ATE71934T1 - Selektionierte difluorverbindungen. - Google Patents
Selektionierte difluorverbindungen.Info
- Publication number
- ATE71934T1 ATE71934T1 AT86304296T AT86304296T ATE71934T1 AT E71934 T1 ATE71934 T1 AT E71934T1 AT 86304296 T AT86304296 T AT 86304296T AT 86304296 T AT86304296 T AT 86304296T AT E71934 T1 ATE71934 T1 AT E71934T1
- Authority
- AT
- Austria
- Prior art keywords
- difluorous
- compounds
- derivatives
- difluoroketone
- intermediates
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 abstract 1
- 102100033174 Neutrophil elastase Human genes 0.000 abstract 1
- IYRWEQXVUNLMAY-UHFFFAOYSA-N carbonyl fluoride Chemical class FC(F)=O IYRWEQXVUNLMAY-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858514440A GB8514440D0 (en) | 1985-06-07 | 1985-06-07 | Difluoro ketone tripeptide derivatives |
| GB858514436A GB8514436D0 (en) | 1985-06-07 | 1985-06-07 | Selected difluoro derivatives |
| GB858514438A GB8514438D0 (en) | 1985-06-07 | 1985-06-07 | Selected difluoro ketone dipeptide derivatives |
| EP86304296A EP0204571B1 (de) | 1985-06-07 | 1986-06-05 | Selektionierte Difluorverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE71934T1 true ATE71934T1 (de) | 1992-02-15 |
Family
ID=27262698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86304296T ATE71934T1 (de) | 1985-06-07 | 1986-06-05 | Selektionierte difluorverbindungen. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4880780A (de) |
| EP (1) | EP0204571B1 (de) |
| JP (1) | JPH07116159B2 (de) |
| AT (1) | ATE71934T1 (de) |
| AU (1) | AU594683B2 (de) |
| DE (1) | DE3683541D1 (de) |
| DK (1) | DK267686A (de) |
| ES (4) | ES8801305A1 (de) |
| FI (1) | FI86859C (de) |
| GR (1) | GR861488B (de) |
| HU (1) | HU208438B (de) |
| IE (1) | IE59146B1 (de) |
| IL (1) | IL79049A0 (de) |
| NO (1) | NO170585C (de) |
| NZ (1) | NZ216437A (de) |
| PT (1) | PT82724B (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| US5496927A (en) * | 1985-02-04 | 1996-03-05 | Merrell Pharmaceuticals Inc. | Peptidase inhibitors |
| DE3782191T2 (de) * | 1986-06-05 | 1993-02-25 | Ici America Inc | Difluorketoverbindungen. |
| GB8613703D0 (en) * | 1986-06-05 | 1986-07-09 | Ici America Inc | Difluoro peptide compounds |
| GB8809316D0 (en) * | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
| EP0371179A1 (de) * | 1988-10-28 | 1990-06-06 | Merrell Dow Pharmaceuticals Inc. | Analoge von Peptidase-Substraten |
| EP0369391A3 (de) * | 1988-11-15 | 1991-09-25 | Boehringer Ingelheim Pharmaceuticals Inc. | N-substituierte Amide |
| GB8910547D0 (en) * | 1989-05-08 | 1989-06-21 | Ici America Inc | Substituted ketones |
| US5221665A (en) * | 1989-10-27 | 1993-06-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | N-substituted amides |
| US5391705A (en) * | 1991-03-15 | 1995-02-21 | Merrell Dow Pharmaceuticals Inc. | Polyfluorinated tripeptide thrombin inhibitors |
| AU655301B2 (en) * | 1991-05-23 | 1994-12-15 | Merrell Pharmaceuticals Inc. | Inhibitors of cathepsin G and elastase for preventing connective tissue degradation |
| US5714470A (en) * | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
| US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
| US5486529A (en) * | 1992-04-16 | 1996-01-23 | Zeneca Limited | Certain pyridyl ketones for treating diseases involving leukocyte elastase |
| IL108031A0 (en) * | 1992-12-22 | 1994-04-12 | Procter & Gamble | Difluoro pentapeptide derivatives and pharmaceutical compositions containing them |
| AU690986B2 (en) * | 1994-06-02 | 1998-05-07 | Merrell Pharmaceuticals Inc. | Perfluoroalkyl ketone inhibitors of elastase and processes for making the same |
| NZ287604A (en) * | 1994-06-02 | 1998-12-23 | Merrell Pharma Inc | Acylated enol derivatives as prodrugs of elastase inhibitors |
| KR100347285B1 (ko) * | 1994-06-02 | 2003-01-15 | 아벤티스 파마슈티칼스 인크. | 신규의엘라스타제저해제 |
| US6069232A (en) * | 1995-10-02 | 2000-05-30 | Hoechst Marion Roussel, Inc. | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors |
| US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
| US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
| US6673784B1 (en) | 1996-03-19 | 2004-01-06 | G. D. Searle & Co. | Electrophilic ketones for the treatment of herpesvirus infections |
| US5739354A (en) * | 1996-03-26 | 1998-04-14 | Hoechst Marion Roussel, Inc. | Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide |
| NZ335276A (en) | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| EP1991229A2 (de) | 2006-02-27 | 2008-11-19 | Vertex Pharmaceuticals Incorporated | Kokristalle und pharmazeutische zusammensetzungen damit |
| JP2009531315A (ja) * | 2006-03-16 | 2009-09-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | 重水素化ｃ型肝炎プロテアーゼインヒビター |
| MX2009005252A (es) * | 2006-11-17 | 2009-05-28 | Abbott Lab | Aminopirrolidinas como antagonistas del receptor de quimiocina. |
| US8575208B2 (en) | 2007-02-27 | 2013-11-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| EA200970806A1 (ru) | 2007-02-27 | 2010-08-30 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы и содержащие их фармацевтические композиции |
| EP2436682A1 (de) | 2007-08-30 | 2012-04-04 | Vertex Pharmceuticals Incorporated | Kokristalle und pharmazeutische Zusammensetzungen damit |
| CA2771575A1 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| WO2011109298A2 (en) | 2010-03-02 | 2011-09-09 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| PE20151179A1 (es) | 2012-11-01 | 2015-09-12 | Abbvie Inc | Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| AR104856A1 (es) * | 2015-05-11 | 2017-08-23 | Hoffmann La Roche | Derivados de difluorocetamida |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| WO2021001244A1 (en) * | 2019-07-01 | 2021-01-07 | Basf Se | Peptide acetals for stabilising enzymes |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787249A (fr) | 1971-08-05 | 1973-02-05 | Squibb & Sons Inc | Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation |
| US3935280A (en) | 1975-01-10 | 1976-01-27 | Aldrich-Boranes, Inc. | Reduction of amino acids in the presence of boron trifluoride |
| US4277395A (en) * | 1980-06-16 | 1981-07-07 | Richardson-Merrell Inc. | Novel enzyme inhibitors |
| EP0124317B1 (de) | 1983-04-27 | 1990-04-11 | Ici Americas Inc. | Prolin-Derivate |
| US4518528A (en) * | 1983-05-19 | 1985-05-21 | Rasnick David W | α Amino fluoro ketones |
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
-
1986
- 1986-06-05 AT AT86304296T patent/ATE71934T1/de not_active IP Right Cessation
- 1986-06-05 EP EP86304296A patent/EP0204571B1/de not_active Expired - Lifetime
- 1986-06-05 DE DE8686304296T patent/DE3683541D1/de not_active Expired - Fee Related
- 1986-06-06 DK DK267686A patent/DK267686A/da not_active Application Discontinuation
- 1986-06-06 HU HU862393A patent/HU208438B/hu not_active IP Right Cessation
- 1986-06-06 NZ NZ216437A patent/NZ216437A/xx unknown
- 1986-06-06 FI FI862434A patent/FI86859C/fi not_active IP Right Cessation
- 1986-06-06 IL IL79049A patent/IL79049A0/xx unknown
- 1986-06-06 NO NO862269A patent/NO170585C/no unknown
- 1986-06-06 AU AU58454/86A patent/AU594683B2/en not_active Ceased
- 1986-06-06 PT PT82724A patent/PT82724B/pt not_active IP Right Cessation
- 1986-06-06 JP JP61130457A patent/JPH07116159B2/ja not_active Expired - Fee Related
- 1986-06-06 ES ES555826A patent/ES8801305A1/es not_active Expired
- 1986-06-06 GR GR861488A patent/GR861488B/el unknown
- 1986-06-06 IE IE151386A patent/IE59146B1/en not_active IP Right Cessation
-
1987
- 1987-06-04 US US07/058,079 patent/US4880780A/en not_active Expired - Lifetime
- 1987-09-16 ES ES557733A patent/ES8802619A1/es not_active Expired
- 1987-09-16 ES ES557735A patent/ES8802321A1/es not_active Expired
- 1987-09-16 ES ES557734A patent/ES8900051A1/es not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |