NO323933B1 - Stabil ikke-vandig formulering av en peptidforbindelse, fremgangsmate for fremstilling av denne og anvendelse av formuleringen til fremstillig av medikament. - Google Patents

Stabil ikke-vandig formulering av en peptidforbindelse, fremgangsmate for fremstilling av denne og anvendelse av formuleringen til fremstillig av medikament. Download PDF

Info

Publication number: NO323933B1
Authority: NO; Norway
Prior art keywords: leuprolide; formulation; formulations; peptide compound; aqueous
Prior art date: 1996-07-03

Application number

NO19986209A

Other languages

English (en)

Norwegian (no)

Other versions

NO986209D0 (no

NO986209L (no

Inventor

Jeremy Corwin Wright

Cynthia L Stevenson

Steven J Prestrelski

Sally Tao

Joe Leonard

James B Eckenhoff

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-03

Filing date

1998-12-30

Publication date

2007-07-23

1998-12-30 Application filed by Alza Corp filed Critical Alza Corp

1998-12-30 Publication of NO986209D0 publication Critical patent/NO986209D0/no

1998-12-30 Publication of NO986209L publication Critical patent/NO986209L/no

2007-07-23 Publication of NO323933B1 publication Critical patent/NO323933B1/no

Links

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CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 1
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BLCLNMBMMGCOAS-UHFFFAOYSA-N n-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amin Chemical compound C1CCC(C(=O)NNC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 BLCLNMBMMGCOAS-UHFFFAOYSA-N 0.000 description 1
PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 description 1
229910052757 nitrogen Chemical group 0.000 description 1
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150000007524 organic acids Chemical class 0.000 description 1
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150000007530 organic bases Chemical class 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
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239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
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208000006155 precocious puberty Diseases 0.000 description 1
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239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
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NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
229960000553 somatostatin Drugs 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
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238000007920 subcutaneous administration Methods 0.000 description 1
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239000007929 subcutaneous injection Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
238000003260 vortexing Methods 0.000 description 1
229940033942 zoladex Drugs 0.000 description 1
NXSIJWJXMWBCBX-NWKQFZAZSA-N α-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 NXSIJWJXMWBCBX-NWKQFZAZSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gynecology & Obstetrics (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

NO19986209A 1996-07-03 1998-12-30 Stabil ikke-vandig formulering av en peptidforbindelse, fremgangsmate for fremstilling av denne og anvendelse av formuleringen til fremstillig av medikament. NO323933B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2112996P	1996-07-03	1996-07-03
PCT/US1997/010815 WO1998000152A1 (en)	1996-07-03	1997-07-01	Non-aqueous protic peptide formulations

Publications (3)

Publication Number	Publication Date
NO986209D0 NO986209D0 (no)	1998-12-30
NO986209L NO986209L (no)	1998-12-30
NO323933B1 true NO323933B1 (no)	2007-07-23

Family

ID=21802501

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19986209A NO323933B1 (no)	1996-07-03	1998-12-30	Stabil ikke-vandig formulering av en peptidforbindelse, fremgangsmate for fremstilling av denne og anvendelse av formuleringen til fremstillig av medikament.

Country Status (27)

Country	Link
EP (1)	EP0909175B1 (de)
JP (3)	JP2001504802A (de)
CN (1)	CN1231256C (de)
AR (1)	AR008060A1 (de)
AT (1)	ATE241997T1 (de)
AU (1)	AU737664B2 (de)
BR (1)	BR9710130A (de)
CA (1)	CA2259403A1 (de)
CO (1)	CO4890854A1 (de)
CZ (1)	CZ433898A3 (de)
DE (1)	DE69722620T2 (de)
DK (1)	DK0909175T3 (de)
ES (1)	ES2201306T3 (de)
HU (1)	HUP9903942A3 (de)
ID (1)	ID19165A (de)
IL (1)	IL127769A (de)
MY (1)	MY121684A (de)
NO (1)	NO323933B1 (de)
NZ (1)	NZ333580A (de)
PL (1)	PL189402B1 (de)
PT (1)	PT909175E (de)
RO (1)	RO119862B1 (de)
RU (1)	RU2203085C2 (de)
SK (1)	SK284490B6 (de)
TW (1)	TW491703B (de)
WO (1)	WO1998000152A1 (de)
ZA (1)	ZA975942B (de)

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US20040247671A1 (en) *	2003-04-25	2004-12-09	Prescott James H.	Solid drug formulation and device for storage and controlled delivery thereof
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US11246913B2 (en)	2005-02-03	2022-02-15	Intarcia Therapeutics, Inc.	Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en)	2005-02-03	2006-08-10	Alza Corporation	Solvent/polymer solutions as suspension vehicles
EP2020990B1 (de)	2006-05-30	2010-09-22	Intarcia Therapeutics, Inc	Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem
PL2359808T3 (pl)	2006-08-09	2013-10-31	Intarcia Therapeutics Inc	Osmotyczne systemy dostawcze i zespoły tłokowe
AU2013203271B2 (en) *	2007-01-19	2016-05-12	Hananja Ehf	Methods and compositions for the delivery of a therapeutic agent
EP2121025B1 (de) *	2007-01-19	2016-11-02	Hananja Ehf	Verfahren und zusammensetzungen zur abgabe eines therapeutischen mittels
US20080275030A1 (en)	2007-01-19	2008-11-06	Sveinbjorn Gizurarson	Methods and Compositions for the Delivery of a Therapeutic Agent
EP2157967B1 (de)	2007-04-23	2013-01-16	Intarcia Therapeutics, Inc	Suspensionsformulierungen insulinotroper peptide und ihre verwendung
EP2170283B1 (de)	2007-06-22	2019-01-09	Board of Regents, The University of Texas System	Bildung eines stabilen submikron-peptids oder von proteinteilchen durch dünnfilm-gefrieren
EP2240155B1 (de)	2008-02-13	2012-06-06	Intarcia Therapeutics, Inc	Vorrichtungen, formulierungen und verfahren zur freisetzung mehrerer wirkstoffe
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RS60101B1 (sr)	2008-08-15	2020-05-29	Ironwood Pharmaceuticals Inc	Formulacije koje sadrže linaklotid za oralnu primenu
US8779094B2 (en)	2008-11-16	2014-07-15	Board Of Regents, The University Of Texas System	Low viscosity highly concentrated suspensions
US8748573B2 (en)	2009-08-06	2014-06-10	Ironwood Pharmaceuticals, Inc.	Formulations comprising linaclotide
EP3323423B1 (de)	2009-09-28	2020-06-17	Intarcia Therapeutics, Inc	Schnelle initiierung und/oder beendigung der verabreichung substantiell stabiler arzneimittel
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CN104053449B (zh)	2011-08-17	2016-12-07	硬木药品公司	胃肠疾患的治疗
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US9956287B2 (en)	2013-02-06	2018-05-01	Perosphere Inc.	Stable glucagon formulations
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BR112020002804A2 (pt)	2017-08-24	2020-07-28	Novo Nordisk A/S	composição farmacêutica líquida, e, kit
IL294521A (en)	2020-02-18	2022-09-01	Novo Nordisk As	glp-1 compounds and their uses
EP4648229A3 (de)	2021-03-01	2026-02-18	Stryker Corporation	Echtzeit-fräs-frassvibrationskompensation bei chirurgischen fräsarbeiten

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1997
- 1997-07-01 BR BR9710130A patent/BR9710130A/pt not_active Application Discontinuation
- 1997-07-01 CN CNB971960534A patent/CN1231256C/zh not_active Expired - Fee Related
- 1997-07-01 HU HU9903942A patent/HUP9903942A3/hu unknown
- 1997-07-01 AU AU34073/97A patent/AU737664B2/en not_active Ceased
- 1997-07-01 NZ NZ333580A patent/NZ333580A/en not_active IP Right Cessation
- 1997-07-01 RO RO98-01769A patent/RO119862B1/ro unknown
- 1997-07-01 JP JP50421898A patent/JP2001504802A/ja not_active Withdrawn
- 1997-07-01 ES ES97930181T patent/ES2201306T3/es not_active Expired - Lifetime
- 1997-07-01 CZ CZ984338A patent/CZ433898A3/cs unknown
- 1997-07-01 EP EP97930181A patent/EP0909175B1/de not_active Expired - Lifetime
- 1997-07-01 RU RU99102540/14A patent/RU2203085C2/ru not_active IP Right Cessation
- 1997-07-01 WO PCT/US1997/010815 patent/WO1998000152A1/en not_active Ceased
- 1997-07-01 AT AT97930181T patent/ATE241997T1/de active
- 1997-07-01 IL IL127769A patent/IL127769A/en not_active IP Right Cessation
- 1997-07-01 SK SK1799-98A patent/SK284490B6/sk not_active IP Right Cessation
- 1997-07-01 CA CA002259403A patent/CA2259403A1/en not_active Abandoned
- 1997-07-01 DK DK97930181T patent/DK0909175T3/da active
- 1997-07-01 PL PL97330869A patent/PL189402B1/pl not_active IP Right Cessation
- 1997-07-01 PT PT97930181T patent/PT909175E/pt unknown
- 1997-07-01 DE DE69722620T patent/DE69722620T2/de not_active Expired - Lifetime
- 1997-07-02 AR ARP970102967A patent/AR008060A1/es unknown
- 1997-07-03 MY MYPI97003024A patent/MY121684A/en unknown
- 1997-07-03 ZA ZA9705942A patent/ZA975942B/xx unknown
- 1997-07-03 ID IDP972315A patent/ID19165A/id unknown
- 1997-07-03 CO CO97037097A patent/CO4890854A1/es unknown
- 1997-08-22 TW TW086109392A patent/TW491703B/zh not_active IP Right Cessation
1998
- 1998-12-30 NO NO19986209A patent/NO323933B1/no not_active IP Right Cessation
2008
- 2008-04-23 JP JP2008112307A patent/JP2008195739A/ja active Pending
2009
- 2009-10-05 JP JP2009231256A patent/JP2010043105A/ja active Pending

Also Published As

Publication number	Publication date
DE69722620T2 (de)	2004-04-29
HUP9903942A2 (hu)	2000-04-28
WO1998000152A1 (en)	1998-01-08
NZ333580A (en)	2000-06-23
IL127769A0 (en)	1999-10-28
DE69722620D1 (de)	2003-07-10
IL127769A (en)	2006-10-31
NO986209D0 (no)	1998-12-30
JP2010043105A (ja)	2010-02-25
CA2259403A1 (en)	1998-01-08
JP2008195739A (ja)	2008-08-28
RO119862B1 (ro)	2005-05-30
NO986209L (no)	1998-12-30
PL330869A1 (en)	1999-06-07
ZA975942B (en)	1998-04-16
ATE241997T1 (de)	2003-06-15
HUP9903942A3 (en)	2000-07-28
DK0909175T3 (da)	2003-09-29
JP2001504802A (ja)	2001-04-10
CN1224356A (zh)	1999-07-28
SK179998A3 (en)	1999-05-07
PT909175E (pt)	2003-10-31
BR9710130A (pt)	1999-08-10
ID19165A (id)	1998-06-28
TW491703B (en)	2002-06-21
RU2203085C2 (ru)	2003-04-27
ES2201306T3 (es)	2004-03-16
AU737664B2 (en)	2001-08-30
PL189402B1 (pl)	2005-08-31
CO4890854A1 (es)	2000-02-28
MY121684A (en)	2006-02-28
CZ433898A3 (cs)	1999-04-14
AR008060A1 (es)	1999-12-09
AU3407397A (en)	1998-01-21
CN1231256C (zh)	2005-12-14
SK284490B6 (sk)	2005-05-05
EP0909175A1 (de)	1999-04-21
EP0909175B1 (de)	2003-06-04

Legal Events

Date	Code	Title	Description
2013-03-11	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP0909175B1 (de)	2003-06-04	Nicht-waessrige protische peptidzubereitungen
EP0909177B1 (de)	2004-02-11	Wässrige peptidzubereitung
EP1208846B1 (de)	2004-04-07	Nichtwässrige polar-aprotische Peptidformulierungen enthaltend LHRH-verwandte Verbindungen
US5981489A (en)	1999-11-09	Non-aqueous protic peptide formulations
AU2004242540B2 (en)	2007-12-13	Aqueous formulations of peptides
KR100594519B1 (ko)	2007-03-02	비수성양성자성펩티드제제
AU775395B2 (en)	2004-07-29	Non-aqueous polar aprotic peptide formulations
HK1124244A (en)	2009-07-10	Non-aqueous polar aprotic peptide formulations