NO324975B1 - Torre analytiske elementer for bestemmelse av protein, samt fremgangsmate for a male protein. - Google Patents

Torre analytiske elementer for bestemmelse av protein, samt fremgangsmate for a male protein. Download PDF

Info

Publication number: NO324975B1
Authority: NO; Norway
Prior art keywords: protein; dye; polymer; dry analytical; acrylamide
Prior art date: 1997-05-06

Application number

NO19982026A

Other languages

English (en)

Norwegian (no)

Other versions

NO982026D0 (no

NO982026L (no

Inventor

Thomas Arter

David B Latart

John C Mauck

James R Schaeffer

Richard C Sutton

Ii Wayne W Weber

Robert F Winterkorn

Original Assignee

Ortho Clinical Diagnostics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-06

Filing date

1998-05-05

Publication date

2008-01-14

1998-05-05 Application filed by Ortho Clinical Diagnostics Inc filed Critical Ortho Clinical Diagnostics Inc

1998-05-05 Publication of NO982026D0 publication Critical patent/NO982026D0/no

1998-11-09 Publication of NO982026L publication Critical patent/NO982026L/no

2008-01-14 Publication of NO324975B1 publication Critical patent/NO324975B1/no

Links

102000004169 proteins and genes Human genes 0.000 title claims abstract description 133
108090000623 proteins and genes Proteins 0.000 title claims abstract description 133
238000000034 method Methods 0.000 title claims description 22
229920000642 polymer Polymers 0.000 claims abstract description 40
MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 claims abstract description 30
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims abstract description 25
230000008859 change Effects 0.000 claims abstract description 16
238000010521 absorption reaction Methods 0.000 claims abstract description 15
230000003595 spectral effect Effects 0.000 claims abstract description 10
239000012530 fluid Substances 0.000 claims description 40
239000006185 dispersion Substances 0.000 claims description 24
HGPSVOAVAYJEIJ-XDHOZWIPSA-N 2-[(e)-(3,4-dihydroxyphenyl)-(3-hydroxy-4-oxoniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzenesulfonate Chemical compound C1=CC(=O)C(O)=C\C1=C(C=1C(=CC=CC=1)S(O)(=O)=O)/C1=CC=C(O)C(O)=C1 HGPSVOAVAYJEIJ-XDHOZWIPSA-N 0.000 claims description 18
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 16
APUPEJJSWDHEBO-UHFFFAOYSA-P ammonium molybdate Chemical group [NH4+].[NH4+].[O-][Mo]([O-])(=O)=O APUPEJJSWDHEBO-UHFFFAOYSA-P 0.000 claims description 9
235000018660 ammonium molybdate Nutrition 0.000 claims description 9
239000011609 ammonium molybdate Substances 0.000 claims description 9
229940010552 ammonium molybdate Drugs 0.000 claims description 9
KUQNCHZOCSYKOR-UHFFFAOYSA-N 1,1-dioxospiro[2,1$l^{6}-benzoxathiole-3,9'-xanthene]-3',4',5',6'-tetrol Chemical compound O1S(=O)(=O)C2=CC=CC=C2C21C1=CC=C(O)C(O)=C1OC1=C(O)C(O)=CC=C21 KUQNCHZOCSYKOR-UHFFFAOYSA-N 0.000 claims description 7
229910052751 metal Inorganic materials 0.000 claims description 7
239000002184 metal Substances 0.000 claims description 7
229920003169 water-soluble polymer Polymers 0.000 claims description 7
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
RUDINRUXCKIXAJ-UHFFFAOYSA-N 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,14-heptacosafluorotetradecanoic acid Chemical compound OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F RUDINRUXCKIXAJ-UHFFFAOYSA-N 0.000 claims description 4
238000002835 absorbance Methods 0.000 claims description 4
PHLYOKFVXIVOJC-UHFFFAOYSA-N gallein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C(O)=C1OC1=C(O)C(O)=CC=C21 PHLYOKFVXIVOJC-UHFFFAOYSA-N 0.000 claims description 4
229910052755 nonmetal Inorganic materials 0.000 claims description 4
150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
150000002500 ions Chemical class 0.000 claims description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract description 15
238000003556 assay Methods 0.000 abstract description 11
150000001875 compounds Chemical class 0.000 abstract description 5
239000000975 dye Substances 0.000 description 37
210000002700 urine Anatomy 0.000 description 28
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 20
239000003153 chemical reaction reagent Substances 0.000 description 18
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 16
238000004458 analytical method Methods 0.000 description 13
-1 molybdenum cations Chemical class 0.000 description 12
239000000243 solution Substances 0.000 description 11
YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 10
230000003287 optical effect Effects 0.000 description 10
230000035945 sensitivity Effects 0.000 description 10
239000003086 colorant Substances 0.000 description 9
102000009027 Albumins Human genes 0.000 description 8
108010088751 Albumins Proteins 0.000 description 8
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 8
229920002401 polyacrylamide Polymers 0.000 description 8
239000000126 substance Substances 0.000 description 8
238000001514 detection method Methods 0.000 description 7
238000005259 measurement Methods 0.000 description 7
238000012360 testing method Methods 0.000 description 7
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
125000003118 aryl group Chemical group 0.000 description 6
239000000872 buffer Substances 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 6
230000000694 effects Effects 0.000 description 6
239000007788 liquid Substances 0.000 description 6
229910021645 metal ion Inorganic materials 0.000 description 6
239000000203 mixture Substances 0.000 description 6
239000004094 surface-active agent Substances 0.000 description 6
102000008100 Human Serum Albumin Human genes 0.000 description 5
108091006905 Human Serum Albumin Proteins 0.000 description 5
239000013060 biological fluid Substances 0.000 description 5
OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 5
239000011248 coating agent Substances 0.000 description 5
239000000463 material Substances 0.000 description 5
229910052750 molybdenum Inorganic materials 0.000 description 5
239000011733 molybdenum Substances 0.000 description 5
238000011002 quantification Methods 0.000 description 5
239000000758 substrate Substances 0.000 description 5
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
238000007792 addition Methods 0.000 description 4
238000000576 coating method Methods 0.000 description 4
239000010949 copper Substances 0.000 description 4
102000004196 processed proteins & peptides Human genes 0.000 description 4
108090000765 processed proteins & peptides Proteins 0.000 description 4
230000007480 spreading Effects 0.000 description 4
238000003892 spreading Methods 0.000 description 4
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 4
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
238000000862 absorption spectrum Methods 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
125000000524 functional group Chemical group 0.000 description 3
229920001519 homopolymer Polymers 0.000 description 3
238000011534 incubation Methods 0.000 description 3
210000002966 serum Anatomy 0.000 description 3
238000001228 spectrum Methods 0.000 description 3
235000002906 tartaric acid Nutrition 0.000 description 3
239000011975 tartaric acid Substances 0.000 description 3
VAPDZNUFNKUROY-UHFFFAOYSA-N 2,4,6-triiodophenol Chemical compound OC1=C(I)C=C(I)C=C1I VAPDZNUFNKUROY-UHFFFAOYSA-N 0.000 description 2
BWLBGMIXKSTLSX-UHFFFAOYSA-N 2-hydroxyisobutyric acid Chemical compound CC(C)(O)C(O)=O BWLBGMIXKSTLSX-UHFFFAOYSA-N 0.000 description 2
QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
238000012801 analytical assay Methods 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
210000001175 cerebrospinal fluid Anatomy 0.000 description 2
239000003638 chemical reducing agent Substances 0.000 description 2
150000004696 coordination complex Chemical class 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
125000004494 ethyl ester group Chemical group 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
239000011521 glass Substances 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
230000003993 interaction Effects 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
230000033001 locomotion Effects 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
235000006408 oxalic acid Nutrition 0.000 description 2
229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 2
229920001184 polypeptide Polymers 0.000 description 2
WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
238000004445 quantitative analysis Methods 0.000 description 2
230000009257 reactivity Effects 0.000 description 2
230000009467 reduction Effects 0.000 description 2
238000011160 research Methods 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
238000011282 treatment Methods 0.000 description 2
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
229910052721 tungsten Inorganic materials 0.000 description 2
239000010937 tungsten Substances 0.000 description 2
ULUZGMIUTMRARO-UHFFFAOYSA-N (carbamoylamino)urea Chemical compound NC(=O)NNC(N)=O ULUZGMIUTMRARO-UHFFFAOYSA-N 0.000 description 1
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
102000003839 Human Proteins Human genes 0.000 description 1
108090000144 Human Proteins Proteins 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
102000004895 Lipoproteins Human genes 0.000 description 1
108090001030 Lipoproteins Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000012620 biological material Substances 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
QFXYYBXMARTXHI-UHFFFAOYSA-N bromopyrogallol red Chemical compound O1S(=O)(=O)C2=CC=CC=C2C21C1=CC(Br)=C(O)C(O)=C1OC1=C(O)C(O)=C(Br)C=C21 QFXYYBXMARTXHI-UHFFFAOYSA-N 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
238000011109 contamination Methods 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
229910001431 copper ion Inorganic materials 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000008021 deposition Effects 0.000 description 1
238000001212 derivatisation Methods 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
230000005670 electromagnetic radiation Effects 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
239000000835 fiber Substances 0.000 description 1
239000011888 foil Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000006870 function Effects 0.000 description 1
OKISBDHRUPZLOC-UHFFFAOYSA-N gallin Chemical compound OC(=O)C1=CC=CC=C1C1C2=CC=C(O)C(O)=C2OC2=C(O)C(O)=CC=C21 OKISBDHRUPZLOC-UHFFFAOYSA-N 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000003349 gelling agent Substances 0.000 description 1
230000005484 gravity Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000003907 kidney function Effects 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 description 1
230000001926 lymphatic effect Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
239000002808 molecular sieve Substances 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
239000002245 particle Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
238000004094 preconcentration Methods 0.000 description 1
238000002203 pretreatment Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000002731 protein assay Methods 0.000 description 1
229940079877 pyrogallol Drugs 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000001055 reflectance spectroscopy Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
102000029752 retinol binding Human genes 0.000 description 1
108091000053 retinol binding Proteins 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000007423 screening assay Methods 0.000 description 1
239000000779 smoke Substances 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
241000894007 species Species 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
210000001179 synovial fluid Anatomy 0.000 description 1
229920001897 terpolymer Polymers 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000002235 transmission spectroscopy Methods 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6827—Total protein determination, e.g. albumin in urine
- G01N33/683—Total protein determination, e.g. albumin in urine involving metal ions

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Hematology (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
General Health & Medical Sciences (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Pathology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Bioinformatics & Computational Biology (AREA)
Biophysics (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

NO19982026A 1997-05-06 1998-05-05 Torre analytiske elementer for bestemmelse av protein, samt fremgangsmate for a male protein. NO324975B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4575497P	1997-05-06	1997-05-06

Publications (3)

Publication Number	Publication Date
NO982026D0 NO982026D0 (no)	1998-05-05
NO982026L NO982026L (no)	1998-11-09
NO324975B1 true NO324975B1 (no)	2008-01-14

Family

ID=21939692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19982026A NO324975B1 (no)	1997-05-06	1998-05-05	Torre analytiske elementer for bestemmelse av protein, samt fremgangsmate for a male protein.

Country Status (13)

Country	Link
EP (1)	EP0877251B1 (da)
JP (1)	JP4065355B2 (da)
KR (1)	KR100503562B1 (da)
CN (1)	CN1119656C (da)
AT (1)	ATE228655T1 (da)
AU (1)	AU727734B2 (da)
CA (1)	CA2236350C (da)
DE (1)	DE69809626T2 (da)
DK (1)	DK0877251T3 (da)
ES (1)	ES2187889T3 (da)
NO (1)	NO324975B1 (da)
PT (1)	PT877251E (da)
SI (1)	SI0877251T1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6046052A (en) *	1997-05-06	2000-04-04	Ortho Clinical Diagnostics, Inc.	Dry analytical elements for the determination of protein
EP1405080B1 (en)	2001-06-25	2008-03-26	Bayer Healthcare LLC	Total protein detection methods and devices at low ph
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1998
- 1998-04-30 CA CA002236350A patent/CA2236350C/en not_active Expired - Fee Related
- 1998-05-04 AU AU63795/98A patent/AU727734B2/en not_active Ceased
- 1998-05-05 EP EP98303483A patent/EP0877251B1/en not_active Expired - Lifetime
- 1998-05-05 DK DK98303483T patent/DK0877251T3/da active
- 1998-05-05 PT PT98303483T patent/PT877251E/pt unknown
- 1998-05-05 DE DE69809626T patent/DE69809626T2/de not_active Expired - Lifetime
- 1998-05-05 ES ES98303483T patent/ES2187889T3/es not_active Expired - Lifetime
- 1998-05-05 AT AT98303483T patent/ATE228655T1/de not_active IP Right Cessation
- 1998-05-05 SI SI9830333T patent/SI0877251T1/xx unknown
- 1998-05-05 NO NO19982026A patent/NO324975B1/no unknown
- 1998-05-06 CN CN98115107A patent/CN1119656C/zh not_active Expired - Fee Related
- 1998-05-06 JP JP12348298A patent/JP4065355B2/ja not_active Expired - Fee Related
- 1998-05-06 KR KR1019980016050A patent/KR100503562B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SI0877251T1 (en)	2003-04-30
AU727734B2 (en)	2000-12-21
EP0877251A1 (en)	1998-11-11
PT877251E (pt)	2003-04-30
EP0877251B1 (en)	2002-11-27
DK0877251T3 (da)	2003-03-10
DE69809626D1 (de)	2003-01-09
CA2236350C (en)	2007-05-15
NO982026D0 (no)	1998-05-05
JP4065355B2 (ja)	2008-03-26
DE69809626T2 (de)	2003-09-18
ES2187889T3 (es)	2003-06-16
AU6379598A (en)	1998-11-12
ATE228655T1 (de)	2002-12-15
NO982026L (no)	1998-11-09
KR100503562B1 (ko)	2006-02-13
JPH1151941A (ja)	1999-02-26
CN1119656C (zh)	2003-08-27
CN1209549A (zh)	1999-03-03
CA2236350A1 (en)	1998-11-06
HK1013204A1 (en)	1999-08-20
KR19980086765A (ko)	1998-12-05

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