NO327713B1 - Sammensetninger for reduksjon av okulaer hypertensjon og anvendelse av sammensetning - Google Patents

Sammensetninger for reduksjon av okulaer hypertensjon og anvendelse av sammensetning Download PDF

Info

Publication number: NO327713B1
Authority: NO; Norway
Prior art keywords: composition according; preservative; weight; prostaglandin; composition
Prior art date: 1997-03-17

Application number

NO19994481A

Other languages

English (en)

Norwegian (no)

Other versions

NO994481L (no

NO994481D0 (no

Inventor

Mary Sou

Shau-Fong Yen

Kenneth W Reed

Regina Flinn Peacock

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-17

Filing date

1999-09-16

Publication date

2009-09-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38729083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO327713(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-09-16 Application filed by Novartis Ag filed Critical Novartis Ag

1999-09-16 Publication of NO994481L publication Critical patent/NO994481L/no

1999-09-16 Publication of NO994481D0 publication Critical patent/NO994481D0/no

2009-09-14 Publication of NO327713B1 publication Critical patent/NO327713B1/no

Links

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239000002504 physiological saline solution Substances 0.000 description 1
HZOTZTANVBDFOF-PBCQUBLHSA-N physostigmine salicylate Chemical compound OC(=O)C1=CC=CC=C1O.C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C HZOTZTANVBDFOF-PBCQUBLHSA-N 0.000 description 1
229960002516 physostigmine salicylate Drugs 0.000 description 1
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RNAICSBVACLLGM-GNAZCLTHSA-N pilocarpine hydrochloride Chemical compound Cl.C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C RNAICSBVACLLGM-GNAZCLTHSA-N 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
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239000000651 prodrug Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000004044 response Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
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229940124530 sulfonamide Drugs 0.000 description 1
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230000002195 synergetic effect Effects 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005207 tetraalkylammonium group Chemical class 0.000 description 1
TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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230000001052 transient effect Effects 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

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Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Ophthalmology & Optometry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO19994481A 1997-03-17 1999-09-16 Sammensetninger for reduksjon av okulaer hypertensjon og anvendelse av sammensetning NO327713B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US81922197A	1997-03-17	1997-03-17
PCT/EP1998/001483 WO1998041208A1 (en)	1997-03-17	1998-03-13	Compositions and methods for reducing ocular hypertension

Publications (3)

Publication Number	Publication Date
NO994481L NO994481L (no)	1999-09-16
NO994481D0 NO994481D0 (no)	1999-09-16
NO327713B1 true NO327713B1 (no)	2009-09-14

Family

ID=38729083

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Application Number	Title	Priority Date	Filing Date
NO19994481A NO327713B1 (no)	1997-03-17	1999-09-16	Sammensetninger for reduksjon av okulaer hypertensjon og anvendelse av sammensetning

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Country	Link
EP (1)	EP0969846B2 (da)
JP (2)	JP4920124B2 (da)
KR (1)	KR100555818B1 (da)
CN (1)	CN1236775C (da)
AR (2)	AR002194A1 (da)
AT (1)	ATE257385T1 (da)
AU (1)	AU738781B2 (da)
BR (2)	BR9808016A (da)
CA (1)	CA2280089C (da)
CL (1)	CL2009001870A1 (da)
CO (1)	CO4940427A1 (da)
CY (1)	CY2526B1 (da)
CZ (1)	CZ299833B6 (da)
DE (1)	DE69820997T3 (da)
DK (1)	DK0969846T4 (da)
EE (1)	EE04091B1 (da)
ES (1)	ES2214706T5 (da)
HU (1)	HU228896B1 (da)
ID (1)	ID22389A (da)
IL (1)	IL131041A0 (da)
MY (1)	MY122237A (da)
NO (1)	NO327713B1 (da)
NZ (1)	NZ337322A (da)
PE (1)	PE61899A1 (da)
PL (1)	PL197509B1 (da)
PT (1)	PT969846E (da)
RU (1)	RU2197970C2 (da)
SI (1)	SI0969846T2 (da)
TW (1)	TW527187B (da)
UA (1)	UA63938C2 (da)
WO (1)	WO1998041208A1 (da)
ZA (1)	ZA982188B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6011062A (en) *	1994-12-22	2000-01-04	Alcon Laboratories, Inc.	Storage-stable prostaglandin compositions
AR002194A1 (es) *	1997-03-17	1998-01-07	Sanchez Reynaldo Alemany	Instrumento computarizado para el analisis del movimiento.
US6187818B1 (en) *	1998-06-17	2001-02-13	Pharmacia & Upjohn Company	Prostaglandins formulation and process
JP4880808B2 (ja) *	1999-11-15	2012-02-22	久光製薬株式会社	人工涙液型点眼剤組成物
JP4000505B2 (ja) *	1999-12-01	2007-10-31	第一三共株式会社	緑内障を治療するための併用剤
CA2422031C (en) *	2000-09-13	2011-11-15	Santen Pharmaceutical Co., Ltd.	Ophthalmic solutions comprising difluoroprostaglandin f2 alpha
WO2002045748A1 (en) *	2000-12-05	2002-06-13	Sankyo Company, Limited	Ocular tension-lowering compositions for topical administration
US20020198209A1 (en) *	2001-05-03	2002-12-26	Allergan Sales Inc.	Compositions having enhanced pharmacokinetic characteristics
US7074827B2 (en)	2002-10-24	2006-07-11	Sucampo Ag (Usa) Inc.	Method for treating ocular hypertension and glaucoma
RU2266572C1 (ru) *	2004-03-17	2005-12-20	Российский государственный медицинский университет	Способ моделирования злокачественной артериальной гипертонии
US20070208068A1 (en) *	2004-03-18	2007-09-06	R-Tech Ueno, Ltd. & Astellas Pharma Inc.	Aqueous Composition Comprising Thiazole Derivative
US8569367B2 (en)	2004-11-16	2013-10-29	Allergan, Inc.	Ophthalmic compositions and methods for treating eyes
GB0501192D0 (en) *	2005-01-20	2005-03-02	Resolution Chemicals Ltd	Stable prostaglandin-containing compositions
US7851504B2 (en) *	2005-03-16	2010-12-14	Allergan, Inc.	Enhanced bimatoprost ophthalmic solution
DE202005005094U1 (de) *	2005-03-31	2005-07-28	Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh	Ophthalmische Zusammensetzung
JP5252787B2 (ja) *	2005-08-02	2013-07-31	参天製薬株式会社	熱的に不安定な薬物の分解抑制方法
US8030349B2 (en) *	2005-08-02	2011-10-04	Santen Pharmaceutical Co., Ltd.	Method for prevention of degradation of thermally unstable medicament
JP2007099647A (ja) *	2005-09-30	2007-04-19	Kobayashi Pharmaceut Co Ltd	粘膜適用組成物
US8168206B1 (en)	2005-10-06	2012-05-01	Allergan, Inc.	Animal protein-free pharmaceutical compositions
CA2645311C (en) *	2006-03-13	2014-11-18	R-Tech Ueno, Ltd.	Aqueous composition comprising 15-keto-prostaglandin for ophthalmic use
AR059927A1 (es) *	2006-03-17	2008-05-07	Johnson & Johnson Vision Care	Metodos para la estabilizacion de composiciones inestables a la oxidacion y composiciones oftalmicas estabilizadas
ZA200902453B (en) *	2006-10-31	2010-07-28	Alcon Res Ltd	PAI-1 binding modulators for the treatment of ocular disorders
US20100120908A1 (en) *	2007-02-07	2010-05-13	Teika Pharmaceutical Co., Ltd	Eye drop preparation comprising latanoprost
JP2009073788A (ja) *	2007-09-21	2009-04-09	Teika Seiyaku Kk	イソプロピルウノプロストン含有眼用組成物
BRPI0819081A8 (pt) *	2007-10-08	2016-08-30	Fovea Pharmaceuticals Sa	Formulação oftálmica aquosa, processo para preparar a mesma, e, método para inibir, tratar ou prevenir doenças oculares e doença ou condição relacionada, em um paciente em necessidade de tal tratamento
CN101959500A (zh) *	2008-03-17	2011-01-26	爱尔康研究有限公司	包含硼酸类化合物-多元醇络合物的水性药物组合物
TWI544927B (zh)	2008-03-17	2016-08-11	愛爾康研究有限公司	具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物
EP2127638A1 (en)	2008-05-30	2009-12-02	Santen Pharmaceutical Co., Ltd	Method and composition for treating ocular hypertension and glaucoma
RU2402316C2 (ru) *	2009-01-11	2010-10-27	Пшеничников Виталий Георгиевич	Фармацевтическая антиглаукомная композиция
US8952051B2 (en) *	2009-11-05	2015-02-10	Allergan, Inc.	Ophthalmic formulations containing substituted gamma lactams and methods for use thereof
KR20140038404A (ko) *	2011-04-12	2014-03-28	가부시키가이샤 아루떼꾸 우에노	수성 안과용 조성물
US20130029919A1 (en) *	2011-07-26	2013-01-31	Allergan, Inc.	Two part formulation system for opthalmic delivery
EP2567689A1 (en)	2011-09-12	2013-03-13	Visiotact Pharma	Ophthtalmic compositions comprising prostaglandin F2 alpha derivatives and hyaluronic acid
US8957048B2 (en)	2011-10-06	2015-02-17	Allergan, Inc.	Compositions for the treatment of dry eye
EP2787969B1 (en)	2011-12-07	2021-09-29	Allergan, Inc.	Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US9907826B2 (en)	2011-12-07	2018-03-06	Allergan, Inc.	Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
EP3223794A1 (en)	2014-11-25	2017-10-04	Allergan, Inc.	Stabilized omega-3 ophthalmic compositions
WO2020061550A1 (en) *	2018-09-21	2020-03-26	Aufbau Medical Innovations Limited	Compositions and methods for glaucoma
MX2021012399A (es)	2019-04-12	2021-12-10	Ecolab Usa Inc	Limpiador antimicrobiano multiuso y métodos de fabricación y uso de este.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2059058T3 (es) *	1990-05-22	1994-11-01	R Tech Ueno Ltd	Combinacion sinergica para uso oftalmico.
US5767154A (en) *	1991-02-07	1998-06-16	Allergan	5-trans-prostaglandins of the F series and their use as ocular hypotensives
WO1992013836A1 (en) *	1991-02-07	1992-08-20	Allergan, Inc.	2-decarboxyl-2-hydroxyalkyl-5-trans prostaglandin f derivatives
CA2166722A1 (en) *	1994-05-06	1995-11-16	Manoj L. Maniar	Use of vitamin e tocopheryl derivatives in ophthalmic compositions
US5631287A (en) †	1994-12-22	1997-05-20	Alcon Laboratories, Inc.	Storage-stable prostaglandin compositions
US5558876A (en) *	1995-03-29	1996-09-24	Alcon Laboratories, Inc.	Topical ophthalmic acidic drug formulations
AR002194A1 (es) *	1997-03-17	1998-01-07	Sanchez Reynaldo Alemany	Instrumento computarizado para el analisis del movimiento.

1996
- 1996-06-03 AR ARP960102868A patent/AR002194A1/es unknown
1998
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Publication number	Publication date
PL197509B1 (pl)	2008-04-30
DE69820997D1 (de)	2004-02-12
CZ299833B6 (cs)	2008-12-10
JP2010043110A (ja)	2010-02-25
EE9900410A (et)	2000-04-17
SI0969846T2 (sl)	2010-12-31
KR20000076330A (ko)	2000-12-26
RU2197970C2 (ru)	2003-02-10
CN1236775C (zh)	2006-01-18
DK0969846T4 (da)	2010-12-20
NO994481L (no)	1999-09-16
SI0969846T1 (en)	2004-06-30
CN1249687A (zh)	2000-04-05
PT969846E (pt)	2004-05-31
PL335168A1 (en)	2000-04-10
MY122237A (en)	2006-04-29
CO4940427A1 (es)	2000-07-24
CL2009001870A1 (es)	2010-01-22
DE69820997T2 (de)	2004-12-09
EE04091B1 (et)	2003-08-15
CY2526B1 (en)	2006-02-08
CA2280089C (en)	2009-03-03
EP0969846A1 (en)	2000-01-12
AR011192A1 (es)	2000-08-02
PE61899A1 (es)	1999-06-30
BR9808016A (pt)	2000-03-08
IL131041A0 (en)	2001-01-28
DE69820997T3 (de)	2011-10-06
HU228896B1 (en)	2013-06-28
CZ325799A3 (cs)	2000-01-12
BRPI9816218B1 (pt)	2016-04-12
AU7035398A (en)	1998-10-12
EP0969846B2 (en)	2010-08-25
JP4920124B2 (ja)	2012-04-18
AU738781B2 (en)	2001-09-27
CA2280089A1 (en)	1998-09-24
DK0969846T3 (da)	2004-04-13
NO994481D0 (no)	1999-09-16
ES2214706T5 (es)	2011-02-02
TW527187B (en)	2003-04-11
NZ337322A (en)	2001-05-25
JP2001515502A (ja)	2001-09-18
ATE257385T1 (de)	2004-01-15
HK1026841A1 (en)	2000-12-29
ID22389A (id)	1999-10-07
KR100555818B1 (ko)	2006-03-03
ZA982188B (en)	1998-09-17
EP0969846B1 (en)	2004-01-07
HUP0002194A2 (hu)	2000-12-28
HUP0002194A3 (en)	2012-08-28
UA63938C2 (uk)	2004-02-16
WO1998041208A1 (en)	1998-09-24
ES2214706T3 (es)	2004-09-16
AR002194A1 (es)	1998-01-07

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2015-10-26	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP0969846B1 (en)	2004-01-07	Compositions and methods for reducing ocular hypertension
US6770675B2 (en)	2004-08-03	Compositions and methods for reducing ocular hypertension
Shah et al.	2000	Oculohypotensive effect of angiotensin-converting enzyme inhibitors in acute and chronic models of glaucoma
EP0473159B1 (en)	1995-03-08	Stable aqueous preparation
US5725887A (en)	1998-03-10	Method of preserving ophthalmic solutions and compositions therefor
JP2012162570A (ja)	2012-08-30	高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物
JP5167499B2 (ja)	2013-03-21	光角膜切除における角膜組織の保護のためのピレノキシンの使用
EP0706802B1 (en)	2004-03-24	A method of preserving ophthalmic solutions and compositions therefor
US20110124734A1 (en)	2011-05-26	N-halogenated amino acid formulations and methods for cleaning and disinfection
CA2146006C (en)	2004-10-12	Use of ergoline derivatives for the treatment of glaucoma
HK1026841B (en)	2004-09-24	Compositions and methods for reducing ocular hypertension
GB2100599A (en)	1983-01-06	Pharmaceutical preparation for treating glaucoma and ocular hypertension
WO2003020283A2 (en)	2003-03-13	Method for treating diabetic retinopathy
CA2076023A1 (en)	1991-09-20	Use of 5-trans prostaglandin f as an ocular hypotensive agent
HK1070830B (en)	2009-07-03	Hypotensive lipid and timolol compositions and methods of using same