NO319793B1 - N-[2-hydroksy-3-(1-piperidinyl)propoksy]pyridin-1-oksid-3-karboksimidoylklorid og dets anvendelse til fremstilling av et farmasoytisk preparat, samt farmasoytisk preparat. - Google Patents

N-[2-hydroksy-3-(1-piperidinyl)propoksy]pyridin-1-oksid-3-karboksimidoylklorid og dets anvendelse til fremstilling av et farmasoytisk preparat, samt farmasoytisk preparat. Download PDF

Info

Publication number: NO319793B1
Authority: NO; Norway
Prior art keywords: pyridine; hydroxy; oxide; propoxy; piperidinyl
Prior art date: 1999-02-26

Application number

NO20014103A

Other languages

English (en)

Norwegian (no)

Other versions

NO20014103L (no

NO20014103D0 (no

Inventor

Jeno Szilbereky

Zoltan Nagy

Ede Marvanyos

Mihaly Barabas

Laszlo Uerogdi

Katalin Biro

Magdolna Torok

Zita Jegesne Csakai

Karoly Nagy

Tamas Mogyorosi

Andras Komaromi

Mihalyne Kardos

Melinda Nagy

Maria Kuerthy

Laszlo Koranyi

Original Assignee

Biorex Kutato Fejlesztoe Kft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-26

Filing date

2001-08-23

Publication date

2005-09-12

2001-08-23 Application filed by Biorex Kutato Fejlesztoe Kft filed Critical Biorex Kutato Fejlesztoe Kft

2001-08-23 Publication of NO20014103D0 publication Critical patent/NO20014103D0/no

2001-10-22 Publication of NO20014103L publication Critical patent/NO20014103L/no

2005-09-12 Publication of NO319793B1 publication Critical patent/NO319793B1/no

Links

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102000005861 leptin receptors Human genes 0.000 description 1
108010019813 leptin receptors Proteins 0.000 description 1
230000037356 lipid metabolism Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
208000019423 liver disease Diseases 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
150000002688 maleic acid derivatives Chemical class 0.000 description 1
229940127554 medical product Drugs 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
238000007431 microscopic evaluation Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000003020 moisturizing effect Effects 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
125000000896 monocarboxylic acid group Chemical group 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
230000035772 mutation Effects 0.000 description 1
229940105631 nembutal Drugs 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
230000003018 neuroregenerative effect Effects 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
238000007474 nonparametric Mann- Whitney U test Methods 0.000 description 1
229960002748 norepinephrine Drugs 0.000 description 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
235000020824 obesity Nutrition 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
231100000915 pathological change Toxicity 0.000 description 1
230000036285 pathological change Effects 0.000 description 1
229960002275 pentobarbital sodium Drugs 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
210000000578 peripheral nerve Anatomy 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
238000010149 post-hoc-test Methods 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000022558 protein metabolic process Effects 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000011514 reflex Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
210000001525 retina Anatomy 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
235000021003 saturated fats Nutrition 0.000 description 1
230000009291 secondary effect Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
238000009495 sugar coating Methods 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000035488 systolic blood pressure Effects 0.000 description 1
229960000790 thymol Drugs 0.000 description 1
210000002972 tibial nerve Anatomy 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
238000012546 transfer Methods 0.000 description 1
GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
229960001641 troglitazone Drugs 0.000 description 1
GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
238000011870 unpaired t-test Methods 0.000 description 1
210000003556 vascular endothelial cell Anatomy 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20014103A 1999-02-26 2001-08-23 N-[2-hydroksy-3-(1-piperidinyl)propoksy]pyridin-1-oksid-3-karboksimidoylklorid og dets anvendelse til fremstilling av et farmasoytisk preparat, samt farmasoytisk preparat. NO319793B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9900475A HUP9900475D0 (en)	1999-02-26	1999-02-26	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
PCT/HU2000/000015 WO2000050403A1 (en)	1999-02-26	2000-02-24	N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance

Publications (3)

Publication Number	Publication Date
NO20014103D0 NO20014103D0 (no)	2001-08-23
NO20014103L NO20014103L (no)	2001-10-22
NO319793B1 true NO319793B1 (no)	2005-09-12

Family

ID=90014224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20014103A NO319793B1 (no)	1999-02-26	2001-08-23	N-[2-hydroksy-3-(1-piperidinyl)propoksy]pyridin-1-oksid-3-karboksimidoylklorid og dets anvendelse til fremstilling av et farmasoytisk preparat, samt farmasoytisk preparat.

Country Status (27)

Country	Link
US (1)	US6649628B1 (sr)
EP (1)	EP1163224B1 (sr)
JP (1)	JP4689838B2 (sr)
KR (1)	KR100676124B1 (sr)
AT (1)	ATE237590T1 (sr)
AU (1)	AU779096B2 (sr)
BG (1)	BG65178B1 (sr)
BR (1)	BR0008969A (sr)
CA (1)	CA2360451C (sr)
CZ (1)	CZ297386B6 (sr)
DE (1)	DE60002187T2 (sr)
DK (1)	DK1163224T3 (sr)
EE (1)	EE04961B1 (sr)
ES (1)	ES2193055T3 (sr)
HR (1)	HRP20010584B1 (sr)
HU (1)	HUP9900475D0 (sr)
IL (2)	IL144866A0 (sr)
NO (1)	NO319793B1 (sr)
PL (1)	PL197692B1 (sr)
PT (1)	PT1163224E (sr)
RS (1)	RS50083B (sr)
RU (1)	RU2250901C2 (sr)
SI (1)	SI1163224T1 (sr)
SK (1)	SK287063B6 (sr)
UA (1)	UA72495C2 (sr)
WO (1)	WO2000050403A1 (sr)
ZA (1)	ZA200106488B (sr)

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HUP0001583A2 (hu) *	2000-04-18	2002-11-28	BIOREX Kutató és Fejlesztő Rt.	Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
HU0103939D0 (en) *	2001-09-27	2001-11-28	Biorex Kutato Fejlesztoe Kft	Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
CA2471752A1 (en)	2002-01-11	2003-07-17	Biorex Kutato Es Fejlesztoe Rt.	Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) *	2003-10-30	2009-12-28	Cytrx Corp	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) *	2006-09-26	2008-08-01	Cytrx Corp	Pharmaceutical compositions and methods for treating diseases
EP2484371B1 (en)	2008-06-26	2014-12-17	Orphazyme APS	Use of Hsp70 as a regulator of enzymatic activity
KR20110084514A (ko) *	2008-11-18	2011-07-25	산텐 세이야꾸 가부시키가이샤	피리딘-3-카르발데히드 ｏ-(피페리딘-1-일-프로필)-옥심 유도체를 유효 성분으로서 함유하는 망맥락막 변성 질환의 치료제
RU2013125923A (ru)	2010-11-30	2015-01-10	Орфазиме Апс	СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70
HUP1100535A2 (en)	2011-09-26	2013-04-29	Bracelia Invest Ltd	Pharmaceutical composition for enhancement of stem cell treatment
HUP1100534A2 (en)	2011-09-26	2013-04-29	Balazs Dr Hazay	Pharmaceutical composition for the treatment of muscle atrophy
PL2892540T3 (pl) *	2012-09-06	2018-12-31	Mcpharma Biotech Inc.	Leczenie biegunki i biegunki po odsadzeniu przy pomocy opornej skrobi ziemniaczanej
ES2912524T3 (es)	2012-09-14	2022-05-26	Saint Gobain	Cristal con un elemento de conexión eléctrica
WO2015015248A1 (en) *	2013-07-30	2015-02-05	Debreceni Egyetem 67%	The use of compounds showing heat shock protein (hsp) co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes
US10709700B2 (en) *	2014-09-15	2020-07-14	Orphazyme A/S	Arimoclomol formulation
EP3442530A1 (en)	2016-04-13	2019-02-20	Orphazyme A/S	Heat shock proteins and cholesterol homeostasis
SI3448382T1 (sl)	2016-04-29	2021-03-31	Orphazyme A/S, c/o COBIS A/S	Arimoclomol za zdravljenje motenj, povezanih z glukocerebrozidazo
JP2020520947A (ja)	2017-05-24	2020-07-16	オーファザイムエー／エス	熱ショックタンパク質誘導因子および前頭側頭障害
US20210164997A1 (en)	2018-05-28	2021-06-03	Orphazyme A/S	Hsp70 protein levels in pbmc samples as biomarker for disease
HUP1800298A1 (hu)	2018-08-30	2020-05-28	N Gene Res Laboratories Inc	Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
WO2021116487A1 (en)	2019-12-13	2021-06-17	Som Innovation Biotech, S.A.	Compounds for use in the treatment of niemann-pick c disease
WO2021260120A1 (en)	2020-06-24	2021-12-30	Orphazyme A/S	Arimoclomol for treating gaucher disease
CN116783164A (zh) *	2020-11-19	2023-09-19	泽维拉丹麦股份有限公司	制备柠檬酸阿瑞洛莫及其中间体的方法
WO2022106614A1 (en) *	2020-11-19	2022-05-27	Orphazyme A/S	Processes for preparing arimoclomol citrate and intermediates thereof
JP2024502304A (ja)	2020-12-24	2024-01-18	ゼブラデンマークエー／エス	Ｅｒ型ミスセンス変異を有する患者におけるニーマンピック病ｃ型の治療用アリモクロモル

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HU207988B (en) *	1988-10-20	1993-07-28	Biorex Kutato Fejlesztoe Kft	Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU222994B1 (hu) *	1995-11-02	2004-01-28	BIOREX Kutató és Fejlesztő Rt.	Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUT78138A (hu) *	1995-12-22	2000-09-28	BIOREX Kutató és Fejlesztő Rt	Hidroximsavszármazékot tartalmazó készítmény a növénytermesztés elősegítésére és alkalmazása
UA64716C2 (en) *	1996-08-09	2004-03-15		Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells
HU220971B1 (hu) *	1997-04-03	2002-07-29	BIOREX Kutató és Fejlesztő Rt.	Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
HUP0001583A2 (hu) *	2000-04-18	2002-11-28	BIOREX Kutató és Fejlesztő Rt.	Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké

1999
- 1999-02-26 HU HU9900475A patent/HUP9900475D0/hu unknown
2000
- 2000-02-24 EP EP00909542A patent/EP1163224B1/en not_active Expired - Lifetime
- 2000-02-24 RU RU2001126126/04A patent/RU2250901C2/ru active
- 2000-02-24 US US09/913,263 patent/US6649628B1/en not_active Expired - Lifetime
- 2000-02-24 AT AT00909542T patent/ATE237590T1/de active
- 2000-02-24 SI SI200030080T patent/SI1163224T1/xx unknown
- 2000-02-24 ES ES00909542T patent/ES2193055T3/es not_active Expired - Lifetime
- 2000-02-24 KR KR1020017010932A patent/KR100676124B1/ko not_active Expired - Fee Related
- 2000-02-24 PT PT00909542T patent/PT1163224E/pt unknown
- 2000-02-24 HR HR20010584A patent/HRP20010584B1/xx not_active IP Right Cessation
- 2000-02-24 UA UA2001085933A patent/UA72495C2/uk unknown
- 2000-02-24 EE EEP200100447A patent/EE04961B1/xx not_active IP Right Cessation
- 2000-02-24 JP JP2000600986A patent/JP4689838B2/ja not_active Expired - Lifetime
- 2000-02-24 IL IL14486600A patent/IL144866A0/xx active IP Right Grant
- 2000-02-24 DE DE60002187T patent/DE60002187T2/de not_active Expired - Lifetime
- 2000-02-24 CZ CZ20013053A patent/CZ297386B6/cs not_active IP Right Cessation
- 2000-02-24 RS YUP-603/01A patent/RS50083B/sr unknown
- 2000-02-24 WO PCT/HU2000/000015 patent/WO2000050403A1/en not_active Ceased
- 2000-02-24 SK SK1158-2001A patent/SK287063B6/sk not_active IP Right Cessation
- 2000-02-24 PL PL350915A patent/PL197692B1/pl unknown
- 2000-02-24 AU AU31824/00A patent/AU779096B2/en not_active Expired
- 2000-02-24 DK DK00909542T patent/DK1163224T3/da active
- 2000-02-24 CA CA2360451A patent/CA2360451C/en not_active Expired - Lifetime
- 2000-02-24 BR BR0008969-9A patent/BR0008969A/pt not_active IP Right Cessation
2001
- 2001-08-07 ZA ZA200106488A patent/ZA200106488B/xx unknown
- 2001-08-13 IL IL144866A patent/IL144866A/en not_active IP Right Cessation
- 2001-08-22 BG BG105837A patent/BG65178B1/bg unknown
- 2001-08-23 NO NO20014103A patent/NO319793B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
SK11582001A3 (sk)	2001-12-03
AU3182400A (en)	2000-09-14
DE60002187T2 (de)	2003-12-11
EE200100447A (et)	2002-12-16
IL144866A (en)	2007-07-04
ZA200106488B (en)	2002-08-07
WO2000050403A1 (en)	2000-08-31
NO20014103L (no)	2001-10-22
IL144866A0 (en)	2002-06-30
CA2360451C (en)	2011-01-04
PL350915A1 (en)	2003-02-10
SK287063B6 (sk)	2009-10-07
ES2193055T3 (es)	2003-11-01
NO20014103D0 (no)	2001-08-23
US6649628B1 (en)	2003-11-18
CZ20013053A3 (cs)	2002-01-16
AU779096B2 (en)	2005-01-06
PT1163224E (pt)	2003-07-31
RS50083B (sr)	2009-01-22
PL197692B1 (pl)	2008-04-30
BR0008969A (pt)	2001-11-27
DE60002187D1 (de)	2003-05-22
UA72495C2 (uk)	2005-03-15
KR100676124B1 (ko)	2007-01-31
BG105837A (en)	2002-03-29
ATE237590T1 (de)	2003-05-15
HUP9900475D0 (en)	1999-04-28
EP1163224A1 (en)	2001-12-19
DK1163224T3 (da)	2003-08-04
JP4689838B2 (ja)	2011-05-25
HRP20010584A2 (en)	2002-08-31
HRP20010584B1 (en)	2010-08-31
RU2250901C2 (ru)	2005-04-27
CA2360451A1 (en)	2000-08-31
SI1163224T1 (en)	2003-08-31
CZ297386B6 (cs)	2006-11-15
EE04961B1 (et)	2008-02-15
YU60301A (sh)	2004-05-12
JP2002537384A (ja)	2002-11-05
KR20010102410A (ko)	2001-11-15
EP1163224B1 (en)	2003-04-16
BG65178B1 (bg)	2007-05-31

Legal Events

Date	Code	Title	Description
2011-09-26	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
RU2250901C2 (ru)	2005-04-27	N-[2-гидрокси-3-(1-пиперидинил)пропокси]пиридин-1-оксид-3- карбоксиимидоилхлорид, фармацевтическая композиция на его основе и способ лечения
RU2188015C2 (ru)	2002-08-27	Способ ингибирования нейропептида y
RS60301B1 (sr)	2020-07-31	Kombinacija protiv regurgitacije za održavanje motiliteta creva
US6486177B2 (en)	2002-11-26	Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
CA2449922C (en)	2008-11-25	Pharmaceutical composition for therapy of interstitial cystitis
NO178696B (no)	1996-02-05	Akridinforbindelse og farmasöytisk preparat inneholdende denne
JPH0354922B2 (sr)	1991-08-21
EP1490057A1 (en)	2004-12-29	Method for treating cognitive disorders
EP1772149A1 (en)	2007-04-11	Drug for prevention or treatment of diabetes
KR20250110947A (ko)	2025-07-21	화합물의 약학적으로 사용 가능한 염 및 이의 제조 방법
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