NO313103B1 - Fremgangsmåte for screening for proteininhibitorer og aktiveringsmidler, samt testceller og testkit - Google Patents

Fremgangsmåte for screening for proteininhibitorer og aktiveringsmidler, samt testceller og testkit Download PDF

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Publication number
NO313103B1
NO313103B1 NO19903494A NO903494A NO313103B1 NO 313103 B1 NO313103 B1 NO 313103B1 NO 19903494 A NO19903494 A NO 19903494A NO 903494 A NO903494 A NO 903494A NO 313103 B1 NO313103 B1 NO 313103B1
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Norway
Prior art keywords
cell
protein
response
phenotypic
compound
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NO19903494A
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English (en)
Norwegian (no)
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NO903494L (no
NO903494D0 (no
Inventor
Gerard M Housey
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Housey Pharmaceuticals Inc
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Application filed by Housey Pharmaceuticals Inc filed Critical Housey Pharmaceuticals Inc
Publication of NO903494D0 publication Critical patent/NO903494D0/no
Publication of NO903494L publication Critical patent/NO903494L/no
Publication of NO313103B1 publication Critical patent/NO313103B1/no

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19903494A 1988-02-10 1990-08-08 Fremgangsmåte for screening for proteininhibitorer og aktiveringsmidler, samt testceller og testkit NO313103B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/154,206 US4980281A (en) 1988-02-10 1988-02-10 Method of screening for protein inhibitors and activators
PCT/US1989/000462 WO1989007654A1 (en) 1988-02-10 1989-02-09 Method of screening for protein inhibitors and activators

Publications (3)

Publication Number Publication Date
NO903494D0 NO903494D0 (no) 1990-08-08
NO903494L NO903494L (no) 1990-10-01
NO313103B1 true NO313103B1 (no) 2002-08-12

Family

ID=22550430

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19903494A NO313103B1 (no) 1988-02-10 1990-08-08 Fremgangsmåte for screening for proteininhibitorer og aktiveringsmidler, samt testceller og testkit
NO20021142A NO20021142D0 (no) 1988-02-10 2002-03-07 Fremgangsmåte for fremstilling av en aktivator eller inhibitorforbindelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20021142A NO20021142D0 (no) 1988-02-10 2002-03-07 Fremgangsmåte for fremstilling av en aktivator eller inhibitorforbindelse

Country Status (18)

Country Link
US (1) US4980281A (de)
EP (1) EP0403506B1 (de)
JP (1) JPH03503598A (de)
AT (1) ATE140267T1 (de)
AU (1) AU612948B2 (de)
BG (1) BG60325B2 (de)
CA (1) CA1334927C (de)
DE (1) DE68926816T2 (de)
DK (2) DK189590A (de)
ES (1) ES2010131A6 (de)
FI (1) FI102618B1 (de)
HU (1) HU208555B (de)
IE (1) IE77332B1 (de)
IL (1) IL89227A (de)
MX (1) MX165993B (de)
NO (2) NO313103B1 (de)
RO (1) RO118452B1 (de)
WO (1) WO1989007654A1 (de)

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US5650276A (en) * 1991-03-11 1997-07-22 Creative Biomolecules, Inc. Morphogenic protein screening method
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US5747341A (en) * 1991-06-24 1998-05-05 Pacific Biomedical Research, Inc. Culture media having low osmolarity for establishing and maintaining hormone-secreting cells in long-term culture
EP0605428B9 (de) * 1991-06-24 2003-01-02 hCell Technology, Inc. In langzeitkultur gehaltene hormon-absondernde pankreatische zellen
US5821121A (en) * 1991-06-24 1998-10-13 Pacific Biomedical Research, Inc. Hormone-secreting cells maintained in long-term culture
WO1993002209A1 (en) * 1991-07-22 1993-02-04 The Regents Of The University Of California Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex
AU696364B2 (en) * 1991-08-30 1998-09-10 Creative Biomolecules, Inc. Morphogenic protein screening method II
EP0825442A3 (de) * 1991-08-30 2004-02-11 Curis, Inc. Screeningverfahren von morphogenischen Proteinen
GB9216654D0 (en) * 1992-08-05 1992-09-16 Imp Cancer Res Tech Transformed cells and assays using them
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US6365344B1 (en) * 1996-01-23 2002-04-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
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Also Published As

Publication number Publication date
JPH03503598A (ja) 1991-08-15
CA1334927C (en) 1995-03-28
DE68926816T2 (de) 1997-01-09
US4980281A (en) 1990-12-25
FI903918A0 (fi) 1990-08-08
EP0403506B1 (de) 1996-07-10
IL89227A0 (en) 1989-09-10
FI102618B (fi) 1999-01-15
HU208555B (en) 1993-11-29
NO20021142L (no) 1990-10-01
NO20021142D0 (no) 2002-03-07
DK189590D0 (da) 1990-08-09
DK189590A (da) 1990-10-02
MX165993B (es) 1992-12-15
DE68926816D1 (de) 1996-08-14
NO903494L (no) 1990-10-01
AU612948B2 (en) 1991-07-18
WO1989007654A1 (en) 1989-08-24
EP0403506A4 (en) 1991-07-24
ES2010131A6 (es) 1989-10-16
AU3184089A (en) 1989-09-06
IE890398L (en) 1989-08-10
IE77332B1 (en) 1997-12-02
NO903494D0 (no) 1990-08-08
FI102618B1 (fi) 1999-01-15
DK200100720A (da) 2001-05-08
RO118452B1 (ro) 2003-05-30
HUT55447A (en) 1991-05-28
EP0403506A1 (de) 1990-12-27
IL89227A (en) 1995-05-26
BG60325B2 (bg) 1994-05-27
ATE140267T1 (de) 1996-07-15

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