NO320909B1 - Pyrimidinforbindelser, samt anvendelse og fremstilling derav og farmasoytisk preparat. - Google Patents

Pyrimidinforbindelser, samt anvendelse og fremstilling derav og farmasoytisk preparat. Download PDF

Info

Publication number: NO320909B1
Authority: NO; Norway
Prior art keywords: formula; pyrimidine; compounds; compound; group
Prior art date: 1999-03-06

Application number

NO20014317A

Other languages

English (en)

Norwegian (no)

Other versions

NO20014317D0 (no

NO20014317L (no

Inventor

Elizabeth Janet Pease

Stewart Russell James

Gloria Anne Breault

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-06

Filing date

2001-09-05

Publication date

2006-02-13

2001-09-05 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2001-09-05 Publication of NO20014317D0 publication Critical patent/NO20014317D0/no

2001-11-01 Publication of NO20014317L publication Critical patent/NO20014317L/no

2006-02-13 Publication of NO320909B1 publication Critical patent/NO320909B1/no

Links

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150000002148 esters Chemical class 0.000 claims abstract description 32
150000003839 salts Chemical class 0.000 claims abstract description 30
238000001727 in vivo Methods 0.000 claims abstract description 29
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238000004519 manufacturing process Methods 0.000 claims abstract description 9
230000008569 process Effects 0.000 claims abstract description 4
125000000623 heterocyclic group Chemical group 0.000 claims abstract description 3
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CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 12
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125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
238000007747 plating Methods 0.000 description 1
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CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
DUYAAUVXQSMXQP-UHFFFAOYSA-M thioacetate Chemical compound CC([S-])=O DUYAAUVXQSMXQP-UHFFFAOYSA-M 0.000 description 1
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UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
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239000001226 triphosphate Substances 0.000 description 1
235000011178 triphosphate Nutrition 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20014317A 1999-03-06 2001-09-05 Pyrimidinforbindelser, samt anvendelse og fremstilling derav og farmasoytisk preparat. NO320909B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9905075.9A GB9905075D0 (en)	1999-03-06	1999-03-06	Chemical compounds
PCT/GB2000/000737 WO2000053595A1 (en)	1999-03-06	2000-03-02	Pyrimidine compounds

Publications (3)

Publication Number	Publication Date
NO20014317D0 NO20014317D0 (no)	2001-09-05
NO20014317L NO20014317L (no)	2001-11-01
NO320909B1 true NO320909B1 (no)	2006-02-13

Family

ID=10849022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20014317A NO320909B1 (no)	1999-03-06	2001-09-05	Pyrimidinforbindelser, samt anvendelse og fremstilling derav og farmasoytisk preparat.

Country Status (20)

Country	Link
US (1)	US6716831B1 (de)
EP (1)	EP1161428B1 (de)
JP (1)	JP2002539120A (de)
KR (1)	KR100683512B1 (de)
CN (1)	CN1227249C (de)
AT (1)	ATE241617T1 (de)
AU (1)	AU754967B2 (de)
BR (1)	BR0008770A (de)
CA (1)	CA2366668A1 (de)
DE (1)	DE60003001T2 (de)
DK (1)	DK1161428T3 (de)
ES (1)	ES2200824T3 (de)
GB (1)	GB9905075D0 (de)
IL (2)	IL145192A0 (de)
MX (1)	MXPA01008960A (de)
NO (1)	NO320909B1 (de)
NZ (1)	NZ513893A (de)
PT (1)	PT1161428E (de)
WO (1)	WO2000053595A1 (de)
ZA (1)	ZA200107252B (de)

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GB0004886D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004888D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004887D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004890D0 (en) *	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0007371D0 (en)	2000-03-28	2000-05-17	Astrazeneca Uk Ltd	Chemical compounds
GB0016877D0 (en)	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
GB0021726D0 (en)	2000-09-05	2000-10-18	Astrazeneca Ab	Chemical compounds
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AU2002312933B2 (en)	2001-05-29	2007-12-06	Schering Ag	CDK inhibiting pyrimidines, production thereof and their use as medicaments
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JP2005519034A (ja) *	2001-11-30	2005-06-30	シンタファーマシューティカルズコーポレーション	ピリミジン化合物
GB0205688D0 (en)	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
JP2005524672A (ja) *	2002-03-09	2005-08-18	アストラゼネカアクチボラグ	Ｃｄｋ阻害活性を有するイミダゾリル置換ピリミジン誘導体
GB0205693D0 (en)	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0205690D0 (en)	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0311276D0 (en)	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
GB0311274D0 (en) *	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
DE10349423A1 (de)	2003-10-16	2005-06-16	Schering Ag	Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
TW200528101A (en)	2004-02-03	2005-09-01	Astrazeneca Ab	Chemical compounds
EP1598343A1 (de) *	2004-05-19	2005-11-23	Boehringer Ingelheim International GmbH	2-Arylaminopyrimidine als PLK Inhibitoren
US20090099160A1 (en) *	2004-12-17	2009-04-16	David Andrews	4-(4-(Imidazol-4-Yl) Pyrimidin-2-Ylamino) Benzamides as CDK Inhibitors
US7563781B2 (en) *	2005-01-14	2009-07-21	Janssen Pharmaceutica Nv	Triazolopyrimidine derivatives
PT1853588E (pt)	2005-02-16	2008-08-25	Astrazeneca Ab	Compostos químicos
PL2559690T3 (pl)	2005-05-10	2016-09-30		Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
JP2008540622A (ja)	2005-05-16	2008-11-20	アストラゼネカアクチボラグ	化合物
US20060281712A1 (en) *	2005-06-14	2006-12-14	Chi-Feng Yen	Pyrimidine compounds
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AU2006274733B2 (en) *	2005-07-30	2010-09-16	Astrazeneca Ab	Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders
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2000
- 2000-03-02 JP JP2000604033A patent/JP2002539120A/ja active Pending
- 2000-03-02 EP EP00906531A patent/EP1161428B1/de not_active Expired - Lifetime
- 2000-03-02 AT AT00906531T patent/ATE241617T1/de not_active IP Right Cessation
- 2000-03-02 PT PT00906531T patent/PT1161428E/pt unknown
- 2000-03-02 BR BR0008770-0A patent/BR0008770A/pt not_active Application Discontinuation
- 2000-03-02 AU AU28187/00A patent/AU754967B2/en not_active Ceased
- 2000-03-02 WO PCT/GB2000/000737 patent/WO2000053595A1/en not_active Ceased
- 2000-03-02 US US09/914,788 patent/US6716831B1/en not_active Expired - Fee Related
- 2000-03-02 NZ NZ513893A patent/NZ513893A/xx unknown
- 2000-03-02 DE DE60003001T patent/DE60003001T2/de not_active Expired - Fee Related
- 2000-03-02 IL IL14519200A patent/IL145192A0/xx active IP Right Grant
- 2000-03-02 ES ES00906531T patent/ES2200824T3/es not_active Expired - Lifetime
- 2000-03-02 DK DK00906531T patent/DK1161428T3/da active
- 2000-03-02 CN CNB008070679A patent/CN1227249C/zh not_active Expired - Fee Related
- 2000-03-02 MX MXPA01008960A patent/MXPA01008960A/es active IP Right Grant
- 2000-03-02 KR KR1020017011289A patent/KR100683512B1/ko not_active Expired - Fee Related
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2001
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- 2001-09-05 NO NO20014317A patent/NO320909B1/no unknown

Also Published As

Publication number	Publication date
AU754967B2 (en)	2002-11-28
PT1161428E (pt)	2003-10-31
IL145192A0 (en)	2002-06-30
ES2200824T3 (es)	2004-03-16
JP2002539120A (ja)	2002-11-19
EP1161428A1 (de)	2001-12-12
MXPA01008960A (es)	2002-04-24
ZA200107252B (en)	2002-12-02
WO2000053595A1 (en)	2000-09-14
GB9905075D0 (en)	1999-04-28
CA2366668A1 (en)	2000-09-14
US6716831B1 (en)	2004-04-06
NZ513893A (en)	2004-03-26
ATE241617T1 (de)	2003-06-15
BR0008770A (pt)	2002-01-08
NO20014317D0 (no)	2001-09-05
NO20014317L (no)	2001-11-01
DK1161428T3 (da)	2003-09-15
IL145192A (en)	2007-06-17
DE60003001D1 (en)	2003-07-03
KR20010102502A (ko)	2001-11-15
AU2818700A (en)	2000-09-28
KR100683512B1 (ko)	2007-02-16
CN1349528A (zh)	2002-05-15
DE60003001T2 (de)	2004-05-06
EP1161428B1 (de)	2003-05-28
CN1227249C (zh)	2005-11-16

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EP1161428B1 (de)	2003-05-28	Pyrimidinverbindungen
KR100762190B1 (ko)	2007-10-04	피리미딘 화합물
AU2001233979B2 (en)	2004-11-11	2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
US6593326B1 (en)	2003-07-15	2,4-diamino pyrimidine compounds having anti-cell proliferative activity
CA2399196C (en)	2010-05-04	Pyrimidine compounds
NO325100B1 (no)	2008-02-04	2,4-di(hetero-)arylamino(-oksy)-5-substituerte pyrimidinderivater, anvendelse og fremstilling derav samt farmasoytisk sammensetning
AU2001233979A1 (en)	2001-11-22	2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
AU2001235768A1 (en)	2001-11-22	Pyrimidine compounds
MXPA01006575A (en)	2002-03-26	Pyrimidine compounds