NO326871B1 - Nye peptidforbindelser med antiangiogene egenskaper, sammensetninger og medikamenter inneholdende disse. - Google Patents

Nye peptidforbindelser med antiangiogene egenskaper, sammensetninger og medikamenter inneholdende disse. Download PDF

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Publication number
NO326871B1
NO326871B1 NO20005890A NO20005890A NO326871B1 NO 326871 B1 NO326871 B1 NO 326871B1 NO 20005890 A NO20005890 A NO 20005890A NO 20005890 A NO20005890 A NO 20005890A NO 326871 B1 NO326871 B1 NO 326871B1
Authority
NO
Norway
Prior art keywords
ile
tfa
fmoc
acetonitrile
gly
Prior art date
Application number
NO20005890A
Other languages
English (en)
Norwegian (no)
Other versions
NO20005890L (no
NO20005890D0 (no
Inventor
Fortuna Haviv
Jack Henkin
Michael F Bradley
Douglas M Kalvin
Andrew J Schneider
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of NO20005890D0 publication Critical patent/NO20005890D0/no
Publication of NO20005890L publication Critical patent/NO20005890L/no
Publication of NO326871B1 publication Critical patent/NO326871B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
NO20005890A 1998-05-22 2000-11-21 Nye peptidforbindelser med antiangiogene egenskaper, sammensetninger og medikamenter inneholdende disse. NO326871B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8374598A 1998-05-22 1998-05-22
US25057499A 1999-02-16 1999-02-16
US27746699A 1999-03-26 1999-03-26
PCT/US1999/011448 WO1999061476A1 (en) 1998-05-22 1999-05-21 Peptide antiangiogenic drugs

Publications (3)

Publication Number Publication Date
NO20005890D0 NO20005890D0 (no) 2000-11-21
NO20005890L NO20005890L (no) 2001-01-12
NO326871B1 true NO326871B1 (no) 2009-03-09

Family

ID=27374598

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005890A NO326871B1 (no) 1998-05-22 2000-11-21 Nye peptidforbindelser med antiangiogene egenskaper, sammensetninger og medikamenter inneholdende disse.

Country Status (25)

Country Link
EP (1) EP1078002B1 (cs)
JP (3) JP3753612B2 (cs)
KR (1) KR100447696B1 (cs)
CN (1) CN1311796A (cs)
AR (1) AR018371A1 (cs)
AT (1) ATE396204T1 (cs)
AU (1) AU764277B2 (cs)
BG (1) BG65065B1 (cs)
BR (1) BR9910639A (cs)
CA (1) CA2329250C (cs)
CO (1) CO5080726A1 (cs)
CY (1) CY1109118T1 (cs)
CZ (1) CZ299639B6 (cs)
DE (1) DE69938782D1 (cs)
ES (1) ES2307337T3 (cs)
HU (1) HUP0102579A3 (cs)
NO (1) NO326871B1 (cs)
NZ (1) NZ507912A (cs)
PL (1) PL200471B1 (cs)
PT (1) PT1078002E (cs)
SI (1) SI1078002T1 (cs)
SK (1) SK286554B6 (cs)
TR (1) TR200003442T2 (cs)
TW (1) TWI247748B (cs)
WO (1) WO1999061476A1 (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774211B1 (en) 1998-05-22 2004-08-10 Abbott Laboratories Peptide antiangiogenic drugs
PT1122262E (pt) 1998-10-16 2010-01-27 Otsuka Pharma Co Ltd Péptidos específicos de zonas neovasculares
HK1042114B (zh) 1998-10-23 2006-09-29 Amgen K-A, Inc. 与mp1受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
US20020183242A1 (en) * 2001-04-11 2002-12-05 Jack Henkin Peptide antiangiogenic drugs
US20030050246A1 (en) * 2001-07-26 2003-03-13 Fortuna Haviv Peptides having antiangiogenic activity
US20030105025A1 (en) * 2001-10-31 2003-06-05 Fortuna Haviv Tri-and tetrapeptides having antiangiogenic activity
US20030125259A1 (en) 2001-10-31 2003-07-03 Fortuna Haviv Octa- and nonapeptides having antiangiogenic activity
US7001984B2 (en) 2001-10-31 2006-02-21 Abbott Laboratories Di-, tri-, and tetra-peptides having antiangiogenic activity
EP1451209A4 (en) * 2001-10-31 2009-06-03 Abbott Lab TETRA-, PENTA-, HEXA- AND HEPTAPEPTIDES HAVING ANTI-ANGIOGENIC ACTIVITY
US7037897B2 (en) 2001-10-31 2006-05-02 Abbott Laboratories TRI-, TETRA-, and penta-peptides having antiangiogenic activity
US7169888B2 (en) 2001-10-31 2007-01-30 Abbott Laboratories Tetra-, penta-, hexa- and heptapeptides having antiangiogenic activity
US20030119746A1 (en) * 2001-10-31 2003-06-26 Fortuna Haviv Hepta-and octapeptides having antiangiogenic activity
PL374238A1 (en) * 2001-10-31 2005-10-03 Abbott Laboratories Hepta-, octa- and nonapeptides having antiangiogenic activity
US7122625B2 (en) 2001-10-31 2006-10-17 Abbott Laboratories Hexa-, hepta-, and octapeptides having antiangiogenic activity
US7067490B2 (en) 2001-10-31 2006-06-27 Abbott Laboratories Hepta-, Octa-and nonapeptides having antiangiogenic activity
US20030125260A1 (en) * 2001-10-31 2003-07-03 Fortuna Haviv Tetra-and pentapeptides having antiangiogenic activity
MXPA04009228A (es) 2002-03-22 2005-08-16 Gpc Biotech Ag Compuestos inmunosupresores, metodos y usos relacionados con los mismos.
US20030228365A1 (en) * 2002-06-07 2003-12-11 Fortuna Haviv Pharmaceutical formulation
US7432245B2 (en) 2002-06-07 2008-10-07 Abbott Laboratories Inc. Pharmaceutical formulation comprising a peptide angiogenesis inhibitor
US7442778B2 (en) 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
EP1853294A4 (en) 2005-03-03 2010-01-27 Covx Technologies Ireland Ltd ANTIANGIOGENIC COMPOUNDS
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
JP2007255910A (ja) * 2006-03-20 2007-10-04 Hokkaido Univ Nmrシグナルの帰属方法
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
WO2008003013A2 (en) * 2006-06-29 2008-01-03 Abbott Laboratories Antitumorigenic drug combination comprising an hdac inhibitor and a tsp-1 peptidomimetic
CN104004057B (zh) * 2013-02-25 2016-08-24 上海市第一人民医院 一类抑制新生血管的小肽及其应用
CN107778355B (zh) * 2016-08-25 2021-04-20 成都圣诺生物制药有限公司 一种合成西曲瑞克的方法
JP2025001049A (ja) * 2021-09-01 2025-01-08 積水メディカル株式会社 アルギニン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200397A (en) * 1990-02-22 1993-04-06 W. R. Grace & Co.-Conn. Use of peptide analogs of thrombospondin for the inhibition of angiogenic activity
WO1993016716A1 (en) * 1992-02-24 1993-09-02 Northwestern University Method and composition for inhibiting angiogenesis
ES2246513T3 (es) * 1996-05-03 2006-02-16 Abbott Laboratories Nuevos peptidos anti-angiogenicos, polinucleotidos que los codifican y procedimientos de inhibicion de la angiogenesis.
CA2255661C (en) * 1997-03-17 2004-08-10 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy

Also Published As

Publication number Publication date
NO20005890L (no) 2001-01-12
SK17632000A3 (sk) 2001-07-10
EP1078002B1 (en) 2008-05-21
AU4407599A (en) 1999-12-13
KR100447696B1 (ko) 2004-09-08
DE69938782D1 (de) 2008-07-03
NO20005890D0 (no) 2000-11-21
TR200003442T2 (tr) 2001-03-21
ES2307337T3 (es) 2008-11-16
CZ299639B6 (cs) 2008-10-01
SK286554B6 (sk) 2008-12-05
BG105064A (en) 2001-08-31
NZ507912A (en) 2002-10-25
KR20010025093A (ko) 2001-03-26
HUP0102579A2 (hu) 2002-01-28
JP2006001923A (ja) 2006-01-05
BR9910639A (pt) 2002-01-15
TWI247748B (en) 2006-01-21
JP2006232840A (ja) 2006-09-07
SI1078002T1 (sl) 2008-10-31
CY1109118T1 (el) 2014-07-02
CZ20004327A3 (cs) 2001-08-15
AR018371A1 (es) 2001-11-14
ATE396204T1 (de) 2008-06-15
CN1311796A (zh) 2001-09-05
CA2329250A1 (en) 1999-12-02
JP3795906B2 (ja) 2006-07-12
CO5080726A1 (es) 2001-09-25
HK1037376A1 (en) 2002-02-08
BG65065B1 (bg) 2007-01-31
PL200471B1 (pl) 2009-01-30
PL344415A1 (en) 2001-11-05
WO1999061476A1 (en) 1999-12-02
JP3753612B2 (ja) 2006-03-08
PT1078002E (pt) 2008-09-02
JP2002516342A (ja) 2002-06-04
HUP0102579A3 (en) 2002-02-28
CA2329250C (en) 2012-03-27
AU764277B2 (en) 2003-08-14
EP1078002A1 (en) 2001-02-28

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