NO312123B1 - Osmotiske anordninger for fordeling av et formålstjenlig middel til et vandig miljö - Google Patents

Osmotiske anordninger for fordeling av et formålstjenlig middel til et vandig miljö Download PDF

Info

Publication number: NO312123B1
Authority: NO; Norway
Prior art keywords: cellulose; agent; coating; sensitive; semi
Prior art date: 1993-02-25

Application number

NO19940642A

Other languages

English (en)

Norwegian (no)

Other versions

NO940642D0 (no

NO940642L (no

Inventor

Scott Max Herbig

Kelly Lincoln Smith

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-25

Filing date

1994-02-24

Publication date

2002-03-25

1994-02-24 Application filed by Pfizer filed Critical Pfizer

1994-02-24 Publication of NO940642D0 publication Critical patent/NO940642D0/no

1994-08-26 Publication of NO940642L publication Critical patent/NO940642L/no

2002-03-25 Publication of NO312123B1 publication Critical patent/NO312123B1/no

Links

230000003204 osmotic effect Effects 0.000 title claims abstract description 34
239000012528 membrane Substances 0.000 claims abstract description 112
239000003795 chemical substances by application Substances 0.000 claims abstract description 83
239000002775 capsule Substances 0.000 claims abstract description 76
230000009172 bursting Effects 0.000 claims abstract description 33
229920002301 cellulose acetate Polymers 0.000 claims description 65
239000000463 material Substances 0.000 claims description 62
229920002678 cellulose Polymers 0.000 claims description 56
229920000642 polymer Polymers 0.000 claims description 55
229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 42
229940081734 cellulose acetate phthalate Drugs 0.000 claims description 42
239000011324 bead Substances 0.000 claims description 30
239000000203 mixture Substances 0.000 claims description 27
229920001577 copolymer Polymers 0.000 claims description 25
229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 24
239000004926 polymethyl methacrylate Substances 0.000 claims description 24
229920002451 polyvinyl alcohol Polymers 0.000 claims description 15
229920002125 Sokalan® Polymers 0.000 claims description 14
239000004584 polyacrylic acid Substances 0.000 claims description 13
235000019422 polyvinyl alcohol Nutrition 0.000 claims description 13
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 12
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 12
229920003086 cellulose ether Polymers 0.000 claims description 12
229920002472 Starch Polymers 0.000 claims description 11
239000008107 starch Substances 0.000 claims description 11
235000019698 starch Nutrition 0.000 claims description 11
239000001856 Ethyl cellulose Substances 0.000 claims description 9
229920001800 Shellac Polymers 0.000 claims description 9
235000019325 ethyl cellulose Nutrition 0.000 claims description 9
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235000013874 shellac Nutrition 0.000 claims description 9
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ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims description 9
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 8
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 8
XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical class OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 8
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims description 8
239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 6
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 6
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 6
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230000001960 triggered effect Effects 0.000 abstract description 87
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KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 48
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GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 12
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 10
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
229940032147 starch Drugs 0.000 description 9
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 8
238000004090 dissolution Methods 0.000 description 8
230000002706 hydrostatic effect Effects 0.000 description 8
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238000009505 enteric coating Methods 0.000 description 7
239000002702 enteric coating Substances 0.000 description 7
238000002474 experimental method Methods 0.000 description 7
239000010410 layer Substances 0.000 description 7
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FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
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238000002360 preparation method Methods 0.000 description 6
238000010791 quenching Methods 0.000 description 6
230000000171 quenching effect Effects 0.000 description 6
238000012546 transfer Methods 0.000 description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 5
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239000002253 acid Substances 0.000 description 5
239000013543 active substance Substances 0.000 description 5
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WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
238000005266 casting Methods 0.000 description 5
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239000000306 component Substances 0.000 description 5
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XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical group [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 5
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238000012360 testing method Methods 0.000 description 5
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 4
DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 description 4
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
241000282412 Homo Species 0.000 description 4
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OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
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239000008367 deionised water Substances 0.000 description 4
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DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 description 4
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GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 3
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
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OKUCEQDKBKYEJY-UHFFFAOYSA-N tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate Chemical compound CNC1CCN(C(=O)OC(C)(C)C)C1 OKUCEQDKBKYEJY-UHFFFAOYSA-N 0.000 description 1
RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Separation Using Semi-Permeable Membranes (AREA)
External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

NO19940642A 1993-02-25 1994-02-24 Osmotiske anordninger for fordeling av et formålstjenlig middel til et vandig miljö NO312123B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/023,227 US5358502A (en)	1993-02-25	1993-02-25	PH-triggered osmotic bursting delivery devices

Publications (3)

Publication Number	Publication Date
NO940642D0 NO940642D0 (no)	1994-02-24
NO940642L NO940642L (no)	1994-08-26
NO312123B1 true NO312123B1 (no)	2002-03-25

Family

ID=21813831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19940642A NO312123B1 (no)	1993-02-25	1994-02-24	Osmotiske anordninger for fordeling av et formålstjenlig middel til et vandig miljö

Country Status (19)

Country	Link
US (2)	US5358502A (ja)
EP (1)	EP0612520B1 (ja)
JP (1)	JP2862222B2 (ja)
CN (1)	CN1098286A (ja)
AT (1)	ATE202927T1 (ja)
AU (1)	AU660386B2 (ja)
CA (1)	CA2116288C (ja)
DE (1)	DE69427664T2 (ja)
DK (1)	DK0612520T3 (ja)
ES (1)	ES2157953T3 (ja)
FI (1)	FI113941B (ja)
GR (1)	GR3036497T3 (ja)
IL (1)	IL108691A0 (ja)
MX (1)	MX9401396A (ja)
NO (1)	NO312123B1 (ja)
NZ (1)	NZ250967A (ja)
PT (1)	PT612520E (ja)
TW (1)	TW283641B (ja)
ZA (1)	ZA941262B (ja)

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1993
- 1993-02-25 US US08/023,227 patent/US5358502A/en not_active Expired - Fee Related
- 1993-11-16 TW TW082109592A patent/TW283641B/zh active
- 1993-12-28 JP JP5338066A patent/JP2862222B2/ja not_active Expired - Fee Related
1994
- 1994-02-11 DK DK94301026T patent/DK0612520T3/da active
- 1994-02-11 DE DE69427664T patent/DE69427664T2/de not_active Expired - Fee Related
- 1994-02-11 ES ES94301026T patent/ES2157953T3/es not_active Expired - Lifetime
- 1994-02-11 AT AT94301026T patent/ATE202927T1/de not_active IP Right Cessation
- 1994-02-11 PT PT94301026T patent/PT612520E/pt unknown
- 1994-02-11 EP EP94301026A patent/EP0612520B1/en not_active Expired - Lifetime
- 1994-02-17 IL IL10869194A patent/IL108691A0/xx unknown
- 1994-02-23 CA CA002116288A patent/CA2116288C/en not_active Expired - Fee Related
- 1994-02-23 MX MX9401396A patent/MX9401396A/es unknown
- 1994-02-24 FI FI940866A patent/FI113941B/fi not_active IP Right Cessation
- 1994-02-24 AU AU56400/94A patent/AU660386B2/en not_active Ceased
- 1994-02-24 ZA ZA941262A patent/ZA941262B/xx unknown
- 1994-02-24 CN CN94102101A patent/CN1098286A/zh active Pending
- 1994-02-24 NO NO19940642A patent/NO312123B1/no unknown
- 1994-02-24 NZ NZ250967A patent/NZ250967A/en unknown
- 1994-10-19 US US08/325,730 patent/US5609590A/en not_active Expired - Fee Related
2001
- 2001-08-31 GR GR20010401357T patent/GR3036497T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0612520B1 (en)	2001-07-11
CN1098286A (zh)	1995-02-08
TW283641B (ja)	1996-08-21
FI940866A0 (fi)	1994-02-24
EP0612520A2 (en)	1994-08-31
NO940642D0 (no)	1994-02-24
CA2116288A1 (en)	1994-08-26
NO940642L (no)	1994-08-26
ES2157953T3 (es)	2001-09-01
AU5640094A (en)	1994-09-22
DE69427664D1 (de)	2001-08-16
US5358502A (en)	1994-10-25
ZA941262B (en)	1995-08-24
GR3036497T3 (en)	2001-11-30
ATE202927T1 (de)	2001-07-15
DK0612520T3 (da)	2001-09-17
CA2116288C (en)	1997-11-18
US5609590A (en)	1997-03-11
MX9401396A (es)	1994-08-31
EP0612520A3 (en)	1995-11-15
JP2862222B2 (ja)	1999-03-03
AU660386B2 (en)	1995-06-22
JPH072645A (ja)	1995-01-06
FI940866L (fi)	1994-08-26
NZ250967A (en)	1996-02-27
FI113941B (fi)	2004-07-15
DE69427664T2 (de)	2001-10-25
IL108691A0 (en)	1994-05-30
PT612520E (pt)	2001-12-28

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JP2005533084A (ja)	2005-11-04	液体の有効成分の製剤を含んでなりかつ膨張可能な浸透圧組成物によりその放出を制御する経口の投薬形態
MXPA99002387A (en)	1999-09-01	Fast decomposing pellets