NO316997B1 - Antifungalt preparat med forokt biologisk tilgjengelighet - Google Patents

Antifungalt preparat med forokt biologisk tilgjengelighet Download PDF

Info

Publication number: NO316997B1
Authority: NO; Norway
Prior art keywords: pharmaceutical preparation; preparation according; weight; preparation; ionic surfactant
Prior art date: 1996-05-24

Application number

NO19985447A

Other languages

English (en)

Norwegian (no)

Other versions

NO985447L (no

NO985447D0 (no

Inventor

Surendra A Sangekar

Winston A Vadino

Ping I Lee

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-24

Filing date

1998-11-23

Publication date

2004-07-19

1998-11-23 Application filed by Schering Corp filed Critical Schering Corp

1998-11-23 Publication of NO985447L publication Critical patent/NO985447L/no

1998-11-23 Publication of NO985447D0 publication Critical patent/NO985447D0/no

2004-07-19 Publication of NO316997B1 publication Critical patent/NO316997B1/no

Links

229940121375 antifungal agent Drugs 0.000 title claims description 44
238000002360 preparation method Methods 0.000 title claims description 37
230000000843 anti-fungal effect Effects 0.000 title description 38
239000002775 capsule Substances 0.000 claims description 32
239000000825 pharmaceutical preparation Substances 0.000 claims description 30
239000000314 lubricant Substances 0.000 claims description 18
239000002736 nonionic surfactant Substances 0.000 claims description 18
239000002552 dosage form Substances 0.000 claims description 17
239000003085 diluting agent Substances 0.000 claims description 14
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
239000011230 binding agent Substances 0.000 claims description 12
239000003429 antifungal agent Substances 0.000 claims description 11
239000000126 substance Substances 0.000 claims description 10
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 9
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 9
239000000843 powder Substances 0.000 claims description 9
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 8
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
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239000007884 disintegrant Substances 0.000 claims description 7
235000019359 magnesium stearate Nutrition 0.000 claims description 7
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239000008108 microcrystalline cellulose Substances 0.000 claims description 7
229920002785 Croscarmellose sodium Polymers 0.000 claims description 6
229960001681 croscarmellose sodium Drugs 0.000 claims description 6
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
239000003795 chemical substances by application Substances 0.000 claims description 5
230000003750 conditioning effect Effects 0.000 claims description 5
235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 4
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 4
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229920001993 poloxamer 188 Polymers 0.000 description 7
HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 6
239000007788 liquid Substances 0.000 description 6
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239000001923 methylcellulose Substances 0.000 description 3
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
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239000008107 starch Substances 0.000 description 3
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IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
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244000061456 Solanum tuberosum Species 0.000 description 2
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
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125000001165 hydrophobic group Chemical group 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
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235000010413 sodium alginate Nutrition 0.000 description 2
239000000661 sodium alginate Substances 0.000 description 2
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LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical class OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
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208000007027 Oral Candidiasis Diseases 0.000 description 1
229920000034 Plastomer Polymers 0.000 description 1
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VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 1
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239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
229940041672 oral gel Drugs 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
125000006353 oxyethylene group Chemical group 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
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229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
229940114930 potassium stearate Drugs 0.000 description 1
ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
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238000005550 wet granulation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO19985447A 1996-05-24 1998-11-23 Antifungalt preparat med forokt biologisk tilgjengelighet NO316997B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65532996A	1996-05-24	1996-05-24
PCT/US1997/019388 WO1998007429A2 (fr)	1996-05-24	1997-05-21	Composition d'antimycosique a biodisponibilite renforcee

Publications (3)

Publication Number	Publication Date
NO985447L NO985447L (no)	1998-11-23
NO985447D0 NO985447D0 (no)	1998-11-23
NO316997B1 true NO316997B1 (no)	2004-07-19

Family

ID=24628452

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19985447A NO316997B1 (no)	1996-05-24	1998-11-23	Antifungalt preparat med forokt biologisk tilgjengelighet

Country Status (27)

Country	Link
EP (1)	EP0914127B1 (fr)
JP (1)	JP3366648B2 (fr)
KR (1)	KR100307427B1 (fr)
CN (1)	CN1121860C (fr)
AR (1)	AR007250A1 (fr)
AT (1)	ATE213632T1 (fr)
AU (1)	AU719109B2 (fr)
BR (1)	BR9711167A (fr)
CA (1)	CA2255663C (fr)
CO (1)	CO4840511A1 (fr)
CZ (1)	CZ293586B6 (fr)
DE (1)	DE69710729T2 (fr)
ES (1)	ES2169440T3 (fr)
HU (1)	HU221371B1 (fr)
ID (1)	ID16956A (fr)
IL (1)	IL126979A (fr)
MY (1)	MY118988A (fr)
NO (1)	NO316997B1 (fr)
NZ (1)	NZ332699A (fr)
PE (1)	PE68898A1 (fr)
PL (1)	PL188401B1 (fr)
RU (1)	RU2207119C2 (fr)
SK (1)	SK281818B6 (fr)
TR (1)	TR199802424T2 (fr)
TW (1)	TW504390B (fr)
WO (1)	WO1998007429A2 (fr)
ZA (1)	ZA974428B (fr)

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* Cited by examiner, † Cited by third party
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ES2157731B1 (es) *	1998-07-21	2002-05-01	Liconsa Liberacion Controlada	Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
WO2001034119A2 (fr)	1999-11-12	2001-05-17	Abbott Laboratories	Inhibiteurs de cristallisation dans une dispersion solide
DE10026698A1 (de)	2000-05-30	2001-12-06	Basf Ag	Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
RS20100015A (sr) *	2001-01-26	2010-12-31	Schering Corporation	Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
WO2004066981A1 (fr) *	2003-01-29	2004-08-12	Sun Pharmaceutical Industries Limited	Composition pharmaceutique orale a liberation controlee contenant du metaxalone en tant qu'agent actif
US8025899B2 (en)	2003-08-28	2011-09-27	Abbott Laboratories	Solid pharmaceutical dosage form
UA114469C2 (uk)	2010-11-01	2017-06-26	Мелінта Терап'Ютікс, Інк.	Фармацевтична композиція, що містить протимікробний агент
RU2450807C1 (ru) *	2011-05-11	2012-05-20	Общество с ограниченной ответственностью фирма "Вита"	Стабилизированный фармацевтический состав с противогрибковым действием
CN103845292A (zh) *	2012-11-29	2014-06-11	正大天晴药业集团股份有限公司	泊沙康唑微丸及其制备方法
US9763934B2 (en) *	2014-03-05	2017-09-19	Professional Compounding Centers Of America	Synergistic effect of poloxamer-based composition and itraconazole on fungus and yeast
TR201620462A2 (tr)	2016-12-31	2018-07-23	Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi	POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4791111A (en) *	1985-12-23	1988-12-13	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
RU2039050C1 (ru) *	1989-09-26	1995-07-09	Такеда Кемикал Индастриз ЛТД	Производные 1,2,4-триазола, оптически инертные или имеющие r- или s-конфигурацию c-2 и c-3 асимметричных центров, или их соли, обладающие фунгицидной активностью, и способ их получения
GB9002375D0 (en) *	1990-02-02	1990-04-04	Pfizer Ltd	Triazole antifungal agents
US5039676A (en) *	1990-05-11	1991-08-13	Schering Corporation	Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
PL181193B1 (pl) *	1993-12-21	2001-06-29	Schering Corp	Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków

1997
- 1997-05-21 ZA ZA9704428A patent/ZA974428B/xx unknown
- 1997-05-21 CA CA002255663A patent/CA2255663C/fr not_active Expired - Fee Related
- 1997-05-21 CO CO97027673A patent/CO4840511A1/es unknown
- 1997-05-21 DE DE69710729T patent/DE69710729T2/de not_active Expired - Lifetime
- 1997-05-21 TW TW086106780A patent/TW504390B/zh not_active IP Right Cessation
- 1997-05-21 IL IL12697997A patent/IL126979A/xx not_active IP Right Cessation
- 1997-05-21 ID IDP971708A patent/ID16956A/id unknown
- 1997-05-21 PE PE1997000400A patent/PE68898A1/es not_active Application Discontinuation
- 1997-05-21 AU AU59399/98A patent/AU719109B2/en not_active Ceased
- 1997-05-21 CZ CZ19983790A patent/CZ293586B6/cs not_active IP Right Cessation
- 1997-05-21 EP EP97949341A patent/EP0914127B1/fr not_active Expired - Lifetime
- 1997-05-21 AT AT97949341T patent/ATE213632T1/de not_active IP Right Cessation
- 1997-05-21 ES ES97949341T patent/ES2169440T3/es not_active Expired - Lifetime
- 1997-05-21 CN CN97196513A patent/CN1121860C/zh not_active Expired - Fee Related
- 1997-05-21 NZ NZ332699A patent/NZ332699A/xx not_active IP Right Cessation
- 1997-05-21 TR TR1998/02424T patent/TR199802424T2/xx unknown
- 1997-05-21 HU HU9904265A patent/HU221371B1/hu not_active IP Right Cessation
- 1997-05-21 PL PL97330480A patent/PL188401B1/pl not_active IP Right Cessation
- 1997-05-21 JP JP50544798A patent/JP3366648B2/ja not_active Expired - Fee Related
- 1997-05-21 RU RU98123611/14A patent/RU2207119C2/ru not_active IP Right Cessation
- 1997-05-21 KR KR1019980709501A patent/KR100307427B1/ko not_active Expired - Fee Related
- 1997-05-21 SK SK1608-98A patent/SK281818B6/sk not_active IP Right Cessation
- 1997-05-21 WO PCT/US1997/019388 patent/WO1998007429A2/fr not_active Ceased
- 1997-05-21 BR BR9711167A patent/BR9711167A/pt not_active IP Right Cessation
- 1997-05-22 AR ARP970102173A patent/AR007250A1/es active IP Right Grant
- 1997-05-22 MY MYPI97002234A patent/MY118988A/en unknown
1998
- 1998-11-23 NO NO19985447A patent/NO316997B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
SK281818B6 (sk)	2001-08-06
CZ293586B6 (cs)	2004-06-16
HUP9904265A3 (en)	2000-05-29
ZA974428B (en)	1997-11-24
HU221371B1 (en)	2002-09-28
WO1998007429A2 (fr)	1998-02-26
MY118988A (en)	2005-02-28
ATE213632T1 (de)	2002-03-15
EP0914127A2 (fr)	1999-05-12
JP3366648B2 (ja)	2003-01-14
TW504390B (en)	2002-10-01
AR007250A1 (es)	1999-10-27
ID16956A (id)	1997-11-27
EP0914127B1 (fr)	2002-02-27
JP2000509720A (ja)	2000-08-02
BR9711167A (pt)	1999-08-17
PL330480A1 (en)	1999-05-24
NZ332699A (en)	2000-01-28
NO985447L (no)	1998-11-23
TR199802424T2 (xx)	1999-03-22
CN1228699A (zh)	1999-09-15
KR20000065222A (ko)	2000-11-06
WO1998007429A3 (fr)	1998-04-23
DE69710729T2 (de)	2002-08-14
AU5939998A (en)	1998-03-06
PE68898A1 (es)	1998-11-10
NO985447D0 (no)	1998-11-23
HUP9904265A2 (hu)	2000-04-28
IL126979A (en)	2000-10-31
IL126979A0 (en)	1999-09-22
CA2255663C (fr)	2002-08-20
SK160898A3 (en)	1999-05-07
KR100307427B1 (ko)	2001-12-28
DE69710729D1 (de)	2002-04-04
RU2207119C2 (ru)	2003-06-27
CZ379098A3 (cs)	1999-03-17
CA2255663A1 (fr)	1998-02-26
CO4840511A1 (es)	1999-09-27
AU719109B2 (en)	2000-05-04
CN1121860C (zh)	2003-09-24
PL188401B1 (pl)	2005-01-31
ES2169440T3 (es)	2002-07-01
HK1017855A1 (en)	1999-12-03

Legal Events

Date

Code

Title

Description

2012-09-24

CHAD

Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: MERCK SHARP AND DOHME CORP

Free format text: NEW ADDRESS: 126 EAST LINCOLN AVENUE, US-NJ07065 RAHWAY, US

2014-12-22

MM1K

Lapsed by not paying the annual fees

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