NO324868B1 - Oksadiazolderivater som har anticancer-effekt samt farmasoytisk preparat - Google Patents

Oksadiazolderivater som har anticancer-effekt samt farmasoytisk preparat Download PDF

Info

Publication number: NO324868B1
Authority: NO; Norway
Prior art keywords: compound; pharmaceutical preparation; mmp; acid; stated
Prior art date: 2000-04-21

Application number

NO20025035A

Other languages

English (en)

Norwegian (no)

Other versions

NO20025035L (no

NO20025035D0 (no

Inventor

Fumihiko Watanabe

Takayuki Yoshioka

Ryuji Maekawa

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-21

Filing date

2002-10-18

Publication date

2007-12-17

2002-10-18 Application filed by Shionogi & Co filed Critical Shionogi & Co

2002-10-18 Publication of NO20025035D0 publication Critical patent/NO20025035D0/no

2002-12-19 Publication of NO20025035L publication Critical patent/NO20025035L/no

2007-12-17 Publication of NO324868B1 publication Critical patent/NO324868B1/no

Links

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229910021645 metal ion Inorganic materials 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
125000006203 morpholinoethyl group Chemical group [H]C([H])(*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000010187 selection method Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000003797 solvolysis reaction Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000001665 trituration Methods 0.000 description 1
210000003462 vein Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO20025035A 2000-04-21 2002-10-18 Oksadiazolderivater som har anticancer-effekt samt farmasoytisk preparat NO324868B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2000120234		2000-04-21
PCT/JP2001/003214 WO2001083463A1 (en)	2000-04-21	2001-04-16	Oxadiazole derivatives having anticancer effects

Publications (3)

Publication Number	Publication Date
NO20025035D0 NO20025035D0 (no)	2002-10-18
NO20025035L NO20025035L (no)	2002-12-19
NO324868B1 true NO324868B1 (no)	2007-12-17

Family

ID=18631080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20025035A NO324868B1 (no)	2000-04-21	2002-10-18	Oksadiazolderivater som har anticancer-effekt samt farmasoytisk preparat

Country Status (16)

Country	Link
US (2)	US6720343B2 (2)
EP (1)	EP1277744A4 (2)
JP (1)	JP3974781B2 (2)
KR (1)	KR100542780B1 (2)
CN (1)	CN1199956C (2)
AU (2)	AU4691601A (2)
BR (1)	BR0110211A (2)
CA (1)	CA2406685C (2)
HU (1)	HUP0300619A3 (2)
MX (1)	MXPA02010325A (2)
NO (1)	NO324868B1 (2)
PL (1)	PL203161B1 (2)
RU (1)	RU2275371C2 (2)
TW (1)	TWI294877B (2)
WO (1)	WO2001083463A1 (2)
ZA (1)	ZA200208307B (2)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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US20030105144A1 (en)	2001-04-17	2003-06-05	Ping Gao	Stabilized oral pharmaceutical composition
US7825146B2 (en) *	2003-07-30	2010-11-02	Shionogi & Co., Ltd.	Sulfonamide derivative having isoxazole ring
AU2005299851B2 (en) *	2004-10-22	2011-03-17	Merck Sharp & Dohme Corp.	2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists
US7576222B2 (en)	2004-12-28	2009-08-18	Wyeth	Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase
GB0601744D0 (en) *	2006-01-27	2006-03-08	Novartis Ag	Organic compounds
EA200802058A1 (ru) *	2006-05-09	2009-06-30	Пфайзер Продактс Инк.	Производные циклоалкиламинокислот и их фармацевтические композиции
KR100783585B1 (ko)	2006-08-22	2007-12-07	한국생명공학연구원	스탯의 활성을 저해하는 옥사다이아졸 우레아 화합물을 유효성분으로 함유하는 암의 예방 또는 치료제
AU2008293542B9 (en)	2007-08-27	2014-08-07	Dart Neuroscience (Cayman) Ltd.	Therapeutic isoxazole compounds
EP2222667B1 (en) *	2007-12-10	2013-02-20	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as agonists of s1p1/edg1
UY32858A (es)	2009-08-31	2011-03-31	Abbott Healthcare Products Bv	Derivados de (tio)morfolina como moduladores de sip
RU2415845C1 (ru) *	2009-10-14	2011-04-10	Государственное образовательное учреждение высшего профессионального образования "Астраханский государственный университет" (АГУ)	Сульфонные производные 2-нитро-2-(3-арил-1,2,4-оксадиазол-5-ил)этана, обладающие противолепрозной и противотуберкулезной активностью
TW201643169A (zh)	2010-07-09	2016-12-16	艾伯維股份有限公司	作為s1p調節劑的螺-哌啶衍生物
TW201206893A (en)	2010-07-09	2012-02-16	Abbott Healthcare Products Bv	Bisaryl (thio) morpholine derivatives as S1P modulators
TWI522361B (zh)	2010-07-09	2016-02-21	艾伯維公司	作為s1p調節劑的稠合雜環衍生物
CN103450167A (zh) *	2012-05-28	2013-12-18	南京大学	一类含1,3,4-噁二唑和吡嗪环的酰腙类衍生物及其制备方法与用途
US10710994B2 (en) *	2018-03-19	2020-07-14	Genentech, Inc.	Oxadiazole transient receptor potential channel inhibitors
CN114728982A (zh)	2019-10-31	2022-07-08	逃逸生物有限公司	固体形式的s1p-受体调节剂
CN113264899B (zh) *	2021-04-09	2022-06-14	台州学院	一种1，3，5-噁二嗪类化合物及其制备和应用

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CA2297011C (en) *	1997-07-22	2007-01-30	Shionogi & Co., Ltd.	Sulfonamide derivatives as therapeutic or prophylactic agent for glomerulopathy
WO2000015213A1 (en) *	1998-09-11	2000-03-23	Shionogi & Co., Ltd.	Remedal or preventive agent for congestive heart failure

2001
- 2001-04-16 CA CA002406685A patent/CA2406685C/en not_active Expired - Fee Related
- 2001-04-16 US US10/257,917 patent/US6720343B2/en not_active Expired - Fee Related
- 2001-04-16 JP JP2001580892A patent/JP3974781B2/ja not_active Expired - Fee Related
- 2001-04-16 MX MXPA02010325A patent/MXPA02010325A/es active IP Right Grant
- 2001-04-16 HU HU0300619A patent/HUP0300619A3/hu unknown
- 2001-04-16 AU AU4691601A patent/AU4691601A/xx active Pending
- 2001-04-16 RU RU2002130247/04A patent/RU2275371C2/ru not_active IP Right Cessation
- 2001-04-16 PL PL359415A patent/PL203161B1/pl not_active IP Right Cessation
- 2001-04-16 BR BR0110211-7A patent/BR0110211A/pt not_active IP Right Cessation
- 2001-04-16 EP EP01919938A patent/EP1277744A4/en not_active Withdrawn
- 2001-04-16 CN CNB018112404A patent/CN1199956C/zh not_active Expired - Fee Related
- 2001-04-16 AU AU2001246916A patent/AU2001246916B2/en not_active Ceased
- 2001-04-16 WO PCT/JP2001/003214 patent/WO2001083463A1/ja not_active Ceased
- 2001-04-16 KR KR1020027013969A patent/KR100542780B1/ko not_active Expired - Fee Related
- 2001-04-19 TW TW090109406A patent/TWI294877B/zh not_active IP Right Cessation
2002
- 2002-10-15 ZA ZA200208307A patent/ZA200208307B/xx unknown
- 2002-10-18 NO NO20025035A patent/NO324868B1/no not_active IP Right Cessation
2003
- 2003-12-10 US US10/730,946 patent/US20040122066A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1436179A (zh)	2003-08-13
US6720343B2 (en)	2004-04-13
CA2406685C (en)	2006-10-31
US20030203940A1 (en)	2003-10-30
AU4691601A (en)	2001-11-12
KR20030019357A (ko)	2003-03-06
NO20025035L (no)	2002-12-19
EP1277744A4 (en)	2007-07-11
RU2275371C2 (ru)	2006-04-27
US20040122066A1 (en)	2004-06-24
EP1277744A1 (en)	2003-01-22
BR0110211A (pt)	2003-06-03
NO20025035D0 (no)	2002-10-18
CA2406685A1 (en)	2002-10-17
TWI294877B (2)	2008-03-21
AU2001246916B2 (en)	2004-10-07
CN1199956C (zh)	2005-05-04
HUP0300619A3 (en)	2006-02-28
ZA200208307B (en)	2003-10-15
HUP0300619A2 (hu)	2003-07-28
PL203161B1 (pl)	2009-08-31
MXPA02010325A (es)	2003-04-25
PL359415A1 (en)	2004-08-23
WO2001083463A1 (en)	2001-11-08
KR100542780B1 (ko)	2006-01-11
JP3974781B2 (ja)	2007-09-12

Legal Events

Date	Code	Title	Description
2012-11-26	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO324868B1 (no)	2007-12-17	Oksadiazolderivater som har anticancer-effekt samt farmasoytisk preparat
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