NO317185B1 - Acylerte enolderivater som prolegemidler av elastaseinhibitorer og farmasoytisk preparat - Google Patents

Acylerte enolderivater som prolegemidler av elastaseinhibitorer og farmasoytisk preparat Download PDF

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Publication number
NO317185B1
NO317185B1 NO19965099A NO965099A NO317185B1 NO 317185 B1 NO317185 B1 NO 317185B1 NO 19965099 A NO19965099 A NO 19965099A NO 965099 A NO965099 A NO 965099A NO 317185 B1 NO317185 B1 NO 317185B1
Authority
NO
Norway
Prior art keywords
prolinamide
formula
valyl
acid
compounds
Prior art date
Application number
NO19965099A
Other languages
English (en)
Norwegian (no)
Other versions
NO965099L (no
NO965099D0 (no
Inventor
Norton Paul Peet
Shujaath Mehdi
Joseph Paul Burkhart
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO965099D0 publication Critical patent/NO965099D0/no
Publication of NO965099L publication Critical patent/NO965099L/no
Publication of NO317185B1 publication Critical patent/NO317185B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO19965099A 1994-06-02 1996-11-29 Acylerte enolderivater som prolegemidler av elastaseinhibitorer og farmasoytisk preparat NO317185B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25279894A 1994-06-02 1994-06-02
US42085995A 1995-04-19 1995-04-19
PCT/US1995/005879 WO1995033478A1 (en) 1994-06-02 1995-05-08 Acylated enol derivatives as prodrugs of elastase inhibitors

Publications (3)

Publication Number Publication Date
NO965099D0 NO965099D0 (no) 1996-11-29
NO965099L NO965099L (no) 1997-01-31
NO317185B1 true NO317185B1 (no) 2004-09-13

Family

ID=26942673

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19965099A NO317185B1 (no) 1994-06-02 1996-11-29 Acylerte enolderivater som prolegemidler av elastaseinhibitorer og farmasoytisk preparat

Country Status (20)

Country Link
US (2) US5698523A (de)
EP (1) EP0762887B1 (de)
JP (1) JP4221059B2 (de)
KR (1) KR100367389B1 (de)
CN (1) CN1149833A (de)
AT (1) ATE206055T1 (de)
AU (1) AU696292B2 (de)
CA (1) CA2191844C (de)
DE (1) DE69522940T2 (de)
DK (1) DK0762887T3 (de)
ES (1) ES2161293T3 (de)
FI (1) FI964749L (de)
HU (1) HU221310B1 (de)
IL (1) IL113869A (de)
MX (1) MX9606034A (de)
NO (1) NO317185B1 (de)
NZ (1) NZ287604A (de)
PT (1) PT762887E (de)
TW (1) TW406087B (de)
WO (1) WO1995033478A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharmaceuticals Inc., Cincinnati Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
CN101534824A (zh) * 2006-11-17 2009-09-16 艾博特公司 作为化学活素受体拮抗剂的氨基吡咯烷

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
CA1267499A (en) * 1983-07-12 1990-04-03 Cedric H. Hassall Peptide amides and aldehydes
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
ATE71934T1 (de) * 1985-06-07 1992-02-15 Ici America Inc Selektionierte difluorverbindungen.
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
US4935405A (en) * 1986-10-31 1990-06-19 Pfizer Inc. Nor-statine and nor-cyclostatine polypeptides
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
EP0318318A1 (de) * 1987-11-27 1989-05-31 Sensititre Limited Urintestverfahren und Testsatz
US5162307A (en) * 1988-09-09 1992-11-10 Board Of Trustees Of The University Of Kentucky Polymer bound elastase inhibitors
EP0371179A1 (de) * 1988-10-28 1990-06-06 Merrell Dow Pharmaceuticals Inc. Analoge von Peptidase-Substraten
EP0369391A3 (de) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituierte Amide
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
AU661270B2 (en) * 1990-03-05 1995-07-20 Cephalon, Inc. Chymotrypsin-like proteases and their inhibitors
CA2056453A1 (en) * 1990-03-30 1991-10-01 Koji Kobayashi 4h-3, 1-benzoxazin-4-one derivative
WO1992012140A1 (en) * 1990-12-28 1992-07-23 Georgia Tech Research Corporation Peptides ketoamides, ketoacids, and ketoesters
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
AU1581692A (en) * 1991-03-01 1992-10-06 Protein Engineering Corporation Inhibitors of human neutrophil elastase and human cathepsin g
DE69229552T2 (de) * 1991-05-23 1999-12-23 Merrell Pharmaceuticals Inc., Cincinnati Hemmstoffe für kathepsin-g und elastase zur verhütung von bindegewebsabbau
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.
NZ274074A (en) * 1993-10-01 1997-11-24 Merrell Pharma Inc Various dipeptide derivatives having a reduced carboxy group, the aldehyde being optionally substituted; pharmaceutical compositions
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharmaceuticals Inc., Cincinnati Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors
EP0804465B1 (de) * 1994-06-02 2003-08-06 Aventis Pharmaceuticals Inc. Elatase-inhibitoren

Also Published As

Publication number Publication date
PT762887E (pt) 2002-01-30
TW406087B (en) 2000-09-21
US5698523A (en) 1997-12-16
AU2636695A (en) 1996-01-04
NO965099L (no) 1997-01-31
CA2191844A1 (en) 1995-12-14
HUT76131A (en) 1997-06-30
CA2191844C (en) 2001-07-24
EP0762887A1 (de) 1997-03-19
EP0762887A4 (de) 1999-03-31
ATE206055T1 (de) 2001-10-15
EP0762887B1 (de) 2001-09-26
WO1995033478A1 (en) 1995-12-14
NO965099D0 (no) 1996-11-29
JPH10501221A (ja) 1998-02-03
DE69522940T2 (de) 2002-04-04
HU221310B1 (en) 2002-09-28
MX9606034A (es) 1998-05-31
CN1149833A (zh) 1997-05-14
NZ287604A (en) 1998-12-23
HU9603309D0 (en) 1997-01-28
ES2161293T3 (es) 2001-12-01
FI964749A7 (fi) 1996-11-28
US5972897A (en) 1999-10-26
IL113869A0 (en) 1995-08-31
KR100367389B1 (ko) 2003-07-18
FI964749A0 (fi) 1996-11-28
IL113869A (en) 2000-01-31
AU696292B2 (en) 1998-09-03
DK0762887T3 (da) 2002-01-14
DE69522940D1 (de) 2001-10-31
FI964749L (fi) 1996-11-28
JP4221059B2 (ja) 2009-02-12

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