NO317992B1 - 7-(1,1-dimetyletyl)-6-(2-etyl-2H-1.2.4-triazol-3-ylmetoksy)-3-(2-fluorfenyl)-1-2-4-triazol[4,3,-6]pyridazin, vannfri polymorf som omfatter denne, farmasoytisk preparat som omfatter denne, anvendelse av denne for fremstilling av et medikament og fremgangsmate for fremstilling av denne forbindelsen - Google Patents

7-(1,1-dimetyletyl)-6-(2-etyl-2H-1.2.4-triazol-3-ylmetoksy)-3-(2-fluorfenyl)-1-2-4-triazol[4,3,-6]pyridazin, vannfri polymorf som omfatter denne, farmasoytisk preparat som omfatter denne, anvendelse av denne for fremstilling av et medikament og fremgangsmate for fremstilling av denne forbindelsen Download PDF

Info

Publication number: NO317992B1
Authority: NO; Norway
Prior art keywords: compound; formula; triazol; pyridazine; ethyl
Prior art date: 1998-06-24

Application number

NO20006576A

Other languages

English (en)

Norwegian (no)

Other versions

NO20006576D0 (no

NO20006576L (no

Inventor

Leslie Joseph Street

William Robert Carling

Jose Luis Castro Pineiro

Andrew Madin

Cameron John Cowden

Anthony John Davies

James Francis Mccabe

Gareth Edward Stephen Pearce

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-24

Filing date

2000-12-21

Publication date

2005-01-17

2000-12-21 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2000-12-21 Publication of NO20006576D0 publication Critical patent/NO20006576D0/no

2001-02-14 Publication of NO20006576L publication Critical patent/NO20006576L/no

2005-01-17 Publication of NO317992B1 publication Critical patent/NO317992B1/no

Links

150000001875 compounds Chemical class 0.000 title claims description 109
238000000034 method Methods 0.000 title claims description 27
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title claims description 18
238000002360 preparation method Methods 0.000 title claims description 16
239000003814 drug Substances 0.000 title claims description 6
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 title description 2
-1 2-ethyl-2H-1,2,4-triazol-3-ylmethoxy Chemical group 0.000 title 1
125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000006243 chemical reaction Methods 0.000 claims description 33
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 12
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 10
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QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims description 3
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239000004480 active ingredient Substances 0.000 description 4
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239000013078 crystal Substances 0.000 description 4
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/24—Antidepressants

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
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Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20006576A 1998-06-24 2000-12-21 7-(1,1-dimetyletyl)-6-(2-etyl-2H-1.2.4-triazol-3-ylmetoksy)-3-(2-fluorfenyl)-1-2-4-triazol[4,3,-6]pyridazin, vannfri polymorf som omfatter denne, farmasoytisk preparat som omfatter denne, anvendelse av denne for fremstilling av et medikament og fremgangsmate for fremstilling av denne forbindelsen NO317992B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9813576.7A GB9813576D0 (en)	1998-06-24	1998-06-24	Therapeutic agents
PCT/GB1999/001897 WO1999067245A1 (en)	1998-06-24	1999-06-15	A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom

Publications (3)

Publication Number	Publication Date
NO20006576D0 NO20006576D0 (no)	2000-12-21
NO20006576L NO20006576L (no)	2001-02-14
NO317992B1 true NO317992B1 (no)	2005-01-17

Family

ID=10834265

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Application Number	Title	Priority Date	Filing Date
NO20006576A NO317992B1 (no)	1998-06-24	2000-12-21	7-(1,1-dimetyletyl)-6-(2-etyl-2H-1.2.4-triazol-3-ylmetoksy)-3-(2-fluorfenyl)-1-2-4-triazol[4,3,-6]pyridazin, vannfri polymorf som omfatter denne, farmasoytisk preparat som omfatter denne, anvendelse av denne for fremstilling av et medikament og fremgangsmate for fremstilling av denne forbindelsen

Country Status (35)

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US (1)	US6630471B1 (cs)
EP (1)	EP1090004B1 (cs)
JP (1)	JP4749545B2 (cs)
KR (1)	KR100604108B1 (cs)
CN (1)	CN1138779C (cs)
AR (1)	AR018925A1 (cs)
AT (1)	ATE239730T1 (cs)
AU (1)	AU757315B2 (cs)
BG (1)	BG64989B1 (cs)
BR (1)	BR9911563A (cs)
CA (1)	CA2335328C (cs)
CO (1)	CO5031239A1 (cs)
CZ (1)	CZ291409B6 (cs)
DE (1)	DE69907675T2 (cs)
EA (1)	EA003332B1 (cs)
EE (1)	EE200000767A (cs)
ES (1)	ES2196824T3 (cs)
GB (1)	GB9813576D0 (cs)
GE (1)	GEP20033143B (cs)
HR (1)	HRP20000879A2 (cs)
HU (1)	HUP0102894A3 (cs)
ID (1)	ID27771A (cs)
IL (2)	IL139775A0 (cs)
IS (1)	IS2258B (cs)
MY (1)	MY124341A (cs)
NO (1)	NO317992B1 (cs)
NZ (1)	NZ508290A (cs)
PE (1)	PE20000710A1 (cs)
PL (1)	PL204650B1 (cs)
RS (1)	RS49746B (cs)
SK (1)	SK285307B6 (cs)
TR (1)	TR200003789T2 (cs)
TW (1)	TWI222449B (cs)
WO (1)	WO1999067245A1 (cs)
ZA (1)	ZA200007485B (cs)

Families Citing this family (19)

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Publication number	Priority date	Publication date	Assignee	Title
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en)	2000-05-11	2005-02-24	A.P. Pharma, Inc.	Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) *	2001-05-08	2001-06-27	Merck Sharp & Dohme	Therapeutic agents
AU2003297161B8 (en)	2002-12-18	2011-03-31	Vertex Pharmaceuticals Incorporated	Triazolopyridazines as protein kinases inhibitors
WO2006061428A2 (en) *	2004-12-10	2006-06-15	Universität Zürich	Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EP2454259A1 (en) *	2009-06-23	2012-05-23	Concert Pharmaceuticals Inc.	Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
EP2456311A4 (en) *	2009-07-24	2013-01-23	Concert Pharmaceuticals Inc	SUBSTITUTED IMIDASOTRIAZINES
US8278460B2 (en)	2009-10-15	2012-10-02	Concert Pharmaceuticals, Inc.	Substituted benzimidazoles
PH12012501361A1 (en)	2009-12-31	2012-10-22	Centro Nac De Investigaciones Oncologicas Cnio	Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) *	2011-01-18	2012-07-26	Centro Nacional De Investigaciones Oncológicas (Cnio)	6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
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BR112018015386A2 (pt)	2016-01-27	2019-03-19	Universität Zürich	uso de moduladores de receptor gabaa para tratamento de prurido
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Also Published As

Publication number	Publication date
BG64989B1 (bg)	2006-11-30
RS49746B (sr)	2008-04-04
CA2335328A1 (en)	1999-12-29
EP1090004B1 (en)	2003-05-07
PE20000710A1 (es)	2000-08-14
PL345332A1 (en)	2001-12-17
IS2258B (is)	2007-06-15
HRP20000879A2 (en)	2001-06-30
AU4630199A (en)	2000-01-10
DE69907675T2 (de)	2004-03-04
ZA200007485B (en)	2002-01-07
IL139775A (en)	2007-02-11
CN1307579A (zh)	2001-08-08
ID27771A (id)	2001-04-26
NO20006576D0 (no)	2000-12-21
HUP0102894A3 (en)	2003-03-28
IL139775A0 (en)	2002-02-10
TWI222449B (en)	2004-10-21
GB9813576D0 (en)	1998-08-19
CZ291409B6 (cs)	2003-03-12
YU77800A (sh)	2003-10-31
MY124341A (en)	2006-06-30
JP2002518501A (ja)	2002-06-25
WO1999067245A1 (en)	1999-12-29
EA200100071A1 (ru)	2001-06-25
ES2196824T3 (es)	2003-12-16
GEP20033143B (en)	2003-12-25
SK19552000A3 (sk)	2001-08-06
KR100604108B1 (ko)	2006-07-26
US6630471B1 (en)	2003-10-07
EE200000767A (et)	2002-06-17
JP4749545B2 (ja)	2011-08-17
KR20010053136A (ko)	2001-06-25
NZ508290A (en)	2003-09-26
EA003332B1 (ru)	2003-04-24
NO20006576L (no)	2001-02-14
BG105152A (en)	2001-10-31
CA2335328C (en)	2007-11-27
PL204650B1 (pl)	2010-01-29
HUP0102894A2 (hu)	2001-11-28
EP1090004A1 (en)	2001-04-11
CN1138779C (zh)	2004-02-18
AU757315B2 (en)	2003-02-13
CZ20004872A3 (cs)	2001-07-11
DE69907675D1 (de)	2003-06-12
IS5730A (is)	2000-11-24
ATE239730T1 (de)	2003-05-15
TR200003789T2 (tr)	2001-04-20
AR018925A1 (es)	2001-12-12
BR9911563A (pt)	2001-03-20
CO5031239A1 (es)	2001-04-27
SK285307B6 (sk)	2006-10-05

Legal Events

Date	Code	Title	Description
2013-02-04	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
AU772947B2 (en)	2004-05-13	Triazolo-pyridazine derivatives as ligands for GABA receptors
AU757315B2 (en)	2003-02-13	A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom
US6541484B2 (en)	2003-04-01	Pyrazolo-pyridine derivatives as ligands for GABA receptors
AU748013B2 (en)	2002-05-30	Triazolo-pyridazine derivatives as ligands for GABA receptors
CA2315219A1 (en)	1999-07-22	Triazolo-pyridazine derivatives as ligands for gaba receptors
AU2286499A (en)	1999-08-09	Triazolo-pyridazine derivatives as ligands for gaba receptors
CA2362400A1 (en)	2000-08-17	Triazolo-pyridazine derivatives as ligands for gaba receptors
AU2002331942B2 (en)	2008-01-31	7-tert-butyl-3-(2-fluorophenyl)-6-(2H-(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo (4,3-b) pyridazine for the treatment of anxiety and convulsions
AU2002331942A1 (en)	2003-06-05	7-tert-butyl-3-(2-fluorophenyl)-6-(2H-(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo (4,3-b) pyridazine for the treatment of anxiety and convulsions
MXPA01000075A (en)	2001-09-07	A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom