NO314693B1 - Heterosyklisk-substituerte piperazinonderivater til fremstilling av takykininreseptorantagonister, fremgangsmåte for fremstilling av disseforbindelser, nye mellomprodukter og farmasöytiske preparater inneholdende de nyepiperazinonderivater - Google Patents

Heterosyklisk-substituerte piperazinonderivater til fremstilling av takykininreseptorantagonister, fremgangsmåte for fremstilling av disseforbindelser, nye mellomprodukter og farmasöytiske preparater inneholdende de nyepiperazinonderivater Download PDF

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Publication number
NO314693B1
NO314693B1 NO19974205A NO974205A NO314693B1 NO 314693 B1 NO314693 B1 NO 314693B1 NO 19974205 A NO19974205 A NO 19974205A NO 974205 A NO974205 A NO 974205A NO 314693 B1 NO314693 B1 NO 314693B1
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NO
Norway
Prior art keywords
indol
oxo
hydrogen
phenylethyl
formula
Prior art date
Application number
NO19974205A
Other languages
English (en)
Norwegian (no)
Other versions
NO974205L (no
NO974205D0 (no
Inventor
Timothy Paul Burkholder
Elizabeth Mary Kudlacz
Tieu-Binh Le
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of NO974205D0 publication Critical patent/NO974205D0/no
Publication of NO974205L publication Critical patent/NO974205L/no
Publication of NO314693B1 publication Critical patent/NO314693B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
NO19974205A 1995-03-15 1997-09-12 Heterosyklisk-substituerte piperazinonderivater til fremstilling av takykininreseptorantagonister, fremgangsmåte for fremstilling av disseforbindelser, nye mellomprodukter og farmasöytiske preparater inneholdende de nyepiperazinonderivater NO314693B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40478895A 1995-03-15 1995-03-15
PCT/US1996/001437 WO1996028441A1 (en) 1995-03-15 1996-02-06 Heterocyclic substituted piperazinone derivatives as tachykinin receptor antagonists

Publications (3)

Publication Number Publication Date
NO974205D0 NO974205D0 (no) 1997-09-12
NO974205L NO974205L (no) 1997-11-13
NO314693B1 true NO314693B1 (no) 2003-05-05

Family

ID=23601038

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19974205A NO314693B1 (no) 1995-03-15 1997-09-12 Heterosyklisk-substituerte piperazinonderivater til fremstilling av takykininreseptorantagonister, fremgangsmåte for fremstilling av disseforbindelser, nye mellomprodukter og farmasöytiske preparater inneholdende de nyepiperazinonderivater

Country Status (21)

Country Link
US (2) US5840726A (de)
EP (1) EP0815105B1 (de)
JP (1) JP3825472B2 (de)
KR (1) KR19980703032A (de)
CN (1) CN1067068C (de)
AR (1) AR002715A1 (de)
AT (1) ATE206421T1 (de)
AU (1) AU697599B2 (de)
CA (1) CA2215333C (de)
DE (1) DE69615670T2 (de)
DK (1) DK0815105T3 (de)
ES (1) ES2164235T3 (de)
FI (1) FI973671A0 (de)
HU (1) HUP9702149A3 (de)
IL (1) IL117453A (de)
NO (1) NO314693B1 (de)
NZ (1) NZ302948A (de)
PT (1) PT815105E (de)
TW (1) TW464647B (de)
WO (1) WO1996028441A1 (de)
ZA (1) ZA961954B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU714931B2 (en) * 1995-12-18 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives as tachykinin antagonists
DE19939910A1 (de) * 1999-08-23 2001-03-01 Morphochem Ag Neue Verbindungen, die Tryptase-Aktivität hemmen
US20040033986A1 (en) * 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
US7456222B2 (en) * 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
CN101404986B (zh) * 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
WO2005034857A2 (en) * 2003-09-05 2005-04-21 Sequella, Inc. Methods and compositions comprising diamines as new anti-tubercular therapeutics
US20090281054A1 (en) * 2008-05-06 2009-11-12 Venkata Reddy Compositions and methods comprising capuramycin analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132882A1 (de) * 1981-08-20 1983-03-03 Cassella Ag, 6000 Frankfurt Neue piperazinone, ihre herstellung und verwendung
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO1994003483A1 (en) * 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
GB9222486D0 (en) * 1992-10-26 1992-12-09 Merck Sharp & Dohme Therapeutic agents
WO1994026735A1 (en) * 1993-05-06 1994-11-24 Merrell Dow Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
CA2215333A1 (en) 1996-09-19
CN1178529A (zh) 1998-04-08
ZA961954B (en) 1996-09-17
AU697599B2 (en) 1998-10-08
FI973671A7 (fi) 1997-09-12
NO974205L (no) 1997-11-13
JP3825472B2 (ja) 2006-09-27
TW464647B (en) 2001-11-21
DK0815105T3 (da) 2002-01-21
ATE206421T1 (de) 2001-10-15
FI973671L (fi) 1997-09-12
DE69615670D1 (de) 2001-11-08
ES2164235T3 (es) 2002-02-16
CN1067068C (zh) 2001-06-13
EP0815105A1 (de) 1998-01-07
NZ302948A (en) 2001-05-25
DE69615670T2 (de) 2002-08-08
AU4930696A (en) 1996-10-02
IL117453A0 (en) 1996-07-23
EP0815105B1 (de) 2001-10-04
HUP9702149A2 (hu) 1999-06-28
PT815105E (pt) 2002-03-28
WO1996028441A1 (en) 1996-09-19
JPH11501917A (ja) 1999-02-16
US5864045A (en) 1999-01-26
US5840726A (en) 1998-11-24
AR002715A1 (es) 1998-04-29
MX9706872A (es) 1997-11-29
KR19980703032A (ko) 1998-09-05
NO974205D0 (no) 1997-09-12
FI973671A0 (fi) 1997-09-12
HUP9702149A3 (en) 1999-07-28
CA2215333C (en) 2002-01-01
IL117453A (en) 2000-07-26

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