NO322614B1 - Indolyl-3-glykosylsyrederivater som har terapeutisk verdifulle egenskaper - Google Patents

Indolyl-3-glykosylsyrederivater som har terapeutisk verdifulle egenskaper Download PDF

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Publication number
NO322614B1
NO322614B1 NO20021367A NO20021367A NO322614B1 NO 322614 B1 NO322614 B1 NO 322614B1 NO 20021367 A NO20021367 A NO 20021367A NO 20021367 A NO20021367 A NO 20021367A NO 322614 B1 NO322614 B1 NO 322614B1
Authority
NO
Norway
Prior art keywords
acid
glyoxylamide
indol
pyridin
fluorobenzyl
Prior art date
Application number
NO20021367A
Other languages
English (en)
Norwegian (no)
Other versions
NO20021367L (no
NO20021367D0 (no
Inventor
Bernd Nickel
Juergen Engel
Gerald Bacher
Erik Bruyneel
Guenter Kam
Kirsten Peters
Thomas Beckers
Thomas Klenner
Peter-Paul Emig
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19946301A external-priority patent/DE19946301A1/de
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of NO20021367D0 publication Critical patent/NO20021367D0/no
Publication of NO20021367L publication Critical patent/NO20021367L/no
Publication of NO322614B1 publication Critical patent/NO322614B1/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20021367A 1999-09-28 2002-03-19 Indolyl-3-glykosylsyrederivater som har terapeutisk verdifulle egenskaper NO322614B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19946301A DE19946301A1 (de) 1998-04-02 1999-09-28 Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
PCT/EP2000/009390 WO2001022954A2 (de) 1999-09-28 2000-09-26 Indolyl-3-glyoxylsäurederivate als antitumormittel

Publications (3)

Publication Number Publication Date
NO20021367D0 NO20021367D0 (no) 2002-03-19
NO20021367L NO20021367L (no) 2002-05-22
NO322614B1 true NO322614B1 (no) 2006-11-06

Family

ID=7923485

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021367A NO322614B1 (no) 1999-09-28 2002-03-19 Indolyl-3-glykosylsyrederivater som har terapeutisk verdifulle egenskaper

Country Status (32)

Country Link
EP (1) EP1218006B1 (sr)
JP (1) JP2003510274A (sr)
KR (1) KR100759242B1 (sr)
CN (1) CN1301712C (sr)
AR (1) AR025885A1 (sr)
AT (1) ATE459356T1 (sr)
AU (1) AU783436B2 (sr)
BG (1) BG106639A (sr)
BR (1) BR0014378A (sr)
CA (1) CA2386069C (sr)
CZ (1) CZ303246B6 (sr)
DE (1) DE50015879D1 (sr)
DZ (1) DZ3196A1 (sr)
EE (1) EE200200169A (sr)
ES (1) ES2342042T3 (sr)
GE (1) GEP20043250B (sr)
HK (1) HK1048941B (sr)
HR (1) HRP20020369A2 (sr)
HU (1) HUP0202788A3 (sr)
IL (2) IL148670A0 (sr)
IS (1) IS6319A (sr)
MX (1) MXPA02002824A (sr)
NO (1) NO322614B1 (sr)
NZ (1) NZ517988A (sr)
PL (1) PL199576B1 (sr)
RS (1) RS51302B (sr)
RU (1) RU2282444C2 (sr)
SK (1) SK287533B6 (sr)
TW (1) TWI269654B (sr)
UA (1) UA75872C2 (sr)
WO (1) WO2001022954A2 (sr)
ZA (1) ZA200202556B (sr)

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DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
AU2001258628A1 (en) 2000-05-31 2001-12-11 Astrazeneca Ab Indole derivatives with vascular damaging activity
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP1595878A1 (de) * 2004-05-15 2005-11-16 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
EP1641777A1 (de) * 2003-06-05 2006-04-05 Zentaris GmbH Indolderivate mit apoptose induzierender wirkung
EP1484329A1 (de) * 2003-06-06 2004-12-08 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
EP3461813A1 (en) * 2004-05-23 2019-04-03 Gerard M. Housey Theramutein modulators
ES2424255T3 (es) * 2004-11-08 2013-09-30 Baxter International Inc. Composiciones particuladas de inhibidores de tubulina
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
CA2605214C (en) 2004-12-31 2016-07-12 Reddy Us Therapeutics, Inc. Benzylamine derivatives as cetp inhibitors
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
CA2670778A1 (en) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
EP2744803A2 (en) 2011-08-18 2014-06-25 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors
MX352074B (es) 2011-09-27 2017-11-08 Dr Reddys Laboratories Ltd Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis.
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
EP2972394A4 (en) 2013-03-15 2016-11-02 Sloan Kettering Inst Cancer HSP90-DESIGNING AND THERAPY
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN109111501B (zh) * 2017-06-23 2022-04-22 首都医科大学 脂肪氨基酸修饰的吲哚乙醇衍生物, 其合成，活性和应用
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
RU2047603C1 (ru) * 1991-12-09 1995-11-10 Матвей Абрамович Рехтер 1-алкил-2-ацилиндолы и способы их получения
NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
WO1994008581A1 (fr) * 1992-10-20 1994-04-28 Toray Industries, Inc. Inhibiteur d'infiltration d'eosinophiles
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
CA2286038A1 (en) 1997-04-08 1998-10-15 Banyu Pharmaceutical Co., Ltd. Cancerous metastasis-associated gene
SK12752000A3 (sk) * 1998-02-25 2001-03-12 Genetics Institute, Inc. Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie
WO1999046237A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
PL198983B1 (pl) * 1998-04-28 2008-08-29 Elbion Ag Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 oraz sposoby ich wytwarzania
JP2000239252A (ja) * 1999-02-16 2000-09-05 Mitsubishi Chemicals Corp インドール誘導体
WO2000067802A1 (en) * 1999-05-10 2000-11-16 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof

Also Published As

Publication number Publication date
HK1048941B (zh) 2007-09-21
KR100759242B1 (ko) 2007-09-18
AU783436B2 (en) 2005-10-27
CZ303246B6 (cs) 2012-06-20
CN1301712C (zh) 2007-02-28
NO20021367L (no) 2002-05-22
NZ517988A (en) 2004-10-29
KR20030019295A (ko) 2003-03-06
HK1048941A1 (en) 2003-04-25
HRP20020369A2 (en) 2004-12-31
CZ20021005A3 (cs) 2004-01-14
UA75872C2 (en) 2006-06-15
YU22702A (sh) 2004-12-31
EP1218006B1 (de) 2010-03-03
PL199576B1 (pl) 2008-10-31
HUP0202788A3 (en) 2003-02-28
IL148670A0 (en) 2002-09-12
DZ3196A1 (fr) 2001-04-05
BG106639A (bg) 2002-12-29
MXPA02002824A (es) 2003-07-21
SK4072002A3 (en) 2003-11-04
DE50015879D1 (de) 2010-04-15
EP1218006A2 (de) 2002-07-03
AU7782900A (en) 2001-04-30
ES2342042T3 (es) 2010-07-01
NO20021367D0 (no) 2002-03-19
TWI269654B (en) 2007-01-01
IL148670A (en) 2009-09-01
HUP0202788A2 (hu) 2003-01-28
ATE459356T1 (de) 2010-03-15
CA2386069A1 (en) 2001-04-05
RU2282444C2 (ru) 2006-08-27
PL364811A1 (en) 2004-12-13
ZA200202556B (en) 2003-08-27
JP2003510274A (ja) 2003-03-18
WO2001022954A2 (de) 2001-04-05
WO2001022954A3 (de) 2002-03-28
EE200200169A (et) 2003-04-15
CA2386069C (en) 2012-08-14
SK287533B6 (sk) 2011-01-04
RS51302B (sr) 2010-12-31
GEP20043250B (en) 2004-06-25
BR0014378A (pt) 2003-07-29
IS6319A (is) 2002-03-21
AR025885A1 (es) 2002-12-18
CN1376064A (zh) 2002-10-23

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