NO320618B1 - Kontrastmiddel-preparat - Google Patents
Kontrastmiddel-preparat Download PDFInfo
- Publication number
- NO320618B1 NO320618B1 NO19995058A NO995058A NO320618B1 NO 320618 B1 NO320618 B1 NO 320618B1 NO 19995058 A NO19995058 A NO 19995058A NO 995058 A NO995058 A NO 995058A NO 320618 B1 NO320618 B1 NO 320618B1
- Authority
- NO
- Norway
- Prior art keywords
- oxalic acid
- lanthanide
- reaction
- dtpa
- lanthanide oxide
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title description 5
- 239000000203 mixture Substances 0.000 title description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims abstract description 102
- 235000006408 oxalic acid Nutrition 0.000 claims abstract description 30
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- 229910000311 lanthanide oxide Inorganic materials 0.000 claims abstract description 24
- 229910052747 lanthanoid Inorganic materials 0.000 claims abstract description 22
- 150000002602 lanthanoids Chemical class 0.000 claims abstract description 20
- 238000006263 metalation reaction Methods 0.000 claims abstract description 18
- RZESKRXOCXWCFX-UHFFFAOYSA-N 2-[bis[2-[carboxymethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetic acid Chemical compound CNC(=O)CN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC(=O)NC RZESKRXOCXWCFX-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000008139 complexing agent Substances 0.000 claims abstract description 9
- 239000003446 ligand Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000012535 impurity Substances 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 6
- 239000012429 reaction media Substances 0.000 claims description 4
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical group OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims description 3
- 239000012431 aqueous reaction media Substances 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 2
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical group [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- CMIHHWBVHJVIGI-UHFFFAOYSA-N gadolinium(III) oxide Inorganic materials [O-2].[O-2].[O-2].[Gd+3].[Gd+3] CMIHHWBVHJVIGI-UHFFFAOYSA-N 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 7
- 229910001938 gadolinium oxide Inorganic materials 0.000 description 5
- 229940075613 gadolinium oxide Drugs 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 3
- HZHFFEYYPYZMNU-UHFFFAOYSA-K gadodiamide Chemical compound [Gd+3].CNC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC(=O)NC HZHFFEYYPYZMNU-UHFFFAOYSA-K 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- -1 lanthanide oxalate Chemical class 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 1
- 229910052691 Erbium Inorganic materials 0.000 description 1
- 229910052693 Europium Inorganic materials 0.000 description 1
- 229910052689 Holmium Inorganic materials 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229910052771 Terbium Inorganic materials 0.000 description 1
- 229910052775 Thulium Inorganic materials 0.000 description 1
- 229910052769 Ytterbium Inorganic materials 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- LGMLJQFQKXPRGA-VPVMAENOSA-K gadopentetate dimeglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O LGMLJQFQKXPRGA-VPVMAENOSA-K 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910021644 lanthanide ion Inorganic materials 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- GEVPUGOOGXGPIO-UHFFFAOYSA-N oxalic acid;dihydrate Chemical compound O.O.OC(=O)C(O)=O GEVPUGOOGXGPIO-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Chemical group 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Length Measuring Devices By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9707880.2A GB9707880D0 (en) | 1997-04-18 | 1997-04-18 | Contrast agent preparation |
| US4440997P | 1997-04-29 | 1997-04-29 | |
| PCT/GB1998/001019 WO1998047856A1 (en) | 1997-04-18 | 1998-04-07 | Contrast agent preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995058L NO995058L (no) | 1999-10-15 |
| NO995058D0 NO995058D0 (no) | 1999-10-15 |
| NO320618B1 true NO320618B1 (no) | 2005-12-27 |
Family
ID=26311410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995058A NO320618B1 (no) | 1997-04-18 | 1999-10-15 | Kontrastmiddel-preparat |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6191262B1 (de) |
| EP (1) | EP0975580B1 (de) |
| JP (1) | JP4035625B2 (de) |
| CN (1) | CN100352802C (de) |
| AT (1) | ATE224867T1 (de) |
| AU (1) | AU745970B2 (de) |
| BR (1) | BR9808924A (de) |
| CA (1) | CA2287245A1 (de) |
| CZ (1) | CZ296233B6 (de) |
| DE (1) | DE69808265T2 (de) |
| ES (1) | ES2187018T3 (de) |
| GB (1) | GB9707880D0 (de) |
| HU (1) | HUP0001861A2 (de) |
| IL (1) | IL132433A0 (de) |
| NO (1) | NO320618B1 (de) |
| NZ (1) | NZ500061A (de) |
| PL (1) | PL336208A1 (de) |
| WO (1) | WO1998047856A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2794032B1 (fr) * | 1999-05-27 | 2002-06-14 | Univ Claude Bernard Lyon | Procede pour separer en milieu aqueux des lanthanides et/ou des actinides par complexation-nanofiltration, et nouveaux complexants mis en oeuvre dans ce procede |
| CN1321122C (zh) * | 2005-02-03 | 2007-06-13 | 华东师范大学 | 一种水热合成钆－二乙三胺五乙酸的方法 |
| EP2338874A1 (de) * | 2009-12-16 | 2011-06-29 | Bracco Imaging S.p.A | Verfahren zur Herstellung von chelatierten Verbindungen |
| CN106008254B (zh) * | 2016-05-27 | 2018-08-21 | 南京正大天晴制药有限公司 | 一种卡地酰胺钠的精制工艺 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| FR2669028B1 (fr) * | 1990-11-13 | 1992-12-31 | Rhone Poulenc Chimie | Procede de fabrication d'oxalates doubles de terres rares et d'ammonium et leurs utilisations pour la fabrication d'oxydes de terres rares. |
| FR2674256B1 (fr) * | 1991-03-21 | 1994-07-29 | Commissariat Energie Atomique | Procede pour separer le fer et/ou le zirconium des actinides et/ou des lanthanides presents dans une solution aqueuse acide au moyen d'un propanediamide. |
-
1997
- 1997-04-18 GB GBGB9707880.2A patent/GB9707880D0/en active Pending
-
1998
- 1998-04-07 ES ES98914995T patent/ES2187018T3/es not_active Expired - Lifetime
- 1998-04-07 DE DE69808265T patent/DE69808265T2/de not_active Expired - Lifetime
- 1998-04-07 CN CNB988041316A patent/CN100352802C/zh not_active Expired - Lifetime
- 1998-04-07 EP EP98914995A patent/EP0975580B1/de not_active Expired - Lifetime
- 1998-04-07 AT AT98914995T patent/ATE224867T1/de not_active IP Right Cessation
- 1998-04-07 JP JP54526398A patent/JP4035625B2/ja not_active Expired - Lifetime
- 1998-04-07 CA CA002287245A patent/CA2287245A1/en not_active Abandoned
- 1998-04-07 BR BR9808924-2A patent/BR9808924A/pt unknown
- 1998-04-07 NZ NZ500061A patent/NZ500061A/en unknown
- 1998-04-07 PL PL98336208A patent/PL336208A1/xx unknown
- 1998-04-07 AU AU69287/98A patent/AU745970B2/en not_active Ceased
- 1998-04-07 WO PCT/GB1998/001019 patent/WO1998047856A1/en not_active Ceased
- 1998-04-07 IL IL13243398A patent/IL132433A0/xx unknown
- 1998-04-07 HU HU0001861A patent/HUP0001861A2/hu unknown
- 1998-04-07 CZ CZ0368899A patent/CZ296233B6/cs unknown
-
1999
- 1999-10-15 US US09/419,290 patent/US6191262B1/en not_active Expired - Lifetime
- 1999-10-15 NO NO19995058A patent/NO320618B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0975580B1 (de) | 2002-09-25 |
| AU6928798A (en) | 1998-11-13 |
| HUP0001861A2 (hu) | 2000-09-28 |
| WO1998047856A1 (en) | 1998-10-29 |
| DE69808265D1 (de) | 2002-10-31 |
| CA2287245A1 (en) | 1998-10-29 |
| NZ500061A (en) | 2001-04-27 |
| BR9808924A (pt) | 2000-08-01 |
| DE69808265T2 (de) | 2003-07-31 |
| CZ296233B6 (cs) | 2006-02-15 |
| IL132433A0 (en) | 2001-03-19 |
| ATE224867T1 (de) | 2002-10-15 |
| CN100352802C (zh) | 2007-12-05 |
| AU745970B2 (en) | 2002-04-11 |
| PL336208A1 (en) | 2000-06-05 |
| CZ368899A3 (cs) | 2000-04-12 |
| US6191262B1 (en) | 2001-02-20 |
| ES2187018T3 (es) | 2003-05-16 |
| NO995058L (no) | 1999-10-15 |
| HK1025313A1 (en) | 2000-11-10 |
| EP0975580A1 (de) | 2000-02-02 |
| JP2001521545A (ja) | 2001-11-06 |
| GB9707880D0 (en) | 1997-06-04 |
| NO995058D0 (no) | 1999-10-15 |
| CN1252051A (zh) | 2000-05-03 |
| JP4035625B2 (ja) | 2008-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |