NO312242B1 - Forbindelser med veksthormonfrigjörende egenskaper, farmasöytiske preparater som omfatter dissse, samt anvendelse avforbindelsene til fremstilling av medikamenter - Google Patents

Forbindelser med veksthormonfrigjörende egenskaper, farmasöytiske preparater som omfatter dissse, samt anvendelse avforbindelsene til fremstilling av medikamenter Download PDF

Info

Publication number: NO312242B1
Authority: NO; Norway
Prior art keywords: methyl; alkyl; hydrogen; pharmaceutically acceptable; independently
Prior art date: 1996-04-24

Application number

NO19984950A

Other languages

English (en)

Norwegian (no)

Other versions

NO984950D0 (no

NO984950L (no

Inventor

Thomas Kruse Hansen

Bernd Peschke

Knud Erik Andersen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-24

Filing date

1998-10-23

Publication date

2002-04-15

1998-10-23 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1998-10-23 Publication of NO984950D0 publication Critical patent/NO984950D0/no

1998-12-21 Publication of NO984950L publication Critical patent/NO984950L/no

2002-04-15 Publication of NO312242B1 publication Critical patent/NO312242B1/no

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
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Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

NO19984950A 1996-04-24 1998-10-23 Forbindelser med veksthormonfrigjörende egenskaper, farmasöytiske preparater som omfatter dissse, samt anvendelse avforbindelsene til fremstilling av medikamenter NO312242B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK48996		1996-04-24
DK134496		1996-11-26
PCT/DK1997/000186 WO1997040023A1 (en)	1996-04-24	1997-04-24	Compounds with growth hormone releasing properties

Publications (3)

Publication Number	Publication Date
NO984950D0 NO984950D0 (no)	1998-10-23
NO984950L NO984950L (no)	1998-12-21
NO312242B1 true NO312242B1 (no)	2002-04-15

Family

ID=26064097

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19984950A NO312242B1 (no)	1996-04-24	1998-10-23	Forbindelser med veksthormonfrigjörende egenskaper, farmasöytiske preparater som omfatter dissse, samt anvendelse avforbindelsene til fremstilling av medikamenter

Country Status (15)

Country	Link
EP (1)	EP0907643B1 (cs)
JP (1)	JP4359859B2 (cs)
KR (1)	KR20000010626A (cs)
CN (1)	CN1127488C (cs)
AT (1)	ATE231131T1 (cs)
AU (1)	AU722421B2 (cs)
BR (1)	BR9708854A (cs)
CA (1)	CA2252761A1 (cs)
CZ (1)	CZ291982B6 (cs)
DE (1)	DE69718469T2 (cs)
HU (1)	HUP9902668A3 (cs)
IL (1)	IL126235A (cs)
NO (1)	NO312242B1 (cs)
PL (1)	PL329413A1 (cs)
WO (1)	WO1997040023A1 (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998054164A1 (en) *	1997-05-30	1998-12-03	Takeda Chemical Industries, Ltd.	Sulfonamide derivatives, their production and use
WO1999040075A1 (en)	1998-02-05	1999-08-12	Takeda Chemical Industries, Ltd.	Sulfonamide derivatives, process for producing the same and utilization thereof
US6919315B1 (en)	1998-06-30	2005-07-19	Novo Nordisk A/S	Compounds with growth hormone releasing properties
JP2002542151A (ja)	1999-02-18	2002-12-10	科研製薬株式会社	成長ホルモン分泌促進物質としての新規なアミド誘導体
DE60140285D1 (de)	2000-05-31	2009-12-10	Pfizer Prod Inc	Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
PE20020420A1 (es)	2000-10-02	2002-06-27	Novartis Ag	Derivados de diazacicloalcanodiona como antagonistas del antigeno asociado a la funcion del linfocito-1 (lfa-1)
US6538017B2 (en)	2001-03-09	2003-03-25	Ortho-Mcneil Pharmaceutical, Inc.	Aminopyrrolidine sulfonamides as serine protease inhibitors
US6710061B2 (en)	2001-03-09	2004-03-23	Ortho-Mcneil Pharamceutical, Inc.	Aminopyrrolidine sulfonamides as serine protease inhibitors
US7476653B2 (en)	2003-06-18	2009-01-13	Tranzyme Pharma, Inc.	Macrocyclic modulators of the ghrelin receptor
CU23558A1 (es)	2006-02-28	2010-07-20	Ct Ingenieria Genetica Biotech	Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CN101657436A (zh)	2007-02-09	2010-02-24	特兰齐姆制药公司	大环生长素释放肽受体调节剂及其使用方法
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
SG11201704764PA (en)	2014-12-11	2017-07-28	Harvard College	Inhibitors of cellular necrosis and related methods
WO2017075535A1 (en)	2015-10-28	2017-05-04	Oxeia Biopharmaceuticals, Inc.	Methods of treating neurodegenerative conditions
CN108129404B (zh) *	2018-01-30	2020-05-01	凯瑞斯德生化(苏州)有限公司	手性哌嗪酮衍生物的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL98910A0 (en) *	1990-07-24	1992-07-15	Polygen Holding Corp	Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them
US5663146A (en) *	1991-08-22	1997-09-02	Administrators Of The Tulane Educational Fund	Polypeptide analogues having growth hormone releasing activity
WO1995017423A1 (en) *	1993-12-23	1995-06-29	Novo Nordisk A/S	Compounds with growth hormone releasing properties

1997
- 1997-04-24 KR KR1019980708527A patent/KR20000010626A/ko not_active Ceased
- 1997-04-24 DE DE69718469T patent/DE69718469T2/de not_active Expired - Fee Related
- 1997-04-24 WO PCT/DK1997/000186 patent/WO1997040023A1/en not_active Ceased
- 1997-04-24 JP JP53762397A patent/JP4359859B2/ja not_active Expired - Lifetime
- 1997-04-24 AT AT97918075T patent/ATE231131T1/de not_active IP Right Cessation
- 1997-04-24 CN CN97194057A patent/CN1127488C/zh not_active Expired - Fee Related
- 1997-04-24 BR BR9708854A patent/BR9708854A/pt not_active IP Right Cessation
- 1997-04-24 CA CA002252761A patent/CA2252761A1/en not_active Abandoned
- 1997-04-24 AU AU26345/97A patent/AU722421B2/en not_active Ceased
- 1997-04-24 HU HU9902668A patent/HUP9902668A3/hu unknown
- 1997-04-24 CZ CZ19983390A patent/CZ291982B6/cs not_active IP Right Cessation
- 1997-04-24 PL PL97329413A patent/PL329413A1/xx unknown
- 1997-04-24 IL IL12623597A patent/IL126235A/xx not_active IP Right Cessation
- 1997-04-24 EP EP97918075A patent/EP0907643B1/en not_active Expired - Lifetime
1998
- 1998-10-23 NO NO19984950A patent/NO312242B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2252761A1 (en)	1997-10-30
DE69718469T2 (de)	2003-10-30
AU2634597A (en)	1997-11-12
HUP9902668A2 (hu)	2000-04-28
KR20000010626A (ko)	2000-02-25
HU9902668D0 (en)	1999-09-28
IL126235A (en)	2003-02-12
CN1216537A (zh)	1999-05-12
EP0907643B1 (en)	2003-01-15
CN1127488C (zh)	2003-11-12
NO984950D0 (no)	1998-10-23
WO1997040023A1 (en)	1997-10-30
BR9708854A (pt)	1999-08-03
AU722421B2 (en)	2000-08-03
ATE231131T1 (de)	2003-02-15
CZ291982B6 (cs)	2003-06-18
JP2000508666A (ja)	2000-07-11
IL126235A0 (en)	1999-05-09
HUP9902668A3 (en)	2000-07-28
DE69718469D1 (de)	2003-02-20
EP0907643A1 (en)	1999-04-14
PL329413A1 (en)	1999-03-29
NO984950L (no)	1998-12-21
JP4359859B2 (ja)	2009-11-11

Legal Events

Date	Code	Title	Description
2004-12-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US6274584B1 (en)	2001-08-14	Compounds with growth hormone releasing properties
EP0869974B1 (en)	2009-03-04	Compounds with growth hormone releasing properties
RU2243215C2 (ru)	2004-12-27	Производные пиперидинкарбоновых кислот, фармацевтические композиции, содержащие их, способ стимуляции секреции гормона роста
US6303620B1 (en)	2001-10-16	Compounds with growth hormone releasing properties
EP0907643B1 (en)	2003-01-15	Compounds with growth hormone releasing properties
US6127341A (en)	2000-10-03	Compounds with growth hormone releasing properties
JP4116097B2 (ja)	2008-07-09	成長ホルモン放出特性をもつ化合物
WO1996024580A1 (en)	1996-08-15	Compounds with growth hormone releasing properties
US5919777A (en)	1999-07-06	Compounds with growth hormone releasing properties
WO1996024587A1 (en)	1996-08-15	Compounds with growth hormone releasing properties
EP1100824B1 (en)	2011-03-02	Compounds with growth hormone releasing properties
US6566337B1 (en)	2003-05-20	Compounds with growth hormone releasing properties
AU1262800A (en)	2000-05-22	Compounds with growth hormone releasing properties
ES2361606T3 (es)	2011-06-20	Composiciones con propiedades de liberación de hormonas del crecimiento.
MXPA00010585A (en)	2001-07-31	Compounds with growth hormone releasing properties