NO326052B1 - Anvendelse av S-(-)-N-propargyl-1-aminoindamin eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament (a) for behandling av neurotrauma eller (b) for forbedring av hukommelsen hos en post-CHI-pasient. - Google Patents

Anvendelse av S-(-)-N-propargyl-1-aminoindamin eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament (a) for behandling av neurotrauma eller (b) for forbedring av hukommelsen hos en post-CHI-pasient. Download PDF

Info

Publication number: NO326052B1
Authority: NO; Norway
Prior art keywords: propargyl; drug; aminoindane; pai; patient
Prior art date: 1996-07-11

Application number

NO19990088A

Other languages

English (en)

Norwegian (no)

Other versions

NO990088L (no

NO990088D0 (no

Inventor

Sasson Cohen

Jeff Sterling

Moussa B H Youdim

John P M Finberg

Ruth Levy

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-11

Filing date

1999-01-08

Publication date

2008-09-08

1999-01-08 Application filed by Teva Pharma filed Critical Teva Pharma

1999-01-08 Publication of NO990088D0 publication Critical patent/NO990088D0/no

1999-03-10 Publication of NO990088L publication Critical patent/NO990088L/no

2008-09-08 Publication of NO326052B1 publication Critical patent/NO326052B1/no

Links

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239000007928 intraperitoneal injection Substances 0.000 description 1
239000013038 irreversible inhibitor Substances 0.000 description 1
208000037906 ischaemic injury Diseases 0.000 description 1
208000027905 limb weakness Diseases 0.000 description 1
231100000861 limb weakness Toxicity 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
210000003141 lower extremity Anatomy 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
210000004373 mandible Anatomy 0.000 description 1
239000003550 marker Substances 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
210000003657 middle cerebral artery Anatomy 0.000 description 1
230000009526 moderate injury Effects 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000003562 morphometric effect Effects 0.000 description 1
238000013425 morphometry Methods 0.000 description 1
230000004973 motor coordination Effects 0.000 description 1
RUOKEQAAGRXIBM-LBPRGKRZSA-N n-propargyl-1(s)-aminoindan Chemical compound C1=CC=C2[C@@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-LBPRGKRZSA-N 0.000 description 1
230000032405 negative regulation of neuron apoptotic process Effects 0.000 description 1
230000001537 neural effect Effects 0.000 description 1
230000004112 neuroprotection Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
210000001328 optic nerve Anatomy 0.000 description 1
238000003305 oral gavage Methods 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229960001779 pargyline Drugs 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
229960001412 pentobarbital Drugs 0.000 description 1
SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
229960001802 phenylephrine Drugs 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000008832 photodamage Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
230000005371 pilomotor reflex Effects 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
238000009101 premedication Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
JKANAVGODYYCQF-UHFFFAOYSA-N prop-2-yn-1-amine Chemical class NCC#C JKANAVGODYYCQF-UHFFFAOYSA-N 0.000 description 1
RAGBYXLIHQFIPK-UHFFFAOYSA-N prop-2-ynyl benzenesulfonate Chemical compound C#CCOS(=O)(=O)C1=CC=CC=C1 RAGBYXLIHQFIPK-UHFFFAOYSA-N 0.000 description 1
LJZPPWWHKPGCHS-UHFFFAOYSA-N propargyl chloride Chemical compound ClCC#C LJZPPWWHKPGCHS-UHFFFAOYSA-N 0.000 description 1
RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical group C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
210000005245 right atrium Anatomy 0.000 description 1
230000036280 sedation Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
230000009528 severe injury Effects 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
229960003732 tyramine Drugs 0.000 description 1
DZGWFCGJZKJUFP-UHFFFAOYSA-O tyraminium Chemical compound [NH3+]CCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-O 0.000 description 1
210000001364 upper extremity Anatomy 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
230000004580 weight loss Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19990088A 1996-07-11 1999-01-08 Anvendelse av S-(-)-N-propargyl-1-aminoindamin eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament (a) for behandling av neurotrauma eller (b) for forbedring av hukommelsen hos en post-CHI-pasient. NO326052B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL11883696A IL118836A (en)	1996-07-11	1996-07-11	Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan
PCT/IL1997/000205 WO1998002152A1 (en)	1996-07-11	1997-06-20	Pharmaceutical compositions comprising s-(-)-n-propargyl-1-amino indan

Publications (3)

Publication Number	Publication Date
NO990088D0 NO990088D0 (no)	1999-01-08
NO990088L NO990088L (no)	1999-03-10
NO326052B1 true NO326052B1 (no)	2008-09-08

Family

ID=11069065

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19990088A NO326052B1 (no)	1996-07-11	1999-01-08	Anvendelse av S-(-)-N-propargyl-1-aminoindamin eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament (a) for behandling av neurotrauma eller (b) for forbedring av hukommelsen hos en post-CHI-pasient.

Country Status (12)

Country	Link
US (1)	US6277886B1 (2)
EP (1)	EP0929298B1 (2)
JP (1)	JP4368421B2 (2)
CN (1)	CN1149985C (2)
AT (1)	ATE328590T1 (2)
AU (1)	AU3188097A (2)
CA (1)	CA2260037C (2)
DE (1)	DE69736066T2 (2)
HU (1)	HU226961B1 (2)
IL (1)	IL118836A (2)
NO (1)	NO326052B1 (2)
WO (1)	WO1998002152A1 (2)

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AU2005330504B2 (en)	2004-09-29	2010-10-28	Harbor Biosciences, Inc.	Steroid analogs and characterization and treatment methods
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US7572834B1 (en)	2005-12-06	2009-08-11	Teva Pharmaceutical Industries, Ltd.	Rasagiline formulations and processes for their preparation
ES2632638T3 (es)	2005-12-09	2017-09-14	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.	Ladostigilo de baja dosis para el tratamiento de la deficiencia cognitiva
ES2551481T3 (es)	2006-02-21	2015-11-19	Teva Pharmaceutical Industries, Ltd.	Uso de rasagilina para el tratamiento de atrofia multisistémica
TW200744576A (en)	2006-02-24	2007-12-16	Teva Pharma	Propargylated aminoindans, processes for preparation, and uses thereof
JP5769923B2 (ja)	2006-04-03	2015-08-26	テバファーマシューティカルインダストリーズリミティド	レストレスレッグス症候群の治療のためのラサギリンの使用
EP1892233A1 (de) *	2006-08-18	2008-02-27	Ratiopharm GmbH	Neue Salze des Wirkstoffs Rasagilin
CN101600346B (zh) *	2006-12-14	2013-08-21	泰华制药工业有限公司	雷沙吉兰的单宁酸盐
CN101557706B (zh) *	2006-12-14	2013-08-07	泰华制药工业有限公司	雷沙吉兰碱结晶固体
EP1987816A1 (de) *	2007-04-30	2008-11-05	Ratiopharm GmbH	Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
CA2698695A1 (en) *	2007-09-05	2009-03-12	Teva Pharmaceutical Industries Ltd.	Method of treating glaucoma using rasagiline
US8188149B2 (en) *	2007-09-17	2012-05-29	Teva Pharmaceutical Industries, Ltd.	Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
EP2234478A4 (en) *	2008-01-11	2013-01-23	Teva Pharma	RASAGILINE FORMULATIONS, THEIR PREPARATION AND USE
WO2009122351A2 (en) *	2008-04-01	2009-10-08	Kangwon National University	Anti-parkinsonian compounds mppe
WO2009151594A1 (en) *	2008-06-10	2009-12-17	Teva Pharmaceutical Industries, Ltd.	Rasagiline soft gelatin capsules
MX2010013766A (es) *	2008-06-13	2011-03-15	Teva Pharmaceutical Ind Ltd Star	Rasagilina para modificacion de enfermedad de parkinson.
US8334409B2 (en) *	2008-06-19	2012-12-18	Teva Pharmaceutical Industries, Ltd.	Process for purifying rasagiline base
BRPI0909997A2 (pt)	2008-06-19	2015-10-27	Teva Pharma	r(+)-n-propargil-1-aminoindano cristalino, composição farmacêutica, processo de secagem de r(+)-n-propargil-1-aminoindano sólido, processo de preparação de uma composição farmacêutica, processo de produção de um lote validado de um produto de farmaco que contém r(+)-n-propargil-1-aminoindano cristalino e pelo menos um veículo farmaceuticamente aceitável para distribuição e processo de prudução de r(+)-n-propargil-1-aminoindano cristalino
US20100189791A1 (en) *	2009-01-23	2010-07-29	Teva Pharmaceutical Industries, Ltd.	Delayed release rasagiline malate formulation
SI2451771T1 (sl)	2009-07-09	2014-10-30	Ratiopharm Gmbh	Soli rasagilina in njihovi farmacevtski pripravki
JP6045347B2 (ja)	2010-02-03	2016-12-14	ファーマツービーリミテッド	ラサギリンの持続放出性製剤およびその使用
AU2011282720B2 (en)	2010-07-27	2016-12-22	Teva Pharmaceutical Industries Ltd.	Use of rasagiline for the treatment of olfactory dysfunction
JP2013537530A (ja)	2010-07-27	2013-10-03	テバファーマシューティカルインダストリーズリミティド	ラサギリンシトレートの分散物
JP2014534197A (ja)	2011-10-10	2014-12-18	テバファーマシューティカルインダストリーズリミティド	Ｒ（＋）−ｎ−メチル−プロパルギルアミノインダン
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1996
- 1996-07-11 IL IL11883696A patent/IL118836A/xx not_active IP Right Cessation
1997
- 1997-06-20 AU AU31880/97A patent/AU3188097A/en not_active Abandoned
- 1997-06-20 AT AT97927353T patent/ATE328590T1/de not_active IP Right Cessation
- 1997-06-20 EP EP97927353A patent/EP0929298B1/en not_active Expired - Lifetime
- 1997-06-20 JP JP50580698A patent/JP4368421B2/ja not_active Expired - Lifetime
- 1997-06-20 CA CA002260037A patent/CA2260037C/en not_active Expired - Lifetime
- 1997-06-20 CN CNB971971994A patent/CN1149985C/zh not_active Expired - Lifetime
- 1997-06-20 DE DE69736066T patent/DE69736066T2/de not_active Expired - Lifetime
- 1997-06-20 WO PCT/IL1997/000205 patent/WO1998002152A1/en not_active Ceased
- 1997-06-20 HU HU9904525A patent/HU226961B1/hu unknown
1999
- 1999-01-08 NO NO19990088A patent/NO326052B1/no not_active IP Right Cessation
- 1999-01-11 US US09/228,153 patent/US6277886B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2260037C (en)	2007-01-23
JP2000514453A (ja)	2000-10-31
HUP9904525A2 (hu)	2000-11-28
IL118836A (en)	2001-01-11
US6277886B1 (en)	2001-08-21
EP0929298A1 (en)	1999-07-21
WO1998002152A1 (en)	1998-01-22
NO990088L (no)	1999-03-10
DE69736066D1 (de)	2006-07-20
IL118836A0 (en)	1996-10-31
CA2260037A1 (en)	1998-01-22
EP0929298B1 (en)	2006-06-07
ATE328590T1 (de)	2006-06-15
HU226961B1 (en)	2010-03-29
DE69736066T2 (de)	2006-12-28
NO990088D0 (no)	1999-01-08
CN1149985C (zh)	2004-05-19
AU3188097A (en)	1998-02-09
JP4368421B2 (ja)	2009-11-18
CN1227486A (zh)	1999-09-01
HUP9904525A3 (en)	2000-12-28

Legal Events

Date	Code	Title	Description
2017-07-10	MK1K	Patent expired

Publication	Publication Date	Title
NO326052B1 (no)	2008-09-08	Anvendelse av S-(-)-N-propargyl-1-aminoindamin eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament (a) for behandling av neurotrauma eller (b) for forbedring av hukommelsen hos en post-CHI-pasient.
KR100412154B1 (ko)	2004-07-05	N-프로파길-1-아미노인단의r-에난시오머,염,및그들의조성물의사용
US5891923A (en)	1999-04-06	R-enantiomer of N-propargyl-1-aminoindan for the treatment of dementia
CA2174449C (en)	2007-01-16	R-enantiomer of n-propargyl-1-aminoindan, salts, compositions and uses thereof
RU2197959C2 (ru)	2003-02-10	Применение аналогов сибутрамина для снижения уровней липидов
NO333987B1 (no)	2013-11-04	Anvendelse av (1S,2R)-enantiomeren av milnacipran for fremstillingen av et medikament
HUP0200026A2 (hu)	2002-05-29	Eljárás terhelés által indukált asztma kezelésére
BR112020009361A2 (pt)	2020-10-13	composto de fórmula i, composição farmacêutica para tratar um distúrbio ocular ou complicações do mesmo, método de síntese de composto, método de tratamento de um distúrbio ocular ou complicações do mesmo em um indivíduo que precisa do mesmo e uso de um composto
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US4141993A (en)	1979-02-27	Compounds of diphenylcyclopentylamine type and methods for their preparation
US4053637A (en)	1977-10-11	Compounds of diphenylcyclopentylamine type and methods for their uses
Kaur et al.	2023	Pharmacotherapeutic Perspectives on Adrenergic Agonists
Zwieten	2011	of Hypertension
ZA200107187B (en)	2002-09-05	Method for treating exercise induced asthma.
Biaggioni	1991	Dopamine/8-Hydroxylase Deficiency A Genetic Disorder of Cardiovascular Regulation
MXPA01008858A (en)	2002-05-09	Method for treating exercise induced asthma