NO328224B1 - Ikke-invasive, grampositive bakterier og anvendelse av disse til fremstilling av adjuvanser eller vaksiner. - Google Patents

Ikke-invasive, grampositive bakterier og anvendelse av disse til fremstilling av adjuvanser eller vaksiner. Download PDF

Info

Publication number
NO328224B1
NO328224B1 NO19981746A NO981746A NO328224B1 NO 328224 B1 NO328224 B1 NO 328224B1 NO 19981746 A NO19981746 A NO 19981746A NO 981746 A NO981746 A NO 981746A NO 328224 B1 NO328224 B1 NO 328224B1
Authority
NO
Norway
Prior art keywords
gram
invasive
bacterium
biologically active
antigen
Prior art date
Application number
NO19981746A
Other languages
English (en)
Norwegian (no)
Other versions
NO981746L (no
NO981746D0 (no
Inventor
Lothar Steidler
Erik Remaut
Jeremy Mark Wells
Richard William Falla Lepage
Original Assignee
Actogenix Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actogenix Nv filed Critical Actogenix Nv
Publication of NO981746D0 publication Critical patent/NO981746D0/no
Publication of NO981746L publication Critical patent/NO981746L/no
Publication of NO328224B1 publication Critical patent/NO328224B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
NO19981746A 1995-10-20 1998-04-17 Ikke-invasive, grampositive bakterier og anvendelse av disse til fremstilling av adjuvanser eller vaksiner. NO328224B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9521568.7A GB9521568D0 (en) 1995-10-20 1995-10-20 Delivery of biologically active polypeptides
PCT/GB1996/002580 WO1997014806A2 (en) 1995-10-20 1996-10-21 Delivery of biologically active polypeptides

Publications (3)

Publication Number Publication Date
NO981746D0 NO981746D0 (no) 1998-04-17
NO981746L NO981746L (no) 1998-06-22
NO328224B1 true NO328224B1 (no) 2010-01-11

Family

ID=10782670

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19981746A NO328224B1 (no) 1995-10-20 1998-04-17 Ikke-invasive, grampositive bakterier og anvendelse av disse til fremstilling av adjuvanser eller vaksiner.

Country Status (17)

Country Link
US (2) US6605286B2 (de)
EP (1) EP0871748B1 (de)
JP (2) JP2000508162A (de)
KR (1) KR19990064308A (de)
CN (1) CN1195860C (de)
AT (1) ATE435294T1 (de)
AU (1) AU7315496A (de)
BR (1) BR9610929A (de)
CA (1) CA2234941C (de)
DE (1) DE69637961D1 (de)
DK (1) DK0871748T3 (de)
ES (1) ES2328751T3 (de)
GB (1) GB9521568D0 (de)
NO (1) NO328224B1 (de)
NZ (1) NZ320418A (de)
WO (1) WO1997014806A2 (de)
ZA (1) ZA968806B (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
ES2255181T3 (es) * 1997-08-05 2006-06-16 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Antigeno inmunoprotector contra la gripe y su uso en vacunacion.
US6080849A (en) * 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
WO1999013053A1 (en) 1997-09-10 1999-03-18 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
AU770726B2 (en) 1998-10-20 2004-02-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of a cytokine-producing lactococcus strain to treat colitis
FR2791998B1 (fr) * 1999-04-07 2001-06-08 Agronomique Inst Nat Rech Lactocoques modifies exprimant une catalase et leurs utilisations
PT1194554E (pt) 1999-07-05 2007-01-31 Vlaams Interuniv Inst Biotech Libertação de péptidos trifólios
US6962696B1 (en) 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
EP1381345B1 (de) 2001-03-23 2008-07-09 Advanced Bionutrition Corporation Abgabe von mitteln zur krankheitskontrolle in aquakultur unter verwendung von bioaktive proteine enthaltender hefe
US7780961B2 (en) 2001-05-03 2010-08-24 Actogenix N.V. Self-containing Lactococcus strain
DE60319822T2 (de) 2002-06-19 2009-06-04 Actogenix Nv Verfahren und mittel zur erhöhung der darmabsorption
US7937704B2 (en) * 2002-06-20 2011-05-03 British Telecommunications Public Limited Company Distributed computer
US20050129711A1 (en) * 2002-11-14 2005-06-16 Janakiraman Ramachandran Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression
CA2506031A1 (en) * 2002-11-15 2004-06-03 Vib Vzw Self-containing lactobacillus strain comprising a thya mutation and therapeutic applications thereof
GB0230331D0 (en) * 2002-12-31 2003-02-05 British Telecomm Method and apparatus for operating a computer network
US7695725B2 (en) * 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
KR101192652B1 (ko) * 2003-02-06 2012-10-19 앤저 테라퓨틱스 인코퍼레이티드 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법
US7833775B2 (en) * 2003-02-06 2010-11-16 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
EP1599170B1 (de) * 2003-02-21 2013-01-16 Hasumi Llc (Dba Shukokai International) Humanes lymphozyten-vakzineadjuvans
US20070298012A1 (en) * 2003-12-16 2007-12-27 Ivan King Compositions and Methods for Tumor-Targeted Delivery of Effector Molecules
GB0412655D0 (en) * 2004-06-07 2004-07-07 British Telecomm Distributed storage network
ES2439698T3 (es) 2004-08-20 2014-01-24 Actogenix N.V. Procedimiento para mejorar la conservación de lactococos
WO2006036406A2 (en) 2004-08-25 2006-04-06 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Live microbial microbicides
EP1784220B1 (de) 2004-08-26 2017-12-20 The University Of Western Ontario Bakterielle eisen-akquisitions-targets
AU2006236629B2 (en) 2005-04-15 2012-04-19 North Carolina State University Methods and compositions to modulate adhesion and stress tolerance in bacteria
WO2007025977A2 (en) * 2005-08-30 2007-03-08 Actogenix Nv Anti-tnf alpha producing lactic acid bacteria for the treatment of chronic enterocolitis
EP1934349A4 (de) * 2005-08-30 2009-05-27 Commw Scient Ind Res Org Bakterielle zuführung biologisch wirksamer polypeptide
AU2006319216B2 (en) 2005-11-29 2012-09-13 Intrexon Actobiotics Nv Induction of mucosal tolerance to antigens
US8278094B2 (en) 2005-12-14 2012-10-02 The Invention Science Fund I, Llc Bone semi-permeable device
US20110172826A1 (en) * 2005-12-14 2011-07-14 Amodei Dario G Device including altered microorganisms, and methods and systems of use
US8852916B2 (en) 2010-01-22 2014-10-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with microorganisms
US8682619B2 (en) * 2005-12-14 2014-03-25 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8734823B2 (en) * 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
RU2008147398A (ru) * 2006-05-02 2010-06-10 Актогеникс Н.В. (Be) Доставка пептидов, связанных с ожирением, через кишечник посредством микроорганизмов
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
JP2010513245A (ja) * 2006-12-14 2010-04-30 アクトジェニックス・エヌブイ 免疫調節を誘起するための結合分子の送達
EP2115146B1 (de) 2007-01-12 2016-07-06 Intrexon Actobiotics NV Lactococcus-promotoren und verwendungen davon
CN103933563B (zh) * 2007-01-25 2016-09-28 英特瑞克斯顿阿克图比奥帝克斯有限公司 使用遗传修饰的乳杆菌通过抗原的粘膜递送治疗免疫疾病
DK3181682T3 (da) 2008-09-29 2021-07-05 Intrexon Actobiotics Nv Reduceret kolonisering af mikrober på slimhinden
US8241623B1 (en) 2009-02-09 2012-08-14 David Bermudes Protease sensitivity expression system
WO2010124855A1 (en) 2009-04-30 2010-11-04 Actogenix Nv Cryoprotectants for freeze drying of lactic acid bacteria
EP2275527A1 (de) 2009-07-17 2011-01-19 ActoGeniX NV Kulturmedium zur Fermentation von Bakterien welches frei von tierischen Bestandteilen ist
WO2011039137A1 (en) 2009-09-29 2011-04-07 Actogenix N.V. Lactobacillus and streptococcus promoters and uses thereof
EP2343319A1 (de) 2010-01-07 2011-07-13 University of Ljubljana Genetisch modifizierter Lebensmittelgradmikroorganismus zur Behandlung der entzündlichen Darmerkrankung
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
EP2582387A2 (de) 2010-06-17 2013-04-24 The United States Of America As Represented By The Secretary, National Institutes Of Health Zusammensetzungen und verfahren zur behandlung von entzündungserkrankungen
CN101921725B (zh) * 2010-07-27 2013-06-05 浙江大学 一种口服免疫阻断鸡生长抑素作用的转化子及其应用
JP5991650B2 (ja) * 2010-08-10 2016-09-14 国立研究開発法人農業・食品産業技術総合研究機構 サイトカインを発現する豚丹毒菌及び豚丹毒菌を用いたサイトカインのデリバリー方法
WO2012164083A1 (en) 2011-06-01 2012-12-06 Actogenix N.V. Polycistronic expression system for bacteria
WO2013041672A1 (en) 2011-09-23 2013-03-28 Actogenix Nv Modified gram positive bacteria and uses thereof
EP3382006B1 (de) 2011-09-23 2021-02-17 Intrexon Actobiotics NV Modifizierte gram-positive bakterien und verwendungen davon
US9234204B2 (en) 2012-08-07 2016-01-12 TopGeniX, Inc. Topical composition comprising transformed bacteria expressing a compound of interest
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
KR102143856B1 (ko) * 2013-06-11 2020-08-12 하우스 웰니스 푸드 코퍼레이션 대식세포에 물질을 송달하는 담체
KR20170019427A (ko) 2014-06-17 2017-02-21 탑제닉스, 인크. Ｕｖ 차단을 위한 국소용 제형
EP3020816A1 (de) * 2014-11-11 2016-05-18 University College Cork Bakteriell vermittelte Gentherapie
CN104476458B (zh) * 2014-11-14 2016-08-17 中黔电气集团股份有限公司 一种带自动夹紧机构的低压柜骨架组装台
EP3237622B1 (de) * 2014-12-23 2021-02-24 Ilya Pharma AB Verfahren zur wundheilung
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CA3011331C (en) 2016-01-14 2025-05-13 Intrexon Actobiotics N.V. Compositions and methods for the treatment of type 1 diabetes
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
KR102553825B1 (ko) * 2018-05-04 2023-07-13 (주)메디톡스 표적 단백질을 코딩하는 폴리뉴클레오티드를 포함하는 재조합 미생물로부터 유래한 세포외 소낭 및 그의 용도
KR102015116B1 (ko) * 2018-05-04 2019-10-21 (주)메디톡스 표적 단백질을 코딩하는 폴리뉴클레오티드를 포함하는 재조합 미생물로부터 유래한 세포외 소낭 및 그의 용도
PL3921422T3 (pl) * 2019-03-04 2024-04-02 Aurealis Therapeutics AG Indukowalny chlorkiem prokariotyczny układ ekspresji

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes
US5417986A (en) * 1984-03-16 1995-05-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
EP0176320B1 (de) * 1984-09-26 1990-07-25 Eli Lilly And Company Verfahren zur Expression und Sekretion in Bacillus
US5032510A (en) * 1984-09-26 1991-07-16 Eli Lilly And Company Method for expression and secretion in bacillus
US5504005A (en) * 1987-03-02 1996-04-02 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacterial vaccine
US5591632A (en) * 1987-03-02 1997-01-07 Beth Israel Hospital Recombinant BCG
US5330753A (en) * 1987-04-29 1994-07-19 President And Fellows Of Harvard College Cholera vaccines
US6130082A (en) * 1988-05-05 2000-10-10 American Cyanamid Company Recombinant flagellin vaccines
US5149532A (en) * 1989-11-01 1992-09-22 Cedars Sinai Medical Center Method of vaccine or toxoid preparation and immunization by colonization with recombinant microorganisms
GB9006400D0 (en) * 1990-03-22 1990-05-23 Ciba Geigy Ag Bacterial vectors
IL99097A0 (en) * 1990-09-05 1992-07-15 Akzo Nv Haemophilus paragallinarum vaccine
DK0574466T3 (da) * 1991-03-05 1999-11-08 Wellcome Found Udtrykkelse af rekombinante proteiner i svækkede bakterier
IL103530A0 (en) * 1991-10-25 1993-03-15 Duphar Int Res Treponema hyodysenteriae vaccine
JPH07504815A (ja) * 1992-02-27 1995-06-01 マイクロバイアル　テクニクス　リミティド 乳酸菌における異種遺伝子の発現およびその発現産物
US5455034A (en) * 1992-06-26 1995-10-03 Kansas State University Research Foundation Fusobacterium necrophorum leukotoxoid vaccine
US5837509A (en) * 1992-12-30 1998-11-17 Bioteknologisk Institut Recombinant lactic acid bacterium containing an inserted promoter and method of constructing same
IT1270123B (it) * 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
US5733540A (en) * 1995-03-08 1998-03-31 Lee; Peter Poon-Hang Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria
US5824538A (en) * 1995-09-06 1998-10-20 The United States Of America As Represented By The Secretary Of The Army Shigella vector for delivering DNA to a mammalian cell
GB9518323D0 (en) * 1995-09-07 1995-11-08 Steidler Lothar Materials and methods relating to the attachment and display of substances on cell surfaces
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
JP2000510332A (ja) * 1996-04-19 2000-08-15 ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン インチミンを単独で、または１以上の他の抗原との融合タンパク質として発現する宿主生物の投与による、免疫応答を刺激する方法
US6685943B1 (en) * 1997-01-21 2004-02-03 The Texas A&M University System Fibronectin binding protein compositions and methods of use
PT892054E (pt) * 1997-06-20 2007-02-28 Intervet Int Bv Vacina de clostridium perfringens
US6100388A (en) * 1998-03-16 2000-08-08 Biogaia Biologies Ab Lactobacilli harboring aggregation gene as a vaccine delivery vehicle
US6190669B1 (en) * 1998-05-13 2001-02-20 University Of Maryland, Baltimore Attenuated mutants of salmonella which constitutively express the Vi antigen
AU770726B2 (en) * 1998-10-20 2004-02-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of a cytokine-producing lactococcus strain to treat colitis
CA2426084C (en) * 2000-10-20 2013-12-10 Bioteknologisk Institut Improved fermentation method for production of heterologous gene products in lactic acid bacteria
US7425449B2 (en) * 2002-04-30 2008-09-16 The Regents Of The University Of California Site specific Listeria integration vectors and methods for using the same

Also Published As

Publication number Publication date
DK0871748T3 (da) 2009-10-19
CA2234941C (en) 2010-09-21
US20010006642A1 (en) 2001-07-05
ZA968806B (en) 1998-04-20
CA2234941A1 (en) 1997-04-24
AU7315496A (en) 1997-05-07
WO1997014806A2 (en) 1997-04-24
US6605286B2 (en) 2003-08-12
CN1202934A (zh) 1998-12-23
ATE435294T1 (de) 2009-07-15
EP0871748B1 (de) 2009-07-01
ES2328751T3 (es) 2009-11-17
KR19990064308A (ko) 1999-07-26
EP0871748A2 (de) 1998-10-21
GB9521568D0 (en) 1995-12-20
DE69637961D1 (de) 2009-08-13
NZ320418A (en) 2000-03-27
JP2008067708A (ja) 2008-03-27
MX9803093A (es) 1998-11-29
US20030202991A1 (en) 2003-10-30
WO1997014806A3 (en) 1997-08-21
CN1195860C (zh) 2005-04-06
NO981746L (no) 1998-06-22
BR9610929A (pt) 1999-12-21
JP2000508162A (ja) 2000-07-04
NO981746D0 (no) 1998-04-17

Similar Documents

Publication Publication Date Title
US6605286B2 (en) Delivery of biologically active polypeptides
Galen et al. A murine model of intranasal immunization to assess the immunogenicity of attenuated Salmonella typhi live vector vaccines in stimulating serum antibody responses to expressed foreign antigens
Yuki et al. New generation of mucosal adjuvants for the induction of protective immunity
Bermúdez-Humarán Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins
Bahey-El-Din et al. Lactococcus lactis as a cell factory for delivery of therapeutic proteins
JP6874031B2 (ja) アイメリアに対する免疫応答を強化するか又はアイメリア感染症を制限する組成物及び方法
AU655556B2 (en) Interleukin-2-leukotoxin gene fusions and uses thereof
WO2010061226A1 (en) Composition and method for enhanced secretion of peptides and proteins from bacteria
US7355027B2 (en) Bacillus anthracis protective antigen
Berggren et al. HIV gp120-specific cell-mediated immune responses in mice after oral immunization with recombinant Salmonella
US5273889A (en) Gamma-iterferon-leukotoxin gene fusions and uses thereof
Medaglini et al. In vivo activation of naive CD4+ T cells in nasal mucosa-associated lymphoid tissue following intranasal immunization with recombinant Streptococcus gordonii
CN101048178B (zh) 作为疫苗的重组分枝杆菌和生物活性剂的组合
EP1941024B1 (de) Gedämpfte enterische salmonellen-paratyphi a und verwendungen davon
AU774535B2 (en) Delivery of biologically active polypeptides
WO1999016466A2 (en) Vaccine compositions and methods of enhancing vaccine efficacy
CN104470537B (zh) 表达鼠疫耶尔森氏菌F1‑V融合蛋白的伤寒沙门氏菌Ty21a及其用途
RU2701733C1 (ru) Живая вакцина на основе штамма пробиотиков ENTEROCOCCUS FAECIUM L3 для профилактики инфекции, вызванной STREPTOCOCCUS PNEUMONIE
MXPA98003093A (en) Supply of polypeptides biologically acti
KR100392916B1 (ko) htrA-프로모터를 사용하여 약독된 박테리아 내에서 이종단백질을 발현시키는 방법
KR102259933B1 (ko) 포자 표면발현을 이용한 탄저 포자 백신의 제조방법 및 탄저 포자 백신
Hu Adjuvanticity of chicken interleukin-2 in DNA vaccines and protein vaccines delivered via microspheres
Shaw Jelle ER Thole, Philip J van Dalen, Carin EG Havenith, Peter H Pouwels, Jos FML Seegers, Frans D Tielen, Michèle D van der Zee, Netty D Zegers &
Cho The development of DNA vaccines containing genes expressing specific enterotoxigenic Escherchia [Escherichia] coli antigens and cytokines for the enhancement of antibody production
HK1106929B (zh) 作为疫苗的重组分枝杆菌和生物活性剂的组合

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees