NO314569B1 - Tokoferol-blandinger for avgivelse av biologisk aktive midler, fremstillingav blandingene og anvendelse av tokoferol deri - Google Patents

Tokoferol-blandinger for avgivelse av biologisk aktive midler, fremstillingav blandingene og anvendelse av tokoferol deri Download PDF

Info

Publication number: NO314569B1
Authority: NO; Norway
Prior art keywords: tocopherol; drugs; biologically active; mixture according; active agent
Prior art date: 1994-05-16

Application number

NO19964832A

Other languages

English (en)

Norwegian (no)

Other versions

NO964832D0 (no

NO964832L (no

Inventor

Mette Rydahl Sonne

Original Assignee

Dumex Alpharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-16

Filing date

1996-11-14

Publication date

2003-04-14

1996-11-14 Application filed by Dumex Alpharma As filed Critical Dumex Alpharma As

1996-11-14 Publication of NO964832D0 publication Critical patent/NO964832D0/no

1997-01-13 Publication of NO964832L publication Critical patent/NO964832L/no

2003-04-14 Publication of NO314569B1 publication Critical patent/NO314569B1/no

Links

239000000203 mixture Substances 0.000 title claims abstract description 92
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title claims abstract description 57
229930003799 tocopherol Natural products 0.000 title claims abstract description 37
239000011732 tocopherol Substances 0.000 title claims abstract description 37
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 33
229960001295 tocopherol Drugs 0.000 title claims abstract description 29
235000010384 tocopherol Nutrition 0.000 title claims abstract description 29
239000013543 active substance Substances 0.000 title claims abstract description 26
238000002360 preparation method Methods 0.000 title description 11
239000002904 solvent Substances 0.000 claims abstract description 20
239000003995 emulsifying agent Substances 0.000 claims abstract description 18
210000000214 mouth Anatomy 0.000 claims abstract description 8
238000004519 manufacturing process Methods 0.000 claims abstract description 4
239000012071 phase Substances 0.000 claims description 67
239000003814 drug Substances 0.000 claims description 50
229940079593 drug Drugs 0.000 claims description 48
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 45
229960003529 diazepam Drugs 0.000 claims description 43
239000000839 emulsion Substances 0.000 claims description 43
AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 claims description 18
AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical group OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims description 15
229940087168 alpha tocopherol Drugs 0.000 claims description 13
-1 local anaesthetics Substances 0.000 claims description 13
229960000984 tocofersolan Drugs 0.000 claims description 13
235000004835 α-tocopherol Nutrition 0.000 claims description 13
239000002076 α-tocopherol Substances 0.000 claims description 13
150000002148 esters Chemical class 0.000 claims description 11
BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 9
229960002563 disulfiram Drugs 0.000 claims description 9
229960002509 miconazole Drugs 0.000 claims description 9
229960003793 midazolam Drugs 0.000 claims description 9
DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 claims description 9
229940049706 benzodiazepine Drugs 0.000 claims description 8
DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 claims description 8
229960000876 cinnarizine Drugs 0.000 claims description 8
229940049918 linoleate Drugs 0.000 claims description 8
238000002156 mixing Methods 0.000 claims description 8
201000003152 motion sickness Diseases 0.000 claims description 8
239000011664 nicotinic acid Substances 0.000 claims description 8
OYHQOLUKZRVURQ-HZJYTTRNSA-M 9-cis,12-cis-Octadecadienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O OYHQOLUKZRVURQ-HZJYTTRNSA-M 0.000 claims description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 7
208000019695 Migraine disease Diseases 0.000 claims description 7
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 7
229940035676 analgesics Drugs 0.000 claims description 7
239000000730 antalgic agent Substances 0.000 claims description 7
239000003242 anti bacterial agent Substances 0.000 claims description 7
239000000043 antiallergic agent Substances 0.000 claims description 7
229940088710 antibiotic agent Drugs 0.000 claims description 7
229940121375 antifungal agent Drugs 0.000 claims description 7
239000000739 antihistaminic agent Substances 0.000 claims description 7
229940125715 antihistaminic agent Drugs 0.000 claims description 7
239000003443 antiviral agent Substances 0.000 claims description 7
239000002249 anxiolytic agent Substances 0.000 claims description 7
230000000949 anxiolytic effect Effects 0.000 claims description 7
229940005530 anxiolytics Drugs 0.000 claims description 7
239000003795 chemical substances by application Substances 0.000 claims description 7
239000005554 hypnotics and sedatives Substances 0.000 claims description 7
229960005015 local anesthetics Drugs 0.000 claims description 7
206010027599 migraine Diseases 0.000 claims description 7
235000001968 nicotinic acid Nutrition 0.000 claims description 7
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 7
229930003448 Vitamin K Natural products 0.000 claims description 6
230000001062 anti-nausea Effects 0.000 claims description 6
239000008346 aqueous phase Substances 0.000 claims description 6
238000000034 method Methods 0.000 claims description 6
SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 6
235000019168 vitamin K Nutrition 0.000 claims description 6
239000011712 vitamin K Substances 0.000 claims description 6
150000003721 vitamin K derivatives Chemical class 0.000 claims description 6
229940046010 vitamin k Drugs 0.000 claims description 6
SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 claims description 5
229940033496 agent against amoebiasis and other protozoal diseases Drugs 0.000 claims description 5
229960004538 alprazolam Drugs 0.000 claims description 5
VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 claims description 5
239000000059 antiamebic agent Substances 0.000 claims description 5
150000003611 tocopherol derivatives Chemical group 0.000 claims description 5
230000000699 topical effect Effects 0.000 claims description 5
DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 claims description 4
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 4
239000000227 bioadhesive Substances 0.000 claims description 4
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 4
239000003589 local anesthetic agent Substances 0.000 claims description 4
229960004391 lorazepam Drugs 0.000 claims description 4
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 4
229920000642 polymer Polymers 0.000 claims description 4
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 3
239000004098 Tetracycline Substances 0.000 claims description 3
239000003429 antifungal agent Substances 0.000 claims description 3
229960004194 lidocaine Drugs 0.000 claims description 3
239000004094 surface-active agent Substances 0.000 claims description 3
235000019364 tetracycline Nutrition 0.000 claims description 3
150000003522 tetracyclines Chemical class 0.000 claims description 3
XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 2
BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 claims description 2
FJIKWRGCXUCUIG-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3h-1,4-benzodiazepin-2-one Chemical compound O=C([C@H](O)N=1)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1Cl FJIKWRGCXUCUIG-HNNXBMFYSA-N 0.000 claims description 2
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 2
LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims description 2
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 2
VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 2
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 2
UMSGKTJDUHERQW-UHFFFAOYSA-N Brotizolam Chemical compound C1=2C=C(Br)SC=2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl UMSGKTJDUHERQW-UHFFFAOYSA-N 0.000 claims description 2
LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 claims description 2
IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 claims description 2
UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 claims description 2
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 2
DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 claims description 2
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 2
239000004100 Oxytetracycline Substances 0.000 claims description 2
PPTYJKAXVCCBDU-UHFFFAOYSA-N Rohypnol Chemical compound N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1F PPTYJKAXVCCBDU-UHFFFAOYSA-N 0.000 claims description 2
HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims description 2
229960004150 aciclovir Drugs 0.000 claims description 2
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 2
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 2
229960003942 amphotericin b Drugs 0.000 claims description 2
230000000398 anti-amebic effect Effects 0.000 claims description 2
229940121357 antivirals Drugs 0.000 claims description 2
239000003124 biologic agent Substances 0.000 claims description 2
229960003051 brotizolam Drugs 0.000 claims description 2
RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 2
229960001736 buprenorphine Drugs 0.000 claims description 2
229960005091 chloramphenicol Drugs 0.000 claims description 2
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 2
CXOXHMZGEKVPMT-UHFFFAOYSA-N clobazam Chemical compound O=C1CC(=O)N(C)C2=CC=C(Cl)C=C2N1C1=CC=CC=C1 CXOXHMZGEKVPMT-UHFFFAOYSA-N 0.000 claims description 2
229960001403 clobazam Drugs 0.000 claims description 2
DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims description 2
229960003120 clonazepam Drugs 0.000 claims description 2
229960001259 diclofenac Drugs 0.000 claims description 2
DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 2
229960005156 digoxin Drugs 0.000 claims description 2
LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 claims description 2
LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 claims description 2
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 2
229960004166 diltiazem Drugs 0.000 claims description 2
229960003722 doxycycline Drugs 0.000 claims description 2
229960003913 econazole Drugs 0.000 claims description 2
229960003276 erythromycin Drugs 0.000 claims description 2
229960002336 estazolam Drugs 0.000 claims description 2
CDCHDCWJMGXXRH-UHFFFAOYSA-N estazolam Chemical compound C=1C(Cl)=CC=C(N2C=NN=C2CN=2)C=1C=2C1=CC=CC=C1 CDCHDCWJMGXXRH-UHFFFAOYSA-N 0.000 claims description 2
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims description 2
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229960002200 flunitrazepam Drugs 0.000 claims description 2
229960003528 flurazepam Drugs 0.000 claims description 2
SAADBVWGJQAEFS-UHFFFAOYSA-N flurazepam Chemical compound N=1CC(=O)N(CCN(CC)CC)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1F SAADBVWGJQAEFS-UHFFFAOYSA-N 0.000 claims description 2
229960003711 glyceryl trinitrate Drugs 0.000 claims description 2
MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims description 2
229960003727 granisetron Drugs 0.000 claims description 2
229960002867 griseofulvin Drugs 0.000 claims description 2
DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 claims description 2
229960001680 ibuprofen Drugs 0.000 claims description 2
229960004716 idoxuridine Drugs 0.000 claims description 2
229960000905 indomethacin Drugs 0.000 claims description 2
229960004130 itraconazole Drugs 0.000 claims description 2
229960004125 ketoconazole Drugs 0.000 claims description 2
229960004033 lormetazepam Drugs 0.000 claims description 2
TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 claims description 2
229960004503 metoclopramide Drugs 0.000 claims description 2
229960000282 metronidazole Drugs 0.000 claims description 2
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 2
229960002476 metronidazole benzoate Drugs 0.000 claims description 2
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A—HUMAN NECESSITIES
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- A61K9/0043—Nose
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
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- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Dispersion Chemistry (AREA)
Gynecology & Obstetrics (AREA)
Otolaryngology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)

NO19964832A 1994-05-16 1996-11-14 Tokoferol-blandinger for avgivelse av biologisk aktive midler, fremstillingav blandingene og anvendelse av tokoferol deri NO314569B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9409778A GB9409778D0 (en)	1994-05-16	1994-05-16	Compositions
PCT/EP1995/001835 WO1995031217A1 (en)	1994-05-16	1995-05-15	Tocopherol compositions for delivery of biologically active agents

Publications (3)

Publication Number	Publication Date
NO964832D0 NO964832D0 (no)	1996-11-14
NO964832L NO964832L (no)	1997-01-13
NO314569B1 true NO314569B1 (no)	2003-04-14

Family

ID=10755206

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19964832A NO314569B1 (no)	1994-05-16	1996-11-14	Tokoferol-blandinger for avgivelse av biologisk aktive midler, fremstillingav blandingene og anvendelse av tokoferol deri

Country Status (13)

Country	Link
US (1)	US6193985B1 (de)
EP (1)	EP0762896B1 (de)
AT (1)	ATE223232T1 (de)
CA (1)	CA2189328C (de)
DE (1)	DE69528057T2 (de)
DK (1)	DK0762896T3 (de)
ES (1)	ES2178674T3 (de)
FI (1)	FI119175B (de)
GB (1)	GB9409778D0 (de)
NO (1)	NO314569B1 (de)
NZ (1)	NZ287857A (de)
PT (1)	PT762896E (de)
WO (1)	WO1995031217A1 (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0708646A1 (de) *	1994-05-06	1996-05-01	Alcon Laboratories, Inc.	Verwendung von vitamin e tocopherolderivaten in ophthalmischen präparaten
GB9514878D0 (en) *	1995-07-20	1995-09-20	Danbiosyst Uk	Vitamin E as a solubilizer for drugs contained in lipid vehicles
GB2317562B (en) *	1995-07-20	1999-08-18	Danbiosyst Uk	Lipid vehicle drug delivery composition containing vitamin E
US5858401A (en) *	1996-01-22	1999-01-12	Sidmak Laboratories, Inc.	Pharmaceutical composition for cyclosporines
ES2118033B1 (es) *	1996-02-16	1999-07-01	Bial Ind Farmaceutica S A	Formulacion farmaceutica antiinflamatoria.
AU724239B2 (en) *	1996-03-22	2000-09-14	Glaxo Group Limited	Compositions comprising an HIV protease inhibitor such as VX 478 and a water soluble vitamin E compound such as vitamin E-TPGS
US6730679B1 (en)	1996-03-22	2004-05-04	Smithkline Beecham Corporation	Pharmaceutical formulations
KR100472581B1 (ko) *	1996-03-22	2005-06-16	글락소 그룹 리미티드	Vx478과같은hiv프로테아제억제제및비타민e-tpgs와같은수용성비타민e화합물을포함하는조성물
MY126358A (en) *	1996-03-22	2006-09-29	Glaxo Group Ltd	Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs
US6284794B1 (en) *	1996-11-05	2001-09-04	Head Explorer Aps	Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase
US6727280B2 (en)	1997-01-07	2004-04-27	Sonus Pharmaceuticals, Inc.	Method for treating colorectal carcinoma using a taxane/tocopherol formulation
US6458373B1 (en)	1997-01-07	2002-10-01	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
AU6919598A (en) *	1997-04-17	1998-11-13	Dumex-Alpharma A/S	A novel bioadhesive drug delivery system based on liquid crystals
US7632517B2 (en)	1997-10-01	2009-12-15	Novadel Pharma Inc.	Buccal, polar and non-polar spray containing zolpidem
US20040141923A1 (en) *	1997-10-01	2004-07-22	Dugger Harry A.	Buccal, polar and non-polar spray containing alprazolam
US20040136914A1 (en)	1997-10-01	2004-07-15	Dugger Harry A.	Buccal, polar and non-polar spray containing ondansetron
CA2320087C (en) *	1998-02-09	2006-12-19	Joel Bolonick	Treatment of chronic inflammatory disorders of the gastrointestinal tract
US7030155B2 (en)	1998-06-05	2006-04-18	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
US8466134B1 (en) *	1998-06-26	2013-06-18	Athena Neurosciences, Inc.	Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
US5869704A (en) *	1998-08-24	1999-02-09	Eastman Chemical Company	Water-dispersible or water-soluble D-tocotrienol compounds and methods for making therefor
SK288117B6 (sk) *	1998-11-20	2013-09-03	Skyepharma Canada Inc.	Rapidly dispersing solid dry therapeutic dosage form
US6248363B1 (en) *	1999-11-23	2001-06-19	Lipocine, Inc.	Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030236236A1 (en) *	1999-06-30	2003-12-25	Feng-Jing Chen	Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
KR20020059415A (ko) *	1999-09-27	2002-07-12	스티븐 씨. 큐웨이	토콜-가용성 치료요법제
RU2162699C1 (ru) *	2000-02-14	2001-02-10	Закрытое Акционерное Общество "Нита-Фарм"	Водно-дисперсная лекарственная форма ивермектина для лечения экто- и эндопаразитозов
US20060083691A1 (en) *	2000-05-10	2006-04-20	Wermeling Daniel P	Intranasal opioid compositions, delivery devices and methods of using same
US6610271B2 (en) *	2000-05-10	2003-08-26	University Of Kentucky Research Foundation	System and method for intranasal administration of lorazepam
US20040115133A1 (en) *	2000-05-10	2004-06-17	Wermeling Daniel P.	Intranasal opioid compositions
EP1315533A4 (de) *	2000-08-15	2007-06-27	Univ Kentucky Res Found	Programmierbare mehrdosenvorrichtung für intranasale medikamentenverabreichung
WO2002026208A2 (en) *	2000-09-27	2002-04-04	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
CN100396287C (zh) *	2000-11-14	2008-06-25	生命健康科学有限公司	含有电子转移剂磷酸盐衍生物的制剂
US20040176359A1 (en) *	2001-02-20	2004-09-09	University Of Kentucky Research Foundation	Intranasal Benzodiazepine compositions
GB0114532D0 (en) *	2001-06-14	2001-08-08	Jagotec Ag	Novel compositions
GB0116107D0 (en) *	2001-06-30	2001-08-22	West Pharm Serv Drug Res Ltd	Pharmaceutical composition
GB0119480D0 (en) *	2001-08-09	2001-10-03	Jagotec Ag	Novel compositions
RU2004107501A (ru) *	2001-08-14	2005-02-20	Байотай Терапис Корпорейшн (Fi)	Способ лечения алкоголизма или злоупотребления алкоголем
US7586050B2 (en) *	2001-09-07	2009-09-08	Lashua John A	Ergonomic snow plow control system
US6858227B1 (en)	2001-11-21	2005-02-22	Sonus Pharmaceuticals, Inc.	Vitamin E conjugates
BR0214679A (pt) *	2001-12-03	2004-12-14	Novacea Inc	Composições farmacêuticas compreendendo compostos a base de vitamina d ativa
AU2002353118A1 (en) *	2001-12-11	2003-07-24	Dor Biopharma, Inc.	Lipid particles and suspensions and uses thereof
NZ537829A (en)	2002-07-30	2006-09-29	Wyeth Corp	Parenteral formulations containing a rapamycin hydroxyester
AU2002950713A0 (en)	2002-08-09	2002-09-12	Vital Health Sciences Pty Ltd	Carrier
US20050026877A1 (en) *	2002-12-03	2005-02-03	Novacea, Inc.	Pharmaceutical compositions comprising active vitamin D compounds
ATE411010T1 (de) *	2002-12-13	2008-10-15	Jagotec Ag	Topische nanopartikel-spironolacton-formulierung
US20050020546A1 (en) *	2003-06-11	2005-01-27	Novacea, Inc.	Pharmaceutical compositions comprising active vitamin D compounds
US8211448B2 (en)	2003-07-07	2012-07-03	Nares Ab	Microemulsions and its use for preventing airway diseases
PL1648412T3 (pl) *	2003-07-07	2008-04-30	Nares Ab	Mikroemulsje i ich zastosowanie do zapobiegania chorobom dróg oddechowych
US20050107465A1 (en) *	2003-10-01	2005-05-19	Papas Andreas M.	Composition for treating inflammatory bowel disease
EP1670838B1 (de) *	2003-10-10	2015-12-09	Samyang Biopharmaceuticals Corporation	Amphiphiles blockcopolymer und dieses enthaltende polymerzusammensetzung für die arzneistoffzufuhr
BRPI0415858A (pt)	2003-10-29	2007-01-09	Sonus Pharma Inc	compostos de medicamentos terapêuticos modificados por tocoferol
US20060003002A1 (en) *	2003-11-03	2006-01-05	Lipocine, Inc.	Pharmaceutical compositions with synchronized solubilizer release
CA2550811C (en) *	2003-12-24	2012-05-01	Jane Hirsh	Temperature-stable formulations, and methods of development thereof
GB0400804D0 (en)	2004-01-14	2004-02-18	Innoscience Technology Bv	Pharmaceutical compositions
KR100582604B1 (ko)	2004-06-16	2006-05-23	보람제약주식회사	항산화제를 포함한 이부프로펜 및 덱시부프로펜의마이크로 에멀젼과 이를 이용한 투명 액제 및 투명연질캡슐 제제
JP2008506780A (ja) *	2004-07-19	2008-03-06	セレーターファーマスーティカルズ、インク．	活性剤放出のための粒子状構築物
CN1925853B (zh) *	2004-07-28	2011-01-26	陈献	琥珀酸α-生育酚酯及其类似物和盐的稳定注射组合物
US20060045865A1 (en) *	2004-08-27	2006-03-02	Spherics, Inc.	Controlled regional oral delivery
ATE533473T1 (de) *	2004-09-24	2011-12-15	Boehringer Ingelheim Pharma	Neue klasse von surfuctantähnlichen materialien mit vitamin-e-tpgs und wasserlöslichem polymer
US9993558B2 (en)	2004-10-01	2018-06-12	Ramscor, Inc.	Sustained release eye drop formulations
US20060231309A1 (en) *	2005-03-23	2006-10-19	Lashua John A	Ergonomic plow control system
US20060240051A1 (en) *	2005-04-26	2006-10-26	Singleton Andy H	Eutectic blends containing a water soluble vitamin derivative
NZ565049A (en)	2005-06-17	2012-02-24	Vital Health Sciences Pty Ltd	A carrier comprising one or more DI and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US20070087055A1 (en) *	2005-10-14	2007-04-19	David Jan	Directly compressible extended release alprazolam formulation
US8497258B2 (en) *	2005-11-12	2013-07-30	The Regents Of The University Of California	Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en)	2005-11-12	2014-03-25	The Regents Of The University Of California	Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US20070167422A1 (en) *	2006-01-18	2007-07-19	Yu Kwok S	Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin
TW200824693A (en) *	2006-08-28	2008-06-16	Jazz Pharmaceuticals Inc	Pharmaceutical compositions of clonazepam and methods of use thereof
US20080275030A1 (en)	2007-01-19	2008-11-06	Sveinbjorn Gizurarson	Methods and Compositions for the Delivery of a Therapeutic Agent
US20080279784A1 (en) *	2007-05-07	2008-11-13	Questcor Pharmaceuticals, Inc.	Nasal administration of benzodiazepines
US8530463B2 (en) *	2007-05-07	2013-09-10	Hale Biopharma Ventures Llc	Multimodal particulate formulations
ES2667945T3 (es)	2007-10-08	2018-05-16	Aurinia Pharmaceuticals Inc.	Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR
EP2257220B1 (de) *	2008-03-13	2017-06-14	Liebel-Flarsheim Company LLC	Fussbetätigte multifunktionssteuerung für bildgebungssystem
MX2010010050A (es) *	2008-03-20	2011-03-15	Virun Inc Star	Emulsiones que incluyen un derivado de polietilen glicol de tocoferol.
WO2009117151A2 (en) *	2008-03-20	2009-09-24	Virun, Inc.	Compositions containing non-polar compounds
CA2756690C (en)	2008-03-28	2016-08-16	Hale Biopharma Ventures, Llc	Administration of benzodiazepine compositions
EP2271214B1 (de) *	2008-03-28	2017-05-03	Particle Sciences, Inc.	Pharmazeutische lösungen und verfahren zur auflösung von therapeutika
US20100041622A1 (en) *	2008-08-13	2010-02-18	Bromley Philip J	Compositions containing aminoalkanes and aminoalkane derivatives
US8236768B2 (en)	2008-10-03	2012-08-07	3B Pharmaceuticals, Inc.	Topical antiviral formulations
US11304960B2 (en)	2009-01-08	2022-04-19	Chandrashekar Giliyar	Steroidal compositions
US8946209B2 (en) *	2009-04-28	2015-02-03	Optmed, Inc.	Compositions and methods for treating and preventing urolithiasis and conditions associated therewith
EP2440185B1 (de) *	2009-06-09	2015-04-08	Aurinia Pharmaceuticals Inc.	Topische arzneimittelabgabesysteme zur ophthalmischen verwendung
ES2999020T3 (en)	2010-02-05	2025-02-24	Phosphagenics Ltd	Carrier comprising non-neutralised tocopheryl phosphate
CN103037708B (zh)	2010-03-23	2015-05-20	维尔恩公司	含有蔗糖脂肪酸酯的纳米乳液
EP2552486B1 (de)	2010-03-30	2020-08-12	Phosphagenics Limited	Pflaster für transdermale verabreichung
CN102232925A (zh) *	2010-04-30	2011-11-09	中南大学	盐酸利多卡因透皮剂及其制备方法
WO2011162802A1 (en)	2010-06-21	2011-12-29	Virun, Inc.	Compositions containing non-polar compounds
US20180153904A1 (en)	2010-11-30	2018-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US9034858B2 (en)	2010-11-30	2015-05-19	Lipocine Inc.	High-strength testosterone undecanoate compositions
US9358241B2 (en)	2010-11-30	2016-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US20120148675A1 (en)	2010-12-10	2012-06-14	Basawaraj Chickmath	Testosterone undecanoate compositions
WO2012122586A1 (en)	2011-03-15	2012-09-20	Phosphagenics Limited	New composition
EP4085899A1 (de)	2011-06-14	2022-11-09	Neurelis, Inc.	Verabreichung von benzodiazepin
WO2013077881A1 (en)	2011-11-23	2013-05-30	3B Pharmaceuticals, Inc.	Antiviral formulations
FR2983731B1 (fr) *	2011-12-07	2014-04-25	Univ Paris Descartes	Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras
EP2811847B1 (de)	2012-02-10	2017-12-13	Virun, Inc.	Zubereitungen für getränke enthaltend neutrale verbindungen
ITRM20120331A1 (it)	2012-07-12	2014-01-13	Guidotti & C Spa Labor	Composizioni pediatriche orali liquide contenenti nepadutant.
US9351517B2 (en)	2013-03-15	2016-05-31	Virun, Inc.	Formulations of water-soluble derivatives of vitamin E and compositions containing same
US9693574B2 (en)	2013-08-08	2017-07-04	Virun, Inc.	Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch
WO2016033549A2 (en)	2014-08-28	2016-03-03	Lipocine Inc.	(17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en)	2014-08-28	2016-11-22	Lipocine Inc.	Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US9861611B2 (en)	2014-09-18	2018-01-09	Virun, Inc.	Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same
US10016363B2 (en)	2014-09-18	2018-07-10	Virun, Inc.	Pre-spray emulsions and powders containing non-polar compounds
US20160361322A1 (en)	2015-06-15	2016-12-15	Lipocine Inc.	Composition and method for oral delivery of androgen prodrugs
MX2018000421A (es) *	2015-07-13	2018-05-17	Dr Reddy´S Laboratories Ltd	Composiciones de retinoides topicos.
US10456435B2 (en)	2015-07-15	2019-10-29	Christopher A. MCELVANY	Topical antiviral formulations and methods of using the same
US10172833B2 (en)	2015-08-11	2019-01-08	Insys Development Company, Inc.	Sublingual ondansetron spray
CN114712308A (zh)	2015-12-09	2022-07-08	磷肌酸有限公司	药物制剂
US10383833B2 (en) *	2016-10-13	2019-08-20	Milanapharm LLC	Topical formulations and treatments
US11559530B2 (en)	2016-11-28	2023-01-24	Lipocine Inc.	Oral testosterone undecanoate therapy
EP3558903B1 (de)	2016-12-21	2024-07-03	Avecho Biotechnology Limited	Verfahren zur phosphorylierung eines komplexen alkohols
US20190224275A1 (en)	2017-05-12	2019-07-25	Aurinia Pharmaceuticals Inc.	Protocol for treatment of lupus nephritis
AU2019231699B2 (en) *	2018-03-07	2023-03-09	Andrew Xian Chen	Aqueous formulations for insoluble drugs
AU2019308326B2 (en)	2018-07-20	2025-07-31	Lipocine Inc.	Liver disease
US10799455B1 (en)	2019-11-11	2020-10-13	King Abdulaziz University	Micellles containing alpha lipoic acid as a transdermal drug delivery system
US10736843B1 (en)	2019-11-22	2020-08-11	King Abdulaziz University	In situ gelling composition containing tocopherol-loaded micelles as an intranasal drug delivery system
US11980636B2 (en)	2020-11-18	2024-05-14	Jazz Pharmaceuticals Ireland Limited	Treatment of hematological disorders
CN117580579A (zh)	2021-06-10	2024-02-20	纽瑞莱斯有限公司	用于治疗儿科患者的癫痫发作病症的方法和组合物
WO2023119230A1 (en)	2021-12-22	2023-06-29	L'oreal	Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7711916A (nl)	1977-10-29	1979-05-02	Akzo Nv	Werkwijze ter bereiding van sterk geconcen- treerde farmaceutische preparaten van steroiden.
US4439432A (en)	1982-03-22	1984-03-27	Peat Raymond F	Treatment of progesterone deficiency and related conditions with a stable composition of progesterone and tocopherols
DE3405240A1 (de)	1984-02-15	1985-08-22	Roshdy Dipl.-Chem. Dr. 5000 Köln Ismail	Rheuma- und venenmittel
GB8501015D0 (en)	1985-01-16	1985-02-20	Riker Laboratories Inc	Drug
US4628052A (en) *	1985-05-28	1986-12-09	Peat Raymond F	Pharmaceutical compositions containing dehydroepiandrosterone and other anesthetic steroids in the treatment of arthritis and other joint disabilities
US4863720A (en)	1986-03-10	1989-09-05	Walter Burghart	Pharmaceutical preparation and methods for its production
AU620048B2 (en)	1987-09-03	1992-02-13	University Of Georgia Research Foundation, Inc., The	Ocular cyclosporin composition
MX9203804A (es) *	1987-10-19	1992-07-01	Liposome Co Inc	Sistemas farmaceuticos a base de tocoferol.
DE3883246T2 (de) *	1987-10-19	1993-12-02	Liposome Co Inc	Auf tocopherol basierte arzneimittelsysteme.
US4847072A (en) *	1987-10-22	1989-07-11	The Procter & Gamble Company	Photoprotection compositions comprising tocopherol sorbate
US4960814A (en)	1988-06-13	1990-10-02	Eastman Kodak Company	Water-dispersible polymeric compositions
US4950664A (en)	1988-09-16	1990-08-21	Rugby-Darby Group Companies, Inc.	Nasal administration of benzodiazepine hypnotics
DE3908047A1 (de)	1989-03-13	1990-09-20	Desitin Arzneimittel Gmbh	Hochdisperse pharmazeutische zusammensetzung
NZ237084A (en)	1990-02-12	1993-10-26	Lucky Ltd	Composition for the prolonged release of somatotropin comprising the somatotropin, a tocopherol component, and an assistant delaying agent
ES2097145T3 (es)	1990-03-28	1997-04-01	Noven Pharma	Metodo y dispositivo para la liberacion de farmacos en la piel.
ES2117642T3 (es)	1990-05-10	1998-08-16	Bechgaard Int Res	Preparado farmaceutico que contiene n-glicofuroles y n-etilen glicoles.
US5179122A (en) *	1991-02-11	1993-01-12	Eastman Kodak Company	Nutritional supplement containing vitamin e
US5223268A (en)	1991-05-16	1993-06-29	Sterling Drug, Inc.	Low solubility drug-coated bead compositions
EP0636618A1 (de)	1991-06-04	1995-02-01	Marigen S.A.	Spontan dispergierbare Konzentrate und Mikroemulsionen mit Vitamin-E-Verbindungen zur Herstellung von Arzneimitteln mit Antitumoraler Wirksamkeit
WO1993003720A2 (en)	1991-08-16	1993-03-04	Trevithick John R	Methods and compositions for treating sunburns
NZ244862A (en)	1991-10-23	1995-07-26	Block Drug Co	Use of vitamin e in topical pharmaceuticals to enhance penetration of the active agent
IL101387A (en)	1992-03-26	1999-11-30	Pharmos Ltd	Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
WO1993021905A1 (en)	1992-04-23	1993-11-11	Berlex Laboratories, Inc.	Bioadhesive solid mineral oil emulsion
JP2811036B2 (ja)	1992-05-26	1998-10-15	参天製薬株式会社	ビタミンｅ点眼剤
CN1118575A (zh) *	1993-03-03	1996-03-13	藤泽药品工业株式会社	旋光异构化抑制剂
DE4322826A1 (de)	1993-07-08	1995-01-12	Galenik Labor Freiburg Gmbh	Pharmazeutisches Präparat
WO1995011039A1 (de) *	1993-10-22	1995-04-27	Hexal Pharma Gmbh	Pharmazeutische zusammensetzung mit cyclosporin a und alpha-tocopherol
EP0804157A1 (de)	1994-03-14	1997-11-05	Abbott Laboratories	Pharmazeutische aerosol-formulierungen mit einem gehalt an vitamin e
US5430021A (en) *	1994-03-18	1995-07-04	Pharmavene, Inc.	Hydrophobic drug delivery systems
EP0708646A1 (de)	1994-05-06	1996-05-01	Alcon Laboratories, Inc.	Verwendung von vitamin e tocopherolderivaten in ophthalmischen präparaten

1994
- 1994-05-16 GB GB9409778A patent/GB9409778D0/en active Pending
1995
- 1995-05-15 DE DE69528057T patent/DE69528057T2/de not_active Expired - Lifetime
- 1995-05-15 ES ES95921750T patent/ES2178674T3/es not_active Expired - Lifetime
- 1995-05-15 EP EP95921750A patent/EP0762896B1/de not_active Expired - Lifetime
- 1995-05-15 NZ NZ287857A patent/NZ287857A/xx not_active IP Right Cessation
- 1995-05-15 AT AT95921750T patent/ATE223232T1/de active
- 1995-05-15 DK DK95921750T patent/DK0762896T3/da active
- 1995-05-15 CA CA002189328A patent/CA2189328C/en not_active Expired - Fee Related
- 1995-05-15 WO PCT/EP1995/001835 patent/WO1995031217A1/en not_active Ceased
- 1995-05-15 PT PT95921750T patent/PT762896E/pt unknown
1996
- 1996-11-14 NO NO19964832A patent/NO314569B1/no not_active IP Right Cessation
- 1996-11-15 FI FI964583A patent/FI119175B/fi not_active IP Right Cessation
1997
- 1997-05-14 US US08/856,054 patent/US6193985B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO964832D0 (no)	1996-11-14
CA2189328C (en)	2003-07-22
GB9409778D0 (en)	1994-07-06
FI119175B (fi)	2008-08-29
WO1995031217A1 (en)	1995-11-23
PT762896E (pt)	2003-01-31
DE69528057D1 (de)	2002-10-10
ES2178674T3 (es)	2003-01-01
DE69528057T2 (de)	2003-11-06
EP0762896A1 (de)	1997-03-19
CA2189328A1 (en)	1995-11-23
NZ287857A (en)	1998-09-24
FI964583L (fi)	1996-11-15
DK0762896T3 (da)	2003-01-06
US6193985B1 (en)	2001-02-27
AU697540B2 (en)	1998-10-08
EP0762896B1 (de)	2002-09-04
FI964583A0 (fi)	1996-11-15
ATE223232T1 (de)	2002-09-15
NO964832L (no)	1997-01-13
AU2670595A (en)	1995-12-05

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