ATE223232T1 - Tocopherolzusammensetzungen zur abgabe von biologisch aktiven substanzen - Google Patents

Tocopherolzusammensetzungen zur abgabe von biologisch aktiven substanzen

Info

Publication number
ATE223232T1
ATE223232T1 AT95921750T AT95921750T ATE223232T1 AT E223232 T1 ATE223232 T1 AT E223232T1 AT 95921750 T AT95921750 T AT 95921750T AT 95921750 T AT95921750 T AT 95921750T AT E223232 T1 ATE223232 T1 AT E223232T1
Authority
AT
Austria
Prior art keywords
biologically active
delivery
active substances
compositions
tocopherol compositions
Prior art date
Application number
AT95921750T
Other languages
English (en)
Inventor
Mette Rydahl Sonne
Original Assignee
Alpharma Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpharma Aps filed Critical Alpharma Aps
Application granted granted Critical
Publication of ATE223232T1 publication Critical patent/ATE223232T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT95921750T 1994-05-16 1995-05-15 Tocopherolzusammensetzungen zur abgabe von biologisch aktiven substanzen ATE223232T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9409778A GB9409778D0 (en) 1994-05-16 1994-05-16 Compositions
PCT/EP1995/001835 WO1995031217A1 (en) 1994-05-16 1995-05-15 Tocopherol compositions for delivery of biologically active agents

Publications (1)

Publication Number Publication Date
ATE223232T1 true ATE223232T1 (de) 2002-09-15

Family

ID=10755206

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95921750T ATE223232T1 (de) 1994-05-16 1995-05-15 Tocopherolzusammensetzungen zur abgabe von biologisch aktiven substanzen

Country Status (13)

Country Link
US (1) US6193985B1 (de)
EP (1) EP0762896B1 (de)
AT (1) ATE223232T1 (de)
CA (1) CA2189328C (de)
DE (1) DE69528057T2 (de)
DK (1) DK0762896T3 (de)
ES (1) ES2178674T3 (de)
FI (1) FI119175B (de)
GB (1) GB9409778D0 (de)
NO (1) NO314569B1 (de)
NZ (1) NZ287857A (de)
PT (1) PT762896E (de)
WO (1) WO1995031217A1 (de)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1129400A (zh) * 1994-05-06 1996-08-21 阿尔康实验室公司 维生素e生育酚衍生物在眼科组合物中的应用
GB9514878D0 (en) * 1995-07-20 1995-09-20 Danbiosyst Uk Vitamin E as a solubilizer for drugs contained in lipid vehicles
GB2317562B (en) * 1995-07-20 1999-08-18 Danbiosyst Uk Lipid vehicle drug delivery composition containing vitamin E
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
ES2118033B1 (es) * 1996-02-16 1999-07-01 Bial Ind Farmaceutica S A Formulacion farmaceutica antiinflamatoria.
KR100472581B1 (ko) * 1996-03-22 2005-06-16 글락소 그룹 리미티드 Vx478과같은hiv프로테아제억제제및비타민e-tpgs와같은수용성비타민e화합물을포함하는조성물
AU724239B2 (en) * 1996-03-22 2000-09-14 Glaxo Group Limited Compositions comprising an HIV protease inhibitor such as VX 478 and a water soluble vitamin E compound such as vitamin E-TPGS
US6730679B1 (en) 1996-03-22 2004-05-04 Smithkline Beecham Corporation Pharmaceutical formulations
MY126358A (en) * 1996-03-22 2006-09-29 Glaxo Group Ltd Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs
US6284794B1 (en) * 1996-11-05 2001-09-04 Head Explorer Aps Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6727280B2 (en) 1997-01-07 2004-04-27 Sonus Pharmaceuticals, Inc. Method for treating colorectal carcinoma using a taxane/tocopherol formulation
CA2286052A1 (en) * 1997-04-17 1998-10-29 Lise Sylvest Nielsen A novel bioadhesive drug delivery system based on liquid crystals
US7632517B2 (en) 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
US20040141923A1 (en) * 1997-10-01 2004-07-22 Dugger Harry A. Buccal, polar and non-polar spray containing alprazolam
US20040136914A1 (en) 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
EP1052977A4 (de) * 1998-02-09 2006-07-12 Joel Bolonick Behandlung chronisch entzündlicher erkrankungen des gastrointestinaltrakts
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US8466134B1 (en) * 1998-06-26 2013-06-18 Athena Neurosciences, Inc. Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
US5869704A (en) * 1998-08-24 1999-02-09 Eastman Chemical Company Water-dispersible or water-soluble D-tocotrienol compounds and methods for making therefor
IL143197A0 (en) * 1998-11-20 2002-04-21 Rtp Pharma Inc Dispersible phospholipid stabilized microparticles
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
AU7719100A (en) 1999-09-27 2001-04-30 Panayiotis Constantinides Compositions of tocol-soluble therapeutics
RU2162699C1 (ru) * 2000-02-14 2001-02-10 Закрытое Акционерное Общество "Нита-Фарм" Водно-дисперсная лекарственная форма ивермектина для лечения экто- и эндопаразитозов
US20060083691A1 (en) * 2000-05-10 2006-04-20 Wermeling Daniel P Intranasal opioid compositions, delivery devices and methods of using same
US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
EP1315533A4 (de) * 2000-08-15 2007-06-27 Univ Kentucky Res Found Programmierbare mehrdosenvorrichtung für intranasale medikamentenverabreichung
WO2002026208A2 (en) * 2000-09-27 2002-04-04 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
CA2426852C (en) * 2000-11-14 2010-01-26 Vital Health Sciences Pty Ltd Formulation containing phosphate derivatives of electron transfer agents
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
GB0114532D0 (en) * 2001-06-14 2001-08-08 Jagotec Ag Novel compositions
GB0116107D0 (en) * 2001-06-30 2001-08-22 West Pharm Serv Drug Res Ltd Pharmaceutical composition
GB0119480D0 (en) * 2001-08-09 2001-10-03 Jagotec Ag Novel compositions
HUP0401022A3 (en) * 2001-08-14 2006-11-28 Biotie Therapies Corp Method for the preparation of pharmaceutical compositions containing opioid antagonist for treating alcoholism or alcohol abuse
US7586050B2 (en) * 2001-09-07 2009-09-08 Lashua John A Ergonomic snow plow control system
US6858227B1 (en) 2001-11-21 2005-02-22 Sonus Pharmaceuticals, Inc. Vitamin E conjugates
MXPA04005260A (es) * 2001-12-03 2005-03-23 Novacea Inc Composiciones farmaceuticas que comprenden compuestos activos de vitamina d.
US20060078618A1 (en) * 2001-12-11 2006-04-13 Constantinides Panayiotis P Lipid particles and suspensions and uses thereof
PT1553940E (pt) 2002-07-30 2008-05-09 Wyeth Corp Formulações parentéricas contendo um hidroxi-éster de rapamicina
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
JP2006511525A (ja) * 2002-12-13 2006-04-06 ヤゴテック アーゲー ナノ粒子状スピロノラクトン局所製剤
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US8211448B2 (en) 2003-07-07 2012-07-03 Nares Ab Microemulsions and its use for preventing airway diseases
EP1648412B1 (de) * 2003-07-07 2007-11-14 Nares AB Mikroemulsionen und ihre verwendung zur prävention von erkrankungen der atemwege
US20050107465A1 (en) * 2003-10-01 2005-05-19 Papas Andreas M. Composition for treating inflammatory bowel disease
KR100703872B1 (ko) * 2003-10-10 2007-04-09 주식회사 삼양사 양친성 블록 공중합체 및 이를 포함하는 약물 전달용고분자 조성물
KR20060110872A (ko) 2003-10-29 2006-10-25 소너스파머슈티칼즈인코포레이티드 토코페롤 변성 치료제 약물 화합물
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US20050153946A1 (en) * 2003-12-24 2005-07-14 Collegium Pharmaceuticals, Inc. Temperature-stable formulations, and methods of development thereof
GB0400804D0 (en) 2004-01-14 2004-02-18 Innoscience Technology Bv Pharmaceutical compositions
KR100582604B1 (ko) 2004-06-16 2006-05-23 보람제약주식회사 항산화제를 포함한 이부프로펜 및 덱시부프로펜의마이크로 에멀젼과 이를 이용한 투명 액제 및 투명연질캡슐 제제
JP2008506780A (ja) * 2004-07-19 2008-03-06 セレーター ファーマスーティカルズ、インク． 活性剤放出のための粒子状構築物
RU2007107359A (ru) * 2004-07-28 2008-09-10 ЭсДи ФАРМАСЬЮТИКАЛЗ, ИНК. (US) Стабильная инъецируемая композиция альфа-токоферилсукцината, его аналогов и солей
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
US20060068007A1 (en) * 2004-09-24 2006-03-30 Boehringer Ingelheim Pharmaceuticals, Inc. Class of surfactant-like materials
US9993558B2 (en) 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
US20060231309A1 (en) * 2005-03-23 2006-10-19 Lashua John A Ergonomic plow control system
US20060240051A1 (en) * 2005-04-26 2006-10-26 Singleton Andy H Eutectic blends containing a water soluble vitamin derivative
EP2548581A3 (de) 2005-06-17 2013-02-20 Vital Health Sciences Pty Ltd. Träger mit einem oder mehreren Di- bzw. Mono-(Elektrontransfermittel) Phosphatderivaten oder Komplexen davon
US20070087055A1 (en) * 2005-10-14 2007-04-19 David Jan Directly compressible extended release alprazolam formulation
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8497258B2 (en) * 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US20070167422A1 (en) * 2006-01-18 2007-07-19 Yu Kwok S Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin
TW200824693A (en) * 2006-08-28 2008-06-16 Jazz Pharmaceuticals Inc Pharmaceutical compositions of clonazepam and methods of use thereof
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
US8530463B2 (en) * 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
EP2152274A4 (de) * 2007-05-07 2010-07-21 Questor Pharmaceuticals Inc Nasale verabreichung von benzodiazepinen
AU2008310956B2 (en) 2007-10-08 2014-08-07 Aurinia Pharmaceuticals Inc. Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors
US8861813B2 (en) * 2008-03-13 2014-10-14 Mallinckrodt Llc Multi-function, foot-activated controller for imaging system
BRPI0909187A2 (pt) * 2008-03-20 2015-08-04 Virun Inc Emulsões incluindo tocoferol de derivados de peg
BRPI0909185A2 (pt) * 2008-03-20 2015-08-25 Virun Inc Derivado de vitamina e e seus usos
US20110038899A1 (en) * 2008-03-28 2011-02-17 Garry Thomas Gwozdz Pharmaceutical Solutions and Method for Solublilizing Therapeutic Agents
ES2586032T3 (es) * 2008-03-28 2016-10-11 Hale Biopharma Ventures, Llc Administración de composiciones de benzodiazepinas
WO2010019255A1 (en) * 2008-08-13 2010-02-18 Virun, Inc. Compositions containing aminoalkanes and aminoalkane derivatives
US8236768B2 (en) 2008-10-03 2012-08-07 3B Pharmaceuticals, Inc. Topical antiviral formulations
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
WO2010126968A1 (en) * 2009-04-28 2010-11-04 Optmed, Inc. Compositions and methods for treating or preventing urolithiasis and conditions associated therewith
MX338355B (es) * 2009-06-09 2016-04-13 Aurinia Pharmaceuticals Inc Sistemas de suministro de farmaco topico para uso oftalmico.
AU2011213557B2 (en) 2010-02-05 2015-05-07 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
KR101622441B1 (ko) 2010-03-23 2016-05-18 버런, 아이엔씨. 자당 지방산 에스테르를 포함하는 나노에멀전
MX2012011355A (es) 2010-03-30 2012-11-30 Phosphagenics Ltd Parche de suministro transdermico.
CN102232925A (zh) * 2010-04-30 2011-11-09 中南大学 盐酸利多卡因透皮剂及其制备方法
WO2011162802A1 (en) 2010-06-21 2011-12-29 Virun, Inc. Compositions containing non-polar compounds
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
CN103796656A (zh) 2011-06-14 2014-05-14 哈尔生物药投资有限责任公司 苯二氮卓的投与
EP2782585B1 (de) 2011-11-23 2018-12-26 3B Pharmaceuticals, Inc. Antivirale formulierungen
FR2983731B1 (fr) * 2011-12-07 2014-04-25 Univ Paris Descartes Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras
EP2811847B1 (de) 2012-02-10 2017-12-13 Virun, Inc. Zubereitungen für getränke enthaltend neutrale verbindungen
ITRM20120331A1 (it) 2012-07-12 2014-01-13 Guidotti & C Spa Labor Composizioni pediatriche orali liquide contenenti nepadutant.
US9351517B2 (en) 2013-03-15 2016-05-31 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and compositions containing same
US9693574B2 (en) 2013-08-08 2017-07-04 Virun, Inc. Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US10016363B2 (en) 2014-09-18 2018-07-10 Virun, Inc. Pre-spray emulsions and powders containing non-polar compounds
US9861611B2 (en) 2014-09-18 2018-01-09 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
RU2699027C2 (ru) * 2015-07-13 2019-09-03 Др. Редди'С Лабораториз Лтд. Ретиноидные композиции для местного применения
US10456435B2 (en) 2015-07-15 2019-10-29 Christopher A. MCELVANY Topical antiviral formulations and methods of using the same
US10172833B2 (en) 2015-08-11 2019-01-08 Insys Development Company, Inc. Sublingual ondansetron spray
CN114712308A (zh) 2015-12-09 2022-07-08 磷肌酸有限公司 药物制剂
EP3525767B1 (de) * 2016-10-13 2023-02-15 Trilogic Pharma Llc Topische formulierungen und behandlungen
US11559530B2 (en) 2016-11-28 2023-01-24 Lipocine Inc. Oral testosterone undecanoate therapy
EP3558903B1 (de) 2016-12-21 2024-07-03 Avecho Biotechnology Limited Verfahren zur phosphorylierung eines komplexen alkohols
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
CN111867562B (zh) * 2018-03-07 2023-07-07 陈献 不溶性药物的水性制剂
EP3824296A4 (de) 2018-07-20 2022-04-27 Lipocine Inc. Lebererkrankung
US10799455B1 (en) 2019-11-11 2020-10-13 King Abdulaziz University Micellles containing alpha lipoic acid as a transdermal drug delivery system
US10736843B1 (en) 2019-11-22 2020-08-11 King Abdulaziz University In situ gelling composition containing tocopherol-loaded micelles as an intranasal drug delivery system
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7711916A (nl) 1977-10-29 1979-05-02 Akzo Nv Werkwijze ter bereiding van sterk geconcen- treerde farmaceutische preparaten van steroiden.
US4439432A (en) 1982-03-22 1984-03-27 Peat Raymond F Treatment of progesterone deficiency and related conditions with a stable composition of progesterone and tocopherols
DE3405240A1 (de) 1984-02-15 1985-08-22 Roshdy Dipl.-Chem. Dr. 5000 Köln Ismail Rheuma- und venenmittel
GB8501015D0 (en) 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
US4628052A (en) * 1985-05-28 1986-12-09 Peat Raymond F Pharmaceutical compositions containing dehydroepiandrosterone and other anesthetic steroids in the treatment of arthritis and other joint disabilities
US4863720A (en) 1986-03-10 1989-09-05 Walter Burghart Pharmaceutical preparation and methods for its production
AU620048B2 (en) 1987-09-03 1992-02-13 University Of Georgia Research Foundation, Inc., The Ocular cyclosporin composition
JP2921792B2 (ja) * 1987-10-19 1999-07-19 ザ リポソーム カンパニー，インコーポレイテッド トコフェロールを基体とした薬剤系
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
US4847072A (en) * 1987-10-22 1989-07-11 The Procter & Gamble Company Photoprotection compositions comprising tocopherol sorbate
US4960814A (en) 1988-06-13 1990-10-02 Eastman Kodak Company Water-dispersible polymeric compositions
US4950664A (en) 1988-09-16 1990-08-21 Rugby-Darby Group Companies, Inc. Nasal administration of benzodiazepine hypnotics
DE3908047A1 (de) 1989-03-13 1990-09-20 Desitin Arzneimittel Gmbh Hochdisperse pharmazeutische zusammensetzung
AU653325B2 (en) 1990-02-12 1994-09-29 Lucky Limited A composition durably releasing bioactive polypeptides
FI924313L (fi) 1990-03-28 1992-09-25 Noven Pharma Metod och anordning foer frigoering av mediciner pao huden
JP3219096B2 (ja) 1990-05-10 2001-10-15 ニコメド ファーマ エイエス ｎ―グリコフロール類及びｎ―エチレングリコール類を含有する医薬製剤
US5179122A (en) * 1991-02-11 1993-01-12 Eastman Kodak Company Nutritional supplement containing vitamin e
US5223268A (en) 1991-05-16 1993-06-29 Sterling Drug, Inc. Low solubility drug-coated bead compositions
EP0636618A1 (de) 1991-06-04 1995-02-01 Marigen S.A. Spontan dispergierbare Konzentrate und Mikroemulsionen mit Vitamin-E-Verbindungen zur Herstellung von Arzneimitteln mit Antitumoraler Wirksamkeit
AU2434992A (en) 1991-08-16 1993-03-16 John R. Trevithick Methods and compositions for treating sunburns
KR930007445A (ko) 1991-10-23 1993-05-20 원본미기재 국소 적용 배합물의 침투 증가방법
IL101387A (en) 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
WO1993021905A1 (en) 1992-04-23 1993-11-11 Berlex Laboratories, Inc. Bioadhesive solid mineral oil emulsion
JP2811036B2 (ja) 1992-05-26 1998-10-15 参天製薬株式会社 ビタミンｅ点眼剤
WO1994020143A1 (fr) * 1993-03-03 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Inhibiteur d'isomerisation optique
DE4322826A1 (de) 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmazeutisches Präparat
WO1995011039A1 (de) * 1993-10-22 1995-04-27 Hexal Pharma Gmbh Pharmazeutische zusammensetzung mit cyclosporin a und alpha-tocopherol
WO1995024892A1 (en) 1994-03-14 1995-09-21 Abbott Laboratories Aerosol drug formulations containing vitamin e
US5430021A (en) * 1994-03-18 1995-07-04 Pharmavene, Inc. Hydrophobic drug delivery systems
CN1129400A (zh) 1994-05-06 1996-08-21 阿尔康实验室公司 维生素e生育酚衍生物在眼科组合物中的应用

Also Published As

Publication number Publication date
NO314569B1 (no) 2003-04-14
FI964583A0 (fi) 1996-11-15
DE69528057T2 (de) 2003-11-06
PT762896E (pt) 2003-01-31
ES2178674T3 (es) 2003-01-01
GB9409778D0 (en) 1994-07-06
AU2670595A (en) 1995-12-05
NO964832D0 (no) 1996-11-14
FI964583L (fi) 1996-11-15
WO1995031217A1 (en) 1995-11-23
EP0762896B1 (de) 2002-09-04
CA2189328C (en) 2003-07-22
NZ287857A (en) 1998-09-24
CA2189328A1 (en) 1995-11-23
DK0762896T3 (da) 2003-01-06
EP0762896A1 (de) 1997-03-19
DE69528057D1 (de) 2002-10-10
NO964832L (no) 1997-01-13
US6193985B1 (en) 2001-02-27
AU697540B2 (en) 1998-10-08
FI119175B (fi) 2008-08-29

Similar Documents

Publication Publication Date Title
DE69528057D1 (de) Tocopherolzusammensetzungen zur Abgabe von biologisch aktiven Substanzen
DE69931930D1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiven substanzen
DE60038183D1 (de) Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe
ATE209491T1 (de) Stabilisierung von säureempfindluchen benzimidazolen unter verwendung von aminosäure/cyclodextrin kombinationen
BR0116452A (pt) Composto, composição farmacêutica, uso de um composto
ATE428729T1 (de) Kovalent verbrückte insulindimere
NO971889D0 (no) Forbindelser og sammensetninger for levering av aktive midler
PT1123120E (pt) Formulacao medicinal em aerossol
DK0960107T3 (da) 6-Thiosubstituerede paclitaxeler
EP1226109A4 (de) Phenylamin-carbonsäure-verbindungen und zubereitungen zur verabreichung von wirkstoffen
DK0993831T3 (da) Forbindelser og præparater til tilförsel af aktive stoffer
CY1108532T1 (el) Ενωσεις και συνθεσεις για την παροχη δραστικων παραγοντων
TR199903191T2 (xx) Vorikonazol i�eren ila� form�lasyonlar�.
DK0994710T3 (da) Farmaceutiske præparater til oral indgivelse omfattende en benzhydrylpiperazin og en cyclodextrin
TR199801861T2 (xx) Farmas�tik olarak yararl� bile�imler.
ATE311373T1 (de) Oxadiazolverbindungen und -zusammensetzungen zur abgabe von wirkstoffen
DE60019334D1 (de) Antivirale arznei
ATE464878T1 (de) Pharmazeutische zusammensetzung zur nasalen anwendung von fentanyl
BR0206960A (pt) Composição farmacêutica oral, e, uso de um polìmero de ftalato de hidroxipropilmetilcelulose
SE9403389D0 (sv) Pharmaceutical composition containing derivattves of sex hormones
SE9902742D0 (sv) New pharmaceutical formultion
TR200001055T2 (tr) Yeni metilenbifosfonik asit türevleri
ATE293635T1 (de) Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen
DK1011329T3 (da) 7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler
PT1150716E (pt) Composicao farmaceutica de proteinas hedgehog hidrofobicamente modificadas e sua utilizacao

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification