NO328048B1 - Farmasoytisk preparat omfattende ZD6474 og et taxan, sett omfattende samme samt anvendelse av samme for fremstilling av medikament for behandling av sykdom - Google Patents

Farmasoytisk preparat omfattende ZD6474 og et taxan, sett omfattende samme samt anvendelse av samme for fremstilling av medikament for behandling av sykdom Download PDF

Info

Publication number: NO328048B1
Authority: NO; Norway
Prior art keywords: taxane; pharmaceutically acceptable; tumor; warm; human
Prior art date: 2001-11-08

Application number

NO20042365A

Other languages

English (en)

Norwegian (no)

Other versions

NO20042365L (no

Inventor

Stephen Robert Wedge

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-08

Filing date

2004-06-07

Publication date

2009-11-16

2004-06-07 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2004-06-07 Publication of NO20042365L publication Critical patent/NO20042365L/no

2009-11-16 Publication of NO328048B1 publication Critical patent/NO328048B1/no

Links

UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 title claims description 97
229940123237 Taxane Drugs 0.000 title claims description 71
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title claims description 70
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

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Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20042365A 2001-11-08 2004-06-07 Farmasoytisk preparat omfattende ZD6474 og et taxan, sett omfattende samme samt anvendelse av samme for fremstilling av medikament for behandling av sykdom NO328048B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0126879.6A GB0126879D0 (en)	2001-11-08	2001-11-08	Combination therapy
PCT/GB2002/005021 WO2003039551A1 (en)	2001-11-08	2002-11-06	Combination therapy comprising zd6474 and a taxane

Publications (2)

Publication Number	Publication Date
NO20042365L NO20042365L (no)	2004-06-07
NO328048B1 true NO328048B1 (no)	2009-11-16

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US (2)	US20050043395A1 (de)
EP (1)	EP1446124B1 (de)
JP (1)	JP4694127B2 (de)
KR (1)	KR100959607B1 (de)
CN (1)	CN1298328C (de)
AR (1)	AR037346A1 (de)
AT (1)	ATE335488T1 (de)
AU (1)	AU2002337382B2 (de)
BR (1)	BR0213906A (de)
CA (1)	CA2464758C (de)
CY (1)	CY1106259T1 (de)
DE (1)	DE60213845T2 (de)
DK (1)	DK1446124T3 (de)
ES (1)	ES2269769T3 (de)
GB (1)	GB0126879D0 (de)
IL (2)	IL161744A0 (de)
MX (1)	MXPA04004355A (de)
NO (1)	NO328048B1 (de)
NZ (1)	NZ532525A (de)
PT (1)	PT1446124E (de)
WO (1)	WO2003039551A1 (de)
ZA (1)	ZA200403455B (de)

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GB0218526D0 (en) *	2002-08-09	2002-09-18	Astrazeneca Ab	Combination therapy
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DE602004032310D1 (de) *	2003-02-13	2011-06-01	Astrazeneca Ab	Kombinationstherapie von zd6474 mit 5-fu oder/und cpt-11
GB0310401D0 (en) *	2003-05-07	2003-06-11	Astrazeneca Ab	Therapeutic agent
JP2007526886A (ja) *	2003-07-10	2007-09-20	アストラゼネカアクチボラグ	血管新生および／または血管透過性増大に関連する疾患の処置における、プラチナ系抗腫瘍剤および任意の電離放射線と組み合わせてのキナゾリン誘導体ｚｄ６４７４の使用
JP2007511509A (ja) *	2003-11-14	2007-05-10	ファルマ・マール・ソシエダード・アノニマ	Ｅｔ−７４３およびパクリタキセルの使用を含むガンの併用療法
GB0406445D0 (en) *	2004-03-23	2004-04-28	Astrazeneca Ab	Combination therapy
GB0411378D0 (en) *	2004-05-21	2004-06-23	Astrazeneca Ab	Pharmaceutical compositions
CA2571421A1 (en) *	2004-06-24	2006-01-05	Nicholas Valiante	Compounds for immunopotentiation
KR20070072543A (ko) *	2004-09-27	2007-07-04	아스트라제네카 아베	Ｚｄ6474 및 이마티닙을 포함하는 병합법
GB0424339D0 (en) *	2004-11-03	2004-12-08	Astrazeneca Ab	Combination therapy
GB0519879D0 (en)	2005-09-30	2005-11-09	Astrazeneca Ab	Chemical process
CA2631764A1 (en) *	2005-12-22	2007-06-28	Astrazeneca Ab	Combination of zd6474 and pemetrexed
US20080045589A1 (en) *	2006-05-26	2008-02-21	Susan Kelley	Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer
WO2008037996A1 (en) *	2006-09-29	2008-04-03	Astrazeneca Ab	Combination of zd6474 and bevacizumab for cancer therapy
US20080190689A1 (en) *	2007-02-12	2008-08-14	Ballard Ebbin C	Inserts for engine exhaust systems
MX2010012442A (es) *	2008-05-13	2011-10-11	Astrazeneca Ab	Sal de fumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(n-m etilcarbamoilmetil) piperidin-4-il]oxi}quinazolina.
WO2010061208A2 (en) *	2008-11-03	2010-06-03	Astrazeneca Ab	Therapeutic treatment 555
CN106397401B (zh) *	2016-08-30	2018-11-13	山东罗欣药业集团股份有限公司	一种抗癌药物的晶体化合物及其制备方法
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AU2003249000B2 (en) *	2002-08-09	2007-04-05	Astrazeneca Ab	Combination of ZD6474, an inhibitor of the vasuclar endothelial growth factor receptor, with radiotherapy in the treatment of cancer
GB0218526D0 (en) *	2002-08-09	2002-09-18	Astrazeneca Ab	Combination therapy
GB0223380D0 (en) *	2002-10-09	2002-11-13	Astrazeneca Ab	Combination therapy
DE602004032310D1 (de) *	2003-02-13	2011-06-01	Astrazeneca Ab	Kombinationstherapie von zd6474 mit 5-fu oder/und cpt-11
JP2007526886A (ja) *	2003-07-10	2007-09-20	アストラゼネカアクチボラグ	血管新生および／または血管透過性増大に関連する疾患の処置における、プラチナ系抗腫瘍剤および任意の電離放射線と組み合わせてのキナゾリン誘導体ｚｄ６４７４の使用
KR20070072543A (ko) *	2004-09-27	2007-07-04	아스트라제네카 아베	Ｚｄ6474 및 이마티닙을 포함하는 병합법
GB0424339D0 (en) *	2004-11-03	2004-12-08	Astrazeneca Ab	Combination therapy
CA2631764A1 (en) *	2005-12-22	2007-06-28	Astrazeneca Ab	Combination of zd6474 and pemetrexed
WO2008037996A1 (en) *	2006-09-29	2008-04-03	Astrazeneca Ab	Combination of zd6474 and bevacizumab for cancer therapy

2001
- 2001-11-08 GB GBGB0126879.6A patent/GB0126879D0/en not_active Ceased
2002
- 2002-11-06 AT AT02772624T patent/ATE335488T1/de active
- 2002-11-06 BR BR0213906-5A patent/BR0213906A/pt not_active IP Right Cessation
- 2002-11-06 EP EP02772624A patent/EP1446124B1/de not_active Expired - Lifetime
- 2002-11-06 DE DE60213845T patent/DE60213845T2/de not_active Expired - Lifetime
- 2002-11-06 KR KR1020047007020A patent/KR100959607B1/ko not_active Expired - Fee Related
- 2002-11-06 IL IL16174402A patent/IL161744A0/xx unknown
- 2002-11-06 MX MXPA04004355A patent/MXPA04004355A/es active IP Right Grant
- 2002-11-06 DK DK02772624T patent/DK1446124T3/da active
- 2002-11-06 ES ES02772624T patent/ES2269769T3/es not_active Expired - Lifetime
- 2002-11-06 CA CA2464758A patent/CA2464758C/en not_active Expired - Fee Related
- 2002-11-06 WO PCT/GB2002/005021 patent/WO2003039551A1/en not_active Ceased
- 2002-11-06 CN CNB028267958A patent/CN1298328C/zh not_active Expired - Fee Related
- 2002-11-06 AU AU2002337382A patent/AU2002337382B2/en not_active Ceased
- 2002-11-06 NZ NZ532525A patent/NZ532525A/en not_active IP Right Cessation
- 2002-11-06 US US10/494,704 patent/US20050043395A1/en not_active Abandoned
- 2002-11-06 JP JP2003541842A patent/JP4694127B2/ja not_active Expired - Fee Related
- 2002-11-06 PT PT02772624T patent/PT1446124E/pt unknown
- 2002-11-08 AR ARP020104292A patent/AR037346A1/es not_active Application Discontinuation
2004
- 2004-05-03 IL IL161744A patent/IL161744A/en not_active IP Right Cessation
- 2004-05-06 ZA ZA200403455A patent/ZA200403455B/en unknown
- 2004-06-07 NO NO20042365A patent/NO328048B1/no not_active IP Right Cessation
2006
- 2006-11-09 CY CY20061101619T patent/CY1106259T1/el unknown
2011
- 2011-11-07 US US13/290,730 patent/US20120252827A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL161744A (en)	2012-01-31
DK1446124T3 (da)	2006-11-13
CN1612738A (zh)	2005-05-04
NO20042365L (no)	2004-06-07
CN1298328C (zh)	2007-02-07
DE60213845T2 (de)	2007-03-29
KR100959607B1 (ko)	2010-05-27
US20050043395A1 (en)	2005-02-24
AU2002337382B2 (en)	2008-06-12
AR037346A1 (es)	2004-11-03
ZA200403455B (en)	2005-08-29
CY1106259T1 (el)	2011-06-08
JP4694127B2 (ja)	2011-06-08
EP1446124A1 (de)	2004-08-18
WO2003039551A1 (en)	2003-05-15
MXPA04004355A (es)	2004-08-11
ES2269769T3 (es)	2007-04-01
PT1446124E (pt)	2006-12-29
CA2464758C (en)	2010-09-28
NZ532525A (en)	2006-11-30
HK1068546A1 (en)	2005-04-29
BR0213906A (pt)	2004-08-31
KR20050043779A (ko)	2005-05-11
IL161744A0 (en)	2005-11-20
CA2464758A1 (en)	2003-05-15
JP2005511597A (ja)	2005-04-28
DE60213845D1 (de)	2006-09-21
ATE335488T1 (de)	2006-09-15
EP1446124B1 (de)	2006-08-09
GB0126879D0 (en)	2002-01-02
US20120252827A1 (en)	2012-10-04

Legal Events

Date	Code	Title	Description
2014-06-23	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US20120252827A1 (en)	2012-10-04	Combination of therapy comprising zd6474 and a taxane
JP5563950B2 (ja)	2014-07-30	組合せ療法
AU2002337382A1 (en)	2003-07-24	Combination therapy comprising ZD6474 and a taxane
US20100029673A1 (en)	2010-02-04	Therapeutic agents comprising an anti-angiogenic agent in combination with an src-inhibitor and their therapeutic use
US20050222183A1 (en)	2005-10-06	Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer
RS58067B1 (sr)	2019-02-28	Antitumorski agens koji uključuje irinotekan hidrohlorid hidrat u niskoj dozi
ES2364030T3 (es)	2011-08-23	Terapia de combinación de zd6474 con 5-fu y/o cpt-11.
US20240024324A1 (en)	2024-01-25	Kinase inhibitor combinations for cancer treatment
HK1068546B (en)	2007-01-05	Combination therapy comprising zd6474 and a taxane