3=CC2=C1 Chemical compound C1=CC=C2[N+]([O-])=C3C(O)=NNC(=O)C3=CC2=C1 CZIVVSZSZNUYHA-UHFFFAOYSA-N 0.000 claims description 7
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OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 6
BUWUYXIYKSUCPC-UHFFFAOYSA-N BrC1=C(Cl)C=C2[N+]([O-])=C3C(O)=NNC(=O)C3=CC2=C1 Chemical compound BrC1=C(Cl)C=C2[N+]([O-])=C3C(O)=NNC(=O)C3=CC2=C1 BUWUYXIYKSUCPC-UHFFFAOYSA-N 0.000 claims description 5
HIGOKJCMNNRPHC-UHFFFAOYSA-N BrC1=CC=C2[N+]([O-])=C3C(O)=NNC(=O)C3=CC2=C1 Chemical compound BrC1=CC=C2[N+]([O-])=C3C(O)=NNC(=O)C3=CC2=C1 HIGOKJCMNNRPHC-UHFFFAOYSA-N 0.000 claims description 5
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NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 claims description 3
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- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Inorganic Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO19990306A 1996-07-25 1999-01-22 Pyridazino[4,5-B]kinolin-5-oksidderivater, deres fremstilling og deres anvendelse i glysinantagonister NO310820B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/686,346 US5776935A (en)	1996-07-25	1996-07-25	Pyrido-phtalazin diones and their use against neurological disorders associated with excitotoxicity and malfunctioning of glutamatergic neurotransmission
PCT/EP1997/004057 WO1998004556A1 (en)	1996-07-25	1997-07-25	Pyridazino [4,5-b]-quinoline 5-oxide derivatives, their preparation and their use as glycine antagonists

Publications (3)

Publication Number	Publication Date
NO990306D0 NO990306D0 (no)	1999-01-22
NO990306L NO990306L (no)	1999-03-15
NO310820B1 true NO310820B1 (no)	2001-09-03

Family

ID=24755940

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NO19990306A NO310820B1 (no)	1996-07-25	1999-01-22	Pyridazino[4,5-B]kinolin-5-oksidderivater, deres fremstilling og deres anvendelse i glysinantagonister

Country Status (30)

Country	Link
US (1)	US5776935A (cs)
EP (1)	EP0931081B1 (cs)
JP (1)	JP3595342B2 (cs)
KR (1)	KR100598206B1 (cs)
CN (1)	CN1093860C (cs)
AR (1)	AR004158A1 (cs)
AT (1)	ATE224894T1 (cs)
AU (1)	AU719993B2 (cs)
BR (1)	BR9710569A (cs)
CA (1)	CA2261923C (cs)
CZ (1)	CZ289293B6 (cs)
DE (1)	DE69715893T2 (cs)
DK (1)	DK0931081T3 (cs)
EA (1)	EA001711B1 (cs)
ES (1)	ES2180041T3 (cs)
FI (1)	FI112946B (cs)
GE (1)	GEP20022801B (cs)
HU (1)	HU223780B1 (cs)
IL (1)	IL128225A (cs)
LT (1)	LT4591B (cs)
LV (1)	LV12260B (cs)
NO (1)	NO310820B1 (cs)
PL (1)	PL189572B1 (cs)
PT (1)	PT931081E (cs)
SI (1)	SI9720048B (cs)
SK (1)	SK283536B6 (cs)
TW (1)	TW402605B (cs)
UA (1)	UA63911C2 (cs)
WO (1)	WO1998004556A1 (cs)
ZA (1)	ZA976612B (cs)

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US6444702B1 (en)	2000-02-22	2002-09-03	Neuromolecular, Inc.	Aminoadamantane derivatives as therapeutic agents
CA2457011C (en) *	2001-08-20	2012-04-24	Maiken Nedergaard	Treatment of glial tumors with glutamate antagonists
EP1298581A1 (fr) *	2001-09-27	2003-04-02	C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa	Procédé et dispositif pour calculer les valeurs des neurones d'un réseau neuronal
US7105185B2 (en)	2001-10-03	2006-09-12	Herbalscience, Llc	Kavalactone profile
US20050069596A1 (en) *	2001-10-03	2005-03-31	Gow Robert T.	Compositions and methods comprising kava and anti-anxiety compounds
US7001620B2 (en)	2001-10-03	2006-02-21	Herbal Science, Llc	Kavalactone product
US7291352B2 (en)	2001-10-03	2007-11-06	Herbalscience Llc	Methods and compositions for oral delivery of Areca and mate' or theobromine
US7029707B2 (en) *	2001-10-03	2006-04-18	Herbalscience, Llc	Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
US7037524B2 (en) *	2001-10-03	2006-05-02	Herbalscience, Llc	Oral delivery of a botanical
US20050037025A1 (en) *	2002-10-03	2005-02-17	Gow Robert T.	Methods and compositions comprising kava and mate' or theobromine
US20040082543A1 (en) *	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
RU2266118C2 (ru) *	2003-10-21	2005-12-20	Общество с ограниченной ответственностью "Абидофарма"	Мазь для лечения аутоиммунных заболеваний
RU2266119C2 (ru) *	2003-10-21	2005-12-20	Общество с ограниченной ответственностью "Абидофарма"	Препарат для ингаляций при лечении туберкулеза
US7294353B2 (en) *	2003-10-24	2007-11-13	Herbalscience, Llc	Methods and compositions comprising ilex
CN1917892A (zh) *	2003-10-24	2007-02-21	草本制药科学有限责任公司	包含冬青的方法和组合物
MX2007012443A (es) *	2005-04-08	2007-12-13	Abbott Lab	Formulaciones farmaceuticas orales que comprenden acido fenofibrico y/o sus sales.
NZ584098A (en) *	2007-09-20	2012-05-25	Cortex Pharma Inc	3-substituted 1,2,3-triazin-4-one's and 3-substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses
EP2264035A1 (en) *	2009-06-04	2010-12-22	Merz Pharma GmbH & Co. KGaA	Glycine B antagonists
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1996
- 1996-07-25 US US08/686,346 patent/US5776935A/en not_active Expired - Fee Related
1997
- 1997-07-23 TW TW086110479A patent/TW402605B/zh not_active IP Right Cessation
- 1997-07-24 ZA ZA9706612A patent/ZA976612B/xx unknown
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- 1997-07-25 JP JP50849998A patent/JP3595342B2/ja not_active Expired - Fee Related
- 1997-07-25 AU AU42969/97A patent/AU719993B2/en not_active Ceased
- 1997-07-25 ES ES97918944T patent/ES2180041T3/es not_active Expired - Lifetime
- 1997-07-25 SK SK103-99A patent/SK283536B6/sk unknown
- 1997-07-25 WO PCT/EP1997/004057 patent/WO1998004556A1/en not_active Ceased
- 1997-07-25 CN CN97197534A patent/CN1093860C/zh not_active Expired - Fee Related
- 1997-07-25 CZ CZ1999201A patent/CZ289293B6/cs unknown
- 1997-07-25 AT AT97918944T patent/ATE224894T1/de not_active IP Right Cessation
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- 1997-07-25 AR ARP970103380A patent/AR004158A1/es active IP Right Grant
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- 1997-07-25 HU HU9903104A patent/HU223780B1/hu active IP Right Grant
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- 1997-07-25 IL IL12822597A patent/IL128225A/xx not_active IP Right Cessation
- 1997-07-25 UA UA99021084A patent/UA63911C2/uk unknown
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1999
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Also Published As

Publication number	Publication date
HU223780B1 (hu)	2005-01-28
JP3595342B2 (ja)	2004-12-02
EP0931081B1 (en)	2002-09-25
EA199900161A1 (ru)	1999-10-28
SI9720048A (sl)	1999-12-31
FI990134L (fi)	1999-03-24
GEP20022801B (en)	2002-09-25
DK0931081T3 (da)	2003-01-27
AU4296997A (en)	1998-02-20
LT99007A (lt)	1999-07-26
NO990306D0 (no)	1999-01-22
SK283536B6 (sk)	2003-09-11
UA63911C2 (uk)	2004-02-16
KR20000029568A (ko)	2000-05-25
CA2261923C (en)	2006-01-24
EA001711B1 (ru)	2001-06-25
CZ289293B6 (cs)	2001-12-12
KR100598206B1 (ko)	2006-07-07
HK1020193A1 (en)	2000-03-31
TW402605B (en)	2000-08-21
IL128225A0 (en)	1999-11-30
CN1228778A (zh)	1999-09-15
SK10399A3 (en)	2000-01-18
AR004158A1 (es)	1998-11-04
LV12260A (lv)	1999-04-20
PL331323A1 (en)	1999-07-05
IL128225A (en)	2005-09-25
FI990134A0 (fi)	1999-01-25
CN1093860C (zh)	2002-11-06
CZ2019997A3 (cs)	1999-09-15
SI9720048B (sl)	2002-02-28
ES2180041T3 (es)	2003-02-01
EP0931081A1 (en)	1999-07-28
LT4591B (lt)	1999-12-27
FI112946B (fi)	2004-02-13
ATE224894T1 (de)	2002-10-15
US5776935A (en)	1998-07-07
HUP9903104A2 (hu)	2000-03-28
DE69715893D1 (de)	2002-10-31
JP2000515872A (ja)	2000-11-28
AU719993B2 (en)	2000-05-18
CA2261923A1 (en)	1998-02-05
NO990306L (no)	1999-03-15
HUP9903104A3 (en)	2000-04-28
ZA976612B (en)	1998-02-10
WO1998004556A1 (en)	1998-02-05
DE69715893T2 (de)	2003-01-30
PT931081E (pt)	2003-02-28
BR9710569A (pt)	1999-08-17
PL189572B1 (pl)	2005-08-31
LV12260B (en)	1999-08-20

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JPS5818363A (ja)	1983-02-02	複素環式置換アミノピラゾリン類およびその薬としての用途
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CS232349B1 (cs)	1985-01-16	1-fenyl-3-(3,4-dihydroxyfenyl)-2-propy!aminy, jejich hydrobromidy a způsob jejich přípravy