NO311029B1 - Fremgangsmate for rensing av 11-<beta>-21-dihydroksy-2'-metyl- 5'-<beta>H-pregna-1,4-dieno-[17,16-d]-oksazol-3,20-dion - Google Patents

Fremgangsmate for rensing av 11-<beta>-21-dihydroksy-2'-metyl- 5'-<beta>H-pregna-1,4-dieno-[17,16-d]-oksazol-3,20-dion Download PDF

Info

Publication number: NO311029B1
Authority: NO; Norway
Prior art keywords: compound; water; resin; formula; mixture
Prior art date: 1996-02-16

Application number

NO19983665A

Other languages

English (en)

Norwegian (no)

Other versions

NO983665L (no

NO983665D0 (no

Inventor

Luigi Forte

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-16

Filing date

1998-08-11

Publication date

2001-10-01

1998-08-11 Application filed by Lepetit Spa filed Critical Lepetit Spa

1998-08-11 Publication of NO983665L publication Critical patent/NO983665L/no

1998-08-11 Publication of NO983665D0 publication Critical patent/NO983665D0/no

2001-10-01 Publication of NO311029B1 publication Critical patent/NO311029B1/no

Links

238000000034 method Methods 0.000 title claims abstract description 33
238000000746 purification Methods 0.000 title claims description 4
150000001875 compounds Chemical class 0.000 claims abstract description 40
238000000855 fermentation Methods 0.000 claims abstract description 29
230000004151 fermentation Effects 0.000 claims abstract description 29
239000000203 mixture Substances 0.000 claims abstract description 28
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
229920005989 resin Polymers 0.000 claims abstract description 20
239000011347 resin Substances 0.000 claims abstract description 20
239000002952 polymeric resin Substances 0.000 claims abstract description 16
229920003002 synthetic resin Polymers 0.000 claims abstract description 16
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 12
239000003960 organic solvent Substances 0.000 claims abstract description 12
239000003463 adsorbent Substances 0.000 claims abstract description 7
239000007864 aqueous solution Substances 0.000 claims abstract description 6
239000011159 matrix material Substances 0.000 claims abstract description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 16
238000005406 washing Methods 0.000 claims description 13
238000010828 elution Methods 0.000 claims description 10
239000000243 solution Substances 0.000 claims description 9
238000001914 filtration Methods 0.000 claims description 7
239000002245 particle Substances 0.000 claims description 6
230000000704 physical effect Effects 0.000 claims description 6
239000011148 porous material Substances 0.000 claims description 6
238000011084 recovery Methods 0.000 claims description 5
238000004140 cleaning Methods 0.000 claims description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
238000003795 desorption Methods 0.000 claims description 3
239000004925 Acrylic resin Substances 0.000 claims description 2
229920000178 Acrylic resin Polymers 0.000 claims description 2
241000186063 Arthrobacter Species 0.000 claims description 2
241000223208 Curvularia Species 0.000 claims description 2
229920001890 Novodur Polymers 0.000 claims description 2
150000002576 ketones Chemical class 0.000 claims description 2
238000001179 sorption measurement Methods 0.000 claims description 2
229940125904 compound 1 Drugs 0.000 claims 1
235000010633 broth Nutrition 0.000 abstract description 11
238000004519 manufacturing process Methods 0.000 abstract 1
239000000047 product Substances 0.000 description 10
241000430521 Alyssum Species 0.000 description 7
241000223211 Curvularia lunata Species 0.000 description 7
239000002609 medium Substances 0.000 description 6
239000002904 solvent Substances 0.000 description 5
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
229920001429 chelating resin Polymers 0.000 description 3
FBHSPRKOSMHSIF-GRMWVWQJSA-N deflazacort Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)=N[C@@]3(C(=O)COC(=O)C)[C@@]1(C)C[C@@H]2O FBHSPRKOSMHSIF-GRMWVWQJSA-N 0.000 description 3
229960001145 deflazacort Drugs 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000004128 high performance liquid chromatography Methods 0.000 description 3
239000002054 inoculum Substances 0.000 description 3
239000012452 mother liquor Substances 0.000 description 3
230000001105 regulatory effect Effects 0.000 description 3
150000003839 salts Chemical class 0.000 description 3
239000000126 substance Substances 0.000 description 3
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000000356 contaminant Substances 0.000 description 2
230000008034 disappearance Effects 0.000 description 2
238000001035 drying Methods 0.000 description 2
239000000284 extract Substances 0.000 description 2
238000000605 extraction Methods 0.000 description 2
239000003862 glucocorticoid Substances 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
239000008272 agar Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
239000003480 eluent Substances 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
239000012467 final product Substances 0.000 description 1
238000007429 general method Methods 0.000 description 1
230000003314 glucocorticoidlike Effects 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000013067 intermediate product Substances 0.000 description 1
239000002050 international nonproprietary name Substances 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
230000007017 scission Effects 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000009466 transformation Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0068—Nitrogen and oxygen at position 16(17)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO19983665A 1996-02-16 1998-08-11 Fremgangsmate for rensing av 11-<beta>-21-dihydroksy-2'-metyl- 5'-<beta>H-pregna-1,4-dieno-[17,16-d]-oksazol-3,20-dion NO311029B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96102325		1996-02-16
PCT/EP1996/005392 WO1997030068A1 (fr)	1996-02-16	1996-12-04	PROCEDE DE PURIFICATION DE 11β-21-DIHYDROXY-2'-METHYL-5'-βH-PREGNA-1,43-DIENO[17,16-D]OXAZOLE-3,20-DIONE

Publications (3)

Publication Number	Publication Date
NO983665L NO983665L (no)	1998-08-11
NO983665D0 NO983665D0 (no)	1998-08-11
NO311029B1 true NO311029B1 (no)	2001-10-01

Family

ID=8222483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19983665A NO311029B1 (no)	1996-02-16	1998-08-11	Fremgangsmate for rensing av 11-<beta>-21-dihydroksy-2'-metyl- 5'-<beta>H-pregna-1,4-dieno-[17,16-d]-oksazol-3,20-dion

Country Status (20)

Country	Link
US (1)	US6228851B1 (fr)
EP (1)	EP0885240B1 (fr)
JP (1)	JP4076098B2 (fr)
KR (1)	KR100440352B1 (fr)
CN (1)	CN1131236C (fr)
AT (1)	ATE198600T1 (fr)
AU (1)	AU709171B2 (fr)
CA (1)	CA2246520C (fr)
DE (1)	DE69611548T2 (fr)
DK (1)	DK0885240T3 (fr)
EA (1)	EA000789B1 (fr)
ES (1)	ES2153996T3 (fr)
GR (1)	GR3035208T3 (fr)
HU (1)	HU226936B1 (fr)
IL (1)	IL125414A (fr)
NO (1)	NO311029B1 (fr)
NZ (1)	NZ324300A (fr)
PT (1)	PT885240E (fr)
WO (1)	WO1997030068A1 (fr)
ZA (1)	ZA971214B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006028817A1 (de) *	2006-06-21	2007-12-27	Evonik Degussa Gmbh	Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen

1996
- 1996-12-04 WO PCT/EP1996/005392 patent/WO1997030068A1/fr not_active Ceased
- 1996-12-04 ES ES96942325T patent/ES2153996T3/es not_active Expired - Lifetime
- 1996-12-04 EP EP96942325A patent/EP0885240B1/fr not_active Expired - Lifetime
- 1996-12-04 US US09/117,882 patent/US6228851B1/en not_active Expired - Lifetime
- 1996-12-04 HU HU9904410A patent/HU226936B1/hu unknown
- 1996-12-04 JP JP52891697A patent/JP4076098B2/ja not_active Expired - Lifetime
- 1996-12-04 PT PT96942325T patent/PT885240E/pt unknown
- 1996-12-04 AU AU11758/97A patent/AU709171B2/en not_active Expired
- 1996-12-04 CA CA002246520A patent/CA2246520C/fr not_active Expired - Lifetime
- 1996-12-04 AT AT96942325T patent/ATE198600T1/de active
- 1996-12-04 EA EA199800732A patent/EA000789B1/ru not_active IP Right Cessation
- 1996-12-04 DE DE69611548T patent/DE69611548T2/de not_active Expired - Lifetime
- 1996-12-04 DK DK96942325T patent/DK0885240T3/da active
- 1996-12-04 IL IL12541496A patent/IL125414A/xx not_active IP Right Cessation
- 1996-12-04 CN CN96180009A patent/CN1131236C/zh not_active Expired - Lifetime
- 1996-12-04 NZ NZ324300A patent/NZ324300A/xx not_active IP Right Cessation
- 1996-12-04 KR KR10-1998-0706178A patent/KR100440352B1/ko not_active Expired - Lifetime
1997
- 1997-02-13 ZA ZA9701214A patent/ZA971214B/xx unknown
1998
- 1998-08-11 NO NO19983665A patent/NO311029B1/no not_active IP Right Cessation
2001
- 2001-01-11 GR GR20000402867T patent/GR3035208T3/el unknown

Also Published As

Publication number	Publication date
EP0885240B1 (fr)	2001-01-10
HU226936B1 (en)	2010-03-29
HUP9904410A3 (en)	2002-05-28
ES2153996T3 (es)	2001-03-16
DE69611548T2 (de)	2001-06-07
AU1175897A (en)	1997-09-02
NO983665L (no)	1998-08-11
US6228851B1 (en)	2001-05-08
DE69611548D1 (de)	2001-02-15
AU709171B2 (en)	1999-08-26
GR3035208T3 (en)	2001-04-30
KR100440352B1 (ko)	2004-09-18
EA000789B1 (ru)	2000-04-24
NZ324300A (en)	1999-02-25
CA2246520C (fr)	2004-03-02
DK0885240T3 (da)	2001-01-29
NO983665D0 (no)	1998-08-11
CA2246520A1 (fr)	1997-08-21
CN1131236C (zh)	2003-12-17
ATE198600T1 (de)	2001-01-15
WO1997030068A1 (fr)	1997-08-21
JP2000511878A (ja)	2000-09-12
CN1209137A (zh)	1999-02-24
EP0885240A1 (fr)	1998-12-23
KR19990082445A (ko)	1999-11-25
IL125414A0 (en)	1999-03-12
JP4076098B2 (ja)	2008-04-16
HK1018276A1 (en)	1999-12-17
IL125414A (en)	2003-10-31
EA199800732A1 (ru)	1999-02-25
PT885240E (pt)	2001-04-30
ZA971214B (en)	1997-11-19
HUP9904410A2 (hu)	2000-05-28

Legal Events

Date	Code	Title	Description
2016-12-12	MK1K	Patent expired

Publication	Publication Date	Title
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CA2065861C (fr)	2001-06-05	Methode de preparation de budesonide
US4861870A (en)	1989-08-29	Process for purifying anthracyclinone glycosides by selective adsorption on resins
SE456913B (sv)	1988-11-14	Foerfarande foer rening av tylosin
NO311029B1 (no)	2001-10-01	Fremgangsmate for rensing av 11-<beta>-21-dihydroksy-2'-metyl- 5'-<beta>H-pregna-1,4-dieno-[17,16-d]-oksazol-3,20-dion
JPH01112989A (ja)	1989-05-01	Ａｂ−００６抗生物質及びその製造方法
US4320225A (en)	1982-03-16	Periandrins extracted from plants of the genus Periandra
US5360917A (en)	1994-11-01	Process for producing macrolide compounds
Slavík et al.	1985	Alkaloids from Papaver bracteatum LINDL.
CA2238691C (fr)	2004-07-20	Preparation de (11.beta.,16.beta.)-21-(acetyloxy)-11-hydroxy-2'-methyl-5'-h-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
JPH01206999A (ja)	1989-08-21	プレグネノーオキサゾリンの製造法
CN104892703B (zh)	2018-01-09	一种从枸杞叶中同时制备芦丁、槲皮素化学对照品的方法
CN109776536A (zh)	2019-05-21	一种苦参碱富集纯化的方法
CA1151090A (fr)	1983-08-02	Fortimicine an
US3573275A (en)	1971-03-30	Isolation and purification of coumermycin antibiotics
Tachibana	1989	Syntheses of 1. BETA.-hydroxyvitamin D2 and D3.
Elliger et al.	1989	Petuniasterones from Petunia parodii and P. integrifolia; unusual ergostane-type steroids
KR810000818B1 (ko)	1981-07-10	모라노린의 제조법
US3715352A (en)	1973-02-06	2-benzyl-1,4-dimethyl-5-hydroxymethyl-2,5-epidithiapiperazine-3,6-dione and 2-benzyl-1,4-dimethyl-5-hydroxymethyl-2,5-epitrithiapiperazine-3,6-dione useful as anti-fungal agents
US3063989A (en)	1962-11-13	2beta-hydroxy-9 alpha-halo-11-oxygenated pregnenes
Robison et al.	1963	Rauwolfia Alkaloids. XLV. Preparation and Transformations of the Ketone Derived from Methyl Reserpate
JPH0710896A (ja)	1995-01-13	Ｄｄｍｐ結合ソヤサポニン
CN101712686B (zh)	2012-08-29	一种发酵液中他克莫司的分离纯化方法
KR20090124511A (ko)	2009-12-03	고순도 타크로리무스의 회수방법
PL179705B1 (pl)	2000-10-31	Sposób wytwarzania alkaloidów, zwlaszcza lupaniny, z roslin zawierajacych alkaloidy PL