NO314127B1 - Injiserbare NMR-billeddannende sammensetninger, fremgangsmåter for fremstilling og anvendelse av disse - Google Patents

Injiserbare NMR-billeddannende sammensetninger, fremgangsmåter for fremstilling og anvendelse av disse Download PDF

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Publication number
NO314127B1
NO314127B1 NO19970665A NO970665A NO314127B1 NO 314127 B1 NO314127 B1 NO 314127B1 NO 19970665 A NO19970665 A NO 19970665A NO 970665 A NO970665 A NO 970665A NO 314127 B1 NO314127 B1 NO 314127B1
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NO
Norway
Prior art keywords
composition according
acid
imaging
surfactant
physiologically acceptable
Prior art date
Application number
NO19970665A
Other languages
English (en)
Norwegian (no)
Other versions
NO970665D0 (no
NO970665L (no
Inventor
Herve Tournier
Bernard Lamy
Roland Hyacinthe
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Publication of NO970665D0 publication Critical patent/NO970665D0/no
Publication of NO970665L publication Critical patent/NO970665L/no
Publication of NO314127B1 publication Critical patent/NO314127B1/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
NO19970665A 1995-06-15 1997-02-13 Injiserbare NMR-billeddannende sammensetninger, fremgangsmåter for fremstilling og anvendelse av disse NO314127B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95810403 1995-06-15
PCT/IB1996/000577 WO1997000087A1 (fr) 1995-06-15 1996-06-14 Compositions d'imagerie de pool sanguin et procede

Publications (3)

Publication Number Publication Date
NO970665D0 NO970665D0 (no) 1997-02-13
NO970665L NO970665L (no) 1997-04-03
NO314127B1 true NO314127B1 (no) 2003-02-03

Family

ID=8221760

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19970665A NO314127B1 (no) 1995-06-15 1997-02-13 Injiserbare NMR-billeddannende sammensetninger, fremgangsmåter for fremstilling og anvendelse av disse

Country Status (13)

Country Link
US (1) US5833948A (fr)
EP (1) EP0804251B1 (fr)
JP (1) JP4335976B2 (fr)
KR (1) KR100399712B1 (fr)
AT (1) ATE224737T1 (fr)
AU (1) AU708328B2 (fr)
CA (1) CA2195633C (fr)
DE (1) DE69623929T2 (fr)
ES (1) ES2180784T3 (fr)
NO (1) NO314127B1 (fr)
PT (1) PT804251E (fr)
WO (1) WO1997000087A1 (fr)
ZA (1) ZA965101B (fr)

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IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
IT1297034B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
US6984395B2 (en) * 2001-04-11 2006-01-10 Qlt, Inc. Drug delivery system for hydrophobic drugs
US6506413B1 (en) * 2001-04-30 2003-01-14 Joseph C. Ramaekers Compositions for treating animal diseases and syndromes
US20060073197A1 (en) * 2004-05-20 2006-04-06 Ramaekers Joseph C Encapsulated transfer factor compositions and methods of use
US20070128253A1 (en) * 2005-04-13 2007-06-07 Ramaekers Joseph C Encapsulated transfer factor compositions and methods of use
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
US7553930B2 (en) * 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US20050130892A1 (en) * 2003-03-07 2005-06-16 Xencor, Inc. BAFF variants and methods thereof
US20060014248A1 (en) * 2003-01-06 2006-01-19 Xencor, Inc. TNF super family members with altered immunogenicity
US20050221443A1 (en) * 2003-01-06 2005-10-06 Xencor, Inc. Tumor necrosis factor super family agonists
EP1590006B1 (fr) 2003-02-04 2010-09-08 Bracco Suisse SA Agents de contraste pour ultrasons et procede pour leur elaboration
EP1675871A2 (fr) 2003-10-10 2006-07-05 Xencor Inc. Variants de tnf-alpha a base proteique destines au traitement de troubles associes au tnf-alpha
CA2547024C (fr) 2003-12-22 2013-12-17 Bracco Research Sa Systeme de microvesicule remplie de gaz pour l'imagerie de contraste
WO2005063304A2 (fr) * 2003-12-24 2005-07-14 Board Of Regents, The University Of Texas_System Complexe de materiaux paramagnetiques et d'acide poly(l-glutamique) et son utilisation comme agent de contraste irm biodegradable
US7749485B2 (en) * 2004-06-03 2010-07-06 Bracco Research S.A. Liposomal assembly for therapeutic and/or diagnostic use
WO2006018433A1 (fr) 2004-08-18 2006-02-23 Bracco Research Sa Composition renfermant des microvesicules remplies de gaz, destinee a l'imagerie de contraste
FR2883562B1 (fr) 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
CA2603437A1 (fr) * 2005-04-01 2006-10-12 The Board Of Regents Of The University Of Texas System Chelateur poly(peptide): procedes de fabrication et d'utilisation
US20090130018A1 (en) * 2005-05-31 2009-05-21 Accardo Antonella Supramolecular aggregates containing chelating agents and bioactive peptides as effective and selective delivery tools for drugs and contrast agents in mri or nuclear medicine
US20090053197A1 (en) * 2006-06-14 2009-02-26 Ramaekers Joseph C Transfer Factor Compositions and Methods
US9125874B2 (en) 2007-11-30 2015-09-08 The Ramaekers Family Trust Administration of transfer factor for improving reproductive health
AU2007293888B2 (en) 2006-09-05 2013-05-02 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
GB0623838D0 (en) * 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
US20090074751A1 (en) * 2007-09-18 2009-03-19 Ramaekers Nutrition, Inc. Growth factor fraction compositions and methods
KR101401217B1 (ko) * 2007-11-07 2014-05-28 충남대학교산학협력단 Ｐｅ－ｄｔｐａ의 새로운 용도
CA2703830A1 (fr) 2007-11-20 2009-05-28 Ambrx, Inc. Polypeptides d'insuline modifies et leurs utilisations
WO2009070788A1 (fr) * 2007-11-30 2009-06-04 The Ramaekers Family Trust Compositions et procédés d'amélioration de la fertilité
JP5647007B2 (ja) 2008-01-30 2014-12-24 ヒストジェン インコーポレイテッド 細胞外マトリックス組成物
EP2398503B1 (fr) * 2009-02-13 2018-10-31 University Of Washington Nanoparticules lipidiques exprimant le gadolinium destinées à l'imagerie par résonance magnétique
WO2010139003A1 (fr) * 2009-06-01 2010-12-09 Commonwealth Scientific And Industrial Research Organisation Amphiphiles chélateurs
PE20140160A1 (es) 2010-08-17 2014-02-08 Ambrx Inc Polipeptidos de relaxina modificados y sus usos
EP2639227A1 (fr) 2012-03-14 2013-09-18 Bracco Imaging S.p.A Nouvelle classe d'agents de chélation dérivés de la diazépine et de complexes dotés de métaux paramagnétiques en tant qu'agents de contraste pour IRM
CN104602715A (zh) 2012-09-07 2015-05-06 伯拉考成像股份公司 用于MRI的包含金属两亲配合物的顺磁性固体脂质纳米颗粒(pSLN)
DK2892547T3 (da) 2012-09-10 2020-10-26 Xencor Inc Dominant, negativ tnf-alpha-hæmmer til anvendelse i behandling af neurologiske cns-forstyrrelser
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
US11352606B2 (en) 2014-02-10 2022-06-07 The Johns Hopkins University Low oxygen tension enhances endothelial fate of human pluripotent stem cells
AU2016275149A1 (en) 2015-06-12 2018-01-04 Georgia State University Research Foundation Compositions and methods for treating opioid tolerance
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations
US12077780B2 (en) 2020-02-14 2024-09-03 Allergan Sales, Llc Conditioned medium from cells cultured under hypoxic conditions and uses thereof

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US5387410A (en) * 1983-03-18 1995-02-07 Mallinckrodt, Inc. Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
JPH06507904A (ja) * 1991-05-23 1994-09-08 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 磁気共鳴画像形成用の油脂可溶化合物
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
US5567410A (en) * 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging

Also Published As

Publication number Publication date
KR100399712B1 (ko) 2004-02-18
NO970665D0 (no) 1997-02-13
EP0804251B1 (fr) 2002-09-25
CA2195633C (fr) 2008-09-16
ZA965101B (en) 1997-01-22
PT804251E (pt) 2003-01-31
ES2180784T3 (es) 2003-02-16
JPH10504044A (ja) 1998-04-14
EP0804251A1 (fr) 1997-11-05
DE69623929D1 (de) 2002-10-31
AU708328B2 (en) 1999-08-05
US5833948A (en) 1998-11-10
KR970704477A (ko) 1997-09-06
AU5843196A (en) 1997-01-15
DE69623929T2 (de) 2003-05-15
NO970665L (no) 1997-04-03
CA2195633A1 (fr) 1997-01-03
ATE224737T1 (de) 2002-10-15
JP4335976B2 (ja) 2009-09-30
WO1997000087A1 (fr) 1997-01-03

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Legal Events

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CB Opposition filed (par. 26,5 patents act)

Opponent name: AMERSHAM HEALTH AS, POSTBOKS 4220 NYDALEN, 0401 OS

Effective date: 20031104

ERR Erratum

Free format text: I PATENTTIDENDE NR 47 BLE INNSIGELSE I PATENT NR 314127 KUNNGJORT MED FEIL INNSIGELSESDAG.

MM1K Lapsed by not paying the annual fees