NO320096B1 - Fremgangsmate ved biotransformasjonen av kolkikonforbindelser til de tilsvarende 3-glykosylderivater - Google Patents

Fremgangsmate ved biotransformasjonen av kolkikonforbindelser til de tilsvarende 3-glykosylderivater Download PDF

Info

Publication number: NO320096B1
Authority: NO; Norway
Prior art keywords: compounds; interval; lies; biotransformation; culture
Prior art date: 1997-10-03

Application number

NO20001706A

Other languages

English (en)

Norwegian (no)

Other versions

NO20001706L (no

NO20001706D0 (no

Inventor

Ezio Bombardelli

Cesare Ponzone

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-03

Filing date

2000-04-03

Publication date

2005-10-24

2000-04-03 Application filed by Indena Spa filed Critical Indena Spa

2000-04-03 Publication of NO20001706D0 publication Critical patent/NO20001706D0/no

2000-06-05 Publication of NO20001706L publication Critical patent/NO20001706L/no

2005-10-24 Publication of NO320096B1 publication Critical patent/NO320096B1/no

Links

238000000034 method Methods 0.000 title claims abstract description 37
230000036983 biotransformation Effects 0.000 title claims abstract description 25
150000001875 compounds Chemical class 0.000 title claims abstract description 21
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239000000758 substrate Substances 0.000 claims description 23
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
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VVPWAFWXRZAOAI-UHFFFAOYSA-N 1-chloroprop-1-en-2-ol Chemical compound CC(O)=CCl VVPWAFWXRZAOAI-UHFFFAOYSA-N 0.000 description 1
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YWPVROCHNBYFTP-UHFFFAOYSA-N Rubusoside Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC1OC(CO)C(O)C(O)C1O YWPVROCHNBYFTP-UHFFFAOYSA-N 0.000 description 1
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CKFGINPQOCXMAZ-UHFFFAOYSA-N methanediol Chemical compound OCO CKFGINPQOCXMAZ-UHFFFAOYSA-N 0.000 description 1
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CMEGANPVAXDBPL-INIZCTEOSA-N n-[(7s)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC CMEGANPVAXDBPL-INIZCTEOSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

NO20001706A 1997-10-03 2000-04-03 Fremgangsmate ved biotransformasjonen av kolkikonforbindelser til de tilsvarende 3-glykosylderivater NO320096B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT97MI002255A IT1295272B1 (it)	1997-10-03	1997-10-03	Biotrasformazione di composti colchiconici nei corrispondenti 3- glicosilderivati
PCT/EP1998/006226 WO1999018229A1 (en)	1997-10-03	1998-09-30	A process for the biotransformation of colchicone compounds into the corresponding 3-glycosyl derivatives

Publications (3)

Publication Number	Publication Date
NO20001706D0 NO20001706D0 (no)	2000-04-03
NO20001706L NO20001706L (no)	2000-06-05
NO320096B1 true NO320096B1 (no)	2005-10-24

Family

ID=11377985

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20001706A NO320096B1 (no)	1997-10-03	2000-04-03	Fremgangsmate ved biotransformasjonen av kolkikonforbindelser til de tilsvarende 3-glykosylderivater

Country Status (20)

Country	Link
US (1)	US6372458B1 (de)
EP (1)	EP1019521B1 (de)
KR (1)	KR100536676B1 (de)
CN (1)	CN1188527C (de)
AT (1)	ATE328106T1 (de)
AU (1)	AU745222B2 (de)
CA (1)	CA2305046C (de)
CZ (1)	CZ295749B6 (de)
DE (1)	DE69834736T2 (de)
DK (1)	DK1019521T3 (de)
ES (1)	ES2264214T3 (de)
HU (1)	HU225686B1 (de)
IL (1)	IL134566A (de)
IT (1)	IT1295272B1 (de)
NO (1)	NO320096B1 (de)
PL (1)	PL190865B1 (de)
PT (1)	PT1019521E (de)
RU (1)	RU2218409C2 (de)
SK (1)	SK285923B6 (de)
WO (1)	WO1999018229A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040175782A1 (en) *	2003-03-06	2004-09-09	Tethys Research Llc	Biotransformation of compounds using non-prokaryotic microalgae
PL1745140T3 (pl) *	2004-05-12	2010-01-29	Indena Spa	Biotransformacja związków kolchicynoidowych
EP2619315A2 (de) *	2010-09-22	2013-07-31	Elysian Life Sciences Private Limited	Mikrobielles verfahren zur biotransformation von colchicinoid-verbindungen
WO2015097567A1 (en)	2013-12-23	2015-07-02	Alkaloids Corporation	Process for the conversion of colchicinoids to their 3-glycosylated derivatives via their respective 3-demethyl analogues
CN105861601B (zh) *	2016-04-29	2019-05-24	中国药科大学	一种生物转化制备二氢去氢双松柏醇葡萄糖单糖苷(hmzg)的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1344157A (fr) *	1959-05-22	1963-11-29	Roussel Uclaf	Nouvelles colchicines et leur procédé d'obtention
US3442953A (en) *	1963-06-19	1969-05-06	Roussel Uclaf	Novel 7-oxo-7-desacetylaminocolchicine compounds
JPS5233195B2 (de) *	1971-09-30	1977-08-26
IT1285777B1 (it) *	1996-10-07	1998-06-18	Indena Spa	Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati

1997
- 1997-10-03 IT IT97MI002255A patent/IT1295272B1/it active IP Right Grant
1998
- 1998-09-30 AT AT98952675T patent/ATE328106T1/de active
- 1998-09-30 SK SK483-2000A patent/SK285923B6/sk not_active IP Right Cessation
- 1998-09-30 EP EP98952675A patent/EP1019521B1/de not_active Expired - Lifetime
- 1998-09-30 DK DK98952675T patent/DK1019521T3/da active
- 1998-09-30 PT PT98952675T patent/PT1019521E/pt unknown
- 1998-09-30 ES ES98952675T patent/ES2264214T3/es not_active Expired - Lifetime
- 1998-09-30 DE DE69834736T patent/DE69834736T2/de not_active Expired - Lifetime
- 1998-09-30 CZ CZ20001196A patent/CZ295749B6/cs not_active IP Right Cessation
- 1998-09-30 CN CNB988098180A patent/CN1188527C/zh not_active Expired - Fee Related
- 1998-09-30 IL IL13456698A patent/IL134566A/en not_active IP Right Cessation
- 1998-09-30 WO PCT/EP1998/006226 patent/WO1999018229A1/en not_active Ceased
- 1998-09-30 CA CA002305046A patent/CA2305046C/en not_active Expired - Fee Related
- 1998-09-30 HU HU0004840A patent/HU225686B1/hu not_active IP Right Cessation
- 1998-09-30 RU RU2000111512/13A patent/RU2218409C2/ru not_active IP Right Cessation
- 1998-09-30 PL PL339620A patent/PL190865B1/pl unknown
- 1998-09-30 AU AU10283/99A patent/AU745222B2/en not_active Ceased
- 1998-09-30 KR KR10-2000-7003216A patent/KR100536676B1/ko not_active Expired - Fee Related
2000
- 2000-03-31 US US09/539,867 patent/US6372458B1/en not_active Expired - Lifetime
- 2000-04-03 NO NO20001706A patent/NO320096B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU1028399A (en)	1999-04-27
US6372458B1 (en)	2002-04-16
IL134566A (en)	2004-06-20
IL134566A0 (en)	2001-04-30
HUP0004840A3 (en)	2002-10-28
RU2218409C2 (ru)	2003-12-10
DE69834736T2 (de)	2007-05-10
PL190865B1 (pl)	2006-02-28
CZ20001196A3 (cs)	2000-10-11
EP1019521B1 (de)	2006-05-31
KR20010030710A (ko)	2001-04-16
NO20001706L (no)	2000-06-05
ES2264214T3 (es)	2006-12-16
PL339620A1 (en)	2001-01-02
CN1273607A (zh)	2000-11-15
CN1188527C (zh)	2005-02-09
HK1031896A1 (en)	2001-06-29
HU225686B1 (en)	2007-06-28
ITMI972255A1 (it)	1999-04-03
NO20001706D0 (no)	2000-04-03
DE69834736D1 (de)	2006-07-06
PT1019521E (pt)	2006-09-29
HUP0004840A2 (hu)	2001-04-28
CA2305046A1 (en)	1999-04-15
IT1295272B1 (it)	1999-05-04
SK285923B6 (sk)	2007-11-02
WO1999018229A1 (en)	1999-04-15
AU745222B2 (en)	2002-03-14
CA2305046C (en)	2008-12-09
EP1019521A1 (de)	2000-07-19
DK1019521T3 (da)	2006-10-02
ATE328106T1 (de)	2006-06-15
KR100536676B1 (ko)	2005-12-14
CZ295749B6 (cs)	2005-10-12
SK4832000A3 (en)	2000-09-12

Legal Events

Date	Code	Title	Description
2017-04-24	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
KR100311067B1 (ko)	2001-12-17	콜히치노이드화합물들을그와상응하는3-글리코실유도체로만드는생물학적변환과정
RU2218409C2 (ru)	2003-12-10	Способ биотрансформации колхиконового соединения в соответствующее 3-0-гликозильное производное
JP4198883B2 (ja)	2008-12-17	コルヒコン化合物を対応する３−グリコシル誘導体に生物学的に転換する方法
NO336051B1 (no)	2015-04-27	Biotransformasjon av colchicinoidforbindelser
WO2012038982A2 (en)	2012-03-29	A microbial method for the biotransformation of colchicinoid compounds
NO134061B (de)	1976-05-03